aminobutane bisphosphonate: may be useful measure for controlling hypercalcemia in patients with carcinoma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 169445 |
| CHEMBL ID | 194557 |
| SCHEMBL ID | 4100418 |
| MeSH ID | M0163272 |
| Synonym |
|---|
| 32545-60-1 |
| aminobutane bisphosphonate |
| CHEMBL194557 , |
| (1-amino-1-phosphono-butyl)-phosphonic acid |
| bdbm50173053 |
| (1-amino-1-phosphonobutyl)phosphonic acid |
| abutbp |
| aminobutylidene diphosphonate |
| phosphonic acid, (1-aminobutylidene)bis- |
| aminobutane 1,1-diphosphonate |
| SCHEMBL4100418 |
| aminobutane diphosphonate |
| (1-aminobutane-1,1-diyl)bis(phosphonic acid) |
| DTXSID30954284 |
| STARBLD0004711 |
| EN300-1147535 |
| BQQ4VYG98L |
| p,p'-(1-aminobutylidene)bis[phosphonic acid] |
| phosphonic acid, p,p'-(1-aminobutylidene)bis- |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | IC50 (µMol) | 30.7700 | 0.0002 | 0.7109 | 9.3600 | AID254959 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cholesterol biosynthetic process | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| geranyl diphosphate biosynthetic process | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| farnesyl diphosphate biosynthetic process | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| RNA binding | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| protein binding | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| metal ion binding | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| dimethylallyltranstransferase activity | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| geranyltranstransferase activity | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nucleoplasm | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| cytosol | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| cytoplasm | Farnesyl pyrophosphate synthase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID255859 | Inhibitory concentration against growth of Trypanosoma cruzi epimastigotes | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21 | Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. |
| AID255851 | Inhibitory concentration against growth of Trypanosoma cruzi amastigotes | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21 | Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. |
| AID254959 | Inhibitory concentration against Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS) | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21 | Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| The use of dichloromethylene bisphosphonate and aminobutane bisphosphonate in hypercalcemia of malignancy. Bone and mineral, Volume: 2, Issue: 5 | 1987 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |