norlichexanthone: isolated from fungus P16; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
norlichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 6 and a methyl group at position 8. It has been isolated from Wardomyces anomalus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 5281657 |
| CHEMBL ID | 466154 |
| CHEBI ID | 7632 |
| MeSH ID | M0568988 |
| Synonym |
|---|
| ACON1_001113 |
| ACON0_000599 |
| 1,3,6-trihydroxy-8-methyl-9h-xanthen-9-one |
| norlichexanthone |
| 20716-98-7 |
| NCGC00169665-01 |
| AKOS000365318 |
| BRD-K97951054-001-01-6 |
| CHEMBL466154 , |
| chebi:7632 , |
| 1,3,6-trihydroxy-8-methylxanthen-9-one |
| AC1NQYTV , |
| 9h-xanthen-9-one, 1,3,6-trihydroxy-8-methyl- |
| bdbm50350423 |
| 1,3,6-trihydroxy-8-methyl-xanthen-9-one |
| AQZHBCDRWFMXIN-UHFFFAOYSA-N |
| xanthen-9-one, 1,3,6-trihydroxy-8-methyl- |
| 1,3,6-trihydroxy-8-methyl-9h-xanthen-9-one # |
| DTXSID20174777 |
| 1,3,6-trihydroxy-8-methylxanthone |
| Q27107546 |
| 3,6,8-trihydroxy-1-methylxanthone; fusarindin |
| GLXC-17037 |
| fusarindin |
| BS-1325 |
| Role | Description |
|---|---|
| antimalarial | A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. |
| fungal metabolite | Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| xanthones | Any member of the class of xanthenes based on a xanthone skeleton. |
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 (µMol) | 33.0000 | 0.0013 | 0.2918 | 5.0900 | AID612483 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 (µMol) | 33.3000 | 0.0003 | 0.4308 | 8.0000 | AID612487 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0004 | 0.3722 | 10.0000 | AID612489 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 (µMol) | 0.3000 | 0.0004 | 0.8871 | 10.0000 | AID612492 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 (µMol) | 35.0000 | 0.0002 | 0.5335 | 10.0000 | AID612495 |
| Tyrosine-protein kinase receptor UFO | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0007 | 0.4116 | 9.1000 | AID612485 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0002 | 0.7387 | 10.0000 | AID612481 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 (µMol) | 11.7000 | 0.0000 | 0.4830 | 8.8000 | AID612496 |
| Serine/threonine-protein kinase Nek2 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.1580 | 2.5160 | 8.0000 | AID612490 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 (µMol) | 75.7000 | 0.0001 | 0.7734 | 9.0000 | AID612493 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0002 | 0.6813 | 9.7000 | AID612488 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 0.0002 | 0.5416 | 8.3000 | AID612486 |
| Serine/threonine-protein kinase N1 | Homo sapiens (human) | IC50 (µMol) | 54.9000 | 0.0010 | 1.1157 | 5.8000 | AID612494 |
| Aurora kinase B | Homo sapiens (human) | IC50 (µMol) | 3.0000 | 0.0003 | 0.9634 | 9.8000 | AID612484 |
| Serine/threonine-protein kinase Nek6 | Homo sapiens (human) | IC50 (µMol) | 100.0000 | 1.0650 | 2.6475 | 4.2300 | AID612491 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 (µMol) | 41.3000 | 0.0001 | 0.3107 | 10.0000 | AID612482 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID612490 | Inhibition of recombinant NEK2 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612484 | Inhibition of recombinant Aurora-b assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612497 | Inhibition of VEGF-A induced HUVEC cell sprouting after 24 hrs by angiogenesis assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID1490957 | Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella. |
| AID612488 | Inhibition of wild type MEK1 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355906 | Antimicrobial activity against Chlorella fusca 50 ug/disk by agar diffusion method | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612483 | Inhibition of recombinant ARK5 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612485 | Inhibition of recombinant AXL assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355896 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID355895 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID1490958 | Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay | 2017 | Journal of natural products, 05-26, Volume: 80, Issue:5 | Halogenated Compounds from Directed Fermentation of Penicillium concentricum, an Endophytic Fungus of the Liverwort Trichocolea tomentella. |
| AID355902 | Antibacterial activity against Bacillus megaterium 50 ug/disk by agar diffusion method | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612482 | Inhibition of recombinant ALK assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID1825215 | Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay | 2022 | Journal of natural products, 01-28, Volume: 85, Issue:1 | Anti-inflammatory Dimeric Benzophenones from an Endophytic Pleosporales Species. |
| AID612455 | Antiproliferative activity against mouse L5178Y cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612477 | Antiproliferative activity against human K562 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID1591945 | Cytotoxicity against mouse L5178Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Journal of natural products, 08-23, Volume: 82, Issue:8 | Brominated Azaphilones from the Sponge-Associated Fungus |
| AID355893 | Antioxidant activity assessed as inhibition of peroxidation of linolenic acid at 37 ug/mL by TBARS assay | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612489 | Inhibition of wild type MET assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612486 | Inhibition of recombinant FAK assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612481 | Inhibition of recombinant AKT1 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612480 | Antiproliferative activity against human cisplatin resistant A2780 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355894 | Antioxidant activity assessed as DPPH radical scavenging activity at 25 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID355892 | Antioxidant activity assessed as inhibition of peroxidation of linolenic acid at 7.4 ug/mL by TBARS assay | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612494 | Inhibition of recombinant PRK1 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355897 | Inhibition of p56-LCK assessed as residual enzyme activity at 200 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612496 | Inhibition of recombinant VEGF-R2 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355904 | Antifungal activity against Eurotium repens 50 ug/disk by agar diffusion method | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612491 | Inhibition of recombinant NEK6 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612493 | Inhibition of recombinant PLK1 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID1591946 | Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Journal of natural products, 08-23, Volume: 82, Issue:8 | Brominated Azaphilones from the Sponge-Associated Fungus |
| AID612492 | Inhibition of recombinant PIM1 assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612487 | Inhibition of recombinant IGF1-R assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355899 | Inhibition of HIV1 reverse transcriptase assessed as residual enzyme activity at 66 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| AID612479 | Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID612495 | Inhibition of recombinant SRC assessed as 33Pi incorporation after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. |
| AID355950 | Antioxidant activity assessed as DPPH radical scavenging activity at 500 ug/mL | 2003 | Journal of natural products, May, Volume: 66, Issue:5 | Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.15) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||