| Assay ID | Title | Year | Journal | Article |
|---|
| AID1440695 | Drug level in TERT-immortalized HMVEC treated with (2S)-2-ethylbutyl 2-((((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate at 1 uM after 2 to 72 hrs | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1661023 | Cytotoxic activity in HAE cells | 2020 | ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7
| Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. |
| AID1440663 | Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTP | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440664 | Inhibition of RNA polymerase 2 in human HeLa cells preincubated for 5 mins with dATP/dGTP/dTTP as substrate followed by addition of cell extract measured after 1 hr by SDS-PAGE method | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440662 | Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent-RNA polymerase preincubated for 5 mins followed by [alpha-33P]GTP addition measured after 90 mins by phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1661024 | Antiviral activity against Feline corona virus infected in CRFK cells | 2020 | ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7
| Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. |
| AID1440667 | Inhibition of recombinant human DNA polymerase gamma preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma-33P]TTP by phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440696 | Drug level in human HeLa cells treated with (2S)-2-ethylbutyl 2-((((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate at 1 uM after 2 to 72 hrs | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440677 | Drug level in rhesus monkey PBMC treated with (S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-Aminopyrrolo-[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate at 10 mg/kg, iv administered as sin | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440665 | Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma-33P]TTP by phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID656940 | Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent RNA polymerase using [33P]ATP after 90 mins by phosphoimaging | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. |
| AID1661022 | Antiviral activity against SARS coronavirus infected in primary HAE cells | 2020 | ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7
| Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. |
| AID1440697 | Drug level in human macrophages treated with (2S)-2-ethylbutyl 2-((((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate at 1 uM after 2 to 72 hrs | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440661 | Inhibition of Respiratory syncytial virus A2 RNA-dependent-RNA polymerase assessed as reduction in RNP transcriptional activity after 90 mins in presence of [gamma-32P]ATP by agarose gel based phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440669 | Inhibition of recombinant human DNA polymerase gamma assessed as single nucleotide incorporation rate after 5 to 90 mins in presence of [32P]-D19/D36 as primer/template by PAGE based phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440666 | Inhibition of recombinant human DNA polymerase beta preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma-33P]TTP by phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1440668 | Inhibition of human mitochondrial RNA polymerase assessed as single nucleotide incorporation rate in presence of 5'-[32P]-R12/D18 as primer/template by PAGE based phosphorimaging assay | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. |
| AID1661025 | Antiviral activity against Middle East respiratory syndrome coronavirus infected in primary HAE cells | 2020 | ACS medicinal chemistry letters, Jul-09, Volume: 11, Issue:7
| Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |