Compounds > oroidin
Page last updated: 2024-12-11

oroidin

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Description

oroidin: from marine sponges of the genus Agelas; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6312649
CHEMBL ID397591
CHEBI ID70037
SCHEMBL ID12597862
MeSH IDM0207438

Synonyms (22)

Synonym
oroidin
CHEMBL397591 ,
chebi:70037 ,
4,5-dibromo-1h-pyrrole-2-carboxylic acid [3-(2-amino-1h-imidazol-4-yl)-allyl]-amide
bdbm50220547
4,5-dibromo-1h-pyrrole-2-carboxylic acid [3-(2-amino-3h-imidazol-4-yl)-allyl]-amide
oroidin base
n-[(e)-3-(2-amino-1h-imidazol-5-yl)prop-2-enyl]-4,5-dibromo-1h-pyrrole-2-carboxamide
unii-pf75e92xkm
34649-22-4
1h-pyrrole-2-carboxamide, n-(3-(2-amino-1h-imidazol-4-yl)-2-propenyl)-4,5-dibromo-, (e)-
pf75e92xkm ,
oroidine
n-[(e)-3-(2-amino-1h-imidazol-5-yl)allyl]-4,5-dibromo-1h-pyrrole-2-carboxamide
1h-pyrrole-2-carboxamide, n-[(2e)-3-(2-amino-1h-imidazol-5-yl)-2-propenyl]-4,5-dibromo-
smr001216083
MLS001250229
SCHEMBL12597862
oroidin [mi]
1h-pyrrole-2-carboxamide, n-((2e)-3-(2-amino-1h-imidazol-4-yl)-2-propenyl)-4,5-dibromo-
Q15425298
DTXSID001020635

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
pyrrolesAn azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.
secondary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (14)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)IC50 (µMol)2.50000.00100.33498.9000AID164360
Potassium voltage-gated channel subfamily A member 3Rattus norvegicus (Norway rat)IC50 (µMol)0.82000.82000.82000.8200AID1379141
Potassium voltage-gated channel subfamily A member 4Rattus norvegicus (Norway rat)IC50 (µMol)5.70005.70005.70005.7000AID1379142
Potassium voltage-gated channel subfamily A member 6Homo sapiens (human)IC50 (µMol)4.90003.70004.30004.9000AID1379140
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)IC50 (µMol)2.50000.00040.764912.5000AID126782
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)IC50 (µMol)4.70000.00203.19698.0000AID1379137
Potassium voltage-gated channel subfamily A member 4Homo sapiens (human)IC50 (µMol)2.10002.10003.70005.3000AID1379138
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)IC50 (µMol)16.00000.03003.73009.0000AID1379139
Mitogen-activated protein kinase 1Homo sapiens (human)IC50 (µMol)2.50000.00031.68789.2000AID126782
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)IC50 (µMol)2.50000.00020.68139.7000AID126618; AID164360
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)Ki0.60000.00000.57785.5000AID309304; AID309305
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (151)

Processvia Protein(s)Taxonomy
apoptotic processRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
protein phosphorylationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
signal transductionRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
activation of adenylate cyclase activityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
negative regulation of cell population proliferationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
insulin receptor signaling pathwayRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptorsRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
Schwann cell developmentRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
thyroid gland developmentRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
negative regulation of protein-containing complex assemblyRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
somatic stem cell population maintenanceRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
regulation of Rho protein signal transductionRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
insulin secretion involved in cellular response to glucose stimulusRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
response to muscle stretchRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
ERBB2-ERBB3 signaling pathwayRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
wound healingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
myelinationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
regulation of apoptotic processRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
negative regulation of apoptotic processRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic processRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
positive regulation of MAPK cascadeRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
type B pancreatic cell proliferationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
intermediate filament cytoskeleton organizationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
regulation of cell differentiationRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
insulin-like growth factor receptor signaling pathwayRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
neurotrophin TRK receptor signaling pathwayRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
thymus developmentRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
face developmentRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
type II interferon-mediated signaling pathwayRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
death-inducing signaling complex assemblyRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
regulation of cell motilityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
MAPK cascadeRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of dopamine secretionPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
neuronal action potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
sensory perception of painPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
optic nerve structural organizationPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
cerebral cortex developmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of circadian sleep/wake cycle, non-REM sleepPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
optic nerve developmentPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hypoxiaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Notch signaling pathwayPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to mechanical stimulusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to organic substancePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of vasoconstrictionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of membrane potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hydrogen peroxidePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of potassium ion transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of insulin secretionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
negative regulation of cytosolic calcium ion concentrationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion homeostasisPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
response to hyperoxiaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane hyperpolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
atrial cardiac muscle cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during bundle of His cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during SA node cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
regulation of heart rate by cardiac conductionPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane repolarization during atrial cardiac muscle cell action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cyclePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
positive regulation of myoblast proliferationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
positive regulation of macrophage chemotaxisMitogen-activated protein kinase 1Homo sapiens (human)
positive regulation of macrophage proliferationMitogen-activated protein kinase 1Homo sapiens (human)
regulation of transcription by RNA polymerase IIMitogen-activated protein kinase 1Homo sapiens (human)
protein phosphorylationMitogen-activated protein kinase 1Homo sapiens (human)
apoptotic processMitogen-activated protein kinase 1Homo sapiens (human)
chemotaxisMitogen-activated protein kinase 1Homo sapiens (human)
DNA damage responseMitogen-activated protein kinase 1Homo sapiens (human)
signal transductionMitogen-activated protein kinase 1Homo sapiens (human)
chemical synaptic transmissionMitogen-activated protein kinase 1Homo sapiens (human)
learning or memoryMitogen-activated protein kinase 1Homo sapiens (human)
insulin receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylationMitogen-activated protein kinase 1Homo sapiens (human)
Schwann cell developmentMitogen-activated protein kinase 1Homo sapiens (human)
peptidyl-serine phosphorylationMitogen-activated protein kinase 1Homo sapiens (human)
peptidyl-threonine phosphorylationMitogen-activated protein kinase 1Homo sapiens (human)
cytosine metabolic processMitogen-activated protein kinase 1Homo sapiens (human)
regulation of ossificationMitogen-activated protein kinase 1Homo sapiens (human)
androgen receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
regulation of cellular pHMitogen-activated protein kinase 1Homo sapiens (human)
thyroid gland developmentMitogen-activated protein kinase 1Homo sapiens (human)
regulation of protein stabilityMitogen-activated protein kinase 1Homo sapiens (human)
lipopolysaccharide-mediated signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
positive regulation of telomere maintenance via telomeraseMitogen-activated protein kinase 1Homo sapiens (human)
regulation of stress-activated MAPK cascadeMitogen-activated protein kinase 1Homo sapiens (human)
mammary gland epithelial cell proliferationMitogen-activated protein kinase 1Homo sapiens (human)
cellular response to amino acid starvationMitogen-activated protein kinase 1Homo sapiens (human)
cellular response to reactive oxygen speciesMitogen-activated protein kinase 1Homo sapiens (human)
response to nicotineMitogen-activated protein kinase 1Homo sapiens (human)
ERBB signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
ERBB2-ERBB3 signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
outer ear morphogenesisMitogen-activated protein kinase 1Homo sapiens (human)
myelinationMitogen-activated protein kinase 1Homo sapiens (human)
response to exogenous dsRNAMitogen-activated protein kinase 1Homo sapiens (human)
steroid hormone mediated signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
negative regulation of cell differentiationMitogen-activated protein kinase 1Homo sapiens (human)
insulin-like growth factor receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
thymus developmentMitogen-activated protein kinase 1Homo sapiens (human)
progesterone receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
T cell receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
B cell receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
stress-activated MAPK cascadeMitogen-activated protein kinase 1Homo sapiens (human)
regulation of cytoskeleton organizationMitogen-activated protein kinase 1Homo sapiens (human)
positive regulation of telomerase activityMitogen-activated protein kinase 1Homo sapiens (human)
Bergmann glial cell differentiationMitogen-activated protein kinase 1Homo sapiens (human)
long-term synaptic potentiationMitogen-activated protein kinase 1Homo sapiens (human)
face developmentMitogen-activated protein kinase 1Homo sapiens (human)
lung morphogenesisMitogen-activated protein kinase 1Homo sapiens (human)
trachea formationMitogen-activated protein kinase 1Homo sapiens (human)
labyrinthine layer blood vessel developmentMitogen-activated protein kinase 1Homo sapiens (human)
cardiac neural crest cell development involved in heart developmentMitogen-activated protein kinase 1Homo sapiens (human)
ERK1 and ERK2 cascadeMitogen-activated protein kinase 1Homo sapiens (human)
response to epidermal growth factorMitogen-activated protein kinase 1Homo sapiens (human)
cellular response to cadmium ionMitogen-activated protein kinase 1Homo sapiens (human)
cellular response to tumor necrosis factorMitogen-activated protein kinase 1Homo sapiens (human)
caveolin-mediated endocytosisMitogen-activated protein kinase 1Homo sapiens (human)
regulation of Golgi inheritanceMitogen-activated protein kinase 1Homo sapiens (human)
positive regulation of telomere cappingMitogen-activated protein kinase 1Homo sapiens (human)
regulation of early endosome to late endosome transportMitogen-activated protein kinase 1Homo sapiens (human)
cell surface receptor signaling pathwayMitogen-activated protein kinase 1Homo sapiens (human)
intracellular signal transductionMitogen-activated protein kinase 1Homo sapiens (human)
chemotaxisDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
signal transductionDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
heart developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
negative regulation of cell population proliferationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of gene expressionDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
Schwann cell developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
cerebellar cortex formationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
keratinocyte differentiationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
thyroid gland developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
regulation of stress-activated MAPK cascadeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
endodermal cell differentiationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
ERBB2-ERBB3 signaling pathwayDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
myelinationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
type B pancreatic cell proliferationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of DNA-templated transcriptionDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
insulin-like growth factor receptor signaling pathwayDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
thymus developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
regulation of axon regenerationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
cell motilityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of axonogenesisDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
Bergmann glial cell differentiationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
face developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
trachea formationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
epithelial cell proliferation involved in lung morphogenesisDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
placenta blood vessel developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
labyrinthine layer developmentDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
ERK1 and ERK2 cascadeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of protein serine/threonine kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
regulation of Golgi inheritanceDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
cellular senescenceDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
positive regulation of endodermal cell differentiationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
regulation of early endosome to late endosome transportDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
neuron differentiationDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
MAPK cascadeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
startle responsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of muscle contractionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuroblast proliferationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein localizationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell communication by electrical couplingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
magnesium ion homeostasisPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
optic nerve developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
hippocampus developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cerebral cortex developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
corpus callosum developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal signal transductionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuromuscular processPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of painPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of touchPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein homooligomerizationPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon developmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cellular response to magnesium ionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
membrane repolarization during action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
action potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (38)

Processvia Protein(s)Taxonomy
small GTPase bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
protein kinase activityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
protein serine/threonine kinase activityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
protein bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
ATP bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
enzyme bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
identical protein bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
metal ion bindingRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
protein serine kinase activityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
MAP kinase kinase kinase activityRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
kinesin bindingPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
voltage-gated monoatomic ion channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
potassium ion bindingPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
signaling receptor bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
outward rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
protein kinase bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
alpha-actinin bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel activity involved in SA node cell action potential repolarizationPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
scaffold protein bindingPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
phosphotyrosine residue bindingMitogen-activated protein kinase 1Homo sapiens (human)
DNA bindingMitogen-activated protein kinase 1Homo sapiens (human)
protein serine/threonine kinase activityMitogen-activated protein kinase 1Homo sapiens (human)
MAP kinase activityMitogen-activated protein kinase 1Homo sapiens (human)
protein bindingMitogen-activated protein kinase 1Homo sapiens (human)
ATP bindingMitogen-activated protein kinase 1Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activityMitogen-activated protein kinase 1Homo sapiens (human)
phosphatase bindingMitogen-activated protein kinase 1Homo sapiens (human)
identical protein bindingMitogen-activated protein kinase 1Homo sapiens (human)
protein serine kinase activityMitogen-activated protein kinase 1Homo sapiens (human)
protein kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein serine/threonine kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
MAP kinase kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein serine/threonine/tyrosine kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein tyrosine kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
MAP-kinase scaffold activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein bindingDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
ATP bindingDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein kinase activator activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein serine/threonine kinase activator activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
scaffold protein bindingDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
protein serine kinase activityDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
disordered domain specific bindingPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (54)

Processvia Protein(s)Taxonomy
plasma membraneRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
nucleusRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
cytoplasmRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
mitochondrial outer membraneRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
Golgi apparatusRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
cytosolRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
plasma membraneRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
pseudopodiumRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
cytosolRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
mitochondrionRAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)
endoplasmic reticulum membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
lamellipodiumPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
lamellipodium membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
neuronal cell body membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
paranodal junctionPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
perikaryonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 2Homo sapiens (human)
cytosolPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
intracellular membrane-bounded organellePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
potassium channel complexPotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 6Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
membrane raftPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 3Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
dendritic spinePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
axonPotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 4Homo sapiens (human)
caveolaPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Golgi apparatusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intercalated discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
Z discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membrane raftPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intracellular canaliculusPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
perinuclear region of cytoplasmPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
potassium channel complexPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
intercalated discPotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 5Homo sapiens (human)
extracellular regionMitogen-activated protein kinase 1Homo sapiens (human)
nucleusMitogen-activated protein kinase 1Homo sapiens (human)
nucleoplasmMitogen-activated protein kinase 1Homo sapiens (human)
cytoplasmMitogen-activated protein kinase 1Homo sapiens (human)
mitochondrionMitogen-activated protein kinase 1Homo sapiens (human)
early endosomeMitogen-activated protein kinase 1Homo sapiens (human)
late endosomeMitogen-activated protein kinase 1Homo sapiens (human)
endoplasmic reticulum lumenMitogen-activated protein kinase 1Homo sapiens (human)
Golgi apparatusMitogen-activated protein kinase 1Homo sapiens (human)
centrosomeMitogen-activated protein kinase 1Homo sapiens (human)
cytosolMitogen-activated protein kinase 1Homo sapiens (human)
cytoskeletonMitogen-activated protein kinase 1Homo sapiens (human)
plasma membraneMitogen-activated protein kinase 1Homo sapiens (human)
caveolaMitogen-activated protein kinase 1Homo sapiens (human)
focal adhesionMitogen-activated protein kinase 1Homo sapiens (human)
pseudopodiumMitogen-activated protein kinase 1Homo sapiens (human)
azurophil granule lumenMitogen-activated protein kinase 1Homo sapiens (human)
synapseMitogen-activated protein kinase 1Homo sapiens (human)
mitotic spindleMitogen-activated protein kinase 1Homo sapiens (human)
ficolin-1-rich granule lumenMitogen-activated protein kinase 1Homo sapiens (human)
cytoplasmMitogen-activated protein kinase 1Homo sapiens (human)
nucleusMitogen-activated protein kinase 1Homo sapiens (human)
nucleusDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
mitochondrionDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
early endosomeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
late endosomeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
endoplasmic reticulumDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
Golgi apparatusDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
centrosomeDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
cytosolDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
plasma membraneDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
focal adhesionDual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)
endoplasmic reticulumPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cytosolPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
apical plasma membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cell junctionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
cytoplasmic vesiclePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
paranode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
presynaptic membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal cell bodyPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon initial segmentPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
perikaryonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
axon terminusPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
calyx of HeldPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
postsynaptic membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
anchoring junctionPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
glutamatergic synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
dendritePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
paranode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
membranePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
synapsePotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
juxtaparanode region of axonPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
neuronal cell bodyPotassium voltage-gated channel subfamily A member 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (116)

Assay IDTitleYearJournalArticle
AID1648078Antibiofilm activity against Sporosarcina sp. NB90 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1067211Cytotoxicity against human SW480 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1296011Antimicrobial activity against methicillin-sensitive Staphylococcus aureus after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1067215Cytotoxicity against human MIA cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID309298Inhibition of Plasmodium falciparum FabI2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID1379136Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1530218Antibiofilm activity against Pseudomonas aeruginosa PA142019European journal of medicinal chemistry, Jan-01, Volume: 161Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance.
AID1296019Cytotoxicity against human FS4-LTM cells after 24 hrs by WST-1 assay2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1067207Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1648080Antibiofilm activity against Pseudomonas sp. isolate ISP2_Ab assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1648071Growth inhibition of Pseudomonas sp. isolate ISP2_16 after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1648081Antibiofilm activity against Pseudomonas sp. isolate ISP2_A10pp assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1379150Inhibition of rat Kv10.1 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379149Inhibition of rat Kv1.6 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID379937Antimycobacterial activity against Mycobacterium tuberculosis at 128 ug/mL2006Journal of natural products, Dec, Volume: 69, Issue:12
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID1648069Growth inhibition of Pseudomonas sp. NB86 after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1067218Cytotoxicity against human DU145 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID309303Cytotoxicity against rat L6 cells after 72 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID1379137Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1332046Potentiation of meropenem-induced antibacterial activity against Acinetobacter baumannii AB5075 assessed as fold reduction in meropenem MIC measured after 16 to 18 hrs by serial dilution assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1332059Ratio of oxacillin MIC for methicillin-resistant Staphylococcus aureus BAA-1556 in presence of test compound to oxacillin MIC for methicillin-resistant Staphylococcus aureus harboring vraR mutant in presence of test compound2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1379141Inhibition of rat Kv1.3 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID587068Inhibition of Prdp5 in Saccharomyces cerevisiae AD124567 assessed as inhibition of glucose-dependent rhodamine 6G efflux after 2 hrs at 100 uM by spectrofluorimetry2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1332058Antibiofilm activity against Pseudomonas aeruginosa PA14 after 24 hrs by crystal violet staining based assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1332056Potentiation of vancomycin-induced antibacterial activity against vancomycin intermediate Staphylococcus aureus ATCC 700699 assessed as vancomycin MIC at 25 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 8 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID309300Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by Alamar blue assay2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID587070Antimicrobial activity against Pdrp5 overexpressing Saccharomyces cerevisiae AD124567 assessed as growth yield reduction at 200 uM after 48 hrs by chemosensitization assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1332053Potentiation of oxacillin-induced antibacterial activity against methicillin-resistant Staphylococcus aureus NE481 assessed as oxacillin MIC at 25 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 32 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1067223Cytotoxicity against human SW480 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID420410Antibioflim activity in Pseudomonas aeruginosa PA14 after 24 hrs by general static inhibition assay2009Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.
AID1379147Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1648082Antibiofilm activity against Bacillus sp. isolate ISP2_A_B assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID309304Inhibition of Plasmodium falciparum FabI in presence of variable crotonyl-coA level2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID126618Inhibition of MEK1 phosphorylation by activated human recombinant Raf2002Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
AID1067206Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1680920Neuroprotective activity against TBHP-induced cytotoxicity in human SH-SY5Y cells assessed as increase in cell viability at 0.001 uM after 6 hrs by MTT assay2020Journal of natural products, 07-24, Volume: 83, Issue:7
Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge
AID1332057Antibiofilm activity against Pseudomonas aeruginosa PAO1 after 24 hrs by crystal violet staining based assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1067203Cytotoxicity against human SJ-G2 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067214Cytotoxicity against mouse SMA cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1296016Cytotoxicity against mouse L929 cells after 5 days by WST-1 assay2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID587067Inhibition of Prdp5 in Saccharomyces cerevisiae AD124567 assessed as inhibition of glucose-dependent rhodamine 6G efflux after 13 mins by spectrofluorimetry in presence of 2-deoxyglucose treated for 30 mins before compound addition2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1379148Inhibition of rat Kv1.5 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1379139Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1067201Cytotoxicity against human U87 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067204Cytotoxicity against human MIA cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067210Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID587071Antimicrobial activity against Pdrp5-deficient Saccharomyces cerevisiae AD124567 assessed as growth yield reduction at 200 uM after 48 hrs by chemosensitization assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1379140Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1067224Cytotoxicity against human HT-29 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1648076Antibiofilm activity against Kocuria isolate Eys10 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1067208Cytotoxicity against human A431 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID309302Antileishmanial activity against Leishmania donovani after 72 hrs by Alamar blue assay2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID1379143Inhibition of rat Kv1.6 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID379927Antifungal activity against Cryptococcus neoformans2006Journal of natural products, Dec, Volume: 69, Issue:12
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID420408Antibioflim activity in Pseudomonas aeruginosa PAO12009Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.
AID420414Toxicity in Caenorhabditis elegans L4 stage larva assessed as toxicity threshold after 6 to 7 days2009Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.
AID1648066Antibiofilm activity against Pseudomonas aeruginosa PAO1 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID379938Antileishmanial activity against Leishmania donovani2006Journal of natural products, Dec, Volume: 69, Issue:12
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID1296017Cytotoxicity against human KB3-1 cells after 5 days by WST-1 assay2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1067216Cytotoxicity against human SJ-G2 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067221Cytotoxicity against human A2780 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1379142Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1648079Antibiofilm activity against Pseudomonas sp. isolate ISP2_16 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID309305Inhibition of Plasmodium falciparum FabI in presence of variable NADH levels2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID1332050Potentiation of oxacillin-induced antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1556 assessed as oxacillin MIC at 25 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 32 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1379135Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1296014Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1332045Antibiofilm activity against methicillin-resistant Staphylococcus aureus BAA-1685 after 24 hrs by crystal violet staining based assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID102170Inhibition of human adenocarcinoma cell line LoVo proliferation2002Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
AID1067212Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1141216Antimicrobial activity against methicillin-resistant Staphylococcus aureus 25762 assessed as biofilm formation at 100 uM after 48 hrs by crystal violet staining-based spectrophotometry relative to control2014Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11
Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin.
AID1648073Growth inhibition of Pseudomonas sp. isolate ISP2_A10pp after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID379936Antiviral activity against HIV1 in human PBM cells2006Journal of natural products, Dec, Volume: 69, Issue:12
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID126782Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-12002Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
AID1379146Inhibition of rat Kv1.3 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1680921Cytotoxicity against mouse BV-2 cells assessed as reduction in cell viability at 0.001 to 10 uM after 24 hrs by MTT assay2020Journal of natural products, 07-24, Volume: 83, Issue:7
Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge
AID1067202Cytotoxicity against mouse SMA cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1296018Cytotoxicity against human MCF7 cells after 5 days by WST-1 assay2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1332042Antibiofilm activity against Acinetobacter baumannii ATCC 19606 after 24 hrs by crystal violet staining based assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1332043Antibiofilm activity against Acinetobacter baumannii ATCC 19606 at 100 uM after 24 hrs by crystal violet staining based assay relative to control2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1680922Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 0.001 to 10 uM after 24 hrs by MTT assay2020Journal of natural products, 07-24, Volume: 83, Issue:7
Futunamine, a Pyrrole-Imidazole Alkaloid from the Sponge
AID1332049Potentiation of oxacillin-induced antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1556 assessed as oxacillin MIC at 40 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 32 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1332054Potentiation of oxacillin-induced antibacterial activity against methicillin-resistant Staphylococcus aureus harboring vraR mutant assessed as oxacillin MIC at 25 uM measured after 16 to 18 hrs by serial dilution assay2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1648074Growth inhibition of Bacillus sp. isolate ISP2_A_B after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1141218Antimicrobial activity against Streptococcus mutans 240 assessed as biofilm formation at 100 uM after 48 hrs by crystal violet staining-based spectrophotometry relative to control2014Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11
Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin.
AID1296015Antimicrobial activity against Candida albicans after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1296013Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1648070Growth inhibition of Sporosarcina sp. NB90 after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1067209Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067222Cytotoxicity against human MCF7 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID587072Inhibition of Prdp5 in Saccharomyces cerevisiae AD124567 assessed as inhibition of glucose-dependent rhodamine 6G efflux after 13 mins at 200 uM by spectrofluorimetry in presence of 2-deoxyglucose treated for 30 mins before compound addition2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1296012Antimicrobial activity against Micrococcus luteus after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
AID1067220Cytotoxicity against human H460 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1067219Cytotoxicity against human A431 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID309301Antitrypanosomal activity against Trypanosoma cruzi after 72 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID587065Inhibition of Pdr5p-dependent ATPase activity in Saccharomyces cerevisiae AD124567 assessed as release of inorganic phosphate after 60 mins by Lineweaver-Burk plot2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID309299Antimalarial activity against chloroquine-resistant, pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
AID45091Inhibition of human adenocarcinoma cell line Caco-2 proliferation2002Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
AID1067213Cytotoxicity against human U87 cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID379932Antimalarial activity against Plasmodium falciparum D62006Journal of natural products, Dec, Volume: 69, Issue:12
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
AID587066Inhibition of Pdr5p-dependent UTPase activity in Saccharomyces cerevisiae AD124567 assessed as release of inorganic phosphate after 60 mins by Lineweaver-Burk plot2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
AID1648068Growth inhibition of Kocuria isolate Eys10 after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1379144Inhibition of rat Kv1.1 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1648067Growth inhibition of Lysinibacillus isolate Eys09 after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1067217Cytotoxicity against human BE(2)-C cells assessed as growth inhibition at 25 uM after 72 hrs by MTT assay relative to control2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1332048Potentiation of oxacillin-induced antibacterial activity against methicillin-resistant Staphylococcus aureus BAA-1556 assessed as oxacillin MIC at 50 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 32 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1067205Cytotoxicity against human BE(2)-C cells assessed as growth inhibition after 72 hrs by MTT assay2014Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.
AID1648077Antibiofilm activity against Pseudomonas sp. NB86 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1648072Growth inhibition of Pseudomonas sp. isolate ISP2_Ab after 24 hrs2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID164360Inhibition of kinase activity of Raf/MEK/ERK kinase cascade in ELISA2002Journal of medicinal chemistry, Jan-17, Volume: 45, Issue:2
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
AID1332055Potentiation of vancomycin-induced antibacterial activity against vancomycin intermediate Staphylococcus aureus ATCC 700699 assessed as vancomycin MIC at 50 uM measured after 16 to 18 hrs by serial dilution assay (Rvb = 8 ug/ml)2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
AID1530217Antibiofilm activity against Pseudomonas aeruginosa PAO12019European journal of medicinal chemistry, Jan-01, Volume: 161Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance.
AID1379145Inhibition of rat Kv1.2 expressed in Xenopus laevis oocytes at 1 uM at -90 mV holding potential by two-electrode voltage clamp assay relative to control2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1648075Antibiofilm activity against Lysinibacillus isolate Eys09 assessed as inhibition of biofilm formation incubated for 24 hrs by crystal violet staining based assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Bromopyrrole Alkaloids of the Sponge
AID1379138Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method2017European journal of medicinal chemistry, Oct-20, Volume: 139Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
AID1296010Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 hrs by microdilution method2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Hybrid Pyrrole-Imidazole Alkaloids from the Sponge Agelas sceptrum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (47)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.13)18.2507
2000's19 (40.43)29.6817
2010's23 (48.94)24.3611
2020's4 (8.51)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.80 (24.57)
Research Supply Index3.87 (2.92)
Research Growth Index6.03 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other45 (95.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-hydroxykynurenine
3-hydroxykynurenine: RN given refers to cpd without isomeric designation. 3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.. hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.		7.110hydroxykynureninehuman metabolite
carbon monoxide
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.		2.2510carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
imidazole
imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.		2.1510imidazole
kynurenine
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.. kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.		7.110aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline		human metabolite
taurine
[no description available]		2.0310amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0510isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.0310phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
pd 98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.		2.0110aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
triclosan
[no description available]		2.0310aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		2.2510chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.0610aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		6.18400pyrrole;
secondary amine
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.0310triazines
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0310furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
hempa
Hempa: A chemosterilant agent that is anticipated to be a carcinogen.		2.0810phosphoramideinsect sterilant;
mutagen
2-aminobenzimidazole
2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd. 2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group.		2.110benzimidazolesmarine xenobiotic metabolite
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		2.0310elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.2510chromium group element atommicronutrient
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.2510copper group element atom;
elemental gold
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.0310C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
staurosporine
[no description available]		2.0110indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
2-aminoimidazole
2-aminoimidazole: from catabolism of arginine		8.1550
pyrrolomycin d
pyrrolomycin D: from Streptomyces strain SF-2080; structure given in first source		3.3110
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.0610amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
sceptrin
sceptrin: structure given in first source; isolated from marine sponges of the genus Agelas; RN from CHEMLINE		2.9240pyrroles;
secondary carboxamide
4,5-dibromo-2-pyrrolic acid
4,5-dibromo-2-pyrrolic acid: isol from marine sponge Agelas flabelliformis; structure given in first source		2.7130
manzacidin a
manzacidin A: structure in first source		2.2510
fti 276
FTI 276: a ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; FTI-277 is the methyl ester derivative of FTI-276		2.0110methionine derivative
parthenin
parthenin: sesqiterpene lactone from Parthenium hysterophorus; structure; RN given refers to 3aS-(3aalpha,6beta,6abeta,9abeta,9balpha)-isomer		2.2510sesquiterpene lactone
tacrolimus
Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.		2.0610macrolide lactambacterial metabolite;
immunosuppressive agent
sesquiterpenes
[no description available]		2.2510
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		2.0510one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
aldisine
[no description available]		2.0110
clathrodin
clathrodin: structure given in first source; isolated from marine sponges of the genus Agelas		3.1550
hymenidin
hymenidin: serotonergic receptor antagonist from Okinawan marine sponge Hymeniacidon; structure given in first source		340
ageladine a
Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai; structure in first source. ageladine A : An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis.		2.0510alkaloid;
aromatic amine;
imidazopyridine;
organobromine compound;
pyrroles		angiogenesis inhibitor;
antineoplastic agent;
matrix metalloproteinase inhibitor;
metabolite
dibromophakellstatin
dibromophakellstatin: from the Indian Ocean sponge, Phakellia mauritiana; structure given in first source		7.0710
phakellistatin 13
phakellistatin 13: isolated from the marine sponge Phakellia; structure in first source		2.0310oligopeptide
ageliferin
ageliferin: structure in first source		2.4720
dibromophakellin
dibromophakellin: an alpha2B receptor agonist; isolated from Acanthella costata and Pseudoaxinyssa cantharella; structure in first source. (-)-dibromophakellin : An alkaloid isolated from the marine sponge Phakellia flabellata and Acanthella costata. It acts as an alpha2B adrenoceptor agonist.		7.0710alkaloid;
guanidines;
organobromine compound		alpha-adrenergic agonist;
animal metabolite;
marine metabolite
palau'amine
palau'amine: structure in first source		7.7330
hymenialdisine
[no description available]		2.0110
debromohymenialdisine
[no description available]		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced
[description not available]		02.2510
Acute Disease
Disease having a short and relatively severe course.		02.2510
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.2510