pirenzepine has been researched along with Tourette Syndrome in 10 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 mg pimozide, and was significant for 5 mg olanzapine vs." | 6.69 | Olanzapine in severe Gilles de la Tourette syndrome: a 52-week double-blind cross-over study vs. low-dose pimozide. ( D'Andreamatteo, G; Onofrj, M; Paci, C; Toma, L, 2000) |
| "Ten adult patients aged 20 to 44 years with Tourette's disorder were treated using an open-label, flexible dosing schedule for 8 weeks." | 2.70 | An open-label study of the treatment efficacy of olanzapine for Tourette's disorder. ( Bruun, RD; Budman, CL; Gayer, A; Lesser, M; Shi, Q, 2001) |
| "Olanzapine is a recently introduced atypical neuroleptic agent for which little information is available on its use in children." | 2.69 | Open-label olanzapine treatment in five preadolescent children. ( King, BH; Krishnamoorthy, J, 1998) |
| "Olanzapine is an atypical antipsychotic drug which shows a high antagonistic affinity to the D1, D2 and D4 and the 5-HT2A and 5-HT2c receptors." | 2.69 | Effective open-label treatment of tourette's disorder with olanzapine. ( Aschauer, HN; De Zwaan, M; Kasper, S; Resinger, E; Schindler, SD; Stamenkovic, M; Willinger, U, 2000) |
| "2 mg pimozide, and was significant for 5 mg olanzapine vs." | 2.69 | Olanzapine in severe Gilles de la Tourette syndrome: a 52-week double-blind cross-over study vs. low-dose pimozide. ( D'Andreamatteo, G; Onofrj, M; Paci, C; Toma, L, 2000) |
| "We reviewed articles in English dealing with research into the effect of atypical antipsychotic drugs on tic reduction in Tourette's syndrome." | 2.41 | [Treatment of tics in Tourette syndrome with atypical antipsychotic drugs]. ( Jørgensen, JI; Sindø, I, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sindø, I | 1 |
| Jørgensen, JI | 1 |
| Bhadrinath, BR | 1 |
| Krishnamoorthy, J | 1 |
| King, BH | 1 |
| Karam-Hage, M | 1 |
| Ghaziuddin, N | 1 |
| Bengi Semerci, Z | 1 |
| Stamenkovic, M | 1 |
| Schindler, SD | 1 |
| Aschauer, HN | 1 |
| De Zwaan, M | 1 |
| Willinger, U | 1 |
| Resinger, E | 1 |
| Kasper, S | 1 |
| Onofrj, M | 1 |
| Paci, C | 1 |
| D'Andreamatteo, G | 1 |
| Toma, L | 1 |
| Budman, CL | 2 |
| Gayer, AI | 1 |
| Gayer, A | 1 |
| Lesser, M | 1 |
| Shi, Q | 1 |
| Bruun, RD | 1 |
| Keck, PE | 1 |
| McElroy, SL | 1 |
| Arnold, LM | 1 |
2 reviews available for pirenzepine and Tourette Syndrome
| Article | Year |
|---|---|
[Treatment of tics in Tourette syndrome with atypical antipsychotic drugs].
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine Antagonists; Humans; Olanzapine; Pirenzep | 2002 |
Ziprasidone: a new atypical antipsychotic.
Topics: Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Dibenzothiazepines; Dopamine Antago | 2001 |
4 trials available for pirenzepine and Tourette Syndrome
| Article | Year |
|---|---|
Open-label olanzapine treatment in five preadolescent children.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzod | 1998 |
Effective open-label treatment of tourette's disorder with olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Middle Aged; Olanzapine; Pirenze | 2000 |
Olanzapine in severe Gilles de la Tourette syndrome: a 52-week double-blind cross-over study vs. low-dose pimozide.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cross-Over Studies; Dose-Response Relationship, Drug; | 2000 |
An open-label study of the treatment efficacy of olanzapine for Tourette's disorder.
Topics: Adult; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Comorbi | 2001 |
4 other studies available for pirenzepine and Tourette Syndrome
| Article | Year |
|---|---|
Olanzapine in Tourette syndrome.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Female; Humans; Olanzapine; Pirenzepine; Tourette | 1998 |
Olanzapine in Tourette's disorder.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Administra | 2000 |
Olanzapine in Tourette's disorder.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Child; Humans; Male; Neurologic Examination; Olan | 2000 |
Low blood glucose and olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Female; Humans; Hypoglycemia; Male; Ola | 2001 |