flutamide has been researched along with Tourette Syndrome in 2 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flutamide was well-tolerated and produced a significant reduction in motor but not phonic tic symptom severity." | 2.69 | A double-blind, placebo-controlled, crossover trial of an antiandrogen in the treatment of Tourette's syndrome. ( Anderson, GM; Leckman, JF; Peterson, BS; Zhang, H, 1998) |
| "We report here the first use in Tourette's syndrome of the nonsteroidal androgen receptor blocking agent flutamide." | 2.67 | Steroid hormones and Tourette's syndrome: early experience with antiandrogen therapy. ( Charest, NJ; Cohen, DJ; Hardin, MT; Keefe, D; King, RA; Leckman, JF; Naftolin, F; Peterson, BS; Scahill, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peterson, BS | 2 |
| Leckman, JF | 2 |
| Scahill, L | 1 |
| Naftolin, F | 1 |
| Keefe, D | 1 |
| Charest, NJ | 1 |
| King, RA | 1 |
| Hardin, MT | 1 |
| Cohen, DJ | 1 |
| Zhang, H | 1 |
| Anderson, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for flutamide and Tourette Syndrome
| Article | Year |
|---|---|
Steroid hormones and Tourette's syndrome: early experience with antiandrogen therapy.
Topics: Adult; Female; Flutamide; Humans; Male; Middle Aged; Tourette Syndrome | 1994 |
A double-blind, placebo-controlled, crossover trial of an antiandrogen in the treatment of Tourette's syndrome.
Topics: Adult; Androgen Antagonists; Cross-Over Studies; Double-Blind Method; Female; Flutamide; Humans; Mal | 1998 |