3,4-dihydroxyphenylacetic acid has been researched along with Tourette Syndrome in 3 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dopamine hypothesis for Tourette's syndrome proposes that the disorder is pathologically related either to an excessive amount of dopamine or to supersensitive receptors." | 1.28 | Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. ( Hahn, IH; Moran, TH; Singer, HS, 1991) |
| "This longitudinal, blind study of Gilles de la Tourette's disease in a 44 year old male patient who was nonresponsive to Haloperidol therapy indicates that dopamine excretion is related to clinical response." | 1.26 | A study of endogenous dopamine metabolism in Gilles de la Tourette's disease. ( Knopp, W; Messiha, FS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Minzer, K | 1 |
| Lee, O | 1 |
| Hong, JJ | 1 |
| Singer, HS | 2 |
| Messiha, FS | 1 |
| Knopp, W | 1 |
| Hahn, IH | 1 |
| Moran, TH | 1 |
3 other studies available for 3,4-dihydroxyphenylacetic acid and Tourette Syndrome
| Article | Year |
|---|---|
Increased prefrontal D2 protein in Tourette syndrome: a postmortem analysis of frontal cortex and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Corpus Striatum; Dopamine; Female; Humans; Male; Middle | 2004 |
A study of endogenous dopamine metabolism in Gilles de la Tourette's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Dopamine; Epinephrine; Haloperidol; Homovanillic Acid; Humans | 1976 |
Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Caudate Nucleus; Chromatography, High Pressure Liquid; Corpus | 1991 |