mecamylamine has been researched along with Tourette Syndrome in 8 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 5.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| "Primary efficacy measures included the Tourette's Disorder Scale-Clinician Rated (TODS-CR) and 21-point Clinical Global Improvement scale; secondary efficacy measures included the Yale Global Tic Severity Scale and a rage-attack scale (RAScal)." | 2.70 | Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder. ( Ramos, A; Sanberg, PR; Sheehan, DV; Sheehan, KH; Shytle, RD; Silver, AA, 2001) |
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 1.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanberg, PR | 6 |
| Vindrola-Padros, C | 1 |
| Shytle, RD | 6 |
| Silver, AA | 5 |
| Sheehan, KH | 2 |
| Sheehan, DV | 2 |
| Hayslett, RL | 1 |
| Tizabi, Y | 1 |
| Singh, A | 1 |
| Das, DK | 1 |
| Kelley, ME | 1 |
| Ramos, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824] | Phase 4 | 1 participants (Actual) | Interventional | 2005-09-30 | Terminated (stopped due to Unable to recruit subjects into the trial.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mecamylamine and Tourette Syndrome
| Article | Year |
|---|---|
Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.
Topics: Animals; Basal Ganglia; Depression; Humans; Mecamylamine; Nicotine; Tourette Syndrome; Translational | 2012 |
3 trials available for mecamylamine and Tourette Syndrome
| Article | Year |
|---|---|
Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder, Major; Double | 2002 |
Mecamylamine in Tourette's syndrome: a two-year retrospective case study.
Topics: Adolescent; Adult; Age Factors; Child; Drug Therapy, Combination; Female; Humans; Male; Mecamylamine | 2000 |
Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder.
Topics: Adolescent; Child; Comorbidity; Depression; Double-Blind Method; Female; Ganglionic Blockers; Heart | 2001 |
4 other studies available for mecamylamine and Tourette Syndrome
| Article | Year |
|---|---|
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice; | 2003 |
Mecamylamine (Targacept).
Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Rela | 2006 |
Treatment of Tourette's syndrome with mecamylamine.
Topics: Adolescent; Adult; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Retrospective Studies; | 1998 |
Comorbid bipolar disorder in Tourette's syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine).
Topics: Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Psyc | 2000 |