reserpine has been researched along with Tourette Syndrome in 3 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tetrabenazine (TBZ) is a non-competitive inhibitor of VMAT2 that is used in the treatment of hyperkinetic disorders associated with Huntington disease and Tourette syndrome." | 3.79 | Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. ( Gros, Y; Schuldiner, S; Segal, T; Ugolev, Y; Yaffe, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ugolev, Y | 1 |
| Segal, T | 1 |
| Yaffe, D | 1 |
| Gros, Y | 1 |
| Schuldiner, S | 1 |
| Rojas, VM | 1 |
| Davies, RK | 1 |
| Marsden, CD | 1 |
3 other studies available for reserpine and Tourette Syndrome
| Article | Year |
|---|---|
Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding Sites; Biological Transport, Active; HEK293 Cells; Hu | 2013 |
Reserpine treatment of comorbid Tourette's disorder and tardive dystonia.
Topics: Adrenergic Uptake Inhibitors; Adult; Comorbidity; Dyskinesia, Drug-Induced; Dystonia; Haloperidol; H | 1999 |
Drug treatment of diseases characterized by abnormal movements.
Topics: Chorea; Diazepam; Ethanol; Haloperidol; Humans; Huntington Disease; Levodopa; Movement Disorders; My | 1973 |