chlorpromazine has been researched along with Tourette Syndrome in 19 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Following 6 years of continuous chlorpromazine therapy for schizophrenia, a young woman developed multifocal tics and vocalizations characteristic of Tourette syndrome." | 7.66 | Gilles de la Tourette syndrome after long-term chlorpromazine therapy. ( Falk, DK; Klawans, HL; Nausieda, PA; Weiner, WJ, 1978) |
| "Following 6 years of continuous chlorpromazine therapy for schizophrenia, a young woman developed multifocal tics and vocalizations characteristic of Tourette syndrome." | 3.66 | Gilles de la Tourette syndrome after long-term chlorpromazine therapy. ( Falk, DK; Klawans, HL; Nausieda, PA; Weiner, WJ, 1978) |
| "Twenty-six children with Tourette's syndrome (TS) and 24 with a temporal form of epilepsy were examined." | 1.27 | [Features of the temporal structure of the respiratory cycle in the Tourette syndrome as a possible reflection of intensified dopaminergic processes]. ( Kenunen, OG; Kharitonov, RA; Shchelkunov, EL; Voronov, IB; Zimin, AL, 1985) |
| "This suggests that symptoms of Gilles de la Tourette syndrome which appear after withdrawal of chronic neuroleptic therapy may be due to transient hypersensitivity of dopamine receptor sites." | 1.26 | Transient Gilles de la Tourette syndrome after chronic neuroleptic withdrawal. ( Singer, WD, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (89.47) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teixeira, AL | 1 |
| Cardoso, F | 1 |
| Maia, DP | 1 |
| Cunningham, MC | 1 |
| BOCKNER, S | 1 |
| WALSH, PJ | 1 |
| ELLISON, RM | 1 |
| DeVeaugh-Geiss, J | 1 |
| Klawans, HL | 2 |
| Nausieda, PA | 2 |
| Goetz, CC | 1 |
| Tanner, CM | 1 |
| Weiner, WJ | 2 |
| Hollister, LE | 1 |
| Singer, WD | 1 |
| Mueller, J | 1 |
| Aminoff, MJ | 1 |
| Whelan, R | 1 |
| Dearlove, OR | 1 |
| Falk, DK | 1 |
| Tomaszewski, J | 1 |
| Seredyński, R | 1 |
| Araneta, E | 1 |
| Magen, J | 1 |
| Musci, MN | 1 |
| Singer, P | 1 |
| Vann, CR | 1 |
| McDaniel, KD | 1 |
| Shchelkunov, EL | 1 |
| Kenunen, OG | 1 |
| Voronov, IB | 1 |
| Zimin, AL | 1 |
| Kharitonov, RA | 1 |
| Carroll, WJ | 1 |
| Levy, BS | 1 |
| Ascher, E | 1 |
| Olivennes, M | 1 |
| DiGiacomo, JN | 1 |
| Fahn, S | 1 |
| Glass, JB | 1 |
| Westlake, RJ | 1 |
1 review available for chlorpromazine and Tourette Syndrome
| Article | Year |
|---|---|
Drug treatment of schizophrenia.
Topics: Antidepressive Agents, Tricyclic; Antiparkinson Agents; Antipsychotic Agents; Chemical Phenomena; Ch | 1984 |
1 trial available for chlorpromazine and Tourette Syndrome
| Article | Year |
|---|---|
Phenothiazines in the treatment of Gilles de la Tourette's disease.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Humans; Male; Tourette Syndrome; Verbal | 1968 |
17 other studies available for chlorpromazine and Tourette Syndrome
| Article | Year |
|---|---|
Sydenham's chorea may be a risk factor for drug induced parkinsonism.
Topics: Antipsychotic Agents; Chlorpromazine; Chorea; Humans; Parkinsonian Disorders; Retrospective Studies; | 2003 |
Gilles de la Tourette's disease.
Topics: Chlorpromazine; Humans; Tics; Tourette Syndrome | 1959 |
Compulsive shouting and Gilles de la Tourette's disease.
Topics: Chlorpromazine; Compulsive Behavior; Humans; Tics; Tourette Syndrome | 1962 |
GILLES DE LA TOURETTE'S SYNDROME.
Topics: Chlorpromazine; Chorea; Geriatrics; Humans; Imipramine; Intelligence Tests; Neurotic Disorders; Obse | 1964 |
Tardive Tourette syndrome.
Topics: Aged; Antipsychotic Agents; Chlorpromazine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Hum | 1980 |
Tourette-like symptoms following chronic neuroleptic therapy.
Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Female; Fluphenazine; Haloperidol; Humans; Time F | 1982 |
Transient Gilles de la Tourette syndrome after chronic neuroleptic withdrawal.
Topics: Adolescent; Chlorpromazine; Drug Hypersensitivity; Haloperidol; Humans; Male; Receptors, Dopamine; S | 1981 |
Tourette-like syndrome after long-term neuroleptic drug treatment.
Topics: Adult; Chlorpromazine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Substance Withdrawal Syn | 1982 |
Management of clonidine overdose in a child with Tourette syndrome.
Topics: Child; Chlorpromazine; Clonidine; Drug Overdose; Humans; Male; Suicide, Attempted; Tourette Syndrome | 1995 |
Gilles de la Tourette syndrome after long-term chlorpromazine therapy.
Topics: Adult; Chlorpromazine; Female; Humans; Receptors, Dopamine; Tourette Syndrome | 1978 |
[Therapeutic attempts in a case of Gilles de la Tourette disease of organic background].
Topics: Adolescent; Chlorpromazine; Drug Therapy, Combination; Haloperidol; Humans; Male; Measles; Tourette | 1979 |
Gilles de la Tourette's syndrome symptom onset at age 35.
Topics: Adult; Age Factors; Chlorpromazine; Electroconvulsive Therapy; Haloperidol; Humans; Male; Marriage; | 1975 |
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2).
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Chlorpromazine; Haloper | 1986 |
[Features of the temporal structure of the respiratory cycle in the Tourette syndrome as a possible reflection of intensified dopaminergic processes].
Topics: Adolescent; Brain; Child; Chlorpromazine; Dopamine; Epilepsy, Temporal Lobe; Female; Haloperidol; Hu | 1985 |
Gilles de la Tourette Syndrome.
Topics: Child; Chlorpromazine; Haloperidol; Humans; Male; Psychotherapy; Tourette Syndrome | 1974 |
[Tic disease].
Topics: Birth Injuries; Child; Chlorpromazine; Chorea; Diagnosis, Differential; Haloperidol; Humans; Intelle | 1970 |
A case with Gilles de la Tourette's syndrome: recurrent refractoriness to haloperidol, and unsuccessful treatment with L-dopa.
Topics: Adult; Chlorpromazine; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Haloperidol; Humans; | 1971 |