4-iodo-2,5-dimethoxyphenylisopropylamine has been researched along with Tourette Syndrome in 6 studies
4-iodo-2,5-dimethoxyphenylisopropylamine: RN given refers to unlabeled parent cpd without isomeric designation; a serotonin agonist
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine : An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 5.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| "To develop a mouse model to mimic the behavioral and neurochemical changes of Tourette syndrome (TS) by 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induction and to investigate the effects of fluoxetine and haloperidol on head twitch response (HTR) induced by DOI." | 3.74 | [Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response]. ( Dai, XM; Lu, Y; Ma, HW; Yao, Y, 2007) |
| "Thus, mouse strains selected for a particular trait may be leveraged to generate hypothesis-driven studies aimed at clarifying the potential role played by the environment in modulating the exhibition of the symptoms of interest." | 1.40 | A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains. ( Ceci, C; Laviola, G; Macrì, S; Proietti Onori, M, 2014) |
| " Initially, we established a dose-response relationship for the acute and chronic haloperidol and DOI-induced HTR." | 1.33 | Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome. ( Hayslett, RL; Tizabi, Y, 2005) |
| "Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease." | 1.32 | Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Long, H | 1 |
| Wang, C | 1 |
| Ruan, J | 1 |
| Zhang, M | 1 |
| Huang, Y | 1 |
| Hongyan, L | 1 |
| Mengjiao, Z | 1 |
| Chunyan, W | 1 |
| Yaruo, H | 1 |
| Proietti Onori, M | 1 |
| Ceci, C | 1 |
| Laviola, G | 1 |
| Macrì, S | 1 |
| Hayslett, RL | 2 |
| Tizabi, Y | 2 |
| Yao, Y | 1 |
| Ma, HW | 1 |
| Lu, Y | 1 |
| Dai, XM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824] | Phase 4 | 1 participants (Actual) | Interventional | 2005-09-30 | Terminated (stopped due to Unable to recruit subjects into the trial.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for 4-iodo-2,5-dimethoxyphenylisopropylamine and Tourette Syndrome
| Article | Year |
|---|---|
Gastrodin attenuates neuroinflammation in DOI-induce Tourette syndrome in rats.
Topics: Amphetamines; Animals; Behavior, Animal; Benzyl Alcohols; Cytokines; Disease Models, Animal; Glucosi | 2019 |
Rhynchophylline Attenuates Neurotoxicity in Tourette Syndrome Rats.
Topics: Amphetamines; Animals; Behavior, Animal; Cell Line; Cell Survival; Corpus Striatum; Disease Models, | 2019 |
A behavioural test battery to investigate tic-like symptoms, stereotypies, attentional capabilities, and spontaneous locomotion in different mouse strains.
Topics: Amphetamine; Amphetamines; Animals; Attention; Central Nervous System Stimulants; Circadian Rhythm; | 2014 |
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice; | 2003 |
Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome.
Topics: Amphetamines; Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Don | 2005 |
[Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response].
Topics: Amphetamines; Animals; Disease Models, Animal; Dopamine; Fluoxetine; Haloperidol; Homovanillic Acid; | 2007 |