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pentylenetetrazole and Tourette Syndrome

pentylenetetrazole has been researched along with Tourette Syndrome in 1 studies

Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

Research Excerpts

ExcerptRelevanceReference
"Seizures are also often associated with tics and compulsions, which likewise involve cortical-limbic hyperactivity."1.31TS+OCD-like neuropotentiated mice are supersensitive to seizure induction. ( Burton, FH; Campbell, KM; McGrath, MJ; Veldman, MB, 2000)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Campbell, KM1
Veldman, MB1
McGrath, MJ1
Burton, FH1

Other Studies

1 other study available for pentylenetetrazole and Tourette Syndrome

ArticleYear
TS+OCD-like neuropotentiated mice are supersensitive to seizure induction.
    Neuroreport, 2000, Jul-14, Volume: 11, Issue:10

    Topics: Animals; Cerebral Cortex; Disease Models, Animal; Humans; Limbic System; Male; Mice; Mice, Inbred BA

2000