Page last updated: 2024-10-31

methylphenidate and Tourette Syndrome

methylphenidate has been researched along with Tourette Syndrome in 46 studies

Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.

Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

Research Excerpts

ExcerptRelevanceReference
"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)."7.73Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006)
"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)."3.73Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006)
"Behavioral reinforcement of tic suppression resulted in lower rates of tics compared to baseline, but dMPH did not enhance this suppression."2.75Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder. ( Bauer, CC; Brandt, BC; Castellanos, FX; Coffey, BJ; Conelea, C; Howard, J; Kemp, JJ; Lawrence, ZE; Lipinski, CM; Lyon, GJ; Samar, SM; Trujillo, MR; Woods, D, 2010)
"Treatment with methylphenidate resulted in marked reductions of hyperactive, disruptive, and aggressive behavior, which was evident even for the 0."2.68School observations of children with attention-deficit hyperactivity disorder and comorbid tic disorder: effects of methylphenidate treatment. ( Gadow, KD; Nolan, E; Sprafkin, J; Sverd, J, 1995)
"Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate."2.67Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? ( Amass, J; Borcherding, BG; Elia, J; Keysor, CS; Rapoport, JL, 1990)
"Desipramine and placebo were similar on "all-cause treatment discontinuation" (RD -0."2.50Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents. ( Castells, X; Ehimare, UP; Otasowie, J; Smith, CH, 2014)
"Approximately half of children with Tourette's syndrome experience comorbid attention-deficit/hyperactivity disorder (ADHD)."2.45Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. ( Bloch, MH; Landeros-Weisenberger, A; Leckman, JF; Panza, KE, 2009)
"Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider, treatment with stimulants."1.26Stimulant medications precipitate Tourette's syndrome. ( Cohen, DJ; Detlor, J; Kremenitzer, MW; Lowe, TL; Shaywitz, BA, 1982)
"Gilles de la Tourette syndrome is frequently associated with symptoms characteristic of hyperactivity and often goes unrecognized for long periods of time."1.26Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette syndrome. ( Sleator, EK, 1980)
"Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider treatment with stimulants."1.26Stimulant medications precipitate Tourette's syndrome. ( Cohen, DJ; Detlor, J; Kremenitzer, MW; Lowe, TL; Shaywitz, BA, 1982)
"The authors treated two children with Gilles de la Tourette's disease and one child with a probable combination of Gilles de la Tourette's disease and minimal brain dysfunction with methylphenidate, which resulted in exacerbation of symptoms."1.26The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children. ( Fras, I; Karlavage, J, 1977)
"Gilles de la Tourette's syndrome was independently ascertained in two male cousins once removed."1.26Gilles de la Tourette's syndrome. Familial occurrence and precipitation by methylphenidate therapy. ( Cohen, NL; Friedhoff, AJ; Pollack, MA, 1977)
"The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome."1.26Tics following methylphenidate administration. A report of 20 cases. ( Bemporad, JR; Denckla, MB; MacKay, MC, 1976)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199020 (43.48)18.7374
1990's12 (26.09)18.2507
2000's10 (21.74)29.6817
2010's4 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Otasowie, J1
Castells, X1
Ehimare, UP1
Smith, CH1
Albin, RL1
Koeppe, RA1
Wernette, K1
Zhuang, W1
Nichols, T1
Kilbourn, MR1
Frey, KA1
Bloch, MH1
Panza, KE1
Landeros-Weisenberger, A1
Leckman, JF1
Lyon, GJ1
Samar, SM1
Conelea, C1
Trujillo, MR1
Lipinski, CM1
Bauer, CC1
Brandt, BC1
Kemp, JJ1
Lawrence, ZE1
Howard, J1
Castellanos, FX3
Woods, D1
Coffey, BJ1
Rickards, H1
Cavanna, AE1
Worrall, R1
Pringsheim, T1
Krause, KH1
Dresel, S1
Krause, J1
Kung, HF1
Tatsch, K1
Lochmüller, H1
Levenson, D1
Benjamin, E1
Salek, S1
Robertson, MM1
Gilbert, DL1
Wang, Z1
Sallee, FR2
Ridel, KR1
Merhar, S1
Zhang, J1
Lipps, TD1
White, C1
Badreldin, N1
Wassermann, EM1
Jaworowski, S1
Benarroch, F1
Gross-Tsur, V1
Yeh, CB1
Lee, CS1
Ma, KH1
Lee, MS1
Chang, CJ1
Huang, WS1
Lowe, TL2
Cohen, DJ2
Detlor, J2
Kremenitzer, MW2
Shaywitz, BA2
Sleator, EK1
Golden, GS4
Rapoport, JL3
Nee, L1
Mitchell, S1
Polinsky, R1
Ebert, M1
Gadow, KD5
Nolan, E1
Sprafkin, J1
Sverd, J6
Nolan, EE2
Walkup, JT1
Scahill, LD1
Riddle, MA1
Giedd, JN1
Elia, J2
Marsh, WL1
Ritchie, GF1
Hamburger, SD1
Millichap, JG2
DeVane, CL1
Ferrell, RE1
Fras, I1
Karlavage, J1
Pollack, MA1
Cohen, NL1
Friedhoff, AJ1
Crosley, CJ1
Bremness, AB1
Denckla, MB1
Bemporad, JR1
MacKay, MC1
Wilens, TE1
Biederman, J1
Dahl, RE1
Borcherding, BG1
Keysor, CS1
Amass, J1
Paolicelli, LM1
Dulcan, MK1
Dillon, DC1
Salzman, IJ1
Schulsinger, DA1
Erenberg, G1
Cruse, RP1
Rothner, AD1
McDaniel, KD1
Caine, ED1
McBride, MC1
Chiverton, P1
Bamford, KA1
Rediess, S1
Shiao, J1
Berlin, CM1

Reviews

8 reviews available for methylphenidate and Tourette Syndrome

ArticleYear
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.
    The Cochrane database of systematic reviews, 2014, Sep-19, Issue:9

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central

2014
Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2009, Volume: 48, Issue:9

    Topics: Adrenergic alpha-Agonists; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity;

2009
Attention deficit hyperactivity disorder, tics and Tourette's syndrome: the relationship and treatment implications. A commentary.
    European child & adolescent psychiatry, 2006, Volume: 15, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi

2006
Disruptive behavior, hyperactivity, and learning disabilities in children with Tourette's syndrome.
    Advances in neurology, 1995, Volume: 65

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child;

1995
Stimulants and tic disorders: from dogma to data.
    Archives of general psychiatry, 1999, Volume: 56, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as

1999
The stimulants.
    The Psychiatric clinics of North America, 1992, Volume: 15, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

1992
The pharmacologic treatment of sleep disorders.
    The Psychiatric clinics of North America, 1992, Volume: 15, Issue:1

    Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Deamino Arginine Vasopressin;

1992
Stimulants for ADHD in child patients with Tourette's syndrome: the issue of relative risk.
    Journal of developmental and behavioral pediatrics : JDBP, 1990, Volume: 11, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Met

1990

Trials

8 trials available for methylphenidate and Tourette Syndrome

ArticleYear
Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder.
    Journal of child and adolescent psychopharmacology, 2010, Volume: 20, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2010
Dopamine transporter genotype influences the physiological response to medication in ADHD.
    Brain : a journal of neurology, 2006, Volume: 129, Issue:Pt 8

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with

2006
School observations of children with attention-deficit hyperactivity disorder and comorbid tic disorder: effects of methylphenidate treatment.
    Journal of developmental and behavioral pediatrics : JDBP, 1995, Volume: 16, Issue:3

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Comorbidity; Dose-Response Relatio

1995
Observations and ratings of tics in school settings.
    Journal of abnormal child psychology, 1994, Volume: 22, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Female; Huma

1994
Controlled stimulant treatment of ADHD and comorbid Tourette's syndrome: effects of stimulant and dose.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:5

    Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan

1997
Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Comorbidity; Dose-Re

1992
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?
    Psychiatry research, 1990, Volume: 33, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Compulsive Behavior; Dextroamphetamine; Double

1990
Methylphenidate treatment of attention-deficit hyperactivity disorder in boys with Tourette's syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Humans; Male

1989

Other Studies

30 other studies available for methylphenidate and Tourette Syndrome

ArticleYear
Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.
    Neurology, 2009, Apr-21, Volume: 72, Issue:16

    Topics: Adolescent; Adult; Binding, Competitive; Carbon Radioisotopes; Corpus Striatum; Dopamine; Dopamine P

2009
Treatment practices in Tourette syndrome: the European perspective.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:4

    Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride

2012
Psychopharmacology for the clinician: management of comorbid Tourette syndrome and attention-deficit/hyperactivity disorder: are psychostimulants an option?
    Journal of psychiatry & neuroscience : JPN, 2012, Volume: 37, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervous

2012
Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit/ hyperactivity disorder: positive effect of methylphenidate.
    Journal of neurology, 2002, Volume: 249, Issue:8

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Corpus Stri

2002
Ritalin is okay for kids with both ADHD and Tourette's syndrome, study says.
    Report on medical guidelines & outcomes research, 2002, Mar-22, Volume: 13, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clinical Tr

2002
Stimulant-atypical antipsychotic interaction and acute dystonia.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:6

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar

2005
Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi

2006
Phasic dysfunction of dopamine transmission in Tourette's syndrome evaluated with 99mTc TRODAT-1 imaging.
    Psychiatry research, 2007, Oct-15, Volume: 156, Issue:1

    Topics: Adult; Brain; Caudate Nucleus; Central Nervous System Stimulants; Dopamine; Humans; Male; Methylphen

2007
Stimulant medications precipitate Tourette's syndrome.
    JAMA, 1982, Feb-26, Volume: 247, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

1982
Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette syndrome.
    Clinical pediatrics, 1980, Volume: 19, Issue:7

    Topics: Child; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Pemoline; Tourette Syndrome

1980
Stimulant medications precipitate Tourette's syndrome.
    JAMA, 1982, Mar-26, Volume: 247, Issue:12

    Topics: Acute Disease; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool;

1982
Tourette syndrome in children: ethnic and genetic factors and response to stimulant drugs.
    Advances in neurology, 1982, Volume: 35

    Topics: Child; Child, Preschool; Ethnicity; Female; Humans; Jews; Male; Methylphenidate; Tourette Syndrome

1982
Hyperkinetic syndrome and Tourette syndrome.
    Advances in neurology, 1982, Volume: 35

    Topics: Adolescent; Child; Dextroamphetamine; Humans; Hyperkinesis; Male; Methylphenidate; Pemoline; Tourett

1982
Prevalence of Tourette syndrome.
    Developmental medicine and child neurology, 1999, Volume: 41, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Methylphen

1999
Methylphenidate role in Tourette syndrome prevalence.
    Journal of the Royal Society of Medicine, 1999, Volume: 92, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Met

1999
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
    Journal of child and adolescent psychopharmacology, 2000,Spring, Volume: 10, Issue:1

    Topics: Antipruritics; Attention Deficit Disorder with Hyperactivity; Child; Cytochrome P-450 CYP2D6; Dopami

2000
The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.
    The American journal of psychiatry, 1977, Volume: 134, Issue:2

    Topics: Acute Disease; Attention Deficit Disorder with Hyperactivity; Catecholamines; Child; Humans; Imipram

1977
The effect of central nervous system stimulants on Tourette syndrome.
    Annals of neurology, 1977, Volume: 2, Issue:1

    Topics: Child, Preschool; Humans; Hyperkinesis; Male; Methylphenidate; Tourette Syndrome

1977
Gilles de la Tourette's syndrome. Familial occurrence and precipitation by methylphenidate therapy.
    Archives of neurology, 1977, Volume: 34, Issue:10

    Topics: Adult; Child; Dextroamphetamine; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Pedigree;

1977
Decreased serotoninergic activity in Tourette syndrome.
    Annals of neurology, 1979, Volume: 5, Issue:6

    Topics: Child; Cyproheptadine; Dopamine; Haloperidol; Humans; Male; Methylphenidate; Serotonin; Tourette Syn

1979
Methylphenidate-induced Tourette syndrome: case report.
    The American journal of psychiatry, 1979, Volume: 136, Issue:10

    Topics: Child; Dose-Response Relationship, Drug; Humans; Hyperkinesis; Male; Methylphenidate; Tourette Syndr

1979
Tics following methylphenidate administration. A report of 20 cases.
    JAMA, 1976, Mar-29, Volume: 235, Issue:13

    Topics: Acute Disease; Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Female

1976
Attention deficit disorder: evaluation and treatment.
    Pediatric annals, 1985, Volume: 14, Issue:5

    Topics: Age Factors; Anorexia; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Body Height;

1985
The use of imipramine in Tourette's syndrome and attention deficit disorder: case report.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

1985
Gilles de la Tourette's syndrome: effects of stimulant drugs.
    Neurology, 1985, Volume: 35, Issue:9

    Topics: Central Nervous System Stimulants; Child; Dextroamphetamine; Humans; Methylphenidate; Pemoline; Tic

1985
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2).
    Clinical pediatrics, 1986, Volume: 25, Issue:3

    Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Chlorpromazine; Haloper

1986
The relationship between stimulant medication and tics.
    Pediatric annals, 1988, Volume: 17, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

1988
Tourette's syndrome in Monroe County school children.
    Neurology, 1988, Volume: 38, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid

1988
Tourette's syndrome.
    Clinical therapeutics, 1987, Volume: 9, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Diagnosis, Differential; Humans; Male; Methylp

1987
Gilles de la Tourette's syndrome following methylphenidate administration.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:1

    Topics: Age Factors; Child; Dopamine; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Neurologic M

1974