methylphenidate has been researched along with Tourette Syndrome in 46 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
Excerpt | Relevance | Reference |
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"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)." | 7.73 | Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006) |
"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)." | 3.73 | Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006) |
"Behavioral reinforcement of tic suppression resulted in lower rates of tics compared to baseline, but dMPH did not enhance this suppression." | 2.75 | Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder. ( Bauer, CC; Brandt, BC; Castellanos, FX; Coffey, BJ; Conelea, C; Howard, J; Kemp, JJ; Lawrence, ZE; Lipinski, CM; Lyon, GJ; Samar, SM; Trujillo, MR; Woods, D, 2010) |
"Treatment with methylphenidate resulted in marked reductions of hyperactive, disruptive, and aggressive behavior, which was evident even for the 0." | 2.68 | School observations of children with attention-deficit hyperactivity disorder and comorbid tic disorder: effects of methylphenidate treatment. ( Gadow, KD; Nolan, E; Sprafkin, J; Sverd, J, 1995) |
"Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate." | 2.67 | Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? ( Amass, J; Borcherding, BG; Elia, J; Keysor, CS; Rapoport, JL, 1990) |
"Desipramine and placebo were similar on "all-cause treatment discontinuation" (RD -0." | 2.50 | Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents. ( Castells, X; Ehimare, UP; Otasowie, J; Smith, CH, 2014) |
"Approximately half of children with Tourette's syndrome experience comorbid attention-deficit/hyperactivity disorder (ADHD)." | 2.45 | Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. ( Bloch, MH; Landeros-Weisenberger, A; Leckman, JF; Panza, KE, 2009) |
"Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider, treatment with stimulants." | 1.26 | Stimulant medications precipitate Tourette's syndrome. ( Cohen, DJ; Detlor, J; Kremenitzer, MW; Lowe, TL; Shaywitz, BA, 1982) |
"Gilles de la Tourette syndrome is frequently associated with symptoms characteristic of hyperactivity and often goes unrecognized for long periods of time." | 1.26 | Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette syndrome. ( Sleator, EK, 1980) |
"Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider treatment with stimulants." | 1.26 | Stimulant medications precipitate Tourette's syndrome. ( Cohen, DJ; Detlor, J; Kremenitzer, MW; Lowe, TL; Shaywitz, BA, 1982) |
"The authors treated two children with Gilles de la Tourette's disease and one child with a probable combination of Gilles de la Tourette's disease and minimal brain dysfunction with methylphenidate, which resulted in exacerbation of symptoms." | 1.26 | The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children. ( Fras, I; Karlavage, J, 1977) |
"Gilles de la Tourette's syndrome was independently ascertained in two male cousins once removed." | 1.26 | Gilles de la Tourette's syndrome. Familial occurrence and precipitation by methylphenidate therapy. ( Cohen, NL; Friedhoff, AJ; Pollack, MA, 1977) |
"The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome." | 1.26 | Tics following methylphenidate administration. A report of 20 cases. ( Bemporad, JR; Denckla, MB; MacKay, MC, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (43.48) | 18.7374 |
1990's | 12 (26.09) | 18.2507 |
2000's | 10 (21.74) | 29.6817 |
2010's | 4 (8.70) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Otasowie, J | 1 |
Castells, X | 1 |
Ehimare, UP | 1 |
Smith, CH | 1 |
Albin, RL | 1 |
Koeppe, RA | 1 |
Wernette, K | 1 |
Zhuang, W | 1 |
Nichols, T | 1 |
Kilbourn, MR | 1 |
Frey, KA | 1 |
Bloch, MH | 1 |
Panza, KE | 1 |
Landeros-Weisenberger, A | 1 |
Leckman, JF | 1 |
Lyon, GJ | 1 |
Samar, SM | 1 |
Conelea, C | 1 |
Trujillo, MR | 1 |
Lipinski, CM | 1 |
Bauer, CC | 1 |
Brandt, BC | 1 |
Kemp, JJ | 1 |
Lawrence, ZE | 1 |
Howard, J | 1 |
Castellanos, FX | 3 |
Woods, D | 1 |
Coffey, BJ | 1 |
Rickards, H | 1 |
Cavanna, AE | 1 |
Worrall, R | 1 |
Pringsheim, T | 1 |
Krause, KH | 1 |
Dresel, S | 1 |
Krause, J | 1 |
Kung, HF | 1 |
Tatsch, K | 1 |
Lochmüller, H | 1 |
Levenson, D | 1 |
Benjamin, E | 1 |
Salek, S | 1 |
Robertson, MM | 1 |
Gilbert, DL | 1 |
Wang, Z | 1 |
Sallee, FR | 2 |
Ridel, KR | 1 |
Merhar, S | 1 |
Zhang, J | 1 |
Lipps, TD | 1 |
White, C | 1 |
Badreldin, N | 1 |
Wassermann, EM | 1 |
Jaworowski, S | 1 |
Benarroch, F | 1 |
Gross-Tsur, V | 1 |
Yeh, CB | 1 |
Lee, CS | 1 |
Ma, KH | 1 |
Lee, MS | 1 |
Chang, CJ | 1 |
Huang, WS | 1 |
Lowe, TL | 2 |
Cohen, DJ | 2 |
Detlor, J | 2 |
Kremenitzer, MW | 2 |
Shaywitz, BA | 2 |
Sleator, EK | 1 |
Golden, GS | 4 |
Rapoport, JL | 3 |
Nee, L | 1 |
Mitchell, S | 1 |
Polinsky, R | 1 |
Ebert, M | 1 |
Gadow, KD | 5 |
Nolan, E | 1 |
Sprafkin, J | 1 |
Sverd, J | 6 |
Nolan, EE | 2 |
Walkup, JT | 1 |
Scahill, LD | 1 |
Riddle, MA | 1 |
Giedd, JN | 1 |
Elia, J | 2 |
Marsh, WL | 1 |
Ritchie, GF | 1 |
Hamburger, SD | 1 |
Millichap, JG | 2 |
DeVane, CL | 1 |
Ferrell, RE | 1 |
Fras, I | 1 |
Karlavage, J | 1 |
Pollack, MA | 1 |
Cohen, NL | 1 |
Friedhoff, AJ | 1 |
Crosley, CJ | 1 |
Bremness, AB | 1 |
Denckla, MB | 1 |
Bemporad, JR | 1 |
MacKay, MC | 1 |
Wilens, TE | 1 |
Biederman, J | 1 |
Dahl, RE | 1 |
Borcherding, BG | 1 |
Keysor, CS | 1 |
Amass, J | 1 |
Paolicelli, LM | 1 |
Dulcan, MK | 1 |
Dillon, DC | 1 |
Salzman, IJ | 1 |
Schulsinger, DA | 1 |
Erenberg, G | 1 |
Cruse, RP | 1 |
Rothner, AD | 1 |
McDaniel, KD | 1 |
Caine, ED | 1 |
McBride, MC | 1 |
Chiverton, P | 1 |
Bamford, KA | 1 |
Rediess, S | 1 |
Shiao, J | 1 |
Berlin, CM | 1 |
8 reviews available for methylphenidate and Tourette Syndrome
Article | Year |
---|---|
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central | 2014 |
Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders.
Topics: Adrenergic alpha-Agonists; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; | 2009 |
Attention deficit hyperactivity disorder, tics and Tourette's syndrome: the relationship and treatment implications. A commentary.
Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi | 2006 |
Disruptive behavior, hyperactivity, and learning disabilities in children with Tourette's syndrome.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; | 1995 |
Stimulants and tic disorders: from dogma to data.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as | 1999 |
The stimulants.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1992 |
The pharmacologic treatment of sleep disorders.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Deamino Arginine Vasopressin; | 1992 |
Stimulants for ADHD in child patients with Tourette's syndrome: the issue of relative risk.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Met | 1990 |
8 trials available for methylphenidate and Tourette Syndrome
Article | Year |
---|---|
Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2010 |
Dopamine transporter genotype influences the physiological response to medication in ADHD.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with | 2006 |
School observations of children with attention-deficit hyperactivity disorder and comorbid tic disorder: effects of methylphenidate treatment.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Comorbidity; Dose-Response Relatio | 1995 |
Observations and ratings of tics in school settings.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Female; Huma | 1994 |
Controlled stimulant treatment of ADHD and comorbid Tourette's syndrome: effects of stimulant and dose.
Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 1997 |
Methylphenidate in hyperactive boys with comorbid tic disorder: II. Short-term behavioral effects in school settings.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Comorbidity; Dose-Re | 1992 |
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Compulsive Behavior; Dextroamphetamine; Double | 1990 |
Methylphenidate treatment of attention-deficit hyperactivity disorder in boys with Tourette's syndrome.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Relationship, Drug; Humans; Male | 1989 |
30 other studies available for methylphenidate and Tourette Syndrome
Article | Year |
---|---|
Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.
Topics: Adolescent; Adult; Binding, Competitive; Carbon Radioisotopes; Corpus Striatum; Dopamine; Dopamine P | 2009 |
Treatment practices in Tourette syndrome: the European perspective.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Atomoxetine Hydrochloride | 2012 |
Psychopharmacology for the clinician: management of comorbid Tourette syndrome and attention-deficit/hyperactivity disorder: are psychostimulants an option?
Topics: Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2012 |
Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit/ hyperactivity disorder: positive effect of methylphenidate.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Corpus Stri | 2002 |
Ritalin is okay for kids with both ADHD and Tourette's syndrome, study says.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clinical Tr | 2002 |
Stimulant-atypical antipsychotic interaction and acute dystonia.
Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar | 2005 |
Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome.
Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi | 2006 |
Phasic dysfunction of dopamine transmission in Tourette's syndrome evaluated with 99mTc TRODAT-1 imaging.
Topics: Adult; Brain; Caudate Nucleus; Central Nervous System Stimulants; Dopamine; Humans; Male; Methylphen | 2007 |
Stimulant medications precipitate Tourette's syndrome.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe | 1982 |
Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette syndrome.
Topics: Child; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Pemoline; Tourette Syndrome | 1980 |
Stimulant medications precipitate Tourette's syndrome.
Topics: Acute Disease; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; | 1982 |
Tourette syndrome in children: ethnic and genetic factors and response to stimulant drugs.
Topics: Child; Child, Preschool; Ethnicity; Female; Humans; Jews; Male; Methylphenidate; Tourette Syndrome | 1982 |
Hyperkinetic syndrome and Tourette syndrome.
Topics: Adolescent; Child; Dextroamphetamine; Humans; Hyperkinesis; Male; Methylphenidate; Pemoline; Tourett | 1982 |
Prevalence of Tourette syndrome.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Methylphen | 1999 |
Methylphenidate role in Tourette syndrome prevalence.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Humans; Met | 1999 |
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
Topics: Antipruritics; Attention Deficit Disorder with Hyperactivity; Child; Cytochrome P-450 CYP2D6; Dopami | 2000 |
The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.
Topics: Acute Disease; Attention Deficit Disorder with Hyperactivity; Catecholamines; Child; Humans; Imipram | 1977 |
The effect of central nervous system stimulants on Tourette syndrome.
Topics: Child, Preschool; Humans; Hyperkinesis; Male; Methylphenidate; Tourette Syndrome | 1977 |
Gilles de la Tourette's syndrome. Familial occurrence and precipitation by methylphenidate therapy.
Topics: Adult; Child; Dextroamphetamine; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Pedigree; | 1977 |
Decreased serotoninergic activity in Tourette syndrome.
Topics: Child; Cyproheptadine; Dopamine; Haloperidol; Humans; Male; Methylphenidate; Serotonin; Tourette Syn | 1979 |
Methylphenidate-induced Tourette syndrome: case report.
Topics: Child; Dose-Response Relationship, Drug; Humans; Hyperkinesis; Male; Methylphenidate; Tourette Syndr | 1979 |
Tics following methylphenidate administration. A report of 20 cases.
Topics: Acute Disease; Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Female | 1976 |
Attention deficit disorder: evaluation and treatment.
Topics: Age Factors; Anorexia; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Body Height; | 1985 |
The use of imipramine in Tourette's syndrome and attention deficit disorder: case report.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe | 1985 |
Gilles de la Tourette's syndrome: effects of stimulant drugs.
Topics: Central Nervous System Stimulants; Child; Dextroamphetamine; Humans; Methylphenidate; Pemoline; Tic | 1985 |
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2).
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Chlorpromazine; Haloper | 1986 |
The relationship between stimulant medication and tics.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe | 1988 |
Tourette's syndrome in Monroe County school children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior; Child; Child, Preschool; Clonid | 1988 |
Tourette's syndrome.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Diagnosis, Differential; Humans; Male; Methylp | 1987 |
Gilles de la Tourette's syndrome following methylphenidate administration.
Topics: Age Factors; Child; Dopamine; Haloperidol; Humans; Hyperkinesis; Male; Methylphenidate; Neurologic M | 1974 |