clomipramine has been researched along with Tourette Syndrome in 27 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment." | 7.68 | Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. ( Cantwell, DP; Hanna, GL; McCracken, JT, 1991) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 5.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| "A young man with a 13 year history of Tourette disorder and obsessive-compulsive disorder developed mania on clomipramine." | 3.72 | Quetiapine treatment in a patient with Tourette's syndrome, obsessive-compulsive disorder and drug-induced mania. ( Matur, Z; Uçok, A, 2003) |
| "Clomipramine hydrochloride, a tricyclic antidepressant that blocks serotonin and norepinephrine reuptake, is indicated in the treatment of Obsessive-Compulsive Disorder." | 3.68 | Tourette's syndrome and treatment with clomipramine hydrochloride. ( Donahoe, DH; Fortune, T; Llorena, R; Meador, M, 1991) |
| "Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment." | 3.68 | Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. ( Cantwell, DP; Hanna, GL; McCracken, JT, 1991) |
| "In a female patient with Gilles-de-la Tourette syndrome (GTS) the clinical improvement during drug therapy of haloperidol and clomipramine was proved with the help of a polygraphic method (simultaneous recording of different electrophysiological and vegetative parameters)." | 3.67 | [Polygraphic therapy control in Gilles de la Tourette syndrome--a case report]. ( Gorynia, I; Seidel, M, 1986) |
| "Independently of the presence of tics, there are several different augmentation strategies for resistant cases with drugs that interfere in the dopamine, serotonin, opioid and gonadal hormone systems." | 2.42 | How to treat OCD in patients with Tourette syndrome. ( Brotto, SA; Diniz, JB; Ferrão, YA; Miguel, EC; Shavitt, RG, 2003) |
| "Only for Tourette's Disorder, Trichotillomania and possibly Sydenham's Chorea have there been convincing biological evidence for continuity with OCD." | 2.39 | [The "obsessive-compulsive spectrum": a useful concept?]. ( Rapoport, JL, 1994) |
| "The frequent comorbidity of OCD and Sydenham's chorea and similar postulates of basal ganglia dysfunction for both disorders suggest that Sydenham's chorea may serve as a medical model for OCD." | 2.39 | Childhood movement disorders and obsessive compulsive disorder. ( Leonard, HL; Swedo, SE, 1994) |
| "A case of a calendar savant with infantile autism and Tourette syndrome is presented." | 2.38 | A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions. ( Nelson, EC; Pribor, EF, 1993) |
| "The authors present a patient with Gilles de la Tourette syndrome who developed abdominal distension and bloating due to air swallowing." | 1.35 | Air swallowing as a tic. ( Cavanna, AE; Robertson, MM; Weil, RS; Willoughby, JM, 2008) |
| "Patients with Tourette's syndrome often develop multiple psychopathological symptoms beyond the basic symptoms (motor and vocal tics)." | 1.31 | [Disguised Tourette's syndrome. A contribution to the differential diagnosis on phobia and fear]. ( Barnett, W; Bednarz, K; Haisch, S, 2002) |
| "A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a." | 1.31 | Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine. ( Dubisar, BM; Farrar, CD; Khan, R; Stoner, SC, 2002) |
| "Erythromycin would inhibit demethylation of clomipramine at the 1A2 isoenzyme and lead to a dual interaction between risperidone and clomipramine at the CYP2D6 isoenzyme." | 1.29 | Erythromycin interaction with risperidone or clomipramine in an adolescent. ( Diaz, P; Fisman, S; Reniers, D, 1996) |
| "Gilles de la Tourette syndrome is a neuropsychiatric disease with a childhood onset below age 16, characterized by chronic involuntary movements, obsessions, compulsions, utterances, echolalia, coprolalia and aggressive behavior symptoms." | 1.26 | Gilles de la Tourette syndrome. Interactions with other neuropsychiatric disorders. ( Yaryura-Tobias, JA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 15 (55.56) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weil, RS | 1 |
| Cavanna, AE | 1 |
| Willoughby, JM | 1 |
| Robertson, MM | 1 |
| Nakamae, T | 1 |
| Bednarz, K | 1 |
| Haisch, S | 1 |
| Barnett, W | 1 |
| Dubisar, BM | 1 |
| Stoner, SC | 1 |
| Khan, R | 1 |
| Farrar, CD | 1 |
| Miguel, EC | 1 |
| Shavitt, RG | 1 |
| Ferrão, YA | 1 |
| Brotto, SA | 1 |
| Diniz, JB | 1 |
| Matur, Z | 1 |
| Uçok, A | 1 |
| Elkins, R | 1 |
| Rapoport, JL | 4 |
| Lipsky, A | 1 |
| McDougle, CJ | 2 |
| Goodman, WK | 3 |
| Price, LH | 2 |
| Como, PG | 1 |
| Swedo, SE | 1 |
| Leonard, HL | 1 |
| Nelson, EC | 1 |
| Pribor, EF | 1 |
| Escobar, R | 1 |
| Bernardo, M | 1 |
| Iancu, I | 1 |
| Kotler, M | 1 |
| Bleich, A | 1 |
| Lepkifker, E | 1 |
| Ward, H | 1 |
| Kablinger, A | 1 |
| Murphy, T | 1 |
| Fisman, S | 1 |
| Reniers, D | 1 |
| Diaz, P | 1 |
| Moshe, K | 1 |
| Iulian, I | 1 |
| Seth, K | 1 |
| Eli, L | 1 |
| Joseph, Z | 1 |
| Yaryura-Tobias, JA | 2 |
| Caine, ED | 1 |
| Polinsky, RJ | 1 |
| Ebert, MH | 1 |
| Mikkelsen, EJ | 1 |
| Cruz, R | 1 |
| Donahoe, DH | 1 |
| Meador, M | 1 |
| Fortune, T | 1 |
| Llorena, R | 1 |
| Hanna, GL | 1 |
| McCracken, JT | 1 |
| Cantwell, DP | 1 |
| Ratzoni, G | 1 |
| Hermesh, H | 1 |
| Brandt, N | 1 |
| Lauffer, M | 1 |
| Munitz, H | 1 |
| Seidel, M | 1 |
| Gorynia, I | 1 |
10 reviews available for clomipramine and Tourette Syndrome
| Article | Year |
|---|---|
[Diversity of obsessive-compulsive disorder and pharmacotherapy associated with obsessive-compulsive spectrum disorders].
Topics: Antipsychotic Agents; Autistic Disorder; Body Dysmorphic Disorders; Clomipramine; Comorbidity; Disru | 2011 |
How to treat OCD in patients with Tourette syndrome.
Topics: Behavior Therapy; Clomipramine; Humans; Neurosurgical Procedures; Obsessive-Compulsive Disorder; Pra | 2003 |
Obsessive-compulsive disorder of childhood and adolescence. A neurobiological viewpoint.
Topics: Adolescent; Child; Child, Preschool; Clomipramine; Diseases in Twins; Encephalitis; Female; Frontal | 1980 |
Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clomipramine; Clozapine; Dopamine Antagonists | 1994 |
Obsessive-compulsive disorder in Tourette's syndrome.
Topics: Behavior Therapy; Clomipramine; Clonidine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Toure | 1995 |
[The "obsessive-compulsive spectrum": a useful concept?].
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Desipramine; Female; Humans; Male; Neuroc | 1994 |
Childhood movement disorders and obsessive compulsive disorder.
Topics: Antipsychotic Agents; Child; Chorea; Clinical Trials as Topic; Clomipramine; Comorbidity; Female; Fl | 1994 |
A calendar savant with autism and Tourette syndrome. Response to treatment and thoughts on the interrelationships of these conditions.
Topics: Aptitude; Autistic Disorder; Clomipramine; Comorbidity; Humans; Intellectual Disability; Male; Middl | 1993 |
Fluvoxamine in the treatment of obsessive-compulsive disorder and related conditions.
Topics: Adolescent; Child; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Disruptive, Impulse | 1997 |
The role of serotonin and dopamine in the pathophysiology of obsessive compulsive disorder.
Topics: Brain; Clomipramine; Dopamine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Serot | 1992 |
1 trial available for clomipramine and Tourette Syndrome
| Article | Year |
|---|---|
Trial of chlorimipramine and desipramine for Gilles de la Tourette syndrome.
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Desipramine; Dibenzazepines; Double-Blind | 1979 |
16 other studies available for clomipramine and Tourette Syndrome
| Article | Year |
|---|---|
Air swallowing as a tic.
Topics: Aerophagy; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Diagnosis, Differential; Gast | 2008 |
[Disguised Tourette's syndrome. A contribution to the differential diagnosis on phobia and fear].
Topics: Adult; Anxiety Disorders; Clomipramine; Clonazepam; Cognitive Behavioral Therapy; Combined Modality | 2002 |
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
Topics: Adult; Asperger Syndrome; Basal Ganglia Diseases; Clomipramine; Humans; Interferon beta-1a; Interfer | 2002 |
Quetiapine treatment in a patient with Tourette's syndrome, obsessive-compulsive disorder and drug-induced mania.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Clomipramine; Dibenzothiazepines; Humans; Male; Obses | 2003 |
Schizophrenia, obsessive-compulsive disorder, and Tourette's syndrome: a case of triple comorbidity.
Topics: Adult; Basal Ganglia Diseases; Brain; Clomipramine; Comorbidity; Female; Haloperidol; Humans; Obsess | 1993 |
Clomipramine efficacy for Tourette syndrome and major depression: a case study.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; Humans; Tourette | 1995 |
Erythromycin interaction with risperidone or clomipramine in an adolescent.
Topics: Acne Vulgaris; Adolescent; Clomipramine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Erythromy | 1996 |
Clomipramine-induced tourettism in obsessive-compulsive disorder: clinical and theoretical implications.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Humans; Male; Obsessive-Compulsive Disorder; | 1994 |
Gilles de la Tourette syndrome. Interactions with other neuropsychiatric disorders.
Topics: Adolescent; Adult; Anorexia Nervosa; Clomipramine; Drug Therapy, Combination; Encephalitis; Female; | 1979 |
Letter: Chlorimipramine in Gilles de la Tourette's disease.
Topics: Clomipramine; Dibenzazepines; Humans; Tourette Syndrome | 1975 |
Clomipramine side effects.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clomipramine; Humans; Male; Obsessive-Compulsi | 1992 |
Tourette's syndrome and treatment with clomipramine hydrochloride.
Topics: Adult; Clomipramine; Drug Administration Schedule; Haloperidol; Humans; Male; Obsessive-Compulsive D | 1991 |
Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine.
Topics: Adolescent; Child; Clomipramine; Dopamine; Female; Humans; Male; Obsessive-Compulsive Disorder; Prol | 1991 |
Clomipramine efficacy for tics, obsessions, and compulsions in Tourette's syndrome and obsessive-compulsive disorder: a case study.
Topics: Adolescent; Clomipramine; Humans; Male; Obsessive-Compulsive Disorder; Stereotyped Behavior; Tic Dis | 1990 |
Childhood obsessive compulsive disorder.
Topics: Adolescent; Anorexia Nervosa; Behavior Therapy; Child; Child, Preschool; Clomipramine; Epilepsy, Tem | 1986 |
[Polygraphic therapy control in Gilles de la Tourette syndrome--a case report].
Topics: Adult; Arousal; Cerebral Cortex; Clomipramine; Drug Therapy, Combination; Electroencephalography; El | 1986 |