kynurenine has been researched along with Tourette Syndrome in 3 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasting plasma kynurenine concentrations were significantly elevated in a group of 7 patients (4 female) conforming to DSM-III-R of the American Psychiatric Association (1987) criteria for Tourette syndrome, in comparison with 10 healthy controls (7 female)." | 7.69 | Elevated plasma kynurenine in Tourette syndrome. ( Betts, T; Corbett, JA; Dursun, SM; Farrar, G; Handley, SL; Rickards, H, 1994) |
| " After thoroughly researching the literature, I hypothesize that magnesium deficiency may be the central precipitating event and common pathway for the subsequent biochemical effects on substance P, kynurenine, NMDA receptors, and vitamin B6 that may result in the symptomatology of Tourette's syndrome and several reported comorbid conditions." | 3.71 | The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditions. ( Grimaldi, BL, 2002) |
| "Fasting plasma kynurenine concentrations were significantly elevated in a group of 7 patients (4 female) conforming to DSM-III-R of the American Psychiatric Association (1987) criteria for Tourette syndrome, in comparison with 10 healthy controls (7 female)." | 3.69 | Elevated plasma kynurenine in Tourette syndrome. ( Betts, T; Corbett, JA; Dursun, SM; Farrar, G; Handley, SL; Rickards, H, 1994) |
| "Fasting plasma levels of tryptophan, kynurenine and the pteridines, neopterin and tetrahydrobiopterin were measured in seven patients with Gilles de la Tourette syndrome (GTS) and 10 healthy controls." | 3.69 | Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome. ( Betts, T; Corbett, JA; Dursun, SM; Farrar, G; Handley, SL; Rickards, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dursun, SM | 2 |
| Farrar, G | 2 |
| Handley, SL | 2 |
| Rickards, H | 2 |
| Betts, T | 2 |
| Corbett, JA | 2 |
| Grimaldi, BL | 1 |
3 other studies available for kynurenine and Tourette Syndrome
| Article | Year |
|---|---|
Elevated plasma kynurenine in Tourette syndrome.
Topics: Adolescent; Adult; Biopterins; Child; Female; Humans; Kynurenine; Male; Neopterin; Reference Values; | 1994 |
Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome.
Topics: Adolescent; Adult; Child; Female; Humans; Kynurenine; Male; Plasma; Pteridines; Tourette Syndrome; T | 1996 |
The central role of magnesium deficiency in Tourette's syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette's syndrome and several reported comorbid conditions.
Topics: Humans; Kynurenine; Magnesium Deficiency; Receptors, N-Methyl-D-Aspartate; Substance P; Tourette Syn | 2002 |