desipramine has been researched along with Tourette Syndrome in 10 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine and placebo were similar on "all-cause treatment discontinuation" (RD -0." | 2.50 | Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents. ( Castells, X; Ehimare, UP; Otasowie, J; Smith, CH, 2014) |
| "Only for Tourette's Disorder, Trichotillomania and possibly Sydenham's Chorea have there been convincing biological evidence for continuity with OCD." | 2.39 | [The "obsessive-compulsive spectrum": a useful concept?]. ( Rapoport, JL, 1994) |
| "Because in many patients with Tourette's syndrome (TS) the ADHD symptoms are the major source of disability, alternative nonstimulant treatments are needed." | 1.29 | Bupropion exacerbates tics in children with attention-deficit hyperactivity disorder and Tourette's syndrome. ( Biederman, J; Spencer, T; Steingard, R; Wilens, T, 1993) |
| "As many as 50% of patients with Tourette's syndrome (TS) also meet diagnostic criteria for attention-deficit hyperactivity disorder (ADHD)." | 1.29 | Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. ( Biederman, J; Kerman, K; Spencer, T; Steingard, R; Wilens, T, 1993) |
| "Therapy for Tourette's syndrome with tricyclic antidepressants has had varied results." | 1.27 | A case of Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine. ( Biederman, J; Hoge, SK, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Otasowie, J | 1 |
| Castells, X | 1 |
| Ehimare, UP | 1 |
| Smith, CH | 1 |
| Rojas-Corrales, MO | 1 |
| Gibert-Rahola, J | 1 |
| Mico, JA | 1 |
| Singer, HS | 1 |
| Brown, J | 1 |
| Quaskey, S | 1 |
| Rosenberg, LA | 1 |
| Mellits, ED | 1 |
| Denckla, MB | 1 |
| Rapoport, JL | 2 |
| Spencer, T | 2 |
| Biederman, J | 3 |
| Steingard, R | 2 |
| Wilens, T | 2 |
| Kerman, K | 1 |
| Sweeney, D | 1 |
| Pickar, D | 1 |
| Redmond, DE | 1 |
| Maas, J | 1 |
| Caine, ED | 1 |
| Polinsky, RJ | 1 |
| Ebert, MH | 1 |
| Mikkelsen, EJ | 1 |
| Hoge, SK | 1 |
| Linet, LS | 1 |
2 reviews available for desipramine and Tourette Syndrome
| Article | Year |
|---|---|
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central | 2014 |
[The "obsessive-compulsive spectrum": a useful concept?].
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Desipramine; Female; Humans; Male; Neuroc | 1994 |
2 trials available for desipramine and Tourette Syndrome
| Article | Year |
|---|---|
The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine.
Topics: Adolescent; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; D | 1995 |
Trial of chlorimipramine and desipramine for Gilles de la Tourette syndrome.
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Desipramine; Dibenzazepines; Double-Blind | 1979 |
6 other studies available for desipramine and Tourette Syndrome
| Article | Year |
|---|---|
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Do | 2007 |
Bupropion exacerbates tics in children with attention-deficit hyperactivity disorder and Tourette's syndrome.
Topics: Attention Deficit Disorder with Hyperactivity; Bupropion; Child; Clonidine; Desipramine; Female; Hum | 1993 |
Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Comorbidity; Des | 1993 |
Noradrenergic and dopaminergic mechanisms in Gilles de la Tourette syndrome.
Topics: Brain; Desipramine; Dopamine; Female; Humans; Middle Aged; Norepinephrine; Tourette Syndrome | 1978 |
A case of Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Desipramine; Humans; Male; Tourette Syndrome | 1986 |
Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Desipramine; Humans; Male; Tourette Syndrome | 1987 |