debrisoquin has been researched along with Tourette Syndrome in 4 studies
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "No debrisoquin was detected in cerebrospinal fluid samples." | 1.28 | Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method. ( Anderson, GM; Cho, SC; Cohen, DJ; Hardin, MT; Jatlow, PI; Leckman, JF; Riddle, MA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riddle, MA | 4 |
| Jatlow, PI | 1 |
| Anderson, GM | 3 |
| Cho, SC | 1 |
| Hardin, MT | 3 |
| Cohen, DJ | 4 |
| Leckman, JF | 4 |
| Shaywitz, BA | 3 |
| Shaywitz, SE | 1 |
| Ort, SI | 3 |
| Anderson, M | 1 |
| Caruso, KA | 1 |
| Towbin, KE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00004325] | 200 participants | Observational | 1988-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for debrisoquin and Tourette Syndrome
| Article | Year |
|---|---|
Plasma debrisoquin levels in the assessment of reduction of plasma homovanillic acid. The debrisoquin method.
Topics: Adult; Debrisoquin; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Isoquinolin | 1989 |
Brief debrisoquin administration to assess central dopaminergic function in children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Debrisoquin; Dopamine; Female; Hom | 1986 |
Assessment of central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration.
Topics: Adolescent; Adult; Blood Pressure; Brain; Child; Debrisoquin; Dopamine; Female; Homovanillic Acid; H | 1986 |
Assessment of dopaminergic function in children and adults: long and brief debrisoquin administration combined with plasma homovanillic acid.
Topics: Adult; Child; Debrisoquin; Dopamine; Homovanillic Acid; Humans; Isoquinolines; Tourette Syndrome | 1987 |