Page last updated: 2024-10-27

flumazenil and Tourette Syndrome

flumazenil has been researched along with Tourette Syndrome in 1 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lerner, A1
Bagic, A1
Simmons, JM1
Mari, Z1
Bonne, O1
Xu, B1
Kazuba, D1
Herscovitch, P1
Carson, RE1
Murphy, DL1
Drevets, WC1
Hallett, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Combined PET and MR Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI[NCT05232955]40 participants (Anticipated)Observational2022-02-28Not yet recruiting
Combined PET and MR Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI[NCT05233306]60 participants (Anticipated)Observational2022-01-27Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

1 other study available for flumazenil and Tourette Syndrome

ArticleYear
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 6

    Topics: Adult; Brain; Carbon Isotopes; Case-Control Studies; Female; Flumazenil; GABA Modulators; gamma-Amin

2012
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 6

    Topics: Adult; Brain; Carbon Isotopes; Case-Control Studies; Female; Flumazenil; GABA Modulators; gamma-Amin

2012
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 6

    Topics: Adult; Brain; Carbon Isotopes; Case-Control Studies; Female; Flumazenil; GABA Modulators; gamma-Amin

2012
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 6

    Topics: Adult; Brain; Carbon Isotopes; Case-Control Studies; Female; Flumazenil; GABA Modulators; gamma-Amin

2012