phenobarbital has been researched along with Tourette Syndrome in 2 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nine of them had generalized tic (Gilles de la Tourette's disease), and 43 had local forms." | 1.26 | [Pathogenesis and treatment of tic-type hyperkinesis in children]. ( Blagosklonov, AV; Bondarenko, ES; Lebedev, VN; Malyshev, IuI, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berlin, CM | 1 |
| Bondarenko, ES | 1 |
| Malyshev, IuI | 1 |
| Blagosklonov, AV | 1 |
| Lebedev, VN | 1 |
1 review available for phenobarbital and Tourette Syndrome
| Article | Year |
|---|---|
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A | 1983 |
1 other study available for phenobarbital and Tourette Syndrome
| Article | Year |
|---|---|
[Pathogenesis and treatment of tic-type hyperkinesis in children].
Topics: Adolescent; Child; Drug Therapy, Combination; Electroencephalography; Electronystagmography; Female; | 1981 |