Page last updated: 2024-09-27

Familial Exudative Vitreoretinopathies

A group of inherited disorders characterized by incomplete development of the retinal vasculature. Its severity can vary from complete blindness in infancy, to mild or no visual problems, where small areas of vascular defects are observable only by FLUORESCEIN ANGIOGRAPHY. Exudative vitreoretinopathy 1 is associated with mutations in the FZD4 gene.

Synonyms(4)

Synonym
Familial Exudative Vitreoretinopathy
XL-FEVR
Familial Exudative Vitreoretinopathies
X-Linked Familial Exudative Vitreoretinopathy

Research

Studies (12)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's9 (75.00)28.8240
2020's3 (25.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
2-propanol0low10
prednisolone0low10
prednisolone acetate0low10
triamcinolone acetonide0low10
evans blue0low10
fluorescein0low10
trolamine salicylate0low10
lithium0low10
indocyanine green0low10
eye0low30

Protein Targets (103)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma3003
GLI family zinc finger 33003
AR protein6006
aldehyde dehydrogenase 1 family, member A11001
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen nuclear receptor alpha6006
peroxisome proliferator-activated receptor delta3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
thyroid hormone receptor beta isoform a1001
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 12002
lamin isoform A-delta102002
Voltage-dependent calcium channel gamma-2 subunit2002
Glutamate receptor 22002
TDP1 protein2002
thyroid hormone receptor beta isoform 22002
Albumin0011
Luciferin 4-monooxygenase0101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Tyrosine-protein phosphatase non-receptor type 10101
Nuclear factor NF-kappa-B p105 subunit0001
Tyrosine-protein phosphatase 10101
10 kDa heat shock protein, mitochondrial0101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Vesicular glutamate transporter 30101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
acetylcholinesterase1001
SMAD family member 22002
SMAD family member 32002
Microtubule-associated protein tau1001
estrogen receptor 2 (ER beta)1001
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]4004
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor1001
pregnane X nuclear receptor3003
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
euchromatic histone-lysine N-methyltransferase 22002
aryl hydrocarbon receptor3003
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Bloom syndrome protein isoform 11001
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 11001
Cellular tumor antigen p533003
luciferase0001
cytochrome P450 family 3 subfamily A polypeptide 42002
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 23003
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Bile salt export pump0202
Interferon beta2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor04110
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Canalicular multispecific organic anion transporter 10202
USP1 protein, partial1001
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
cytochrome P450 2D62002
IDH12002
transcriptional regulator ERG isoform 31001
DNA polymerase iota isoform a (long)1001
Chain A, Beta-lactamase1001
ATAD5 protein, partial1001
chromobox protein homolog 11001
nuclear receptor ROR-gamma isoform 11001
geminin1001
TAR DNA-binding protein 431001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]