prednisolone acetate has been researched along with Corneal Endothelial Cell Damage in 5 studies
prednisolone acetate: RN given refers to cpd with locant for acetate group in position 21 & (11 beta)-isomer
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare intraocular pressure (IOP) elevation and graft rejection with loteprednol etabonate 0." | 5.20 | Loteprednol Etabonate 0.5% Gel Vs. Prednisolone Acetate 1% Solution After Descemet Membrane Endothelial Keratoplasty: Prospective Randomized Trial. ( Feng, MT; Price, FW; Price, MO; Scanameo, A, 2015) |
| " Dosing was 4 times daily in months 1 to 3, thrice daily in month 4, twice daily in month 5, and once daily in months 6 to 12." | 2.79 | Randomized comparison of topical prednisolone acetate 1% versus fluorometholone 0.1% in the first year after descemet membrane endothelial keratoplasty. ( Bachmann, BO; Kruse, FE; Price, FW; Price, MO; Tourtas, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Price, MO | 3 |
| Price, FW | 3 |
| Kruse, FE | 1 |
| Bachmann, BO | 1 |
| Tourtas, T | 1 |
| Feng, MT | 2 |
| Scanameo, A | 2 |
| Li, JY | 1 |
| Terry, MA | 1 |
| Goshe, J | 1 |
| Shamie, N | 1 |
| Davis-Boozer, D | 1 |
| Ramappa, M | 1 |
| Ashar, J | 1 |
| Vaddavalli, PK | 1 |
| Chaurasia, S | 1 |
| Murthy, SI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Analysis of Loteprednol Etabonate Ophthalmic Suspension 0.25% for Prevention of Immunologic Rejection After Descemet Membrane Endothelial Keratoplasty[NCT05136443] | Phase 4 | 71 participants (Actual) | Interventional | 2021-11-23 | Completed | ||
| Comparison Of Two Corticosteroid Dosing Regimens For Prevention Of Corneal Transplant Rejection Episodes After Descemet's Membrane Endothelial Keratoplasty[NCT01448213] | Phase 2 | 264 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Prospective, Randomized Comparison of Corticosteroid Dosing Regimens Following Endothelial Keratoplasty[NCT01853696] | Phase 4 | 167 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt in Conjunction With Topical Prednisolone Acetate 1% Treating Pain, and inflamMation Following Corneal Transplant Surgery Compared to Topical Prednisolone Acetate 1%.[NCT04521140] | Phase 4 | 36 participants (Actual) | Interventional | 2020-10-16 | Completed | ||
| Open-enrollment, Prospective Study of Endothelial Keratoplasty Outcomes[NCT00800111] | 2,593 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01448213)
Timeframe: Within 1 year
| Intervention | eyes (Number) |
|---|---|
| Fluorometholone 0.1% Solution | 2 |
| Prednisolone Acetate 1% Solution | 0 |
Absolute IOP greater than or equal to 24 mm Hg or a relative increase of 10 mm Hg over the baseline preoperative reading. (NCT01448213)
Timeframe: one day, two days, one week, one month, 3 months, 6 months and 12 months after DMEK
| Intervention | eyes (Number) |
|---|---|
| Fluorometholone 0.1% Solution | 9 |
| Prednisolone Acetate 1% Solution | 32 |
Rejection episodes were assessed by slit lamp examination and categorized as definite when an endothelial rejection line was detected in a previously clear graft, probable when inflammation (stromal infiltrate, keratic precipitates, cells in the anterior chamber, or ciliary injection) was detected in a previously clear graft without an endothelial rejection line, and possible if central corneal pachymetry increased by 30 microns or more, even if the cornea was clear and no inflammation was detected by slit lamp examination. (NCT01853696)
Timeframe: within first year after cornea transplantation
| Intervention | eyes (Number) |
|---|---|
| Loteprednol | 0 |
| Prednisolone Acetate | 0 |
Number of eyes in which the absolute intraocular pressure equaled or exceeded 24 mm Hg OR in which there was a relative increase of at least 10 mm Hg over the baseline preoperative reading. (NCT01853696)
Timeframe: from 1 to 12 months after transplant
| Intervention | eyes (Number) |
|---|---|
| Loteprednol | 11 |
| Prednisolone Acetate | 27 |
2 trials available for prednisolone acetate and Corneal Endothelial Cell Damage
3 other studies available for prednisolone acetate and Corneal Endothelial Cell Damage
| Article | Year |
|---|---|
Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Cell Count; Corneal Endothelial Cell Loss; | 2016 |
Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Cell Count; Corneal Endothelial Cell Loss; | 2016 |
Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Cell Count; Corneal Endothelial Cell Loss; | 2016 |
Descemet's Membrane Endothelial Keratoplasty: Risk of Immunologic Rejection Episodes after Discontinuing Topical Corticosteroids.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Cell Count; Corneal Endothelial Cell Loss; | 2016 |
Graft rejection after Descemet's stripping automated endothelial keratoplasty: graft survival and endothelial cell loss.
Topics: Aged; Cell Count; Corneal Endothelial Cell Loss; Descemet Stripping Endothelial Keratoplasty; Endoth | 2012 |
Endothelial keratoplasty in children: surgical challenges and early outcomes.
Topics: Adolescent; Child; Child, Preschool; Corneal Diseases; Corneal Endothelial Cell Loss; Descemet Strip | 2012 |