Page last updated: 2024-10-15

acetoacetic acid and Acetonemia

acetoacetic acid has been researched along with Acetonemia in 60 studies

acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.

Research Excerpts

ExcerptRelevanceReference
"Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment."5.48Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018)
"Erythrocytes were washed, suspended in buffers containing 5 mM glucose (simulates euglycemia) or 25 mM glucose (simulates hyperglycemia), and incubated with acetone (5 and 10 mM, acetoacetate (5 and 10 mM), or beta-hydroxybutyrate (5 and 25 mM) for 24 hours at 37 C."3.69In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"In diabetes, mainly type-1, ketoacidosis is the pathological response to glucose malabsorption."2.66Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. ( Balcerczyk, A; Dąbek, A; Pirola, L; Wojtala, M, 2020)
"In cases of ketosis, a decrease in activity may be observed 5 days before the clinical diagnosis is made."2.61[Overview on the relationship between changes in activity and ketosis in dairy cows]. ( Hajek, F; Mansfeld, R, 2019)
"Hyperketonemia is a condition with elevated blood levels of acetoacetate, 3-β-hydroxybutyrate, and acetone."2.53Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes. ( Jain, SK; Kanikarla-Marie, P, 2016)
"Normally, the presence of ketosis implies 2 things: that lipid energy metabolism has been activated and that the entire pathway of lipid degradation is intact."2.39Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995)
"Ketosis is normal during fasting, after prolonged exercise, and when a high-fat diet is consumed."2.39Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995)
"Alcoholic ketoacidosis (AKA) is an important and probably underdiagnosed differential diagnosis for metabolic acidosis with an increased anion gap."2.38[Alcoholic ketoacidosis]. ( Caspar, CB; Iten, PX; Jost, R; Risti, B; Russi, EW; Speich, R, 1993)
"Ketosis is a metabolic disorder often triggered by anorexia in animals fed on high energy diets."1.56Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs. ( Bochmann, M; Clauss, M; Hatt, JM; Hetzel, U; Riond, B; Schmid, NS, 2020)
"Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Soft-drink diabetic ketosis, characterized by acute onset ketosis induced by excessive ingestion of sugar-containing drinks, is often seen in obese, young patients, even with undiagnosed type 2 diabetes."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"The eruptive xanthoma lesions gradually diminished in size and number and eventually disappeared by 12 months."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment."1.48Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018)
"Dairy cows with ketosis are characterized by oxidative stress, hepatic damage, and hyperketonemia."1.46Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows. ( Du, X; Li, X; Liu, G; Peng, Z; Shi, Z; Wang, Z; Zhang, Y; Zhao, C, 2017)
"The model predicted clinical ketosis with a sensitivity of 100% and a specificity of 100%."1.40(1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis. ( Shu, S; Sun, LW; Wu, L; Xia, C; Xu, C; Zhang, HY; Zheng, JS, 2014)
"This degree of ketonemia is estimated to contribute up to 8% to 9% of brain energy metabolism."1.39Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. ( Castellano, CA; Chouinard-Watkins, R; Courchesne-Loyer, A; Cunnane, SC; Fortier, M; Nugent, S; Roy, M; Tremblay-Mercier, J, 2013)
"However, in ketosis, acetone can be reduced to IPA."1.38Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations. ( Augsburger, M; Bardy, D; Mangin, P; Palmiere, C; Sporkert, F; Werner, D, 2012)
"Subclinical ketosis is a metabolic disorder in high-producing dairy cattle that can be detected by ketone bodies in milk: acetone (Ac), acetoacetate (AcAc), and beta-hydroxybutyrate (BHBA)."1.34Screening for subclinical ketosis in dairy cattle by Fourier transform infrared spectrometry. ( de Jong, G; de Roos, AP; Hørlyk, J; van den Bijgaart, HJ, 2007)
"Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)."1.33A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats. ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006)
"The sample proportion of subclinical ketosis was 7."1.32Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows. ( Carrier, J; Fetrow, J; Godden, S; Rapnicki, P; Stewart, S, 2004)
"For the detection of subclinical ketosis, the best sensitivity-specificity combination was obtained with the determination of acetoacetate in blood or milk, with threshold concentrations of 125 and 50 micromol/L, respectively."1.31Ketone bodies in milk and blood of dairy cows: relationship between concentrations and utilization for detection of subclinical ketosis. ( Bayourthe, C; Enjalbert, F; Moncoulon, R; Nicot, MC, 2001)
"To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed."1.31Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002)
"As an indicator of ketosis in epilepsy patients consuming a ketogenic diet, breath acetone may be useful for understanding the mechanism of the diet, elucidating the importance of ketosis in seizure protection, and ultimately, enhancing the efficacy of the diet by improving patient monitoring."1.31Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002)
"This apparent ketosis resistance is similar to that observed in some forms of human diabetes."1.30Ketosis resistance in the male offspring of protein-malnourished rat dams. ( Hales, CN; Ozanne, SE; Petry, CJ; Smith, JM; Wang, CL, 1998)
"The mechanism by which ketosis causes accelerated cellular damage and vascular disease in diabetes is not known."1.30Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells. ( Jain, SK; Kannan, K; Lim, G, 1998)
"To achieve this aim, one would need ketosis, severe hypoglycemia, and low lactatemia."1.29Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. ( Agarwal, KC; Ciraolo, ST; David, F; Fernandez, CA; Koshy, J; Lucas, D; Previs, SF; Stevens, MP; Tammaro, A; Tserng, KY, 1995)
"To investigate in vitro effects of ketosis and hyperglycemia on feline erythrocyte Heinz body formation, reduced glutathione (GSH) concentration, and D- and L-lactate production, and to identify potential metabolic mechanisms of oxidative stress in diabetic cats."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"Neither high glucose concentration nor ketosis had direct effects on Heinz body formation or GSH values."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"High glucose concentration and ketosis do not account directly for oxidative damage and glyoxalase induction in feline erythrocytes in vitro, although high concentrations of beta-hydroxybutyrate may stimulate D-lactate formation."1.29In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996)
"Propionic acid was used as a possible preventive agent against ketogenesis."1.27Effect of propionic acid on ketogenesis in lactating sheep fed restricted rations or deprived of food. ( Emmanuel, B; Kennelly, JJ, 1984)
"A mild ketosis is known to prevail in the mother, fetus, and newborn infant during the 3rd trimester and in the early neonatal period."1.27Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations. ( Auestad, N; Benson, J; Edmond, J; Picone, T; Rambathla, S; Wu, PY, 1986)
"The greater the ketosis, the greater the discrepancy."1.27Characterization of creatinine error in ketotic patients. A prospective comparison of alkaline picrate methods with an enzymatic method. ( Gerard, SK; Khayam-Bashi, H, 1985)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199020 (33.33)18.7374
1990's10 (16.67)18.2507
2000's12 (20.00)29.6817
2010's14 (23.33)24.3611
2020's4 (6.67)2.80

Authors

AuthorsStudies
Evans, M1
McClure, TS1
Koutnik, AP2
Egan, B2
Spigoni, V1
Cinquegrani, G1
Iannozzi, NT1
Frigeri, G1
Maggiolo, G1
Maggi, M1
Parello, V1
Dei Cas, A1
Hajek, F1
Mansfeld, R1
Schmid, NS1
Clauss, M1
Hetzel, U1
Riond, B1
Bochmann, M1
Hatt, JM1
Dąbek, A1
Wojtala, M1
Pirola, L1
Balcerczyk, A1
Min, SH1
Oh, TJ1
Baek, SI1
Lee, DH1
Kim, KM1
Moon, JH1
Choi, SH1
Park, KS1
Jang, HC1
Lim, S1
Tsuchiya, S1
Sawada, S1
Takeda, K1
Takahashi, K1
Nakajima, T1
Kohata, M1
Kurosawa, S1
Satake, C1
Imai, J1
Kikuchi, K1
Aiba, S1
Katagiri, H1
D'Agostino, DP1
Ho, CF1
Chan, KW1
Yeh, HI1
Kuo, J1
Liu, HJ1
Wang, CY1
Sun, LW1
Zhang, HY1
Wu, L1
Shu, S1
Xia, C1
Xu, C1
Zheng, JS1
Kanikarla-Marie, P3
Jain, SK4
Du, X1
Shi, Z1
Peng, Z1
Zhao, C1
Zhang, Y1
Wang, Z1
Li, X2
Liu, G1
Tilbrook, LK1
Slater, J1
Agarwal, A1
Cyriac, J1
Bentourkia, M1
Tremblay, S1
Pifferi, F1
Rousseau, J1
Lecomte, R1
Cunnane, S1
Prevost, M1
Sun, Y1
Servilla, KS1
Massie, L1
Glew, RH1
Tzamaloukas, AH1
Ganini, D1
Christoff, M1
Ehrenshaft, M1
Kadiiska, MB1
Mason, RP1
Bechara, EJ1
Palmiere, C1
Sporkert, F1
Werner, D1
Bardy, D1
Augsburger, M1
Mangin, P1
Rains, JL1
Courchesne-Loyer, A1
Fortier, M1
Tremblay-Mercier, J1
Chouinard-Watkins, R1
Roy, M1
Nugent, S1
Castellano, CA1
Cunnane, SC2
BAHNER, FW1
TAYLOR, NR1
FREE, AH1
FREE, HM1
WIELAND, O1
LOEFFLER, G1
WEISS, L1
NEUFELDT, I1
BERGMAN, EN1
KON, K1
SAUER, F1
Jánosi, S1
Kulcsár, M1
Kóródi, P1
Kátai, L1
Reiczigel, J1
Dieleman, SJ1
Nikolic, JA1
Sályi, G1
Ribiczey-Szabó, P1
Huszenicza, G1
Carrier, J1
Stewart, S1
Godden, S1
Fetrow, J1
Rapnicki, P1
Nylen, K1
Likhodii, SS2
Hum, KM1
Burnham, WM1
de Roos, AP1
van den Bijgaart, HJ1
Hørlyk, J1
de Jong, G1
Kauppinen, K3
Owen, OE1
Caprio, S1
Reichard, GA1
Mozzoli, MA1
Boden, G1
Owen, RS1
Gröhn, Y2
Lindberg, LA1
Bruss, ML1
Farver, TB1
Emmanuel, B1
Kennelly, JJ1
Mitchell, GA1
Kassovska-Bratinova, S1
Boukaftane, Y1
Robert, MF1
Wang, SP1
Ashmarina, L1
Lambert, M1
Lapierre, P1
Potier, E1
Ciraolo, ST1
Previs, SF1
Fernandez, CA1
Agarwal, KC1
David, F1
Koshy, J1
Lucas, D1
Tammaro, A1
Stevens, MP1
Tserng, KY1
Sato, S1
Suzuki, T1
Okada, K1
Caspar, CB1
Risti, B1
Iten, PX1
Jost, R1
Russi, EW1
Speich, R1
Fallin, CW1
Christopher, MM1
Pounder, DJ1
Stevenson, RJ1
Taylor, KK1
Ozanne, SE1
Wang, CL1
Petry, CJ1
Smith, JM1
Hales, CN1
Kannan, K1
Lim, G1
Geishauser, T1
Leslie, K1
Tenhag, J1
Bashiri, A1
Saeed, FA1
Carpente, KH1
Wilcken, B1
Christodoulou, J1
Thorburn, DR1
Enjalbert, F1
Nicot, MC1
Bayourthe, C1
Moncoulon, R1
Fritzsche, I1
Bührdel, P1
Melcher, R1
Böhme, HJ1
Musa-Veloso, K1
Tveit, B2
Lingaas, F2
Svendsen, M1
Sjaastad, OV1
Sorisky, A1
Devlin, JT1
Mamer, OA1
Zusman, I1
Ornoy, A1
Wu, PY1
Edmond, J1
Auestad, N1
Rambathla, S1
Benson, J1
Picone, T1
Czervionke, RL1
Johnson, GF1
Nuwayhid, NF1
Feld, RD1
Féry, F1
Balasse, EO1
Barac-Nieto, M1
Gerard, SK1
Khayam-Bashi, H1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants[NCT03830268]20 participants (Actual)Interventional2017-06-02Completed
Effect of a Ketogenic Supplement on Brain Energy Metabolism Measured by Neuroimaging in Mild Cognitive Impairment[NCT02551419]82 participants (Actual)Interventional2015-06-30Completed
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724]21 participants (Actual)Observational2019-10-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for acetoacetic acid and Acetonemia

ArticleYear
Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future.
    Sports medicine (Auckland, N.Z.), 2022, Volume: 52, Issue:Suppl 1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Dietary Supplements; Humans; Ketone Bodies; Ketones; Ketosis

2022
Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Carbohydrates; Diet, Ketogenic; Humans; Ketone Bodies; Ketones

2022
[Overview on the relationship between changes in activity and ketosis in dairy cows].
    Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere, 2019, Volume: 47, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Behavior, Animal; Cattle; Cattle Diseases; Diagnosis,

2019
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.
    Nutrients, 2020, Mar-17, Volume: 12, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Type 1; Diet, Ketogenic; Epigenesi

2020
Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.
    Trends in endocrinology and metabolism: TEM, 2019, Volume: 30, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Diet, Ketogenic; Humans; Inflammation; Ketone Bodies; Ketosis;

2019
Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
    Free radical biology & medicine, 2016, Volume: 95

    Topics: Acetoacetates; Diabetes Mellitus, Type 1; Energy Metabolism; Glucose; Humans; Ketone Bodies; Ketones

2016
Ketosis of starvation: a revisit and new perspectives.
    Clinics in endocrinology and metabolism, 1983, Volume: 12, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Gluconeogenesis; Humans; Hydrogen; Hydroxyb

1983
Medical aspects of ketone body metabolism.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1995, Volume: 18, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biological Evolution; Brain; Humans; Hydroxybutyrates

1995
[Alcoholic ketoacidosis].
    Schweizerische medizinische Wochenschrift, 1993, Oct-16, Volume: 123, Issue:41

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Alcoholism; Diagnosis, Differential; Ethanol; Female

1993

Other Studies

51 other studies available for acetoacetic acid and Acetonemia

ArticleYear
Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs.
    BMC veterinary research, 2020, Feb-03, Volume: 16, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animal Nutritional Physiological Phenomena; Animals;

2020
Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes.
    Diabetes & metabolism, 2018, Volume: 44, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Benzhydryl Compounds; Case-Control Studies; Diabe

2018
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
    Endocrine journal, 2019, Jan-28, Volume: 66, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B

2019
Ketone bodies upregulate endothelial connexin 43 (Cx43) gap junctions.
    Veterinary journal (London, England : 1997), 2013, Volume: 198, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Aorta; Blotting, Western; Cattle; Connexin 4

2013
(1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis.
    Journal of dairy science, 2014, Volume: 97, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Blood Glucose; Cattle; Cattle Diseases; Chol

2014
1,25(OH)2D3 inhibits oxidative stress and monocyte adhesion by mediating the upregulation of GCLC and GSH in endothelial cells treated with acetoacetate (ketosis).
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 159

    Topics: Acetoacetates; Calcitriol; Cell Adhesion; Cell Line; Cytokines; Drug Evaluation, Preclinical; Glutam

2016
Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows.
    Journal of cellular physiology, 2017, Volume: 232, Issue:12

    Topics: Acetoacetates; Animals; Apoptosis; Cattle; Cells, Cultured; Female; Hepatocytes; Ketosis; MAP Kinase

2017
An unusual cause of interference in a salicylate assay caused by mitochondrial acetoacetyl-CoA thiolase deficiency.
    Annals of clinical biochemistry, 2008, Volume: 45, Issue:Pt 5

    Topics: Acetoacetates; Acetyl-CoA C-Acetyltransferase; Acidosis; Acids; Amino Acid Metabolism, Inborn Errors

2008
PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:4

    Topics: Acetoacetates; Animals; Brain; Carbon Radioisotopes; Diet; Ketosis; Magnetic Resonance Imaging; Mode

2009
Repeated intoxication presenting with azotemia, elevated serum osmolal gap, and metabolic acidosis with high anion gap: differential diagnosis, management, and prognosis.
    International urology and nephrology, 2012, Volume: 44, Issue:1

    Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Acid-Base Equilibrium; Acidosis; Aged; Al

2012
Myoglobin-H2O2 catalyzes the oxidation of β-ketoacids to α-dicarbonyls: mechanism and implications in ketosis.
    Free radical biology & medicine, 2011, Aug-01, Volume: 51, Issue:3

    Topics: Acetoacetates; Biocatalysis; Diabetes Complications; Diacetyl; Humans; Ketosis; Myoglobin; Oxidation

2011
Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations.
    Legal medicine (Tokyo, Japan), 2012, Volume: 14, Issue:1

    Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biomarkers; Case-Control Studies; Flame I

2012
Hyperketonemia induces upregulation of LFA-1 in monocytes, which is mediated by ROS and P38 MAPK activation.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:12

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetylcysteine; Cardiovascular Diseases; Cell Adhesion Molecul

2012
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
    Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di

2013
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
    Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di

2013
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
    Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di

2013
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
    Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di

2013
Fasting ketosis in hypophysectomised and normal rats.
    Quarterly journal of experimental physiology and cognate medical sciences, 1952, Volume: 37, Issue:4

    Topics: Acetoacetates; Animals; Fasting; Ketosis; Pituitary Gland; Rats

1952
Nature of nitroprusside reactive material in urine in ketosis.
    American journal of clinical pathology, 1958, Volume: 30, Issue:1

    Topics: Acetoacetates; Acidosis; Body Fluids; Humans; Ketosis; Nitroprusside

1958
[On acetoacetic acid and cholesterin formation in experimental ketosis].
    Biochemische Zeitschrift, 1960, Volume: 333

    Topics: Acetoacetates; Acidosis; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Ketone Bod

1960
ACETOACETATE TURNOVER AND OXIDATION RATES IN OVINE PREGNANCY KETOSIS.
    The American journal of physiology, 1964, Volume: 206

    Topics: Acetoacetates; Acidosis; Animals; Blood Chemical Analysis; Carbon Isotopes; Fasting; Female; Glucose

1964
Acetoacetate and beta-hydroxy-beta-methyl glutaryl coenzyme A metabolism in normal and ketotic guinea pigs.
    Canadian journal of biochemistry and physiology, 1961, Volume: 39

    Topics: Acetoacetates; Acidosis; Acyl Coenzyme A; Coenzymes; Glycine; Guinea Pigs; Ketoses; Ketosis

1961
Energy imbalance related predisposition to mastitis in group-fed high-producing postpartum dairy cows.
    Acta veterinaria Hungarica, 2003, Volume: 51, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Aspartate Aminotransferases; Blood Glucose; Cattle; C

2003
Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows.
    Journal of dairy science, 2004, Volume: 87, Issue:11

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; False Negative Reactions; Fa

2004
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
    Epilepsy research, 2006, Volume: 71, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Antic

2006
Screening for subclinical ketosis in dairy cattle by Fourier transform infrared spectrometry.
    Journal of dairy science, 2007, Volume: 90, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Calibration; Cattle; Cattle Diseases; Dairyi

2007
ALAT, AP, ASAT, GGT, OCT activities and urea and total bilirubin concentrations in plasma of normal and ketotic dairy cows.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1984, Volume: 31, Issue:8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Alanine Transaminase; Alkaline Phosphatase; Animals;

1984
Annual milk yield and reproductive performance of ketotic and non-ketotic dairy cows.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1984, Volume: 31, Issue:9

    Topics: Acetoacetates; Acidosis; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Pregnan

1984
Fatty infiltration of liver in spontaneously ketotic dairy cows.
    Journal of dairy science, 1983, Volume: 66, Issue:11

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Biopsy, Needle; Blood Glucose; Cattle; Catt

1983
Prevalence of bovine ketosis in relation to number and stage of lactation.
    Acta veterinaria Scandinavica, 1983, Volume: 24, Issue:4

    Topics: Acetoacetates; Acidosis; Animals; Cattle; Cattle Diseases; Female; Finland; Ketosis; Lactation; Pari

1983
Effect of propionic acid on ketogenesis in lactating sheep fed restricted rations or deprived of food.
    Journal of dairy science, 1984, Volume: 67, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Diet; Fatty Acids, Nonesteri

1984
Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters.
    The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Butylene Glycols; Dichloroacetic Acid;

1995
Suppression of mitogenic response of bovine peripheral blood lymphocytes by ketone bodies.
    The Journal of veterinary medical science, 1995, Volume: 57, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Female; Hydroxybutyrates; Ke

1995
In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production.
    American journal of veterinary research, 1996, Volume: 57, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Cat Diseases; Cats; Erythrocytes; Female; Gl

1996
Alcoholic ketoacidosis at autopsy.
    Journal of forensic sciences, 1998, Volume: 43, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis

1998
Ketosis resistance in the male offspring of protein-malnourished rat dams.
    Metabolism: clinical and experimental, 1998, Volume: 47, Issue:12

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Cholesterol; Diet, Protein-Restricted;

1998
Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells.
    Free radical biology & medicine, 1998, Volume: 25, Issue:9

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cell Division; Cells, Cultured; Cytochrome c Group; Diabetes M

1998
Evaluation of eight cow-side ketone tests in milk for detection of subclinical ketosis in dairy cows.
    Journal of dairy science, 2000, Volume: 83, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Cell Count; Female; Ketones;

2000
Production of pyruvate by Candida albicans: proposed role in virulence.
    FEMS microbiology letters, 2000, Sep-01, Volume: 190, Issue:1

    Topics: Acetoacetates; Candida albicans; Culture Media; Humans; Hydrogen Peroxide; Ketosis; Lactobacillus ac

2000
Holocarboxylase synthetase deficiency: urinary metabolites masked by gross ketosis.
    Journal of inherited metabolic disease, 2000, Volume: 23, Issue:8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis, Lactic; Carbon-Nitrogen Ligases; Carboxy-Lyases; Chi

2000
Ketone bodies in milk and blood of dairy cows: relationship between concentrations and utilization for detection of subclinical ketosis.
    Journal of dairy science, 2001, Volume: 84, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Cattle; Cattle Diseases; Female; Ketone Bodi

2001
Stability of ketone bodies in serum in dependence on storage time and storage temperature.
    Clinical laboratory, 2001, Volume: 47, Issue:7-8

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Preservation; Child; Cryopreservation; Female; Humans; K

2001
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
    The American journal of clinical nutrition, 2002, Volume: 76, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa

2002
Etiology of acetonemia in Norwegian cattle. 1. Effect of ketogenic silage, season, energy level, and genetic factors.
    Journal of dairy science, 1992, Volume: 75, Issue:9

    Topics: Acetoacetates; Animals; Body Weight; Cattle; Cattle Diseases; Energy Metabolism; Female; Ketosis; La

1992
Etiology of acetonemia in Norwegian cattle. 2. Effect of butyric acid, valeric acid, and putrescine.
    Journal of dairy science, 1992, Volume: 75, Issue:9

    Topics: Acetoacetates; Animals; Butyrates; Butyric Acid; Cattle; Cattle Diseases; Female; Ketosis; Lactation

1992
Intraoperative ketoacidosis and malnutrition.
    Annals of internal medicine, 1988, Aug-15, Volume: 109, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Acute Disease; Drug Therapy, Combination; Female; Gl

1988
Measurement of urinary lactic, 3-hydroxybutyric, pyruvic and acetoacetic acids in a single analysis using selected ion monitoring and stable isotope labelling techniques.
    Biomedical & environmental mass spectrometry, 1988, Jan-01, Volume: 15, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Deuterium; Gas Chromatography-Mass Spectrometry; Humans

1988
Effects of hyperglycemia and ketone bodies on the in vitro development of early somite rate embryos.
    Pediatric pathology, 1987, Volume: 7, Issue:5-6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Congenital Abnormalities; Cu

1987
Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations.
    Pediatric research, 1986, Volume: 20, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Dietary Fats; Fetal Blood; Humans; Hydroxybutyrates; Infant Fo

1986
Quantification of analyte and interferent by multipoint analysis.
    Clinical chemistry, 1986, Volume: 32, Issue:9

    Topics: Acetoacetates; Cefoxitin; Creatinine; Humans; Ketone Bodies; Ketosis; Kinetics; Mathematics; Models,

1986
Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis.
    Diabetes, 1985, Volume: 34, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabet

1985
Renal hydroxybutyrate and acetoacetate reabsorption and utilization in the rat.
    The American journal of physiology, 1985, Volume: 249, Issue:1 Pt 2

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biological Transport; Carbon Radioisotopes; Glomerula

1985
Propionate loading test for liver function in spontaneously ketotic dairy cows.
    Research in veterinary science, 1985, Volume: 39, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Fem

1985
Characterization of creatinine error in ketotic patients. A prospective comparison of alkaline picrate methods with an enzymatic method.
    American journal of clinical pathology, 1985, Volume: 84, Issue:5

    Topics: Acetoacetates; Acidosis; Adolescent; Adult; Aged; Child; Child, Preschool; Creatinine; Female; Human

1985