3-hydroxybutyric acid has been researched along with Acetonemia in 453 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia." | 7.88 | Nutritional ketosis delays the onset of isoflurane induced anesthesia. ( Ari, C; D'Agostino, DP; Diamond, D; Goldhagen, CR; Koutnik, AP; Kovács, Z; Murdun, C; Rogers, C, 2018) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 7.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| " Seizure threshold was tested by intravenous infusion of pentylenetetrazole (PTZ) whereas seizure severity was determined from measuring the hindlimb extension to flexion (E/F) ratio after seizures were evoked by maximal electroshock stimulation (MES)." | 7.70 | A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. ( Bough, KJ; Eagles, DA; Matthews, PJ, 2000) |
| "The objective of this study was to assess the effects of treatment with propylene glycol (PG) and cyanocobalamin (B12) on health, milk production, and reproductive outcomes of cows diagnosed with hyperketonemia (HK), hypoglycemia (HG), or concurrent HKHG." | 5.51 | A randomized controlled trial examining the effects of treatment with propylene glycol and injectable cyanocobalamin on naturally occurring disease, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypo ( Aldridge, BM; Canisso, IF; Coelho, WM; Hubner, AM; Lima, FS; Peixoto, PM; Ribeiro, L, 2022) |
| "Insulin resistance was evaluated using an intravenous glucose tolerance test and intravenous insulin challenge test (IVICT) in a subgroup of cows (n = 20/treatment) at 10 and 11 DIM, respectively." | 5.51 | Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle IV: Insulin resistance, dry matter intake, and blood parameters. ( Batista, CP; Bicalho, RC; Bringhenti, L; Lima, FS; McDonough, SP; Meira, EBS; Zinicola, M, 2019) |
| "Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment." | 5.48 | Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018) |
| "To test glucagon as a treatment for fatty liver, either glucagon at 10 mg/d or excipient was infused via the jugular vein from 21 to 35 d postpartum." | 5.30 | Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon. ( Beitz, DC; Hippen, AR; Lindberg, GL; Richardson, LF; She, P; Tucker, RW; Young, JW, 1999) |
| "The sympathoadrenal counterregulatory response to hypoglycemia is critical for individuals with type 1 diabetes due to impaired ability to produce glucagon." | 4.02 | Slow but Steady-The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats. ( Cohen, M; Farnham, MM; Nedoboy, PE, 2021) |
| " Plasma β-hydroxybutyrate concentration, on-farm cow data (milk yield, percentage of fat, protein and lactose, fat- and protein-corrected milk yield, body weight, body weight change, dry period length, parity, and somatic cell count), and NEI of 424 individual cows were available weekly through lactation wk 1 to 5 postpartum." | 3.96 | Short communication: Prediction of hyperketonemia in dairy cows in early lactation using on-farm cow data and net energy intake by partial least square discriminant analysis. ( Bruckmaier, RM; Kemp, B; Saccenti, E; van Knegsel, ATM; Vervoort, J; Xu, W, 2020) |
| " However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia." | 3.88 | Nutritional ketosis delays the onset of isoflurane induced anesthesia. ( Ari, C; D'Agostino, DP; Diamond, D; Goldhagen, CR; Koutnik, AP; Kovács, Z; Murdun, C; Rogers, C, 2018) |
| " The method quantifies glycolic acid, beta-hydroxybutyric acid with good linearity and pyroglutamic acid with a reproducible curvature relation between 1 and 20 mmol/L and can help the clinician distinguish effectively between ethylene glycol poisoning, alcoholic and diabetic ketoacidosis and cysteine deficiency so early that it will have clinical consequences." | 3.85 | Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis. ( Føreid, S; Gadeholt, G, 2017) |
| " Alcoholism may cause hypoglycemia accompanying with AKA, due to a low carbohydrate intake, the inhibition of gluconeogenesis, and reduced hepaticglycogen storage as seen in this case." | 3.81 | Case of alcoholic ketoacidosis accompanied with severe hypoglycemia. ( Iwanaga, Y; Matsuzaki, T; Shiraishi, W; Yamamoto, A, 2015) |
| " Following weight loss, circulating concentrations of glucose, insulin, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), leptin, gastrointestinal hormones and subjective ratings of appetite were compared when subjects were ketotic, and after refeeding." | 3.79 | Ketosis and appetite-mediating nutrients and hormones after weight loss. ( Delbridge, E; Kriketos, A; Prendergast, LA; Proietto, J; Purcell, K; Shulkes, A; Sumithran, P, 2013) |
| "Data from 191 post-mortem cases where post-mortem blood beta-hydroxybutyrate (βHB) and acetone concentrations and vitreous humor glucose concentrations (where available) had been measured were retrospectively investigated to determine the markers required to identify and distinguish between Alcoholic Ketoacidosis (AKA), Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS)." | 3.78 | Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples. ( Andrews, R; Dhillo, W; Hockenhull, J; Paterson, S, 2012) |
| " Seizures were induced by the volatile convulsant agent flurothyl." | 3.77 | Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats. ( Khazipov, R; Minlebaev, M, 2011) |
| " On day 140 of pregnancy the ewes were sampled for determination of betaOH-butyrate (BHB), AST, glucose, non-esterified fatty acids (NEFA), total cholesterol (TCH), insulin, T4, T3, cortisol, IGF-1 and leptin." | 3.73 | Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season. ( Cernescu, H; Chilliard, Y; Cseh, S; Dankó, G; Delavaud, C; Gáspárdy, A; Huszenicza, G; Kulcsár, M; Mircu, C; Nikolic, AJ; Rudas, P, 2006) |
| "The purpose of this study was to test the hypothesis that a ketogenic diet would increase the resistance of rats to pentylenetetrazole (PTZ)-induced seizures and to understand the relation of ketonemia to seizure resistance." | 3.70 | A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. ( Bough, KJ; Eagles, DA, 1999) |
| "The present study was designed to evaluate the effects of age on the efficacy of the ketogenic diet in suppressing seizures evoked by tail-vein infusion of pentylenetetrazole (PTZ)." | 3.70 | Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. ( Bough, KJ; Eagles, DA; Han, FT; Valiyil, R, 1999) |
| " Results also showed that the animals fed calorie-restricted high-fat diets exhibited significant ketonemia and protection from pentylenetetrazole (PTZ)-induced seizures." | 3.70 | Higher ketogenic diet ratios confer protection from seizures without neurotoxicity. ( Bough, KJ; Eagles, DA; Yao, SG, 2000) |
| " Seizure threshold was tested by intravenous infusion of pentylenetetrazole (PTZ) whereas seizure severity was determined from measuring the hindlimb extension to flexion (E/F) ratio after seizures were evoked by maximal electroshock stimulation (MES)." | 3.70 | A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. ( Bough, KJ; Eagles, DA; Matthews, PJ, 2000) |
| "Erythrocytes were washed, suspended in buffers containing 5 mM glucose (simulates euglycemia) or 25 mM glucose (simulates hyperglycemia), and incubated with acetone (5 and 10 mM, acetoacetate (5 and 10 mM), or beta-hydroxybutyrate (5 and 25 mM) for 24 hours at 37 C." | 3.69 | In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production. ( Christopher, MM; Fallin, CW, 1996) |
| "Ketosis has been reported to benefit healthspan and resilience, which has driven considerable interest in development of exogenous ketones to induce ketosis without dietary changes." | 3.30 | Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults. ( Anthony, JC; Blade, T; Buga, A; Crabtree, CD; Hyde, PN; Kackley, ML; Newman, JC; Panda, O; Roa-Diaz, S; Sapper, TN; Stubbs, BJ; Volek, JS, 2023) |
| "Acute ketosis consistently does not affect both objective and subjective parameters of appetite regulation in prediabetes." | 3.30 | Effect of d-β-Hydroxybutyrate-(R)-1,3 Butanediol on Appetite Regulation in People with Prediabetes. ( Bharmal, SH; Kimita, W; Liu, Y; Petrov, MS, 2023) |
| "Rather than during illness while diabetic ketoacidosis (DKA) is developing, we aimed to determine if levels of routine point-of-care capillary blood ketones could predict future DKA." | 3.30 | Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes. ( Bakhsh, A; Bapat, P; Budhram, D; Cherney, DZI; Dhaliwal, S; Fralick, M; Ivers, NM; Lovblom, LE; Mumford, D; Perkins, BA; Scarr, D; Song, C; Tomlinson, G; Verhoeff, NJ; Weisman, A, 2023) |
| "To detect ketosis [blood β-hydroxybutyrate (BHB) ≥1." | 3.11 | Reducing milking frequency from twice to once daily as an adjunct treatment for ketosis in lactating dairy cows-A randomized controlled trial. ( Couto Serrenho, R; DeVries, TJ; Duffield, TF; LeBlanc, SJ; McBride, BW; Williamson, M, 2022) |
| "Acute ketosis resulted in significantly lower AUCs for remnant cholesterol (p = 0." | 3.11 | Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial. ( Bharmal, SH; Kimita, W; Liu, Y; Petrov, MS, 2022) |
| " We conclude that supplementing with exogenous beta-hydroxybutyrate salts is safe and well-tolerated by healthy adolescents." | 3.01 | The Effect of Exogenous Beta-Hydroxybutyrate Salt Supplementation on Metrics of Safety and Health in Adolescents. ( Gheith, R; Lowery, R; Sharp, M; Stefan, M; Wilson, J, 2021) |
| "Effect of treatment on ketonemia and prevalence of HYK were evaluated for 4 specific time periods: 1 to 3, 4 to 7, 8 to 17, and 18 to 26 DIM." | 2.87 | A randomized controlled trial on the effect of incomplete milking during early lactation on ketonemia and body condition loss in Holstein dairy cows. ( Chorfi, Y; Dubuc, J; Dufour, S; Krug, C; Lacasse, P; Morin, PA; Roy, JP; Santschi, DE, 2018) |
| "Outcomes of interest on all farms were ketosis cure (blood BHB <1." | 2.84 | Effects of a combination butaphosphan and cyanocobalamin product and insulin on ketosis resolution and milk production. ( Duffield, TF; Gordon, JL; Herdt, TH; Kelton, DF; LeBlanc, SJ; Neuder, L, 2017) |
| "Ketosis was defined as blood β-hydroxybutyrate (BHB) ≥1." | 2.84 | Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production. ( Duffield, TF; Gordon, JL; Herdt, TH; Kelton, DF; LeBlanc, SJ; Neuder, L, 2017) |
| " Concentrations of BHB in vivo during subclinical ketosis did not alter the proliferative capability of bovine PBMC in vitro, which was first significantly decreased at a dosage of 5 mM BHB." | 2.80 | Effects of elevated parameters of subclinical ketosis on the immune system of dairy cows: in vivo and in vitro results. ( Dänicke, S; Frahm, J; Kersten, S; Meyer, U; Reiche, D; Sauerwein, H; Schulz, K, 2015) |
| "Propylene glycol was not different from GPG for glucose, insulin, or BHBA responses." | 2.80 | Evaluation of propylene glycol and glycerol infusions as treatments for ketosis in dairy cows. ( Allen, MS; Piantoni, P, 2015) |
| "Subclinical ketosis was defined as a β-hydroxybutyrate (BHBA) concentration of 1." | 2.76 | A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with subclinical ketosis. ( McArt, JA; Nydam, DV; Oetzel, GR; Ospina, PA, 2011) |
| "It is widely accepted that ketosis (increased blood ketone body levels, e." | 2.72 | Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases. ( Ari, C; Brunner, B; Kovács, Z, 2021) |
| "Cows treated with monensin were 0." | 2.72 | Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA. ( Archbald, LF; Donovan, GA; Goff, JP; Littell, R; Melendez, P; Risco, CA, 2006) |
| "Urea was higher at wk 6 compared with wk -1." | 2.71 | Effects of monensin and stage of lactation on variation of blood metabolites within twenty-four hours in dairy cows. ( Azevedo, PA; Bagg, R; Crow, GH; Dick, P; Duffield, TF; Fairfield, AM; McBride, BW; Nikkhah, A; Plaizier, JC, 2005) |
| "Urea and BCS were not significantly associated with LDA in any of the weeks examined." | 2.69 | The association between selected metabolic parameters and left abomasal displacement in dairy cows. ( Duffield, T; Edge, V; Geishauser, T; Leslie, K; Sandals, D, 1998) |
| "Monensin treatment significantly reduced the incidence of subclinical ketosis when the threshold was defined using higher concentrations of serum beta-hydroxybutyrate (1400 and 2000 mumol/L)." | 2.69 | Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows. ( Bagg, R; Dick, P; Duffield, TF; Leslie, KE; Lissemore, K; Lumsden, JH; McBride, BW; Sandals, D, 1998) |
| "To compare relative efficacy of dexamethasone and flumethasone alone or in combination with rapid IV infusion of glucose for treatment of ketosis in cattle." | 2.68 | Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows. ( Avidar, Y; Bogin, E; Chen, R; Shpigel, NY, 1996) |
| "In diabetes, mainly type-1, ketoacidosis is the pathological response to glucose malabsorption." | 2.66 | Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States. ( Balcerczyk, A; Dąbek, A; Pirola, L; Wojtala, M, 2020) |
| "However, the exact threshold of ketosis needed to induce appetite suppression, as well as the exact mechanisms that mediate such an effect, has yet to be elucidated." | 2.66 | Impact of ketosis on appetite regulation-a review. ( Deemer, SE; Martins, C; Plaisance, EP, 2020) |
| "In cases of ketosis, a decrease in activity may be observed 5 days before the clinical diagnosis is made." | 2.61 | [Overview on the relationship between changes in activity and ketosis in dairy cows]. ( Hajek, F; Mansfeld, R, 2019) |
| "Hyperketonemia has been associated with greater milk fat content, fat-to-protein ratio and energy-corrected milk, and lower protein and urea nitrogen in milk." | 2.61 | Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance. ( Benedet, A; De Marchi, M; Manuelian, CL; Penasa, M; Zidi, A, 2019) |
| "Subclinical ketosis (serum BHB >1200 to 1400 micromol/l) in the first or second week after calving is associated with increased risk of DA, metritis, clinical ketosis, endometritis, prolonged postpartum anovulation, increased severity of mastitis, and lower milk production in early lactation." | 2.46 | Monitoring metabolic health of dairy cattle in the transition period. ( LeBlanc, S, 2010) |
| "Normally, the presence of ketosis implies 2 things: that lipid energy metabolism has been activated and that the entire pathway of lipid degradation is intact." | 2.39 | Medical aspects of ketone body metabolism. ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995) |
| "Alcoholic ketoacidosis (AKA) is an important and probably underdiagnosed differential diagnosis for metabolic acidosis with an increased anion gap." | 2.38 | [Alcoholic ketoacidosis]. ( Caspar, CB; Iten, PX; Jost, R; Risti, B; Russi, EW; Speich, R, 1993) |
| "The LI of clinical ketosis was 3." | 1.91 | Associations of parity with health disorders and blood metabolite concentrations in Holstein cows in different production systems. ( Duffield, T; Golder, HM; Lean, IJ; LeBlanc, SJ; Santos, JEP; Sheedy, DB, 2023) |
| "Ketosis is a metabolic disease of dairy cows in the perinatal period, β-hydroxybutyrate (β-HB) is the main component of ketosis." | 1.91 | Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways. ( Chen, M; Gao, X; Hong, H; Jiang, L; Jiang, Y; Jin, Q; Jin, Z; Liu, W; Qian, Y; Wei, Z; Xu, J; Yang, Z; Zhang, H; Zhang, X, 2023) |
| "Metabolic disorders as ketosis are manifestations of the animal's inability to manage the increase in energy requirement during early lactation." | 1.91 | Serum metabolomics assessment of etiological processes predisposing ketosis in water buffalo during early lactation. ( Alterisio, MC; Ciaramella, P; Contiero, B; Faillace, V; Fiore, E; Guccione, J; Harvatine, KJ; Laghi, L; Lisuzzo, A; Mazzotta, E; Zhu, C, 2023) |
| "Distinguishing physiologic ketosis from pathologic over-production/underutilization of ketones is critical as part of the diagnostic evaluation of disorders of carbohydrate metabolism, but there is limited literature on normal ketone production with fasting." | 1.91 | Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia. ( Mosha, M; Parmar, K; Riba-Wolman, R; Weinstein, DA, 2023) |
| "Although there is evidence that ketosis negatively affects fertility, the effect of late and early ketosis on the reproductive performance of lactating cows has not been systematically investigated." | 1.91 | Reproductive performance of lactating dairy cows with elevated milk β-hydroxybutyrate levels during first 6 weeks of lactation. ( Alemu, TW; Cue, RI; Duggavathi, R; Santschi, DE, 2023) |
| "Ketosis is a common nutritional metabolic disease during the perinatal period in dairy cows." | 1.91 | Gene co-expression network and differential expression analyses of subcutaneous white adipose tissue reveal novel insights into the pathological mechanisms underlying ketosis in dairy cows. ( Cao, J; Dai, D; Fang, L; Liu, H; Ning, M; Wang, B; Yao, C; Zhang, Y; Zhao, Y, 2023) |
| "Originally described in diabetic ketoacidosis, renal vacuoles can be found in other ketogenic states such as alcoholic ketoacidosis (AKA), starvation, and hypothermia, underpinned by deranged fatty acid metabolism." | 1.91 | Subnuclear renal tubular vacuoles in alcohol use disorder. ( Auld, FM; Milroy, CM; Parai, JL, 2023) |
| "The diagnosis of alcoholic ketoacidosis (AKA) has traditionally been made based only on clinical history and the presence of severe metabolic acidosis with a high anion gap (AG); however, the concentration of beta-hydroxybutyrate (BOHB), a pivotal ketone body in AKA, is not evaluated in most cases." | 1.91 | Alcoholic ketoacidosis evaluated with a point-of-care capillary beta-hydroxybutyrate measurement device. ( Matsumoto, T; Nishizawa, T; Sasano, M; Todaka, T, 2023) |
| "However, there is little data about the ketoacidosis risk and the level of physiological nutritional ketosis in individuals following these diets." | 1.91 | Type 1 diabetes and low carbohydrate diets-Defining the degree of nutritional ketosis. ( Dyson, P; Karpe, F; Matheou, M; Ozoran, H; Tan, GD, 2023) |
| "Hyperketonemia was diagnosed in wk1 and wk2 of lactation based on the blood concentration of beta-hydroxybutyrate (BHB > 1." | 1.91 | Evaluating variations in metabolic profiles during the dry period related to the time of hyperketonemia onset in dairy cows. ( Caixeta, L; Cramer, G; Gaire, TN; Nakagawa, K; Noyes, N; Picasso-Risso, C; Rodriguez, Z, 2023) |
| "Cows with ketosis most often had the CC genotype, while cows with the TT genotype had the lowest incidence of ketosis." | 1.91 | Gene association analysis of an osteopontin polymorphism and ketosis resistance in dairy cattle. ( Bauer, EA; Kułaj, D; Pokorska, J; Sawicki, S, 2023) |
| "The main background of ketoacidosis was considered as alcohol abuse in 6 cases, diabetes in 5, malnutrition in 3, and hypothermia and infection in 1 case each." | 1.72 | Clinicopathologic Appearance of Advanced Ketoacidosis With Basal Vacuolation in Renal Tubules. ( Hata, Y; Ichimata, S; Nishida, N, 2022) |
| "Previously, ketosis was reported to be associated with hematological and serum biochemical parameters." | 1.72 | Predicting ketosis during the transition period in Holstein Friesian cows using hematological and serum biochemical parameters on the calving date. ( Chung, H; Ha, S; Han, M; Kang, S; Kim, S; Lee, J; Oh, SI; Park, J, 2022) |
| "For cows diagnosed with a lesion (digital dermatitis, corkscrew, toe, foot rot, or other lesion) at their precalving hoof trim (n = 199), the odds of having SUWL for HYK+ cows were 0." | 1.72 | Using a target trial approach to evaluate the role of hyperketonemia in sole ulcer and white line hoof lesion development. ( Caixeta, LS; Cramer, G; Wynands, EM, 2022) |
| "When ketosis occurs, supraphysiological levels of free fatty acids (FFA) can cause oxidative injury to the mammary gland and autophagy can regulate the cellular oxidative status." | 1.72 | Impaired autophagy aggravates oxidative stress in mammary gland of dairy cows with clinical ketosis. ( Dong, J; Du, X; Gao, W; Jiang, Q; Lei, L; Li, G; Li, X; Liu, G; Loor, JJ; Pu, X; Shen, T; Song, Y; Yue, K, 2022) |
| "The median time to diagnosis of ketosis in blood was 5 DIM (95% CI 5 to 7 DIM); moreover, MT and UT had 2 d greater median time to diagnosis of ketosis compared with the BT [7 DIM (6 to 11 d); and 7 DIM (6 to 13 d), respectively]." | 1.72 | An investigation of blood, milk, and urine test patterns for the diagnosis of ketosis in dairy cows in early lactation. ( Berke, O; DeVries, TJ; Duffield, TF; LeBlanc, SJ; McBride, BW; Serrenho, RC; Williamson, M, 2022) |
| "Ketosis is a common metabolic disorder in peripartal dairy cows that is caused by excessive mobilization of fat and incomplete hepatic metabolism of fatty acids (FFA)." | 1.72 | Role of sortilin 1 (SORT1) on fatty acid-mediated cholesterol metabolism in primary calf hepatocytes. ( Fan, W; Gao, C; Jiang, Q; Li, M; Loor, JJ; Tian, Y; Wang, S; Xu, C; Yang, M; Yang, W; Zhang, B, 2022) |
| "Ketosis is one of the most important health problems in dairy sheep." | 1.72 | Evaluation of the metabolomic profile through ( Faillace, V; Fiore, E; Fiore, F; Harvatine, K; Laghi, L; Lisuzzo, A; Mazzotta, E; Moscati, L; Spissu, N; Zhu, C, 2022) |
| "Subclinical ketosis (SCK) in dairy cows, a common metabolic disorder during the perinatal period, is accompanied by systemic inflammation and a high concentration of blood β-hydroxybutyrate (BHB)." | 1.72 | β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy. ( Batbaatar, T; Du, X; He, J; Lei, L; Li, D; Li, Y; Liu, G; Liu, M; Liu, S; Majigsuren, Z; Song, Y; Wang, K; Zeng, W, 2022) |
| "KEKS-supplemented food-generated ketosis may increase adenosine levels, and may thus modulate both neuroinflammatory processes and epileptic activity through adenosine receptors (such as A1Rs and A2ARs)." | 1.62 | Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats. ( Ari, C; Brunner, B; D'Agostino, DP; Kovács, Z, 2021) |
| "The ketosis has negative effects on the high-yielding dairy cows during early lactation." | 1.62 | Effect of functional single nucleotide polymorphism g.-572 A > G of apolipoprotein A1 gene on resistance to ketosis in Chinese Holstein cows. ( Bai, J; Gao, Y; Huang, J; Jiang, Q; Ju, Z; Wang, J; Wei, X; Yang, L; Zhang, Y, 2021) |
| "Subclinical or clinical ketosis also led to greater activity of caspase 1 and protein abundance of caspase 1, NLRP3, Bax, caspase 3, and caspase 9." | 1.62 | Oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows. ( Cao, Z; Jia, H; Jiang, C; Liang, Y; Loor, JJ; Luo, S; Shao, G; Sun, X; Tang, Y; Xu, C; Xu, Q; Zhao, C, 2021) |
| "Cows with ketosis had also greater postpartum serum concentrations of NEFA, BHB, GGT and aspartate transaminase (AST) when compared with control cows." | 1.62 | Common and specific mineral and metabolic features in dairy cows with clinical metritis, hypocalcaemia or ketosis. ( Colazo, M; Dervishi, E; Hoff, B; Plastow, G, 2021) |
| "Subclinical ketosis (serum β-hydroxybutyrate≥1." | 1.62 | Subclinical hypocalcaemia follows specific time-related and severity patterns in post-partum Holstein cows. ( Arsenos, G; Banos, G; Gelasakis, AI; Kougioumtzis, A; Panousis, N; Siachos, N; Tsiamadis, V; Valergakis, GE, 2021) |
| "Clinical ketosis is common during the dairy cows' transition period and is responsible for considerable economic loss." | 1.62 | [Validation of a cow-side blood test for beta-hydroxybutyrate concentration in dairy cows]. ( Bannert, E; Baumgartner, W; Kadáši, M; Kaiser, A; Klein, R; Köller, G; Leonhardt, AS; Pietsch, F; Rachidi, F; Schären, M; Snedec, T; Spilke, J; Starke, A; Theile, S; Theinert, K, 2021) |
| "Ketosis is a common metabolic disorder in high-producing dairy cows during the peripartal period." | 1.62 | Enhanced mitochondrial dysfunction and oxidative stress in the mammary gland of cows with clinical ketosis. ( Du, X; Feng, X; Li, C; Li, N; Li, X; Liang, Y; Liu, G; Loor, JJ; Shu, X; Song, Y; Wang, Z; Yang, Y, 2021) |
| "Furthermore, dairy cows with ketosis had greater protein abundance of ER stress markers in liver tissue, including protein kinase RNA-like ER kinase (PERK), inositol-requiring protein-1α (IRE1α), and cleaved activating transcription factor-6 (ATF6)." | 1.62 | Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows. ( Aboragah, A; Du, X; Fang, Z; Gao, W; Gao, X; Li, X; Liu, G; Loor, JJ; Shi, Z; Song, Y; Yu, H; Zhu, Y, 2021) |
| "Ketosis is one of the most frequent metabolic diseases in high-yielding dairy cows and is characterized by high concentrations of ketone bodies in blood, urine, and milk, causing high economic losses." | 1.62 | Genome-wide association study and functional analyses for clinical and subclinical ketosis in Holstein cattle. ( Duffield, T; Schenkel, F; Soares, RAN; Squires, EJ; Vargas, G, 2021) |
| "Cases with moderate ketosis had a lower BMI than controls (P<0." | 1.62 | Characteristics of post-mortem beta-hydroxybutyrate-positivet cases - A retrospective study on age, sex and BMI in 1407 forensic autopsies. ( Ahlström, S; Green, H; Jönsson, AK; Thiblin, I, 2021) |
| "During ketosis, high concentrations of β-hydroxybutyrate (BHBA) in follicular, uterine and oviductal fluid have been considered to cause subfertility in cows." | 1.62 | High concentrations of β-hydroxybutyrate alter the kinetics of bovine spermatozoa. ( Dalle Laste Dacampo, L; Dias Gonçalves, PB; Dos Santos Brum, D; Ferreira, R; Fiordalisi, G; Germano Ferst, J; Missio, D; Silveira Mesquita, F; Weber Santos Cibin, F, 2021) |
| "Ketoacidosis is a dangerous complication of diabetes mellitus in which plasma levels of ketone bodies can reach 20-25 mM." | 1.56 | High Concentration of Ketone Body β-Hydroxybutyrate Modifies Synaptic Vesicle Cycle and Depolarizes Plasma Membrane of Rat Brain Synaptosomes. ( Adamovich, KV; Adamovich, TV; Dubouskaya, TG; Fedorovich, SV; Hrynevich, SV; Voronina, PP; Waseem, TV, 2020) |
| "Hyperketonemia is a metabolic disease in dairy cows, associated with negative nutrition balance (NNB) induced by low dry matter intake (DMI) and increased nutrient requirements." | 1.56 | Increased autophagy mediates the adaptive mechanism of the mammary gland in dairy cows with hyperketonemia. ( Abdelatty, AM; Du, X; Li, G; Li, X; Liu, G; Mohamed, FF; Peng, Z; Sun, X; Wang, Z; Xu, Q; Zhao, C, 2020) |
| "Ketosis is a metabolic disorder often triggered by anorexia in animals fed on high energy diets." | 1.56 | Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs. ( Bochmann, M; Clauss, M; Hatt, JM; Hetzel, U; Riond, B; Schmid, NS, 2020) |
| "Subclinical metabolic disorders such as ketosis cause substantial economic losses for dairy farmers in addition to the serious welfare issues they pose for dairy cows." | 1.56 | Predictive ability of host genetics and rumen microbiome for subclinical ketosis. ( Buitenhuis, B; Difford, GF; Gebreyesus, G; Højberg, O; Lassen, J; Løvendahl, P; Noel, SJ; Plichta, DR; Poulsen, NA; Sahana, G; Sundekilde, UK; Zhu, Z, 2020) |
| "Subclinical (SCK) and clinical (CK) ketosis are metabolic disorders responsible for big losses in dairy production." | 1.56 | Opportunities and limitations of milk mid-infrared spectra-based estimation of acetone and β-hydroxybutyrate for the prediction of metabolic stress and ketosis in dairy cows. ( Bruckmaier, RM; Caldeira, MO; Dan, D; Glauser, DL; Gross, JJ; Moll, J; Neuheuser, AL; Schuler, U; Stierli, M; Stürmlin, R; Weber, C; Wegmann, S, 2020) |
| "Positive BHB is proof of endogenous ketoacidosis, whereas negative BHB indicates isopropanol intoxication or postmortem acetone/isopropanol formation by microorganisms in cases of decomposition." | 1.56 | Postmortem diagnosis of ketoacidosis: Levels of beta-hydroxybutyrate, acetone and isopropanol in different causes of death. ( Eriksson Hydara, Y; Zilg, B, 2020) |
| "Ketosis or blood values associated with ketosis such as β-hydroxybutyrate >1." | 1.56 | Relationship between milk constituents from milk testing and health, feeding, and metabolic data of dairy cows. ( Boldt, A; Glatz-Hoppe, J; Losand, B; Mohr, E; Spiekers, H, 2020) |
| "Ketosis is a metabolic disorder of increasing importance in high-yielding dairy cows, but accurate population-wide binary health trait recording is difficult to implement." | 1.56 | Genetic and nongenetic profiling of milk β-hydroxybutyrate and acetone and their associations with ketosis in Holstein cows. ( Klein, SL; König, S; May, K; Scheper, C, 2020) |
| "Subclinical ketosis (SCK) causes economic losses in the dairy industry because it reduces the milk production and reproductive performance of cows." | 1.56 | Metabolic alterations in dairy cows with subclinical ketosis after treatment with carboxymethyl chitosan-loaded, reduced glutathione nanoparticles. ( Bai, Y; Fu, S; Wu, L; Xia, C; Xu, C; Zhao, C, 2020) |
| "However, cows with ketosis showed higher concentrations of BHBA and NEFA which restored later." | 1.56 | Characterization of serum adiponectin and leptin in healthy perinatal dairy cows or cows with ketosis, and their effectson ketosis involved indices. ( Cai, D; Cao, S; Deng, J; Hu, Y; Hussain, S; Liu, H; Ma, X; Peng, G; Qian, B; Ren, Z; Shen, L; Wang, Y; Xiao, J; Yu, S; Zhong, Z; Zhou, Z; Zhu, Y; Zong, X; Zou, L; Zuo, Z, 2020) |
| "Growth of primary breast tumors and lung metastases were inhibited, and lifespans were longer in the KD mice compared to mice on the SD (p<0." | 1.56 | The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. ( Feinman, RD; Fine, EJ; Fineberg, S; Pearlman, A; Zou, Y, 2020) |
| "Insulin resistance was evaluated using an intravenous glucose tolerance test and intravenous insulin challenge test (IVICT) in a subgroup of cows (n = 20/treatment) at 10 and 11 DIM, respectively." | 1.51 | Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle IV: Insulin resistance, dry matter intake, and blood parameters. ( Batista, CP; Bicalho, RC; Bringhenti, L; Lima, FS; McDonough, SP; Meira, EBS; Zinicola, M, 2019) |
| "Cows with ketosis had triacylglycerol accumulation in the liver." | 1.51 | Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows. ( Du, X; Fang, Z; Li, X; Liu, G; Loor, JJ; Shen, T; Shi, Z; Wang, X; Xing, D; Zhu, Y, 2019) |
| "Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype." | 1.51 | Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019) |
| "Subclinical ketosis is a common metabolic disorder affecting dairy cattle that results in a greater risk for the development of subsequent metabolic and infectious disease." | 1.51 | Short communication: Validation of a test-day milk test for β-hydroxybutyrate for identifying cows with hyperketonemia. ( Duffield, TF; Kelton, DF; Renaud, DL, 2019) |
| "Whether ketosis alters the expression of CIDEA in mammary gland tissue and the extent to which it may contribute to regulation of milk fat synthesis and secretion are unknown." | 1.51 | High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis. ( Bucktrout, R; Dong, J; Jia, H; Li, X; Liu, G; Loor, JJ; Shu, X; Sun, X; Wang, Y; Zuo, R, 2019) |
| "Ketosis is a metabolic disorder that has an important impact on health and productivity in dairy cattle during early lactation." | 1.51 | Incidence and risk factors for ketosis in grazing dairy cattle in the Cundi-Boyacencian Andean plateau, Colombia. ( Garzón-Audor, A; Oliver-Espinosa, O, 2019) |
| "Dairy cows with ketosis display severe oxidative stress as well as high blood concentrations of non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB)." | 1.51 | The effects of non-esterified fatty acids and β-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis. ( Li, X; Liu, G; Peng, Z; Wang, Z, 2019) |
| "Dairy cows with ketosis display excessive lipolysis in adipose tissue." | 1.51 | Effect of heat-shock protein B7 on oxidative stress in adipocytes from preruminant calves. ( Bucktrout, R; Dong, J; Jia, H; Li, X; Liu, G; Loor, JJ; Shu, X; Sun, X; Wang, Y; Xu, Q; Yang, L; Zuo, R, 2019) |
| "Diabetic ketoacidosis is defined as hyperglycemia >250 mg/dL with metabolic acidosis of arterial pH <7." | 1.51 | Ketoacidosis in Euglycemic Patients With Type 2 Diabetes After Abdominal Surgery. ( Bennett, A; Geehan, D; Moncure, M; Segebrecht, R; Van Way, CW; Weide, L, 2019) |
| "In this study, we examined the anti-ketosis effects of silibinin, a major active component of silymarin." | 1.51 | Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions. ( Do Park, K; Kang, DY; Lee, HK; Song, KD; Sp, N; Yang, YM, 2019) |
| "The top pathways differing between ketosis and control cows were glycolysis/gluconeogenesis, glucagon signaling pathway, cysteine and methionine metabolism, biosynthesis of amino acids, and the cGMP-PKG signaling pathway." | 1.51 | Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation1. ( Coleman, DN; Jia, H; Li, X; Liu, G; Loor, JJ; Ma, L; Wang, Y; Xu, C; Xu, Q, 2019) |
| "Subclinical ketosis (SCK) may impair white blood cell (WBC) function and thus contribute to the risk of disease postpartum." | 1.51 | The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation. ( Amadori, M; Bionaz, M; Mezzetti, M; Minuti, A; Piccioli-Cappelli, F; Trevisi, E, 2019) |
| "Last, subclinical ketosis (SCK) was diagnosed 1×/wk; cows with at least one blood sample with β-hydroxybutyrate ≥1." | 1.48 | Association of rumination time and health status with milk yield and composition in early-lactation dairy cows. ( Asselstine, VH; DeVries, TJ; Duffield, TF; Kaufman, EI; LeBlanc, SJ, 2018) |
| "Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment." | 1.48 | Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018) |
| "Hyperketonemia was defined as β-hydroxybutyrate ≥1." | 1.48 | Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows. ( Buczinski, S; Dubuc, J, 2018) |
| "Systemic ketosis (approx." | 1.48 | Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy. ( Kim, KS; Lee, BS; Woo, CW; Woo, DC, 2018) |
| "The major cause of ketosis is a negative energy balance." | 1.48 | The concentration of free amino acids in blood serum of dairy cows with primary ketosis. ( Brodzki, A; Brodzki, P; Kurek, Ł; Marczuk, J, 2018) |
| "Hyperketonemia was successfully achieved, demonstrated by serum BHB concentrations of 3." | 1.48 | Potential prophylactic effect of recombinant bovine somatotropin (rbST) in sheep with experimentally induced hyperketonemia. ( Araújo, CASC; Minervino, AHH; Monteiro, BM; Mori, CS; Oliveira, FLC; Ortolani, EL; Rodrigues, FAML; Sousa, RS; Vale, RG, 2018) |
| "Dairy cows with clinical ketosis display a negative energy balance and high blood concentrations of non-esterified fatty acids (NEFAs), the latter of which is an important pathological factor of ketosis in cows." | 1.48 | Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows. ( Li, X; Liu, G; Peng, Z; Wang, Z; Zhang, H; Zhang, Y; Zhao, Z, 2018) |
| "Fetal ketoacidosis with hypoxic-ischemic brain damage was determined to be the cause of death." | 1.48 | Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis. ( Fliss, B; Gascho, D; Heimer, J; Martinez, RM; Zoelch, N, 2018) |
| "We hypothesised that ketosis in postparturient dairy cows would result in altered levels on inflammation-related proteins not only in plasma but also in the milk fat globule membranes (MFGM)." | 1.46 | Significant changes in ITIH4, AHSG, ORM1, and CD46 content in milk fat globule membrane proteins of ketotic dairy cows. ( Dong, Z; Gao, S; Liu, R; Xia, C; Xu, C; Yang, W; Yu, H; Zhang, H, 2017) |
| "Ketosis is a very frequent metabolic disease in dairy cows, resulting in lower milk production, impaired fertility and increased frequency of other diseases." | 1.46 | Beta-hydroxybutyrate in milk as screening test for subclinical ketosis in dairy cows. ( Belić, B; Cincović, MR; Djoković, R; Ježek, J; Klinkon, M; Nemec, M; Starič, J, 2017) |
| "Fatal ketoacidosis due to diabetes mellitus, alcoholism, and starvation may produce characteristic basal vacuolization of renal tubular epithelial cells (RTEC)." | 1.46 | Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization. ( Byard, RW; Zhou, C, 2017) |
| "The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes." | 1.46 | Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice. ( Cavino, K; Cheng, X; Gromada, J; Kim, SY; Krumm, E; Murphy, AJ; Na, E; Okamoto, H; Yancopoulos, GD, 2017) |
| "Metabolic diseases included clinical ketosis (KET) and displaced abomasum (DA); fertility disorders were metritis (MET) and retained placenta (RP); and disease indicators were fat-to-protein ratio, milk β-hydroxybutyrate, and body condition score (BCS) in the first lactation." | 1.43 | Multiple-trait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holsteins. ( Jamrozik, J; Kistemaker, GJ; Koeck, A; Miglior, F, 2016) |
| "To manage negative energy balance and ketosis in dairy farms, rapid and cost-effective detection is needed." | 1.43 | Development of Fourier transform mid-infrared calibrations to predict acetone, β-hydroxybutyrate, and citrate contents in bovine milk through a European dairy network. ( Bastin, C; Colinet, FG; Dardenne, P; Davière, JB; Dehareng, F; Fernandez Pierna, JA; Gelé, M; Gengler, N; Grelet, C; Johan, M; Reding, R; Soyeurt, H; Werner, A, 2016) |
| "Starvation ketoacidosis is a rare cause of metabolic acidosis and is a phenomenon that occurs normally during fasting, as the body switches from carbohydrate to lipid energy sources." | 1.43 | Postmortem biochemistry in suspected starvation-induced ketoacidosis. ( Augsburger, M; Burkhardt, S; Lardi, C; Palmiere, C; Sabatasso, S; Tettamanti, C; Werner, D, 2016) |
| "Results showed that cows with ketosis had greater concentrations of serum β-hydroxybutyric acid (BHBA), interleukin (IL)-6, tumor necrosis factor (TNF), serum amyloid A (SAA), and lactate in comparison with the CON animals." | 1.43 | Dairy cows affected by ketosis show alterations in innate immunity and lipid and carbohydrate metabolism during the dry off period and postpartum. ( Ametaj, BN; Deng, Q; Dervishi, E; Dunn, SM; Goldansaz, SA; Hailemariam, D; Zhang, G, 2016) |
| "Dairy cows with ketosis display oxidative stress that may be associated with high levels of BHB." | 1.43 | β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway. ( Fu, S; Gu, J; Li, N; Li, X; Liu, G; Peng, Z; Song, Y; Wang, Z; Zhang, Y; Zhao, C, 2016) |
| "KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet." | 1.42 | A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease. ( Kashiwaya, Y; King, MT; Newport, MT; VanItallie, TB; Veech, RL, 2015) |
| "Subclinical ketosis is one of the most prevalent metabolic disorders in high-producing dairy cows during early lactation." | 1.42 | Short communication: Use of genomic and metabolic information as well as milk performance records for prediction of subclinical ketosis risk via artificial neural networks. ( Ehret, A; Gronwald, W; Hochstuhl, D; Klein, MS; Krattenmacher, N; Tetens, J; Thaller, G, 2015) |
| "Retrospectively, 15 cows with clinical ketosis (3 consecutive BHBA samples >1." | 1.42 | Clinical ketosis and standing behavior in transition cows. ( Huzzey, JM; Itle, AJ; von Keyserlingk, MA; Weary, DM, 2015) |
| "Subclinical ketosis and CK were associated with a higher milk yield, a higher milk fat percentage, and a lower milk protein percentage at first DHI test day." | 1.42 | Risk factors for subclinical and clinical ketosis and association with production parameters in dairy cows in the Netherlands. ( Bemers, R; Berge, AC; Papen, J; Vanholder, T; Vertenten, G, 2015) |
| "Subclinical ketosis is common and is significantly associated with reproductive performance in mainly pasture-fed New Zealand dairy cattle." | 1.42 | Subclinical ketosis in post-partum dairy cows fed a predominantly pasture-based diet: defining cut-points for diagnosis using concentrations of beta-hydroxybutyrate in blood and determining prevalence. ( Compton, CW; McDougall, S; Young, L, 2015) |
| "Clinical endometritis was diagnosed by observation of vaginal discharges (>50% pus), and subclinical endometritis was diagnosed by evaluation of uterine cytology (>18% neutrophils) at 4 weeks postpartum." | 1.42 | Relationships among ketosis, serum metabolites, body condition, and reproductive outcomes in dairy cows. ( Choi, IS; Hur, TY; Jeong, JK; Jung, YH; Kang, HG; Kim, IH; Shin, EK, 2015) |
| "The model predicted clinical ketosis with a sensitivity of 100% and a specificity of 100%." | 1.40 | (1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis. ( Shu, S; Sun, LW; Wu, L; Xia, C; Xu, C; Zhang, HY; Zheng, JS, 2014) |
| "Subclinical ketosis (SCK), an important disease in lactating dairy cows, is defined as the presence of elevated concentrations of circulating ketone bodies without the development of clinical signs." | 1.40 | [Evaluation of a new electronic handheld meter for measurement of β-hydroxybutyric acid in dairy cows]. ( Burfeind, O; Heuwieser, W; Mahrt, A; Müller, A; Voigtsberger, R, 2014) |
| "Subclinical ketosis is a metabolic disorder which often goes undiagnosed and leads to constricted performance and an impairment of general condition." | 1.40 | Effects of prepartal body condition score and peripartal energy supply of dairy cows on postpartal lipolysis, energy balance and ketogenesis: an animal model to investigate subclinical ketosis. ( Dänicke, S; Frahm, J; Kersten, S; Meyer, U; Rehage, J; Reiche, D; Schulz, K, 2014) |
| "Hyperketonemia was defined by a blood BHBA concentration ≥ 1." | 1.40 | Accuracy of milk ketone bodies from flow-injection analysis for the diagnosis of hyperketonemia in dairy cows. ( Denis-Robichaud, J; DesCôteaux, L; Dubuc, J; Lefebvre, D, 2014) |
| "Fasting ketoacidosis was postulated to have precipitated the Addisonian crisis." | 1.40 | Ketoacidosis and adrenocortical insufficiency. ( de Froidmont, S; Lobrinus, JA; Mangin, P; Palmiere, C; Werner, D, 2014) |
| "Data on clinical ketosis and displaced abomasum recorded by producers were available from the national dairy cattle health system in Canada." | 1.40 | Genetic analysis of milk β-hydroxybutyrate and its association with fat-to-protein ratio, body condition score, clinical ketosis, and displaced abomasum in early first lactation of Canadian Holsteins. ( Jamrozik, J; Kelton, DF; Koeck, A; Lefebvre, DM; Miglior, F; Moore, RK; Schenkel, FS, 2014) |
| "Subclinical ketosis (SCK) is defined as concentrations of β-hydroxybutyrate (BHBA) ≥ 1." | 1.39 | Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows. ( Canelas-Raposo, J; Deniz, A; Heuwieser, W; Suthar, VS, 2013) |
| "Ketonuria was defined as a urine ketone value of 3+ or 4+ and was analyzed as a dichotomous, categorical variable." | 1.39 | Diagnostic accuracy of fingerstick β-hydroxybutyrate for ketonuria in pregnant women with nausea and vomiting. ( Ferguson, I; Mullins, ME, 2013) |
| "Based on thresholds for subclinical ketosis of 1." | 1.39 | Comparison of 2 electronic cowside tests to detect subclinical ketosis in dairy cows and the influence of the temperature and type of blood sample on the test results. ( Drillich, M; Fidlschuster, B; Iwersen, M; Klein-Jöbstl, D; Pichler, M; Roland, L; Schwendenwein, I, 2013) |
| "Hyperketonemia was defined as a blood BHBA concentration of ≥1." | 1.39 | Dry period and parturient predictors of early lactation hyperketonemia in dairy cattle. ( McArt, JA; Nydam, DV; Oetzel, GR, 2013) |
| "Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature." | 1.39 | Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient. ( Dwyer, JB; Tamama, K, 2013) |
| "This degree of ketonemia is estimated to contribute up to 8% to 9% of brain energy metabolism." | 1.39 | Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. ( Castellano, CA; Chouinard-Watkins, R; Courchesne-Loyer, A; Cunnane, SC; Fortier, M; Nugent, S; Roy, M; Tremblay-Mercier, J, 2013) |
| "Ketosis is estimated to affect 15% of early lactation dairy cows." | 1.39 | Short communication: the effect of temperature on performance of milk ketone test strips. ( Gordon, JL; Karcher, EL; Shire, J, 2013) |
| "To examine the effect of ketoacidosis on renal cells in isolation, five cases of lethal alcoholic ketoacidosis without hyperglycemia were examined (vitreous humor β-hydroxybutyrate: 6." | 1.38 | Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis. ( Byard, RW; Zhou, C, 2012) |
| "However, in ketosis, acetone can be reduced to IPA." | 1.38 | Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations. ( Augsburger, M; Bardy, D; Mangin, P; Palmiere, C; Sporkert, F; Werner, D, 2012) |
| "Vitreous BHB was a marker of diabetic ketoacidosis when above 6." | 1.38 | Postmortem vitreous beta-hydroxybutyrate: interpretation in a forensic setting. ( Heninger, M, 2012) |
| "Dairy cows are highly susceptible to ketosis after parturition." | 1.38 | Alterations of fatty acid β-oxidation capability in the liver of ketotic cows. ( Fu, SX; Li, P; Li, XB; Liu, GW; Long, M; Wang, XX; Wang, Z; Wu, CC; Yu, GJ, 2012) |
| " The diagnostic model is, in our opinion, valuable for herd-level monitoring of hyperketonemia, especially when the model is combined with wet chemistry analysis of milk acetone or milk BHBA concentrations." | 1.38 | Routine detection of hyperketonemia in dairy cows using Fourier transform infrared spectroscopy analysis of β-hydroxybutyrate and acetone in milk in combination with test-day information. ( Jorritsma, R; Knijn, HM; Schonewille, JT; Stegeman, JA; van der Drift, SGA, 2012) |
| "Subclinical ketosis was defined as a BHBA concentration of 1." | 1.38 | Epidemiology of subclinical ketosis in early lactation dairy cattle. ( McArt, JAA; Nydam, DV; Oetzel, GR, 2012) |
| "Severe ketoacidosis induces heart failure and cardiac arrest, but its mechanism is unknown." | 1.38 | Inhibitory effect of β-hydroxybutyric acid on L-type Ca(2+) current under β-adrenergic stimulation in guinea pig cardiac ventricular myocytes. ( Akama, Y; Kimura, J; Kurihara, M, 2012) |
| "The odds of clinical ketosis were 6." | 1.37 | Metabolic predictors of post-partum disease and culling risk in dairy cattle. ( Duffield, TF; Leblanc, SJ; Leslie, KE; Seifi, HA, 2011) |
| "Acetone was about 16-fold higher with LC-75/10 only (P < 0." | 1.37 | Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. ( Bidlingmaier, M; Bielohuby, M; Christ, B; Hempel, M; Kienzle, E; Kirchner, H; Menhofer, D; Müller, TD; Pfluger, PT; Stemmer, K; Stock, P; Stoehr, BJ; Tschöp, MH, 2011) |
| "Hyperketonemia is increasingly being identified in type 2 diabetic patients in addition to those with type 1 diabetes." | 1.37 | Hyperketonemia decreases mitochondrial membrane potential and its normalization with chromium (III) supplementation in monocytes. ( Jain, SK; Rains, JL, 2011) |
| "The patient was lethargic." | 1.37 | Beta-ketothiolase deficiency brought with lethargy: case report. ( Arica, SG; Arica, V; Dag, H; Gülbayzar, S; Obut, O; Onur, H, 2011) |
| "Subclinical ketosis (SCK) is simply a condition marked by increased levels of circulating ketone bodies without the presence of the clinical signs of ketosis." | 1.37 | Prevalence of subclinical ketosis in dairy cattle in the Southwestern Iran and detection of cutoff point for NEFA and glucose concentrations for diagnosis of subclinical ketosis. ( Asl, AN; Ghasrodashti, AR; Nazifi, S; Olyaee, A, 2011) |
| "However, chronic in vitro ketosis abolished hippocampal network hyperexcitability following a metabolic insult, hypoxia, demonstrating for the first time a direct link between metabolic resistance and better control of excessive, synchronous, abnormal electrical activity." | 1.36 | Chronic in vitro ketosis is neuroprotective but not anti-convulsant. ( Abdelmalik, P; Carlen, PL; Samoilova, M; Velumian, AA; Weisspapir, M, 2010) |
| "Biochemically, in clinical ketosis compared with subclinical and control cases, there was a significant increase (p<0." | 1.36 | Ketosis in buffalo (Bubalus bubalis): clinical findings and the associated oxidative stress level. ( Abou El-Amaiem, WE; El-deeb, WM; El-Khodery, SA; Youssef, MA, 2010) |
| "Niacin has showed an increase in the level of plasma glucose and a notable decrease in the amount of blood triglyceride, beta-hydroxy butyrate and total protein, which may be due to the effect of this vitamin on the energy metabolism in cows." | 1.35 | Effects of niacin on milk production and blood parameters in early lactation of dairy cows. ( Ghorbani, B; Vahdani, N; Zerehdaran, S, 2008) |
| "Sensitivity and specificity are excellent for a cowside test and higher than 2 commonly used chemical dipsticks (Ketostix and Ketolac)." | 1.35 | Evaluation of an electronic cowside test to detect subclinical ketosis in dairy cows. ( Falkenberg, U; Forderung, D; Heuwieser, W; Iwersen, M; Voigtsberger, R, 2009) |
| "Cows diagnosed with subclinical ketosis (SCK) after calving are at increased risk of developing other diseases and compromised reproductive performance." | 1.35 | Prepartum feeding behavior is an early indicator of subclinical ketosis. ( Chapinal, N; Goldhawk, C; Veira, DM; von Keyserlingk, MA; Weary, DM, 2009) |
| "Ketosis is a common metabolic disease, and affected dairy cows are known to have increased risk for mastitis and other infectious conditions." | 1.35 | Beta-hydroxybutyrate abrogates formation of bovine neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia coli. ( Elazar, S; Grinberg, N; Rosenshine, I; Shpigel, NY, 2008) |
| "A consistently strong ketosis (beta-hydroxybutyrate of >3 mmol/L) seemed to be important for maintaining the efficacy of the diet therapy." | 1.34 | Use of a modified Atkins diet in intractable childhood epilepsy. ( Kang, du C; Kang, HC; Kim, HD; Ko, TS; Lee, HS; You, SJ, 2007) |
| "These data suggest that diet-induced ketosis results in increased vascular density at the blood-brain barrier without changes in blood flow." | 1.34 | Diet-induced ketosis increases capillary density without altered blood flow in rat brain. ( Emancipator, D; Ivy, A; LaManna, JC; Puchowicz, MA; Sun, X; Xu, K, 2007) |
| "Subclinical ketosis (SCK) is defined as elevated concentrations of ketone bodies in the absence of clinical signs of ketosis." | 1.34 | Bovine subclinical ketosis in dairy herds in Iran. ( Ameri, M; Sakha, M; Sharifi, H; Taheri, I, 2007) |
| "Subclinical ketosis is a metabolic disorder in high-producing dairy cattle that can be detected by ketone bodies in milk: acetone (Ac), acetoacetate (AcAc), and beta-hydroxybutyrate (BHBA)." | 1.34 | Screening for subclinical ketosis in dairy cattle by Fourier transform infrared spectrometry. ( de Jong, G; de Roos, AP; Hørlyk, J; van den Bijgaart, HJ, 2007) |
| "Outputs of the model are the risk of ketosis (value between 0 and 1, where 0 = no risk and 1 = clinical ketosis) and how many days until the next milk sample should be taken and analyzed for BHBA." | 1.33 | Predicting risk of ketosis in dairy cows using in-line measurements of beta-hydroxybutyrate: a biological model. ( Chagunda, MG; Friggens, NC; Ingvartsen, KL; Nielsen, NI, 2005) |
| "All subjects were seizure tested by using the PTZ infusion test." | 1.33 | A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats. ( Abdelmalik, PA; Burnham, WM; Clarke, J; Likhodii, S; Nylen, K, 2005) |
| "During the ketosis induction period, KI cows had lower intake, milk yield, and serum glucose concentration but higher concentrations of nonesterified fatty acids and beta-hydroxybutyrate in serum as well as total lipid and triacylglycerol in liver than did control cows." | 1.33 | Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows. ( Bollero, GA; Dann, HM; Drackley, JK; Morin, DE; Murphy, MR, 2005) |
| "Subclinical/clinical ketosis was quantitatively determined using a plasma BHBA threshold of 1,200 microM." | 1.33 | Plasma vitamin C concentration is not related to the incidence of ketosis in dairy cows during the early lactation period. ( Inoue, J; Matsui, T; Padilla, L; Shibano, K; Yano, H, 2005) |
| "PD), or ketosis induction status (control vs." | 1.33 | Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders. ( Dann, HM; Drackley, JK, 2005) |
| "Acetone has been shown to have broad-spectrum anticonvulsant actions in animal seizure models and has been hypothesized to play a role in the anticonvulsant mechanism of the ketogenic diet (KD)." | 1.33 | A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats. ( Burnham, WM; Hum, KM; Likhodii, SS; Nylen, K, 2006) |
| "Hemolysis is a common artifact in samples submitted to diagnostic laboratories." | 1.33 | Effect of hemolysis on nonesterified fatty acid and beta-hydroxybutyrate concentrations in bovine blood. ( Nydam, DV; Stokol, T, 2006) |
| "Diabetic ketoacidosis, alcoholic ketoacidosis, starvation ketosis and hypoglycaemic ketoacidosis were all ruled out, and his toxin screen was negative for salicylates." | 1.32 | An unusual cause for ketoacidosis. ( Brunengraber, H; Davids, MR; Halperin, ML; Segal, AS, 2004) |
| "The sample proportion of subclinical ketosis was 7." | 1.32 | Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows. ( Carrier, J; Fetrow, J; Godden, S; Rapnicki, P; Stewart, S, 2004) |
| "The level of ketosis, however, was not predictive of seizure protection in EL mice." | 1.31 | The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. ( Madore, RA; Seyfried, TN; Stafstrom, CE; Tandon, P; Todorova, MT, 2000) |
| "For the detection of subclinical ketosis, the best sensitivity-specificity combination was obtained with the determination of acetoacetate in blood or milk, with threshold concentrations of 125 and 50 micromol/L, respectively." | 1.31 | Ketone bodies in milk and blood of dairy cows: relationship between concentrations and utilization for detection of subclinical ketosis. ( Bayourthe, C; Enjalbert, F; Moncoulon, R; Nicot, MC, 2001) |
| "To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed." | 1.31 | Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. ( Cunnane, SC; Likhodii, SS; Musa-Veloso, K, 2002) |
| "These data suggest that severe CHF is a ketosis-prone state." | 1.30 | Heart failure ketosis. ( Härkönen, M; Koskinen, P; Kupari, M; Lommi, J; Näveri, H, 1997) |
| "When subclinical ketosis was defined as a serum BHB level of 1200 mumol/L or higher, the prevalence of ketosis for cows in early lactation (< 65 days in milk (DIM)) was 14." | 1.30 | Use of test day milk fat and milk protein to detect subclinical ketosis in dairy cattle in Ontario. ( Duffield, TF; Kelton, DF; Leslie, KE; Lissemore, KD; Lumsden, JH, 1997) |
| "The prevalence of subclinical ketosis was highest during the first 6 wk of lactation, and a peak was detected during the 2nd wk of lactation." | 1.30 | Evaluation of five cowside tests for use with milk to detect subclinical ketosis in dairy cows. ( Duffield, T; Geishauser, T; Kelton, D; Leslie, K, 1998) |
| "In the latter the onset of ketosis was earlier in pregnancy (day 143 +/- 7 vs." | 1.30 | Spontaneous pregnancy toxaemia (ketosis) in sheep and the role of insulin. ( Bickhardt, K; Fuhrmann, H; Henze, P; Sallmann, HP, 1998) |
| "This apparent ketosis resistance is similar to that observed in some forms of human diabetes." | 1.30 | Ketosis resistance in the male offspring of protein-malnourished rat dams. ( Hales, CN; Ozanne, SE; Petry, CJ; Smith, JM; Wang, CL, 1998) |
| "The mechanism by which ketosis causes accelerated cellular damage and vascular disease in diabetes is not known." | 1.30 | Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells. ( Jain, SK; Kannan, K; Lim, G, 1998) |
| "Subclinical ketosis was induced through a 10% feed restriction and was quantitatively determined using a blood beta-hydroxybutyrate (BHBA) threshold of 1200 mumol/L." | 1.30 | The impact of a monensin controlled-release capsule on subclinical ketosis in the transition dairy cow. ( Bagg, R; Dick, P; Green, BL; Leslie, KE; McBride, BW; Sandals, D, 1999) |
| "To test glucagon as a treatment for fatty liver, either glucagon at 10 mg/d or excipient was infused via the jugular vein from 21 to 35 d postpartum." | 1.30 | Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon. ( Beitz, DC; Hippen, AR; Lindberg, GL; Richardson, LF; She, P; Tucker, RW; Young, JW, 1999) |
| "Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i." | 1.30 | Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. ( Bough, KJ; Chen, RS; Eagles, DA, 1999) |
| "To achieve this aim, one would need ketosis, severe hypoglycemia, and low lactatemia." | 1.29 | Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters. ( Agarwal, KC; Ciraolo, ST; David, F; Fernandez, CA; Koshy, J; Lucas, D; Previs, SF; Stevens, MP; Tammaro, A; Tserng, KY, 1995) |
| "Subclinical ketosis was defined with serum beta-hydroxybutyrate measurements." | 1.29 | Evaluation of two cowside tests for the detection of subclinical ketosis in dairy cows. ( Aarts, MG; Jonkers, AG; Nielen, M; Schukken, YH; Wensing, T, 1994) |
| "Alcoholic ketoacidosis is rare and must be considered in the differential diagnosis of any alcoholic patient with acidosis." | 1.29 | [Alcoholic ketoacidosis. Apropos of a case with coma]. ( Jobard, JM, 1993) |
| "Forensic pathologists are familiar with alcohol abusers, who are found dead and in whom the cause of death cannot be ascertained." | 1.29 | Alcoholic ketoacidosis as a cause of death in forensic cases. ( Felby, S; Nielsen, E; Theilade, P; Thomsen, JL, 1995) |
| "Susceptibility to clinical ketosis, therefore, may be indicated by increased hepatic triglyceride to glycogen ratios during the peripartal period." | 1.28 | Metabolic changes in dairy cows with ketonemia in response to feed restriction and dietary 1,3-butanediol. ( Beitz, DC; Drackley, JK; Richard, MJ; Young, JW, 1992) |
| "Results indicate that experimental ketosis was preceded by metabolic abnormalities up to 2 wk before clinical ketosis occurred." | 1.28 | Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. ( Drackley, JK; Miller, LD; Richard, MJ; Sanderson, TP; Veenhuizen, JJ; Young, JW, 1991) |
| "Post-exercise ketosis is known to be suppressed by physical training and by a high carbohydrate diet." | 1.28 | Post-exercise ketosis and the glycogen content of liver and muscle in rats on a high carbohydrate diet. ( Adams, JH; Koeslag, JH, 1989) |
| "Metoclopramide has previously been shown to inhibit the ketosis of starvation in rats and humans." | 1.28 | D2-dopaminergic blockade does not influence post-exercise ketosis in non-athletes. ( Koeslag, JH; Lochner, JV; Vahed, YA, 1989) |
| "Propionic acid was used as a possible preventive agent against ketogenesis." | 1.27 | Effect of propionic acid on ketogenesis in lactating sheep fed restricted rations or deprived of food. ( Emmanuel, B; Kennelly, JJ, 1984) |
| "Systemic ketosis was induced in first-parity gilts by the isocaloric substitution of glucose with 1,3-butylene glycol to supply 20% of the total dietary energy beginning on d 23 (23 BG) or d 60 (60 BG) of gestation." | 1.27 | Fetal hepatic and neural substrate utilization as affected by induced nutritional ketosis in swine. ( McMurtry, JP; Rosebrough, RW; Steele, NC, 1984) |
| "Post-exercise ketosis is not abolished by glucose ingestion immediately after exercise but is counteracted by simultaneous beta-adrenergic blockade." | 1.27 | beta-Adrenergic blockade counteracts starvational ketosis, but aggravates post-exercise ketosis in non-athletes. ( J de V Lochner, J; Koeslag, JH; Vahed, YA, 1988) |
| "Alcoholic ketosis occurs in alcoholics, who have been shown also to be more predisposed than normal to post-exercise ketosis (Chalmers, Sulaiman & Johnson, 1977)." | 1.27 | Ethanol ingestion and the development of post-exercise ketosis in non-alcoholic human subjects. ( Hadley, W; Koeslag, JH; Lochner, JD, 1988) |
| "3." | 1.27 | The effects of post-exercise glucose and alanine ingestion on plasma carnitine and ketosis in humans. ( Carlin, JI; Olson, EB; Peters, HA; Reddan, WG, 1987) |
| "The ketosis was reversed by glucagon administration." | 1.27 | Clinical and laboratory observations in a child with hepatic phosphorylase kinase deficiency. ( Brown, BI; Burke, BA; Tuchman, M; Ulstrom, RA, 1986) |
| "Diabetic ketoacidosis is often associated with a temporary increase in protein excretion, but the mechanisms are not completely known." | 1.27 | Effect of 3-hydroxybutyrate infusion on urinary protein excretion in healthy man. ( Alberti, KG; Christensen, CK; Mogensen, CE; Pedersen, EB; Schmitz, O, 1986) |
| "A mild ketosis is known to prevail in the mother, fetus, and newborn infant during the 3rd trimester and in the early neonatal period." | 1.27 | Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations. ( Auestad, N; Benson, J; Edmond, J; Picone, T; Rambathla, S; Wu, PY, 1986) |
| "Both patients had episodic ketosis and metabolic acidosis." | 1.27 | 3-Ketothiolase deficiency. ( Bartlett, K; Cannon, RA; Conde, C; Gomez Vazquez, J; Lipson, M; Middleton, B; Nyhan, WL; Romanos, A; Sweetman, L, 1986) |
| "This study examined ketosis in response to 90 min of running before and after the ingestion of 50 g glucose or 50 g L-alanine in thirty-three athletes." | 1.27 | Post-exercise ketosis in post-prandial exercise: effect of glucose and alanine ingestion in humans. ( Koeslag, JH; Levinrad, LI; Lochner, JD; Sive, AA, 1985) |
| "The effects of ketosis on the norepinephrine-induced high rates of cardiac uptake of non-esterified fatty acids (NEFA = free fatty acids = FFA) and oxygen consumption were studied in anesthetized intact dogs." | 1.27 | Inhibitory effects of the D(-)isomer of 3-hydroxybutyrate on cardiac non-esterified fatty acid uptake and oxygen demand induced by norepinephrine in the intact dog. ( Huynh-Thu, T; Kolanowski, J; Lammerant, J, 1985) |
| "Experimental ketosis was induced by feeding calves a diet containing 1,3 butanediol for 9 or 10 days." | 1.27 | Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves. ( Hoy, DA; Klucinski, W; Littledike, ET; Targowski, SP, 1985) |
| "Maternal ketosis was induced in sows by feeding 20% of the dietary energy as 1,3-butylene glycol (BG), medium-chain triglycerides (MCT), or a combination of the two." | 1.26 | Effect of ketogenic diets in gestation on some characteristics of carbohydrate metabolism in fetal pig brain and liver. ( Frobish, LT; Rosebrough, RW; Steele, NC, 1981) |
| "Hyperketonemia was induced by 3 days of starvation or by infusion of 3-hydroxybutyrate in fed rats." | 1.26 | No effect of hyperketonemia on local cerebral glucose utilization in conscious rats. ( Corddry, DH; London, ED; Rapoport, SI, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (9.71) | 18.7374 |
| 1990's | 46 (10.15) | 18.2507 |
| 2000's | 67 (14.79) | 29.6817 |
| 2010's | 179 (39.51) | 24.3611 |
| 2020's | 117 (25.83) | 2.80 |
| Authors | Studies |
|---|---|
| Akturk, HK | 1 |
| Snell-Bergeon, J | 1 |
| Pyle, L | 1 |
| Fivekiller, E | 1 |
| Garg, S | 1 |
| Cobry, E | 1 |
| Lei, L | 4 |
| Gao, W | 4 |
| Loor, JJ | 19 |
| Aboragah, A | 3 |
| Fang, Z | 6 |
| Du, X | 13 |
| Zhang, M | 1 |
| Song, Y | 11 |
| Liu, G | 21 |
| Li, X | 30 |
| Yang, Y | 4 |
| Zeng, W | 2 |
| Jiang, Q | 8 |
| Peng, Z | 6 |
| Li, Y | 4 |
| Jiang, S | 2 |
| Feng, X | 3 |
| Williamson, M | 2 |
| Couto Serrenho, R | 1 |
| McBride, BW | 8 |
| LeBlanc, SJ | 18 |
| DeVries, TJ | 10 |
| Duffield, TF | 23 |
| Brunner, B | 2 |
| Ari, C | 3 |
| D'Agostino, DP | 3 |
| Kovács, Z | 3 |
| Mank, MM | 1 |
| Reed, LF | 1 |
| Walton, CJ | 1 |
| Barup, MLT | 1 |
| Ather, JL | 1 |
| Poynter, ME | 1 |
| Ichimata, S | 1 |
| Hata, Y | 1 |
| Nishida, N | 1 |
| Ha, S | 1 |
| Kang, S | 1 |
| Han, M | 1 |
| Lee, J | 1 |
| Chung, H | 1 |
| Oh, SI | 1 |
| Kim, S | 1 |
| Park, J | 1 |
| Loiklung, C | 1 |
| Sukon, P | 1 |
| Thamrongyoswittayakul, C | 1 |
| Wang, K | 2 |
| Liu, S | 2 |
| He, J | 2 |
| Lisuzzo, A | 3 |
| Laghi, L | 3 |
| Faillace, V | 3 |
| Zhu, C | 3 |
| Contiero, B | 3 |
| Morgante, M | 3 |
| Mazzotta, E | 3 |
| Gianesella, M | 3 |
| Fiore, E | 5 |
| Rodriguez, Z | 2 |
| Shepley, E | 1 |
| Endres, MI | 1 |
| Cramer, G | 3 |
| Caixeta, LS | 4 |
| Wang, S | 2 |
| Jiang, X | 2 |
| Ju, L | 2 |
| Yu, H | 4 |
| Shen, T | 6 |
| Chen, M | 5 |
| Wang, Z | 17 |
| Bjerg, LN | 1 |
| Thomsen, HH | 2 |
| Madsen, JB | 1 |
| Sandfeld-Paulsen, B | 1 |
| Kerwin, AL | 1 |
| Burhans, WS | 1 |
| Mann, S | 8 |
| Nydam, DV | 10 |
| Wall, SK | 1 |
| Schoenberg, KM | 1 |
| Perfield, KL | 1 |
| Overton, TR | 7 |
| Crabtree, CD | 1 |
| Blade, T | 1 |
| Hyde, PN | 1 |
| Buga, A | 1 |
| Kackley, ML | 1 |
| Sapper, TN | 1 |
| Panda, O | 1 |
| Roa-Diaz, S | 1 |
| Anthony, JC | 1 |
| Newman, JC | 1 |
| Volek, JS | 1 |
| Stubbs, BJ | 1 |
| Wynands, EM | 1 |
| Yue, K | 1 |
| Pu, X | 1 |
| Dong, J | 3 |
| Li, G | 2 |
| Seely, CR | 2 |
| Bach, KD | 5 |
| Barbano, DM | 3 |
| McArt, JAA | 13 |
| Fan, M | 1 |
| Chen, X | 1 |
| Zhang, C | 1 |
| Bai, H | 1 |
| Xiang, K | 1 |
| Li, S | 1 |
| Tuniyazi, M | 1 |
| Mu, R | 1 |
| Wang, Y | 5 |
| Zhang, N | 1 |
| Hu, X | 1 |
| Fu, Y | 1 |
| Liu, Y | 2 |
| Bharmal, SH | 3 |
| Kimita, W | 2 |
| Petrov, MS | 3 |
| Serrenho, RC | 2 |
| Berke, O | 1 |
| Gao, C | 1 |
| Yang, M | 1 |
| Tian, Y | 1 |
| Fan, W | 1 |
| Zhang, B | 1 |
| Li, M | 1 |
| Xu, C | 9 |
| Yang, W | 2 |
| Puppel, K | 2 |
| Slósarz, J | 2 |
| Grodkowski, G | 2 |
| Solarczyk, P | 2 |
| Kostusiak, P | 1 |
| Kunowska-Slósarz, M | 2 |
| Grodkowska, K | 1 |
| Zalewska, A | 1 |
| Kuczyńska, B | 2 |
| Gołębiewski, M | 2 |
| Hubner, AM | 1 |
| Canisso, IF | 2 |
| Peixoto, PM | 2 |
| Coelho, WM | 2 |
| Ribeiro, L | 2 |
| Aldridge, BM | 2 |
| Lima, FS | 3 |
| Hubner, A | 1 |
| Menta, P | 1 |
| Machado, VS | 2 |
| Xu, Q | 5 |
| Fan, Y | 1 |
| Zheng, X | 1 |
| Yang, T | 1 |
| Sun, X | 6 |
| Jia, H | 5 |
| Fiore, F | 1 |
| Harvatine, K | 1 |
| Spissu, N | 1 |
| Moscati, L | 1 |
| Wehrle-Martinez, A | 1 |
| Dittmer, KE | 1 |
| Back, PJ | 1 |
| Rogers, CW | 1 |
| Lawrence, K | 1 |
| Evans, M | 2 |
| McClure, TS | 1 |
| Koutnik, AP | 3 |
| Egan, B | 3 |
| Lean, IJ | 2 |
| Sheedy, DB | 1 |
| Duffield, T | 7 |
| Santos, JEP | 1 |
| Golder, HM | 1 |
| Spigoni, V | 1 |
| Cinquegrani, G | 1 |
| Iannozzi, NT | 1 |
| Frigeri, G | 1 |
| Maggiolo, G | 1 |
| Maggi, M | 1 |
| Parello, V | 1 |
| Dei Cas, A | 1 |
| Mandujano Reyes, JF | 3 |
| Walleser, E | 4 |
| Sawalski, A | 3 |
| Anklam, K | 4 |
| Döpfer, D | 5 |
| Miles, AM | 3 |
| Lima, SF | 3 |
| Neves, RC | 3 |
| Ganda, E | 3 |
| Gao, X | 4 |
| Zhang, X | 3 |
| Jiang, L | 3 |
| Xu, J | 3 |
| Liu, W | 3 |
| Qian, Y | 3 |
| Jiang, Y | 3 |
| Jin, Q | 3 |
| Hong, H | 3 |
| Jin, Z | 3 |
| Wei, Z | 3 |
| Yang, Z | 3 |
| Zhang, H | 5 |
| Liu, M | 1 |
| Li, D | 1 |
| Majigsuren, Z | 1 |
| Batbaatar, T | 1 |
| Reyes, JFM | 1 |
| Pralle, RS | 7 |
| White, HM | 7 |
| Unger, S | 1 |
| Panne, N | 1 |
| Kammer, M | 2 |
| Plattner, S | 2 |
| Church, C | 1 |
| McGee, D | 1 |
| Harvatine, KJ | 1 |
| Alterisio, MC | 1 |
| Ciaramella, P | 1 |
| Guccione, J | 1 |
| Matsuura, TR | 1 |
| Puchalska, P | 1 |
| Crawford, PA | 1 |
| Kelly, DP | 1 |
| Huang, Y | 1 |
| Kong, Y | 1 |
| Shen, B | 1 |
| Li, B | 1 |
| Tan, P | 1 |
| Wei, B | 1 |
| Mei, L | 1 |
| Zhang, Z | 3 |
| Zhao, C | 5 |
| Zhu, X | 1 |
| Qi, S | 1 |
| Wang, J | 3 |
| Hui, SA | 1 |
| Chiew, AL | 1 |
| Depczynski, B | 1 |
| Parmar, K | 1 |
| Mosha, M | 1 |
| Weinstein, DA | 1 |
| Riba-Wolman, R | 1 |
| Alemu, TW | 1 |
| Santschi, DE | 3 |
| Cue, RI | 1 |
| Duggavathi, R | 1 |
| Ning, M | 1 |
| Zhao, Y | 1 |
| Dai, D | 1 |
| Yao, C | 1 |
| Liu, H | 2 |
| Fang, L | 1 |
| Wang, B | 1 |
| Zhang, Y | 6 |
| Cao, J | 1 |
| Avila, A | 1 |
| Málaga, I | 1 |
| Sirsi, D | 1 |
| Kayani, S | 1 |
| Primeaux, S | 1 |
| Kathote, GA | 1 |
| Jakkamsetti, V | 1 |
| Kallem, RR | 1 |
| Putnam, WC | 1 |
| Park, JY | 1 |
| Shinnar, S | 1 |
| Pascual, JM | 1 |
| Wang, Q | 1 |
| Cui, Y | 2 |
| Indugu, N | 1 |
| Yu, Z | 1 |
| Baker, L | 1 |
| Pitta, D | 1 |
| Deng, Z | 1 |
| Zhang, MQ | 1 |
| Heirbaut, S | 1 |
| Jing, XP | 1 |
| Stefańska, B | 1 |
| Vandaele, L | 1 |
| De Neve, N | 1 |
| Fievez, V | 3 |
| Auld, FM | 1 |
| Parai, JL | 2 |
| Milroy, CM | 2 |
| Nishizawa, T | 1 |
| Matsumoto, T | 1 |
| Todaka, T | 1 |
| Sasano, M | 1 |
| Ozoran, H | 1 |
| Matheou, M | 1 |
| Dyson, P | 1 |
| Karpe, F | 1 |
| Tan, GD | 1 |
| Li, K | 1 |
| Wang, WH | 1 |
| Wu, JB | 1 |
| Xiao, WH | 1 |
| Picasso-Risso, C | 1 |
| Gaire, TN | 1 |
| Nakagawa, K | 1 |
| Noyes, N | 1 |
| Caixeta, L | 1 |
| Song, C | 1 |
| Dhaliwal, S | 1 |
| Bapat, P | 1 |
| Scarr, D | 1 |
| Bakhsh, A | 1 |
| Budhram, D | 1 |
| Verhoeff, NJ | 1 |
| Weisman, A | 1 |
| Fralick, M | 1 |
| Ivers, NM | 1 |
| Cherney, DZI | 1 |
| Tomlinson, G | 1 |
| Lovblom, LE | 1 |
| Mumford, D | 1 |
| Perkins, BA | 1 |
| Jurado-Aguirre, MA | 1 |
| Pérez-Verdín, AE | 1 |
| Valergakis, GE | 2 |
| Siachos, N | 2 |
| Kougioumtzis, A | 2 |
| Banos, G | 2 |
| Panousis, N | 3 |
| Tsiamadis, V | 2 |
| Bauer, EA | 1 |
| Kułaj, D | 1 |
| Sawicki, S | 1 |
| Pokorska, J | 1 |
| Zinicola, M | 3 |
| Bicalho, MLS | 1 |
| Santin, T | 1 |
| Marques, EC | 1 |
| Bisinotto, RS | 1 |
| Bicalho, RC | 3 |
| Batista, CP | 1 |
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| Zhu, Y | 5 |
| Wang, X | 2 |
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| Mrug, M | 1 |
| Lyons, LA | 1 |
| Weimbs, T | 1 |
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| Adamovich, KV | 1 |
| Adamovich, TV | 1 |
| Dubouskaya, TG | 1 |
| Hrynevich, SV | 1 |
| Waseem, TV | 1 |
| Fedorovich, SV | 1 |
| Balcerak, M | 1 |
| Przysucha, T | 1 |
| Kalińska, A | 1 |
| Sahar, MW | 1 |
| Beaver, A | 1 |
| Weary, DM | 6 |
| von Keyserlingk, MAG | 3 |
| Daros, RR | 1 |
| Eriksson, HK | 1 |
| Hajek, F | 2 |
| Mansfeld, R | 2 |
| Norgren, J | 1 |
| Sindi, S | 1 |
| Sandebring-Matton, A | 1 |
| Kåreholt, I | 1 |
| Akenine, U | 1 |
| Nordin, K | 1 |
| Rosenborg, S | 1 |
| Ngandu, T | 1 |
| Kivipelto, M | 1 |
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| Kitic, CM | 1 |
| Thiruvengadam, M | 2 |
| Venkidasamy, B | 2 |
| Subramanian, U | 2 |
| Selvaraj, D | 1 |
| Samynathan, R | 1 |
| Fukumori, R | 1 |
| Elsayed, HK | 1 |
| Oba, M | 1 |
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| Nakada, K | 1 |
| Oikawa, S | 2 |
| Abdelatty, AM | 1 |
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| Riond, B | 1 |
| Bochmann, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Feasibility Pilot Study to Evaluate the Tolerability and Safety of a Novel Ketone Ester Ingredient in Healthy Older Men and Women.[NCT05585762] | 30 participants (Actual) | Interventional | 2022-11-28 | Active, not recruiting | |||
| Cross-over, Placebo-controlled, Randomized Trial of β-hydroxybutyrate in Prediabetes[NCT03889210] | 18 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| Short Term Induction of Ketosis in PKD[NCT04472624] | 10 participants (Actual) | Interventional | 2020-07-01 | Completed | |||
| Ketosis and Appetite Suppression - What is the Maximum Carbohydrate Intake That is Still Associated With Appetite Suppression in a Low Energy Diet?[NCT02944253] | 100 participants (Actual) | Interventional | 2017-05-01 | Completed | |||
| Metabolic Differences of an Oral and Intravenous Dose of 3-hydroxybutyrate (3-OHB).[NCT03935841] | 8 participants (Actual) | Interventional | 2019-06-07 | Completed | |||
| A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma[NCT05119010] | 60 participants (Anticipated) | Interventional | 2023-03-24 | Recruiting | |||
| Markers of Appetite Regulation During Exogenous Ketosis - a Placebo Controlled Randomized Study of Appetite Regulatory and Metabolic Markers After Intake of a Keto- or Glucogenic Drink.[NCT04156477] | 10 participants (Actual) | Interventional | 2019-10-24 | Active, not recruiting | |||
| Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants[NCT03830268] | 20 participants (Actual) | Interventional | 2017-06-02 | Completed | |||
| Effect of a Ketogenic Supplement on Brain Energy Metabolism Measured by Neuroimaging in Mild Cognitive Impairment[NCT02551419] | 82 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| The Role of ATGL and G0/G1 Switch Gene Complex in Lipopolysaccaride (LPS) Induced Ketosis - a Controlled, Randomised, Clinical Experimental Study[NCT02157155] | 9 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome[NCT05469997] | 50 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | |||
| A Randomised Controlled Trial Evaluating the Efficacy and Mechanisms of a Ketogenic Diet as an Adjunctive Treatment for People With Treatment-resistant Depression[NCT06091163] | 100 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'[NCT05225467] | 58 participants (Actual) | Observational [Patient Registry] | 2022-03-15 | Completed | |||
| Efficacy of Exogenous Ketone Esters for Children With Refractory Convulsive Status Epileptics[NCT05674552] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Efficacy of Ketone Esters for Children With Drug Resistant Epilepsy[NCT05670847] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing[NCT04130724] | 21 participants (Actual) | Observational | 2019-10-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
32 reviews available for 3-hydroxybutyric acid and Acetonemia
| Article | Year |
|---|---|
Global prevalence of subclinical ketosis in dairy cows: A systematic review and meta-analysis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Pregnancy | 2022 |
Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Dietary Supplements; Humans; Ketone Bodies; Ketones; Ketosis | 2022 |
Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Carbohydrates; Diet, Ketogenic; Humans; Ketone Bodies; Ketones | 2022 |
Ketones and the Heart: Metabolic Principles and Therapeutic Implications.
Topics: 3-Hydroxybutyric Acid; Epigenesis, Genetic; Heart Failure; Humans; Ketone Bodies; Ketones; Ketosis | 2023 |
Hyperketonemia: A Marker of Disease, a Sign of a High-Producing Dairy Cow, or Both?
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketones; Ketosis; Lactation; Milk | 2023 |
What is the utility of blood beta-hydroxybutyrate measurements in emergency department in patients without diabetes: a systematic review.
Topics: 3-Hydroxybutyric Acid; Adult; Child; Diabetes Mellitus; Emergency Service, Hospital; Gastroenteritis | 2023 |
β-hydroxybutyrate: A crucial therapeutic target for diverse liver diseases.
Topics: 3-Hydroxybutyric Acid; Diet, Ketogenic; Humans; Ketone Bodies; Ketosis; Liver Diseases | 2023 |
Utility of Ketone Supplementation to Enhance Physical Performance: A Systematic Review.
Topics: 3-Hydroxybutyric Acid; Adult; Dietary Supplements; Female; Gastrointestinal Diseases; Humans; Ketone | 2020 |
[Overview on the relationship between changes in activity and ketosis in dairy cows].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Behavior, Animal; Cattle; Cattle Diseases; Diagnosis, | 2019 |
Symposium review: Big data, big predictions: Utilizing milk Fourier-transform infrared and genomics to improve hyperketonemia management.
Topics: 3-Hydroxybutyric Acid; Animals; Big Data; Cattle; Cattle Diseases; Female; Genomics; Humans; Ketosis | 2020 |
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Diabetes Mellitus, Type 1; Diet, Ketogenic; Epigenesi | 2020 |
Impact of ketosis on appetite regulation-a review.
Topics: 3-Hydroxybutyric Acid; Animals; Appetite Regulation; Body Weight; Diet, Ketogenic; Diet, Reducing; D | 2020 |
The use of point-of-care testing to establish cause of death in the autopsy setting.
Topics: 3-Hydroxybutyric Acid; Autopsy; Bacteria; Blood Alcohol Content; Blood Glucose; C-Reactive Protein; | 2020 |
Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases.
Topics: 3-Hydroxybutyric Acid; Aging; Alzheimer Disease; Diet, Ketogenic; Dietary Supplements; Epigenomics; | 2021 |
Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Diet, Ketogenic; Humans; Inflammation; Ketone Bodies; Ketosis; | 2019 |
Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Milk; Pregnancy | 2019 |
Review: Metabolic challenges in lactating dairy cows and their assessment via established and novel indicators in milk.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Biomarkers; Cattle; Cattle Diseases; Diet; Fatty Acids; Fe | 2019 |
Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Dairying; Energy Metabolism; Fatty Acids, N | 2013 |
Diseases, reproductive performance, and changes in milk production associated with subclinical ketosis in dairy cows: a meta-analysis and review.
Topics: 3-Hydroxybutyric Acid; Animals; Asymptomatic Infections; Cattle; Cattle Diseases; Fatty Acids, Nones | 2014 |
A systematic review and meta-analysis of the diagnostic accuracy of point-of-care tests for the detection of hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Ketosis; | 2016 |
Role of beta-hydroxybutyric acid in the central regulation of energy balance.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Animals, Suckling; Biological Transport; Bra | 2010 |
Monitoring metabolic health of dairy cattle in the transition period.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Dairying; Diet; Early Diagnosis; Energy Met | 2010 |
Ketoacids? Good medicine?
Topics: 3-Hydroxybutyric Acid; Animals; Cerebral Cortex; Diet; Epilepsy; Fasting; Humans; Ketone Bodies; Ket | 2003 |
Fuel metabolism in starvation.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Brain; Energy Metabolism; Fatty Acids, Nonesterified; Humans; | 2006 |
Fuel metabolism in starvation.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Brain; Energy Metabolism; Fatty Acids, Nonesterified; Humans; | 2006 |
Fuel metabolism in starvation.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Brain; Energy Metabolism; Fatty Acids, Nonesterified; Humans; | 2006 |
Fuel metabolism in starvation.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Brain; Energy Metabolism; Fatty Acids, Nonesterified; Humans; | 2006 |
Ketotic hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adrenocorticotropic Hormone; Adult; Alan | 1983 |
Ketosis of starvation: a revisit and new perspectives.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Gluconeogenesis; Humans; Hydrogen; Hydroxyb | 1983 |
Acid-base aspects of ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alcoholism; Alkalosis | 1984 |
Medical aspects of ketone body metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biological Evolution; Brain; Humans; Hydroxybutyrates | 1995 |
[Alcoholic ketoacidosis].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Alcoholism; Diagnosis, Differential; Ethanol; Female | 1993 |
Metabolic and endocrine aspects of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Anticonvulsants; Carnitine; Dietary Fats; Energy Metabolism; Epilepsy; Fatty | 1999 |
Treatment of acquired epileptic aphasia with the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Adolescent; Anticonvulsants; Aphasia; Child; Combined Modality Therapy; Dieta | 1999 |
Ketone bodies, potential therapeutic uses.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Energy Metabolism; Epilepsy; Fasting; Humans; Ketone Bodies; | 2001 |
44 trials available for 3-hydroxybutyric acid and Acetonemia
| Article | Year |
|---|---|
Reducing milking frequency from twice to once daily as an adjunct treatment for ketosis in lactating dairy cows-A randomized controlled trial.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Dairying; Female; Ketosis; Lactation; Milk; Milk Proteins | 2022 |
Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.
Topics: 3-Hydroxybutyric Acid; Adult; Esters; Humans; Hydroxybutyrates; Ketone Bodies; Ketones; Ketosis | 2023 |
Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial.
Topics: 3-Hydroxybutyric Acid; Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; F | 2022 |
A randomized controlled trial examining the effects of treatment with propylene glycol and injectable cyanocobalamin on naturally occurring disease, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypo
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Glucose; Hypoglycemia; Ketosis; Lac | 2022 |
Effect of d-β-Hydroxybutyrate-(R)-1,3 Butanediol on Appetite Regulation in People with Prediabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Appetite; Appetite Regulation; Ghrelin; Humans; Ketosis; Peptide YY; P | 2023 |
Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes.
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Humans; Ketones; Ketosis; P | 2023 |
Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle II: Postpartum uterine health, ketosis, and milk production.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Chemotaxis; Endometritis; Female; Fermentat | 2019 |
Oral D/L-3-Hydroxybutyrate Stimulates Cholecystokinin and Insulin Secretion and Slows Gastric Emptying in Healthy Males.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Adult; C-Peptide; Cholecystokinin; Cross-Over Studies; | 2020 |
The Effect of Blood Ketone Concentration and Exercise Intensity on Exogenous Ketone Oxidation Rates in Athletes.
Topics: 3-Hydroxybutyric Acid; Athletes; Cross-Over Studies; Energy Metabolism; Exercise; Exercise Test; Fem | 2021 |
Effects of prepartum stocking density and a blind on physiological biomarkers, health, and hygiene of transition Holstein dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Dairying; Fatty Acids, Nonester | 2021 |
A randomized controlled trial to evaluate propylene glycol alone or in combination with dextrose as a treatment for hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Glucose; | 2021 |
Reliability and diagnostic performance of a new blood ketone and glucose meter in humans.
Topics: 3-Hydroxybutyric Acid; Area Under Curve; Athletes; Blood Glucose; Cross-Over Studies; Diagnostic Equ | 2021 |
Acute Nutritional Ketosis and Its Implications for Plasma Glucose and Glucoregulatory Peptides in Adults with Prediabetes: A Crossover Placebo-Controlled Randomized Trial.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Dietary Supplement | 2021 |
Comparison between two preventive treatments for hyperketonaemia carried out
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Proteins; Cattle; Cattle Diseases; Fatty Acids, N | 2021 |
The Effect of Exogenous Beta-Hydroxybutyrate Salt Supplementation on Metrics of Safety and Health in Adolescents.
Topics: 3-Hydroxybutyric Acid; Adolescent; Diet, Ketogenic; Dietary Supplements; Fasting; Female; Healthy Vo | 2021 |
Association between ketosis and metabolic adaptation at the level of resting metabolic rate.
Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Adult; Basal Metabolism; Caloric Restriction; Fema | 2021 |
Effect of two treatment protocols for ketosis on the resolution, postpartum health, milk yield, and reproductive outcomes of dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Carnitine; Cattle; Cattle Diseases; Female; Haptoglobins; Ketosis; L | 2018 |
The effect of different treatments for early-lactation hyperketonemia on liver triglycerides, glycogen, and expression of key metabolic enzymes in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Female; Gene Expression Regu | 2018 |
Effect of acute ingestion of β-hydroxybutyrate salts on the response to graded exercise in trained cyclists.
Topics: 3-Hydroxybutyric Acid; Adult; Bicycling; Blood Glucose; Cross-Over Studies; Eating; Ergometry; Femal | 2018 |
A randomized controlled trial on the effect of incomplete milking during early lactation on ketonemia and body condition loss in Holstein dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Body Composition; Cattle; Cattle Diseases; Dairying; Female; Ketosis | 2018 |
The effect of 1,3-butanediol and carbohydrate supplementation on running performance.
Topics: 3-Hydroxybutyric Acid; Adult; Athletic Performance; Blood Glucose; Butylene Glycols; Cross-Over Stud | 2019 |
Effects of folic acid and vitamin B12 supplementation on culling rate, diseases, and reproduction in commercial dairy herds.
Topics: 3-Hydroxybutyric Acid; Animal Culling; Animals; Cattle; Cattle Diseases; Dietary Supplements; Female | 2014 |
Hyperketonemia during lipopolysaccharide-induced mastitis affects systemic and local intramammary metabolism in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Animals; Blood Glucose; Cattle; Citrate (si)-Synthase | 2014 |
Effects of elevated parameters of subclinical ketosis on the immune system of dairy cows: in vivo and in vitro results.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Body Composition; Body Weight; Cattle; Cattle Diseases; | 2015 |
Dry period plane of energy: Effects on feed intake, energy balance, milk production, and composition in transition dairy cows.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Cattle; Diet; Dietary Fiber; Energy Metabolism; Fatty A | 2015 |
Effect of administration of recombinant bovine somatotropin on health and performance of lactating dairy cows diagnosed with hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Growth | 2015 |
Evaluation of propylene glycol and glycerol infusions as treatments for ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Blood Glucose; Cattle; Cattle Diseases; Cross-Over Studies | 2015 |
Effects of direct-fed Bacillus pumilus 8G-134 on feed intake, milk yield, milk composition, feed conversion, and health condition of pre- and postpartum Holstein cows.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Bacillus; Body Weight; Cattle; Diet; Dietary Fats; Fema | 2015 |
A randomized controlled trial of dexamethasone as an adjunctive therapy to propylene glycol for treatment of hyperketonemia in postpartum dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Dairying; Dexamethasone; Female; Ketones; K | 2016 |
Effects of a combination butaphosphan and cyanocobalamin product and insulin on ketosis resolution and milk production.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Insulin; Ketosis; Lactation; Milk; | 2017 |
Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Drug Combinations; Female; Ketosis; Lactati | 2017 |
Metabolic response to a ketogenic breakfast in the healthy elderly.
Topics: 3-Hydroxybutyric Acid; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Apolipoprotein E4 | 2009 |
A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Propylene | 2011 |
Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
Topics: 3-Hydroxybutyric Acid; Adult; Cholesterol, LDL; Diet; Dietary Fats; Fatty Acids; Fatty Acids, Unsatu | 2004 |
Point of care blood ketone testing of diabetic patients in the emergency department.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Critical Illness; Diabetes Complications; Diabetes M | 2004 |
Effects of monensin and stage of lactation on variation of blood metabolites within twenty-four hours in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Canada; Cattle; Circadian Rhythm; Delayed-Action Prep | 2005 |
Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Animals; Cattle; Cattle Diseases; Delayed-Action Prepar | 2006 |
Effect of isoflupredone acetate with or without insulin on energy metabolism, reproduction, milk production, and health in dairy cows in early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Composition; Calcium; Cattle; Cattle Diseases; D | 2007 |
Bovine ketosis and somatotrophin: risk factors for ketosis and effects of ketosis on health and production.
Topics: 3-Hydroxybutyric Acid; Aging; Analysis of Variance; Animals; Blood Glucose; Body Weight; Cattle; Cat | 1994 |
Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Cattle; Cattle Diseases; Dexamethasone | 1996 |
The association between selected metabolic parameters and left abomasal displacement in dairy cows.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Aspartate Aminotransferases; Blood Glucose; Calcium; Cattl | 1998 |
Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Monensin; Placebos; Pregna | 1998 |
Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Brain; Carbon Radioisotopes; Diabetes Mellitus, Type 1; | 2002 |
Mood and appetite during minimal-carbohydrate and carbohydrate-supplemented hypocaloric diets.
Topics: 3-Hydroxybutyric Acid; Adult; Appetite; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; Emo | 1985 |
377 other studies available for 3-hydroxybutyric acid and Acetonemia
| Article | Year |
|---|---|
Accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Breath Tests; Child; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; | 2021 |
Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of β-hydroxybutyrate in bovine hepatocytes.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Endoplasmic Reticulum Stress; Endoribonucleases; Female; Hep | 2021 |
β-Hydroxybutyrate impairs neutrophil migration distance through activation of a protein kinase C and myosin light chain 2 signaling pathway in ketotic cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cardiac Myosins; Cattle; Cattle Diseases; Female; Ketoses; Ketosis; | 2022 |
Adenosine Receptors Modulate the Exogenous Ketogenic Supplement-Evoked Alleviating Effect on Lipopolysaccharide-Generated Increase in Absence Epileptic Activity in WAG/Rij Rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Dietary Supplements; Disease Models, Ani | 2021 |
Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
Topics: 3-Hydroxybutyric Acid; Animals; Asthma; Bronchial Hyperreactivity; Diet, High-Fat; Diet, Ketogenic; | 2022 |
Clinicopathologic Appearance of Advanced Ketoacidosis With Basal Vacuolation in Renal Tubules.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Epithelial Cells; Glucose; Humans; Ketosis; Perilipin-2; Retrospe | 2022 |
Predicting ketosis during the transition period in Holstein Friesian cows using hematological and serum biochemical parameters on the calving date.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Disease Susceptibility; Female; | 2022 |
β-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Cattle; Cattle Diseases; Female; Ketosis; Lactation; MAP | 2022 |
Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Cross-Sectional Studies; Fatty | 2022 |
Assessment of milk yield and composition, early reproductive performance, and herd removal in multiparous dairy cattle based on the week of diagnosis of hyperketonemia in early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Humans; Ketosis; Lactation; Milk; P | 2022 |
Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Cattle; Fatty Acids, Nonesterified; Female; Glycogen Synt | 2022 |
Evaluation of the point-of-care devices KetoSure
Topics: 3-Hydroxybutyric Acid; Diabetic Ketoacidosis; Humans; Ketones; Ketosis; Point-of-Care Systems | 2022 |
Transition cow nutrition and management strategies of dairy herds in the northeastern United States: Part II-Associations of metabolic- and inflammation-related analytes with health, milk yield, and reproduction.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Fem | 2022 |
Using a target trial approach to evaluate the role of hyperketonemia in sole ulcer and white line hoof lesion development.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Digital Dermatitis; Female; Hoof and Claw; | 2022 |
Impaired autophagy aggravates oxidative stress in mammary gland of dairy cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Catalase; Cattle; Fatty Acids, Nonesterified; Female; Glu | 2022 |
Diurnal variation of milk fatty acids in early-lactation Holstein cows with and without hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids; Female; Ketosis; Lactation; Mi | 2022 |
Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues.
Topics: 3-Hydroxybutyric Acid; Acetylglucosaminidase; Adipose Tissue; Animals; Autophagy; Cathepsin D; Cattl | 2022 |
Changes in the rumen microbiota community in ketosis cows during propylene glycol treatment.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diet; Female; Ketosis; Lactation; Microbiot | 2022 |
An investigation of blood, milk, and urine test patterns for the diagnosis of ketosis in dairy cows in early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketone Bodies; Ketosis; Lactation; | 2022 |
Role of sortilin 1 (SORT1) on fatty acid-mediated cholesterol metabolism in primary calf hepatocytes.
Topics: 3-Hydroxybutyric Acid; Adaptor Proteins, Vesicular Transport; Animals; Cattle; Cholesterol; Fatty Ac | 2022 |
Comparison of Enzyme Activity in Order to Describe the Metabolic Profile of Dairy Cows during Early Lactation.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Aspartate Aminotransferases; Cattle; Cattle Diseases; Fema | 2022 |
Characterization of metabolic profile, health, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Animals; Calcium; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female | 2022 |
Effects of diacylglycerol O-acyltransferase 1 (DGAT1) on endoplasmic reticulum stress and inflammatory responses in adipose tissue of ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Cattle; Cytokines; Diacylglycerol O-Acyltransferase; | 2022 |
Evaluation of the metabolomic profile through
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Humans; Ketosis; Lactation; Magneti | 2022 |
Biochemical profile of heifers with spontaneous humeral fractures suggest that protein-energy malnutrition could be an important factor in the pathology of this disease.
Topics: 3-Hydroxybutyric Acid; Albumins; Animals; Cattle; Cattle Diseases; Creatinine; Fatty Acids, Nonester | 2023 |
Associations of parity with health disorders and blood metabolite concentrations in Holstein cows in different production systems.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Glucose | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
Dynamics of metabolic characteristics in dairy cows and their impact on disease-free survival time.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Disease-Free Survival; Fatty Acids, Noneste | 2023 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
The association of hyperketonemia with fecal and rumen microbiota at time of diagnosis in a case-control cohort of early lactation cows.
Topics: 3-Hydroxybutyric Acid; Animals; Case-Control Studies; Cattle; Cattle Diseases; Female; Ketosis; Lact | 2022 |
Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cattle; Cattle Diseases; Female; Ketosis; Macrophages; | 2023 |
Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cattle; Cattle Diseases; Female; Ketosis; Macrophages; | 2023 |
Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cattle; Cattle Diseases; Female; Ketosis; Macrophages; | 2023 |
Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cattle; Cattle Diseases; Female; Ketosis; Macrophages; | 2023 |
β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Cattle; Cell Adhesion Molecules; Female; Inflammation; Ke | 2022 |
Novel prediction models for hyperketonemia using bovine milk Fourier-transform infrared spectroscopy.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Spectrosc | 2023 |
Association of herd hyperketolactia prevalence with transition management practices and herd productivity on Canadian dairy farms-A retrospective cross-sectional study.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Dairying; Farms; F | 2023 |
Serum metabolomics assessment of etiological processes predisposing ketosis in water buffalo during early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Buffaloes; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Meta | 2023 |
Untargeted metabolomics and lipidomics to assess plasma metabolite changes in dairy goats with subclinical hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Fatty Acids, Nonesterified; Female; Goat Diseases; Goats; K | 2023 |
Fasting ketone levels vary by age: implications for differentiating physiologic from pathologic ketotic hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Fasting; Female; Humans; Hypoglycemia; I | 2023 |
Reproductive performance of lactating dairy cows with elevated milk β-hydroxybutyrate levels during first 6 weeks of lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk | 2023 |
Gene co-expression network and differential expression analyses of subcutaneous white adipose tissue reveal novel insights into the pathological mechanisms underlying ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Bilirubin; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Fema | 2023 |
Combination of triheptanoin with the ketogenic diet in Glucose transporter type 1 deficiency (G1D).
Topics: 3-Hydroxybutyric Acid; Animals; Diet, Ketogenic; Glucose Transporter Type 1; Humans; Ketone Bodies; | 2023 |
Integrated meta-omics analyses reveal a role of ruminal microorganisms in ketone body accumulation and ketosis in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Butyrates; Cattle; Cattle Diseases; Diet; Female; Ketosis; Lactation | 2023 |
Transition cow clusters with distinctive antioxidant ability and their relation to performance and metabolic status in early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; F | 2023 |
Subnuclear renal tubular vacuoles in alcohol use disorder.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Diabetic Ketoacidosis; Epithelial Cells; Fatty Liver; Forensic Pa | 2023 |
Alcoholic ketoacidosis evaluated with a point-of-care capillary beta-hydroxybutyrate measurement device.
Topics: 3-Hydroxybutyric Acid; Acidosis; Electrolytes; Humans; Ketosis; Point-of-Care Systems; Retrospective | 2023 |
Type 1 diabetes and low carbohydrate diets-Defining the degree of nutritional ketosis.
Topics: 3-Hydroxybutyric Acid; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Diet, Carboh | 2023 |
Evaluating variations in metabolic profiles during the dry period related to the time of hyperketonemia onset in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cohort Studies; Female; Ketosis; Lactation; | 2023 |
[Succinyl CoA:3 oxoacid CoA transferase deficiency: A case report].
Topics: 3-Hydroxybutyric Acid; Coenzyme A-Transferases; Humans; Hyperglycemia; Ketone Bodies; Ketosis | 2023 |
Associations among post-partum rumen fill and motility, subclinical ketosis and fertility in Holstein dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Fertility; Humans; Ketosis; Lactati | 2024 |
Gene association analysis of an osteopontin polymorphism and ketosis resistance in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Osteopont | 2023 |
Effects of recombinant bovine interleukin-8 (rbIL-8) treatment on health, metabolism, and lactation performance in Holstein cattle IV: Insulin resistance, dry matter intake, and blood parameters.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Cattle; Cell Proliferation; Diet; Eating; Fatty Acids; Fe | 2019 |
Hepatic nuclear factor kappa B signaling pathway and NLR family pyrin domain containing 3 inflammasome is over-activated in ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Ca | 2019 |
Evaluation of a handheld device for the measurement of beta-hydroxybutyrate in capillary blood obtained by the puncture of the vulva as well as in venous whole blood in cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Vulva | 2019 |
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease.
Topics: 3-Hydroxybutyric Acid; Animals; Cats; Cysts; Diet, Ketogenic; Disease Models, Animal; Disease Progre | 2019 |
High Concentration of Ketone Body β-Hydroxybutyrate Modifies Synaptic Vesicle Cycle and Depolarizes Plasma Membrane of Rat Brain Synaptosomes.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Endocytosis; Exocytosis; Hydrogen-Ion Concentration; Ketosis; | 2020 |
The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Dairying; Fatty Acids, Nonester | 2019 |
Feeding behavior and agonistic interactions at the feed bunk are associated with hyperketonemia and metritis diagnosis in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Agonistic Behavior; Animal Feed; Animal Husbandry; Animals; Cattle; Cattle Di | 2020 |
The relationship between transition period diseases and lameness, feeding time, and body condition during the dry period.
Topics: 3-Hydroxybutyric Acid; Animals; British Columbia; Cattle; Cattle Diseases; Dairying; Farms; Feeding | 2020 |
Capillary blood tests may overestimate ketosis: triangulation between three different measures of β-hydroxybutyrate.
Topics: 3-Hydroxybutyric Acid; Adult; Capillaries; Diet, Ketogenic; Fatty Acids; Female; Healthy Volunteers; | 2020 |
Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diet Records; Dietary Carbohydrates; Energy Intake; Ene | 2020 |
Up-converting phosphor technology-based lateral flow assay for quantitative detection of β-hydroxybutyrate in biological samples.
Topics: 3-Hydroxybutyric Acid; Animals; Biological Assay; Biomarkers; Biosensing Techniques; Cattle; Female; | 2020 |
Sensitive screen-printed electrodes with the colorimetric zone for simultaneous determination of mastitis and ketosis in bovine milk samples.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Colorimetry; Electrochemical Techniques; Electrodes; Female; | 2020 |
Serum paraoxonase-1 activity in tail and mammary veins of ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Aryldialkylphosphatase; Blood Chemical Analysis; Cattle; Cattle Dise | 2020 |
Increased autophagy mediates the adaptive mechanism of the mammary gland in dairy cows with hyperketonemia.
Topics: 3-Hydroxybutyric Acid; AMP-Activated Protein Kinases; Animals; Autophagosomes; Autophagy; Autophagy- | 2020 |
Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animal Nutritional Physiological Phenomena; Animals; | 2020 |
Predictive ability of host genetics and rumen microbiome for subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Female; Gastrointestinal Microbiom | 2020 |
Opportunities and limitations of milk mid-infrared spectra-based estimation of acetone and β-hydroxybutyrate for the prediction of metabolic stress and ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; | 2020 |
Short communication: Associations between nonesterified fatty acids, β-hydroxybutyrate, and glucose in periparturient dairy goats.
Topics: 3-Hydroxybutyric Acid; Animals; Australia; Blood Glucose; Fatty Acids, Nonesterified; Female; Goat D | 2020 |
Utility of Postmortem Vitreous Beta-Hydroxybutyrate Testing for Distinguishing Sudden from Prolonged Deaths and for Diagnosing Ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Death, S | 2020 |
Heritability estimates of predicted blood β-hydroxybutyrate and nonesterified fatty acids and relationships with milk traits in early-lactation Holstein cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Inherit | 2020 |
Short communication: Prediction of hyperketonemia in dairy cows in early lactation using on-farm cow data and net energy intake by partial least square discriminant analysis.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Cattle; Cattle Diseases; Discriminant Analysis; Energy | 2020 |
Changes of milk fatty acid composition in four lipid classes as biomarkers for the diagnosis of bovine ketosis using bioanalytical Thin Layer Chromatography and Gas Chromatographic techniques (TLC-GC).
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Chromatography, Gas; Chromatogr | 2020 |
Ketoacidosis associated with ketogenic diet in a non-diabetic lactating woman.
Topics: 3-Hydroxybutyric Acid; Abdominal Pain; Acid-Base Equilibrium; Adult; Blood Glucose; Breast Feeding; | 2020 |
Hyperketonemia GWAS and parity-dependent SNP associations in Holstein dairy cows intensively sampled for blood β-hydroxybutyrate concentration.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Genes; Genetic Predisposition to Di | 2020 |
Postmortem diagnosis of ketoacidosis: Levels of beta-hydroxybutyrate, acetone and isopropanol in different causes of death.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drin | 2020 |
[Use of serum haptoglobin concentration as an indicator in animal health monitoring of dairy cows].
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Cattle; Cattle Diseases; Dairying; Fatty Acids, Nonester | 2020 |
Relationship between milk constituents from milk testing and health, feeding, and metabolic data of dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Cattle; Cattle Diseases; Cultured Milk Products; Dairyi | 2020 |
Genetic and nongenetic profiling of milk β-hydroxybutyrate and acetone and their associations with ketosis in Holstein cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Female; Genome-Wide Association St | 2020 |
Metabolic alterations in dairy cows with subclinical ketosis after treatment with carboxymethyl chitosan-loaded, reduced glutathione nanoparticles.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Chitosan; Female; Glutathione; Ketosis; Lac | 2020 |
Characterization of serum adiponectin and leptin in healthy perinatal dairy cows or cows with ketosis, and their effectson ketosis involved indices.
Topics: 3-Hydroxybutyric Acid; Adiponectin; Animals; Biomarkers; Blood Glucose; Cattle; Cattle Diseases; Fat | 2020 |
Effect of functional single nucleotide polymorphism g.-572 A > G of apolipoprotein A1 gene on resistance to ketosis in Chinese Holstein cows.
Topics: 3-Hydroxybutyric Acid; Animals; Apolipoprotein A-I; Cattle; Cattle Diseases; China; Female; Genetic | 2021 |
Oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Caspases; Cattle; Cattle Diseases; Female; Inflammasomes; | 2021 |
Common and specific mineral and metabolic features in dairy cows with clinical metritis, hypocalcaemia or ketosis.
Topics: 3-Hydroxybutyric Acid; Alberta; Animals; Aspartate Aminotransferases; Cattle; Cattle Diseases; Chole | 2021 |
Effect of hyperketonemia on the diurnal patterns of energy-related blood metabolites in early-lactation dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Circadian Rhythm; Energy Metabolism; Fatty | 2021 |
The relationship of excessive energy deficit with milk somatic cell score and clinical mastitis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Fatty Acids; Fatty Acids, Nonesterified; Female; Incidence; | 2021 |
The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.
Topics: 3-Hydroxybutyric Acid; Animals; Antineoplastic Agents; Blood Glucose; Breast Neoplasms; Diet, Ketoge | 2020 |
Subclinical hypocalcaemia follows specific time-related and severity patterns in post-partum Holstein cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Hypocalcemia; Ketosis; Lactation; P | 2021 |
Hepatic autophagy and mitophagy status in dairy cows with subclinical and clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Live | 2021 |
[Validation of a cow-side blood test for beta-hydroxybutyrate concentration in dairy cows].
Topics: 3-Hydroxybutyric Acid; Animals; Capillaries; Cattle; Cattle Diseases; Dairying; Female; Jugular Vein | 2021 |
Enhanced mitochondrial dysfunction and oxidative stress in the mammary gland of cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Ketosis | 2021 |
Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Endoplasmic Reticulum; Endoplasmic Reticulu | 2021 |
Genome-wide association study and functional analyses for clinical and subclinical ketosis in Holstein cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Genome-Wide Association Study; Keto | 2021 |
Characteristics of post-mortem beta-hydroxybutyrate-positivet cases - A retrospective study on age, sex and BMI in 1407 forensic autopsies.
Topics: 3-Hydroxybutyric Acid; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Case-Control St | 2021 |
High concentrations of β-hydroxybutyrate alter the kinetics of bovine spermatozoa.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Kinetics; Male; Spermatozo | 2021 |
Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Anesthetics; Animals; Citrates; Citric Acid; Fatty Ac | 2021 |
Connecting Metabolism to Mastitis: Hyperketonemia Impaired Mammary Gland Defenses During a
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Female; Ketosis; Macrophages; Mammary Glands, Animal; Mastit | 2021 |
Slow but Steady-The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats.
Topics: 3-Hydroxybutyric Acid; Adrenal Glands; Animals; Blood Glucose; Diet, Ketogenic; Disease Models, Anim | 2021 |
Evaluation of a point-of-care electrochemical meter to detect subclinical ketosis and hypoglycaemia in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Chemical Analysis; Blood Glucose; Cattle; Cattle Diseases; Dai | 2017 |
Short communication: Repeatability of β-hydroxybutyrate measurements in capillary blood obtained from the external vulvar skin.
Topics: 3-Hydroxybutyric Acid; Animals; Capillaries; Cattle; Cattle Diseases; Female; Germany; Ketosis; Punc | 2017 |
Prediction of whole-genome risk for selection and management of hyperketonemia in Holstein dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Breeding; Cattle; Cattle Diseases; Disease Management; Female; Genet | 2017 |
The effect of different treatments for early-lactation hyperketonemia on blood β-hydroxybutyrate, plasma nonesterified fatty acids, glucose, insulin, and glucagon in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; | 2017 |
Genetic parameters of blood β-hydroxybutyrate predicted from milk infrared spectra and clinical ketosis, and their associations with milk production traits in Norwegian Red cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Denmark; Female; Ketosis; Lactation; Milk; | 2017 |
Accuracy of a cow-side test for the diagnosis of hyperketonemia and hypoglycemia in lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Glucose; | 2017 |
Liquid exfoliation of 2D MoS
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Biosensing Techniques; Electrochemical Techniques; Elect | 2017 |
Association of rumination time and health status with milk yield and composition in early-lactation dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Health Status; Ketosis; Milk; Milk | 2018 |
Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Aged; Benzhydryl Compounds; Case-Control Studies; Diabe | 2018 |
Short communication: The association of adiponectin and leptin concentrations with prepartum dietary energy supply, parity, body condition, and postpartum hyperketonemia in transition dairy cows.
Topics: 3-Hydroxybutyric Acid; Adiponectin; Adipose Tissue; Animals; Cattle; Cattle Diseases; Diet; Energy M | 2018 |
Significant changes in ITIH4, AHSG, ORM1, and CD46 content in milk fat globule membrane proteins of ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Acute-Phase Proteins; Acute-Phase Reaction; alpha-2-HS-Glycoprotein; Alpha-Gl | 2017 |
Beta-hydroxybutyrate in milk as screening test for subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Milk; Sensitivity and Spec | 2017 |
Technical note: Validation of the BHBCheck blood β-hydroxybutyrate meter as a diagnostic tool for hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Ketosis; | 2018 |
Predicting hyperketonemia by logistic and linear regression using test-day milk and performance variables in early-lactation Holstein and Jersey cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Dairying; | 2018 |
High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids; Female; Growth Hormone; Janus | 2018 |
Short communication: Cow- and herd-level prevalence of hypoglycemia in hyperketonemic postpartum dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Canada; Cattle; Cattle Diseases; Dairying; Female; Hypoglycemia; Ket | 2018 |
Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Brain; Disease Models, Animal; Hypoxia-Ischemia, B | 2018 |
Predicting blood β-hydroxybutyrate using milk Fourier transform infrared spectrum, milk composition, and producer-reported variables with multiple linear regression, partial least squares regression, and artificial neural network.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Diagnostic Tests, Routine; Female; Ketosis; | 2018 |
Metabolic predictors of peri-partum diseases and their association with parity in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Endometritis; Fatty Acids, Nonesterified; F | 2018 |
The concentration of free amino acids in blood serum of dairy cows with primary ketosis.
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Cat | 2018 |
Risk factors for clinical ketosis and association with milk production and reproduction variables in dairy cows in a hot environment.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Climate; Dairying; Female; Fertilization; H | 2018 |
Evaluation of the Nova Vet Meter for sheep-side monitoring of β-hydroxybutyric acid (BHBA) and description of ewe BHBA during late gestation in three flocks from the Northeastern U.S.
Topics: 3-Hydroxybutyric Acid; Animals; Female; Ketosis; Parturition; Pregnancy; Pregnancy, Animal; ROC Curv | 2018 |
Prepartal standing behavior as a parameter for early detection of postpartal subclinical ketosis associated with inflammation and liver function biomarkers in peripartal dairy cows.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Cattle; Catt | 2018 |
Methylglyoxal: A newly detected and potentially harmful metabolite in the blood of ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; | 2018 |
Potential prophylactic effect of recombinant bovine somatotropin (rbST) in sheep with experimentally induced hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Female; Growth Hormone; Insulin; Insulin-Like Growth Factor | 2018 |
Nutritional ketosis delays the onset of isoflurane induced anesthesia.
Topics: 3-Hydroxybutyric Acid; Administration, Inhalation; Anesthesia; Animals; Diet, Ketogenic; Food-Drug I | 2018 |
Non-Esterified Fatty Acids Over-Activate the TLR2/4-NF-Κb Signaling Pathway to Increase Inflammatory Cytokine Synthesis in Neutrophils from Ketotic Cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cells, Cultured; Cytokines; Electrophoretic Mobility Shift A | 2018 |
Detection of elevated ketone bodies by postmortem 1H-MRS in a case of fetal ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Acetone; Acidosis, Lactic; Alcoholism; Cerebrum; Fasting; Female; Fetal Blood | 2018 |
Milk yield relative to supplement intake and rumination time differs by health status for fresh cows milked with automated systems.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Dietary Supplements; Digestion; Eating; Ene | 2018 |
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B | 2019 |
Short communication: Validation of a test-day milk test for β-hydroxybutyrate for identifying cows with hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Diagnostic Tests, | 2019 |
Evaluation of the Precision Xtra meter for monitoring blood β-hydroxybutyrate concentrations in late-gestation ewes.
Topics: 3-Hydroxybutyric Acid; Animals; Diagnostic Tests, Routine; Female; Ketosis; Pregnancy; Sheep; Sheep | 2019 |
High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis Regulatory Proteins; Cattle; Cattle Diseases; Cell Count; | 2019 |
Incidence and risk factors for ketosis in grazing dairy cattle in the Cundi-Boyacencian Andean plateau, Colombia.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Colombia; Female; Incidence; Ketosis; Lacta | 2019 |
The effects of non-esterified fatty acids and β-hydroxybutyrate on the hepatic CYP2E1 in cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; China; Cytochrome P-450 CYP2E1; Dairying; F | 2019 |
Associations of pre- and postpartum lying time with metabolic, inflammation, and health status of lactating dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Haptogl | 2019 |
Effect of heat-shock protein B7 on oxidative stress in adipocytes from preruminant calves.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Antioxidants; Cattle; Cattle Diseases; Fatty Acids, None | 2019 |
Ketoacidosis in Euglycemic Patients With Type 2 Diabetes After Abdominal Surgery.
Topics: 3-Hydroxybutyric Acid; Abdomen; Acidosis; Aged; Anions; Bicarbonates; Blood Glucose; Diabetes Mellit | 2019 |
Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions.
Topics: 3-Hydroxybutyric Acid; Animals; Cell Line; Cell Proliferation; Colorimetry; DNA-Binding Proteins; Ge | 2019 |
Elevated β-hydroxybutyric acid with no ketoacidosis in type 2 diabetic patients using sodium-glucose cotransporter-2 inhibitors.
Topics: 3-Hydroxybutyric Acid; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Ketosis; Sodium-Glu | 2019 |
Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation1.
Topics: 3-Hydroxybutyric Acid; Adaptation, Physiological; Adipocytes; Adipose Tissue; Animals; Biomarkers; C | 2019 |
Short communication: Assessing the accuracy of inline milk fat-to-protein ratio data as an indicator of hyperketonemia in dairy cows in herds with automated milking systems.
Topics: 3-Hydroxybutyric Acid; Animals; Automation; Cattle; Cattle Diseases; Dairying; Fats; Female; Ketosis | 2019 |
The role of altered immune function during the dry period in promoting the development of subclinical ketosis in early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Bilirubin; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Fema | 2019 |
Renal cortical pallor--a useful macroscopic marker for metabolic derangements at autopsy.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Biomarkers; Epithelial Cells; Female; Forensi | 2013 |
Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Comorbidity; Endometritis; Europe; Female; | 2013 |
Basal epithelial formalin pigment deposition in the kidneys--a useful marker for ketoacidosis at autopsy.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Case-Control Studies; | 2013 |
Short communication: evaluation of the accuracy of an electronic on-farm test to quantify blood β-hydroxybutyrate concentration in dairy goats.
Topics: 3-Hydroxybutyric Acid; Animals; Cross-Sectional Studies; Dairying; Female; Goat Diseases; Goats; Ket | 2013 |
Ketosis and appetite-mediating nutrients and hormones after weight loss.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Appetite Regulation; Body Mass Index; Caloric Restriction; Diet, | 2013 |
Diagnostic accuracy of fingerstick β-hydroxybutyrate for ketonuria in pregnant women with nausea and vomiting.
Topics: 3-Hydroxybutyric Acid; Adult; Female; Humans; Ketosis; Nausea; Pregnancy; Prospective Studies; ROC C | 2013 |
Comparison of 2 electronic cowside tests to detect subclinical ketosis in dairy cows and the influence of the temperature and type of blood sample on the test results.
Topics: 3-Hydroxybutyric Acid; Animals; Anticoagulants; Austria; Blood Specimen Collection; Cattle; Cattle D | 2013 |
Ketone bodies upregulate endothelial connexin 43 (Cx43) gap junctions.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Aorta; Blotting, Western; Cattle; Connexin 4 | 2013 |
Effects of time and sampling location on concentrations of β-hydroxybutyric acid in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Jugular Veins; Ketosis; Lactation; | 2014 |
Induced hyperketonemia affects the mammary immune response during lipopolysaccharide challenge in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acute-Phase Proteins; Animals; Cattle; Cell Count; Energy Metabolism; Fatty A | 2014 |
(1)H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Blood Glucose; Cattle; Cattle Diseases; Chol | 2014 |
Thresholds of whole-blood β-hydroxybutyrate and glucose concentrations measured with an electronic hand-held device to identify ovine hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animals; Austria; Blood Chemical Analysis; Blood Glucose; Blood Specimen Coll | 2014 |
[Evaluation of a new electronic handheld meter for measurement of β-hydroxybutyric acid in dairy cows].
Topics: 3-Hydroxybutyric Acid; Animals; Blood Chemical Analysis; Cattle; Cattle Diseases; Computers, Handhel | 2014 |
Effects of prepartal body condition score and peripartal energy supply of dairy cows on postpartal lipolysis, energy balance and ketogenesis: an animal model to investigate subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Body Constitution; Cattl | 2014 |
Accuracy of milk ketone bodies from flow-injection analysis for the diagnosis of hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Dietary F | 2014 |
Ketoacidosis and adrenocortical insufficiency.
Topics: 17-Hydroxycorticosteroids; 3-Hydroxybutyric Acid; Addison Disease; Adult; Aldosterone; C-Reactive Pr | 2014 |
Endogenous concentrations of GHB in postmortem blood from deaths unrelated to GHB use.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Autopsy; Biomarkers; Female; Gas Chromatography-Mass Spectrometr | 2014 |
Genetic analysis of milk β-hydroxybutyrate and its association with fat-to-protein ratio, body condition score, clinical ketosis, and displaced abomasum in early first lactation of Canadian Holsteins.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Canada; Cattle; Cattle Diseases; Fats; Female; Fertility; | 2014 |
Evaluation of 2 electronic handheld devices for diagnosis of ketonemia and glycemia in dairy goats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Computers, Handheld; Female; Glucose Metabolism Disor | 2014 |
A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease.
Topics: 3-Hydroxybutyric Acid; Alzheimer Disease; Dietary Supplements; Glucose; Humans; Hydroxybutyrates; Ke | 2015 |
Short communication: Use of genomic and metabolic information as well as milk performance records for prediction of subclinical ketosis risk via artificial neural networks.
Topics: 3-Hydroxybutyric Acid; Animals; Asymptomatic Infections; Cattle; Cattle Diseases; Female; Genomics; | 2015 |
Clinical ketosis and standing behavior in transition cows.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Cattle; Cattle Diseases; Dairying; Female; Ketosis | 2015 |
Risk factors for subclinical and clinical ketosis and association with production parameters in dairy cows in the Netherlands.
Topics: 3-Hydroxybutyric Acid; Animals; Asymptomatic Infections; Body Constitution; Cattle; Cattle Diseases; | 2015 |
Subclinical ketosis in post-partum dairy cows fed a predominantly pasture-based diet: defining cut-points for diagnosis using concentrations of beta-hydroxybutyrate in blood and determining prevalence.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Cat | 2015 |
Evaluation of hyperketonemia risk period and screening protocols for early-lactation dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Point-of-Care S | 2015 |
Case of alcoholic ketoacidosis accompanied with severe hypoglycemia.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Coma; Dietary Carbohydrates; Fluid Therapy; Gluconeogenesis; Gluc | 2015 |
The effect of intrauterine infusion of dextrose on clinical endometritis cure rate and reproductive performance of dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Anovulation; Cattle; Cattle Diseases; Endometritis; Female; Glucose; | 2015 |
Transition diseases in grazing dairy cows are related to serum cholesterol and other analytes.
Topics: 3-Hydroxybutyric Acid; Animals; Calcium; Cattle; Cattle Diseases; Cholesterol; Fatty Acids, Nonester | 2015 |
Relationships among ketosis, serum metabolites, body condition, and reproductive outcomes in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartate Aminotransferases; Blood Glucose; Blood Urea Nitrogen; Bod | 2015 |
Microfluidic biosensor for β-Hydroxybutyrate (βHBA) determination of subclinical ketosis diagnosis.
Topics: 3-Hydroxybutyric Acid; Animals; Biosensing Techniques; Cattle; Cattle Diseases; Equipment Design; Fe | 2015 |
Factors associated with survival in the herd for dairy cows following surgery to correct left displaced abomasum.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Canada; Cattle; Cattle Diseases; Fatty Acids, Nonesterifie | 2015 |
Evaluation of a handheld device for measurement of β-hydroxybutyrate concentration to identify prepartum dairy cattle at risk of developing postpartum hyperketonemia.
Topics: 3-Hydroxybutyric Acid; Animal Husbandry; Animals; Blood Chemical Analysis; Cattle; Cattle Diseases; | 2015 |
Definition of prepartum hyperketonemia in dairy goats.
Topics: 3-Hydroxybutyric Acid; Animals; Canada; Cattle; Cohort Studies; Female; Goat Diseases; Goats; Ketosi | 2015 |
Development of quantum dots-based biosensor towards on-farm detection of subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Biosensing Techniques; Cattle; Cattle Diseases; Equipment Design; Fe | 2015 |
Milk fatty acids as possible biomarkers to diagnose hyperketonemia in early lactation.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Biomarkers; Cattle; Cattle Diseases; Diet; Fatty Acids; | 2015 |
Suitability of capillary blood obtained by a minimally invasive lancet technique to detect subclinical ketosis in dairy cows by using 3 different electronic hand-held devices.
Topics: 3-Hydroxybutyric Acid; Animals; Asymptomatic Infections; Cattle; Cattle Diseases; Dairying; Electron | 2015 |
Technical note: Validation of a handheld meter for measuring β-hydroxybutyrate concentrations in plasma and serum from dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Chemical Analysis; Cats; Cattle; Cattle Diseases; Dairying; Fe | 2015 |
A putative low-carbohydrate ketogenic diet elicits mild nutritional ketosis but does not impair the acute or chronic hypertrophic responses to resistance exercise in rodents.
Topics: 3-Hydroxybutyric Acid; Amino Acids, Essential; Animals; Blood Glucose; Diet, Carbohydrate-Restricted | 2016 |
Multiple-trait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holsteins.
Topics: 3-Hydroxybutyric Acid; Animals; Bayes Theorem; Canada; Cattle; Cattle Diseases; Female; Fertility; G | 2016 |
The effect of subclinical ketosis on activity at estrus and reproductive performance in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; England; Estrus; Female; Ketosis; Lactation | 2016 |
Development of Fourier transform mid-infrared calibrations to predict acetone, β-hydroxybutyrate, and citrate contents in bovine milk through a European dairy network.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Calibration; Cattle; Cattle Diseases; Citric Acid; Cost-Ben | 2016 |
An association between the level of oxidative stress and the concentrations of NEFA and BHBA in the plasma of ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Ketosis | 2016 |
Study on some risk factors and effects of bovine ketosis on dairy cows from the Galicia region (Spain).
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Milk; Risk Factors; Spain | 2017 |
Association of rumination time with subclinical ketosis in transition dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Postpartum Peri | 2016 |
Short communication: Association of milk fatty acids with early lactation hyperketonemia and elevated concentration of nonesterified fatty acids.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Energy Metabolism; Fatty Acids; Fatty Acids, Nonesterified; | 2016 |
Postmortem biochemistry in suspected starvation-induced ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Acetone; Adult; Albumins; Biomarkers; Blood Urea Nitrogen; Creatinine; Female | 2016 |
Measurement of β-hydroxybutyrate in capillary blood obtained from an ear to detect hyperketonemia in dairy cows by using an electronic handheld device.
Topics: 3-Hydroxybutyric Acid; Animals; Capillaries; Cattle; Cattle Diseases; Electronics; Female; Ketosis; | 2016 |
Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part III. Metritis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Endometritis; Female; Ketosis; Lactation; P | 2016 |
Use of rumination and activity monitoring for the identification of dairy cows with health disorders: Part I. Metabolic and digestive disorders.
Topics: 3-Hydroxybutyric Acid; Algorithms; Animals; Behavior, Animal; Calcium; Cattle; Cattle Diseases; Dair | 2016 |
Short communication: Association of lying behavior and subclinical ketosis in transition dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Postpartum Peri | 2016 |
Dairy cows affected by ketosis show alterations in innate immunity and lipid and carbohydrate metabolism during the dry off period and postpartum.
Topics: 3-Hydroxybutyric Acid; Animals; Carbohydrate Metabolism; Cattle; Cattle Diseases; Female; Immunity, | 2016 |
Technical note: Comparison of 4 electronic handheld meters for diagnosing hyperketonemia in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Milk; Sensitivity and Spec | 2016 |
Short communication: Rumination and feeding behaviors differ between healthy and sick dairy cows during the transition period.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Cattle; Cattle Diseases; Feeding Behavior; Female; | 2016 |
β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway.
Topics: 3-Hydroxybutyric Acid; Animals; Apoptosis; Cattle; Cattle Diseases; Female; Hepatocytes; Ketosis; Ox | 2016 |
Septic Ketoacidosis-A Potentially Lethal Entity with Renal Tubular Epithelial Vacuolization.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Epithelial Cells; Fatal Outcome; Female; Humans; Ketones; Ketosi | 2017 |
Armanni-Ebstein Lesions in Terminal Hyperglycemia.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Epithelial | 2017 |
Investigating the within-herd prevalence and risk factors for ketosis in dairy cattle in Ontario as diagnosed by the test-day concentration of β-hydroxybutyrate in milk.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Ontario; | 2017 |
The (non)sense of routinely analysing beta-hydroxybutyric acid in forensic toxicology casework.
Topics: 3-Hydroxybutyric Acid; Acetone; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; K | 2017 |
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-S | 2017 |
Basal Vacuolization in Renal Tubular Epithelial Cells at Autopsy and Their Relation to Ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Child, Prescho | 2017 |
Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Calibration; Cysteine; Diabetic Ketoacidosis; Diagnosis, Differen | 2017 |
Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.
Topics: 3-Hydroxybutyric Acid; Aging; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precurs | 2008 |
Metabolic profiles in five high-producing Swedish dairy herds with a history of abomasal displacement and ketosis.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Aspartate Aminotransferases; Blood Glucose; Cattle; Cattle | 2008 |
Effects of niacin on milk production and blood parameters in early lactation of dairy cows.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Dai | 2008 |
Short communication: elevated concentrations of oleic acid and long-chain fatty acids in milk fat of multiparous subclinical ketotic cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fats; Fatty Acids; Fatty Acids, Nonesterifi | 2008 |
Impact of hyperketonemia in early lactation dairy cows on health and production.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Cattle; Cattle Diseases; Dairying; Endometriosis; Energy M | 2009 |
Evaluation of an electronic cowside test to detect subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Dairying; Diagnostic Tests, Routine; Female | 2009 |
Lecithin cholesterol acyltransferase (LCAT) activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Blood Proteins; Buffaloes; Cholesterol; Fatty Acids, | 2010 |
Prepartum feeding behavior is an early indicator of subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Cattle; Cattle Diseases; Eating; Female; Ketosis; | 2009 |
Determination of beta-hydroxybutyrate in blood and urine using gas chromatography- mass spectrometry.
Topics: 3-Hydroxybutyric Acid; Alcoholism; Biomarkers; Drug Stability; Gas Chromatography-Mass Spectrometry; | 2009 |
Evaluation of the change of serum copper and zinc concentrations of dairy cows with subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Copper; Fatty Acids, Nonesterified; Female; Ketosis; Zinc | 2010 |
Chronic in vitro ketosis is neuroprotective but not anti-convulsant.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Cytoprotection; Diet, Ketogenic; Disease Models, A | 2010 |
The effect of injectable butaphosphan and cyanocobalamin on postpartum serum beta-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Calcium; Cattle; Cattle Diseases; Dairying; Female; Ketosis; Logisti | 2010 |
Metabolic predictors of post-partum disease and culling risk in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Biomarkers; Blood Glucose; Calcium; Cattle; Cattle Disease | 2011 |
Use of a hand-held meter for detecting subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Clinical Laboratory Techniqu | 2010 |
Low cortisol levels in blood from dairy cows with ketosis: a field study.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Calcium; Cattle; Cattle Diseases; Fatty Acids, Nonest | 2010 |
Ketosis in buffalo (Bubalus bubalis): clinical findings and the associated oxidative stress level.
Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Bu | 2010 |
Repeated intoxication presenting with azotemia, elevated serum osmolal gap, and metabolic acidosis with high anion gap: differential diagnosis, management, and prognosis.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Acid-Base Equilibrium; Acidosis; Aged; Al | 2012 |
Association between the proportion of sampled transition cows with increased nonesterified fatty acids and beta-hydroxybutyrate and disease incidence, pregnancy rate, and milk production at the herd level.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Inciden | 2010 |
An evaluation of beta-hydroxybutyrate in milk and blood for prediction of subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Milk; Predictiv | 2010 |
Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Body Weight; Diet, Ketogenic; Diet, Protein-Restricted; Die | 2011 |
Use of a point-of-care beta-hydroxybutyrate sensor for detection of ketonemia in dogs.
Topics: 3-Hydroxybutyric Acid; Animals; Dog Diseases; Dogs; Ketosis; Point-of-Care Systems; Sensitivity and | 2010 |
Hyperketonemia decreases mitochondrial membrane potential and its normalization with chromium (III) supplementation in monocytes.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cell Survival; Dietary Supplements; Humans; Ketosis; Membrane | 2011 |
Beta-ketothiolase deficiency brought with lethargy: case report.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA C-Acyltransferase; Amino Acid Metabolism, Inborn Errors; Carnitine | 2011 |
Serum antioxidant capacity of dairy cows with subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Case-Control Studies; Catalase; Cattle; Cattle Disease | 2011 |
Oxidant and antioxidant profile of hyperketonemic ewes affected by pregnancy toxemia.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Blood Glucose; Catalase; Female; Glutathione Peroxidas | 2011 |
Prevalence of subclinical ketosis in dairy cattle in the Southwestern Iran and detection of cutoff point for NEFA and glucose concentrations for diagnosis of subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; | 2011 |
Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Suckling; Anticonvulsants; Brain; Bumetanide; Convulsants; | 2011 |
Latent class evaluation of a milk test, a urine test, and the fat-to-protein percentage ratio in milk to diagnose ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Dietary Fats; Female; Ketosi | 2011 |
Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood-Brain Barrier; Brain; Cholesterol; Contrast Med | 2011 |
Renal function of dairy cows with subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Case | 2011 |
[Ethanol, sugar, acid and coma].
Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Acidosis; Alcohol-Related Disorders; Blood Glucose; Di | 2011 |
Concentrations of sodium, potassium, magnesium, and iron in the serum of dairy cows with subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Electrolytes; Fatty Acids, N | 2011 |
Evaluation of Precision Xceed® meter for on-site monitoring of blood β-hydroxybutyric acid and glucose concentrations in dairy sheep.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Female; Ketosis; Lactation; Pre-Eclampsia; Pregnancy; | 2012 |
Investigation of markers to indicate and distinguish death due to alcoholic ketoacidosis, diabetic ketoacidosis and hyperosmolar hyperglycemic state using post-mortem samples.
Topics: 3-Hydroxybutyric Acid; Acetone; Adult; Aged; Alcoholism; Biomarkers; Diabetic Ketoacidosis; Female; | 2012 |
Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartate Aminotransferases; Blood Glucose; Blood Proteins; Cattle; | 2011 |
Basal renal tubular epithelial cell vacuolization and alcoholic ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alcoholism; Case-Control Studies; Epithelial Cells; Female; Fore | 2012 |
Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Biomarkers; Case-Control Studies; Flame I | 2012 |
A woman with ketoacidosis but not diabetes.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Abdominal Pain; Acidosis; Adult; Alcoholism; Diabetic Ketoacidosi | 2012 |
Postmortem vitreous beta-hydroxybutyrate: interpretation in a forensic setting.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Central N | 2012 |
Alterations of fatty acid β-oxidation capability in the liver of ketotic cows.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenases; Animals; Blood Glucose; Carn | 2012 |
Evaluation of the use of nonesterified fatty acids and β-hydroxybutyrate concentrations in pooled serum samples for herd-based detection of subclinical ketosis in dairy cows during the first week after parturition.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Dairying; Fatty Ac | 2012 |
Routine detection of hyperketonemia in dairy cows using Fourier transform infrared spectroscopy analysis of β-hydroxybutyrate and acetone in milk in combination with test-day information.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Female; Humans; Ketosis; Milk; Par | 2012 |
Protein and fat mobilization and associations with serum β-hydroxybutyrate concentrations in dairy cows.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Cattle; Fatty Acids, Nonesterified; Female; Ketosis; | 2012 |
Epidemiology of subclinical ketosis in early lactation dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Lactation; Pregnancy | 2012 |
Genetic and nongenetic variation in plasma and milk β-hydroxybutyrate and milk acetone concentrations of early-lactation dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Cattle; Cattle Diseases; Female; Genetic Variation; Ketosis | 2012 |
Dry period and parturient predictors of early lactation hyperketonemia in dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Fatty Acids, Nonesterified; Female; Ketosis | 2013 |
Ketoacidosis and trace amounts of isopropanol in a chronic alcoholic patient.
Topics: 2-Propanol; 3-Hydroxybutyric Acid; Acetone; Adult; Alcoholism; Blood Glucose; Chronic Disease; Human | 2013 |
Hyperketonemia induces upregulation of LFA-1 in monocytes, which is mediated by ROS and P38 MAPK activation.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetylcysteine; Cardiovascular Diseases; Cell Adhesion Molecul | 2012 |
Inhibitory effect of β-hydroxybutyric acid on L-type Ca(2+) current under β-adrenergic stimulation in guinea pig cardiac ventricular myocytes.
Topics: 3-Hydroxybutyric Acid; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; GTP-Binding Prot | 2012 |
Effects of β-hydroxybutyrate and isoproterenol on lipolysis in isolated adipocytes from periparturient dairy cows and cows with clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Adipocytes; Animals; Cattle; Cattle Diseases; Dose-Response Relationship, Dru | 2013 |
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di | 2013 |
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di | 2013 |
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di | 2013 |
Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Brain; Caprylates; Carbon Isotopes; Diet, Ketogenic; Di | 2013 |
Short communication: the effect of temperature on performance of milk ketone test strips.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketone Bodies; Ketosis; Milk; Reage | 2013 |
Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Butyrates; Carnitine; Carnitine O-Palmitoyltransferas | 2003 |
Use of threshold serum and milk ketone concentrations to identify risk for ketosis and endometritis in high-yielding dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animal Feed; Animal Husbandry; Animals; Cattle; Dairying; Endometrio | 2003 |
Energy imbalance related predisposition to mastitis in group-fed high-producing postpartum dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Aspartate Aminotransferases; Blood Glucose; Cattle; C | 2003 |
An unusual cause for ketoacidosis.
Topics: 3-Hydroxybutyric Acid; Adult; Anxiety; Beverages; Diagnosis, Differential; Dietary Carbohydrates; Hu | 2004 |
A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Diet; Gene Expression Profiling; Gene Expression Regula | 2004 |
Evaluation and use of three cowside tests for detection of subclinical ketosis in early postpartum cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; False Negative Reactions; Fa | 2004 |
The antidepressant properties of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Depression; Di | 2004 |
Predicting risk of ketosis in dairy cows using in-line measurements of beta-hydroxybutyrate: a biological model.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Female; Ketosis; Milk; Models, Biological; | 2005 |
A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Blood Glucose; Body Weight; Dietary Fats; Disease Model | 2005 |
Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Cattle; C | 2005 |
Plasma vitamin C concentration is not related to the incidence of ketosis in dairy cows during the early lactation period.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Ascorbic Acid; Blood Glucose; Cattle; Cattle D | 2005 |
Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders.
Topics: 3-Hydroxybutyric Acid; Animals; Carnitine O-Palmitoyltransferase; Cattle; Cattle Diseases; Diet; Ene | 2005 |
Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Diet; Digestion; Endometriti | 2006 |
Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Diet; Energy Metabolism; Esc | 2006 |
A ketogenic diet and diallyl sulfide do not elevate afterdischarge thresholds in adult kindled rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Allyl Compounds; Analysis of Variance; Animals; Antic | 2006 |
Endocrine characteristics of late pregnant hyperketonaemic ewes and their reproductive performance following the induction of ovarian cyclicity out of the breeding season.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Fatty Acids, Nonesterified; Female; Gona | 2006 |
The serum glucose and beta-hydroxybutyrate levels in sheep with experimental Fasciola hepatica and Fasciola gigantica infection.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Fasciola; Fasciola hepatica; Fascioliasis; gamma-Glut | 2007 |
Effect of hemolysis on nonesterified fatty acid and beta-hydroxybutyrate concentrations in bovine blood.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Energy Metabolism; Fatty Acids, Nonesterified; Female; Hemol | 2006 |
Use of a modified Atkins diet in intractable childhood epilepsy.
Topics: 3-Hydroxybutyric Acid; Age Factors; Child; Cohort Studies; Diet, Carbohydrate-Restricted; Dietary Pr | 2007 |
Diet-induced ketosis increases capillary density without altered blood flow in rat brain.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Vessels; Blood-Brain Barrier; Brain; Capillaries; Cerebrovascu | 2007 |
Bovine subclinical ketosis in dairy herds in Iran.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Female; Incidence; Iran; Ket | 2007 |
Screening for subclinical ketosis in dairy cattle by Fourier transform infrared spectrometry.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Calibration; Cattle; Cattle Diseases; Dairyi | 2007 |
The effect of subclinical ketosis in early lactation on reproductive performance of postpartum dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cluster Analysis; Delayed-Action Preparatio | 2007 |
Effects of beta-hydroxybutyric acid on bovine milk leukocytes function in vitro.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Female; Hydrogen Peroxide; Ketone Bodies; Ketosis; Leukocyte | 2007 |
Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cerebral Cortex; Di | 2008 |
Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production.
Topics: 3-Hydroxybutyric Acid; Amino Acid Substitution; Animals; Blood Glucose; Carrier Proteins; Fasting; G | 2008 |
Efficacy of the ketogenic diet in the 6-Hz seizure test.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Confounding Factors, Epidemiologic; Diet | 2008 |
Comparative proteomic analysis of livers from ketotic cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Electrophoresis, Gel, Two-Di | 2008 |
Beta-hydroxybutyrate abrogates formation of bovine neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia coli.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Dairying; Escherichia coli; Escherichia coli Infections; Fem | 2008 |
Mechanism of training-induced attenuation of postexercise ketosis.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Carnitine; Cyclic AMP; Hydroxybutyrates; Ketosis; Liver; L | 1984 |
ALAT, AP, ASAT, GGT, OCT activities and urea and total bilirubin concentrations in plasma of normal and ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Alanine Transaminase; Alkaline Phosphatase; Animals; | 1984 |
Reduction in mitogenic response of bovine lymphocytes by ketone bodies.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Butyrates; Butyric Acid; Cattle; Cattle Diseases; Dairying | 1983 |
Ketosis in dairy cows caused by low levels of lincomycin in concentrate feed.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animal Feed; Animals; Cattle; Cattle Diseases; Disease Outbreaks; F | 1983 |
Fatty infiltration of liver in spontaneously ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Biopsy, Needle; Blood Glucose; Cattle; Catt | 1983 |
Effect of niacin supplementation on milk production and ketosis of dairy cattle.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Fatty Acids, Nones | 1983 |
Automated kinetic method for D-3-hydroxybutyrate in plasma or serum.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Autoanalysis; Cattle; Humans; Hydrogen-Ion Concentration; | 1984 |
Effect of propionic acid on ketogenesis in lactating sheep fed restricted rations or deprived of food.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Diet; Fatty Acids, Nonesteri | 1984 |
Colorimetric measurement of abnormal levels of 3-hydroxybutyrate in plasma.
Topics: 3-Hydroxybutyric Acid; Colorimetry; Formazans; Humans; Hydroxybutyrates; Ketosis; NAD | 1984 |
Fetal hepatic and neural substrate utilization as affected by induced nutritional ketosis in swine.
Topics: 3-Hydroxybutyric Acid; Acetates; Acidosis; Animal Feed; Animals; Brain; Butylene Glycols; Fatty Acid | 1984 |
Effect of ketogenic diets in gestation on some characteristics of carbohydrate metabolism in fetal pig brain and liver.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Body Composition; Brain; Butylene Glycols; Dietary Carbohy | 1981 |
[Ketogenesis and rumen function following intraruminal administration of saturated fatty acids (C8, C10, C12) in cattle].
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Fatty Acids; Female; Hydroxy | 1981 |
[The influence of the level of production on ketogenesis in milking cows and the effect of a niacin supplement (author's transl)].
Topics: 3-Hydroxybutyric Acid; Amino Acids; Animals; Cattle; Cattle Diseases; Female; Hydroxybutyrates; Keto | 1981 |
Modulation of leucine oxidation and turnover by graded amounts of carbohydrate intake in obese subjects.
Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Blood Glucose; Diet, Reducing; Dietary Carbohydrates; Fem | 1982 |
No effect of hyperketonemia on local cerebral glucose utilization in conscious rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Brain; Deoxy Sugars; Deoxyglucose; Glucose; | 1982 |
Blood concentrations of beta hydroxybutyrate in clinically normal Holstein-Friesian herds and in those with a high prevalence of clinical ketosis.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Female; Hydroxybut | 1981 |
Impaired ketogenesis in fructose-1,6-bisphosphatase deficiency: a pitfall in the investigation of hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Fatty Acids, Nonesterified; Female; Fructose-1,6-Diphosphatase Deficiency; Gl | 1995 |
Model of extreme hypoglycemia in dogs made ketotic with (R,S)-1,3-butanediol acetoacetate esters.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Butylene Glycols; Dichloroacetic Acid; | 1995 |
Suppression of mitogenic response of bovine peripheral blood lymphocytes by ketone bodies.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Female; Hydroxybutyrates; Ke | 1995 |
Alcoholic ketoacidosis: the late presentation of acidosis in an alcoholic.
Topics: 3-Hydroxybutyric Acid; Acidosis; Alcoholism; Analgesics; Antiemetics; Blood Chemical Analysis; Fluid | 1994 |
Evaluation of two cowside tests for the detection of subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Evaluation Studies as Topic; Female; Hydrox | 1994 |
[The effectiveness of intravenous administration of large quantities of glucose in the treatment of bovine ketosis].
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Dose-Response Relationship, | 1993 |
[Alcoholic ketoacidosis. Apropos of a case with coma].
Topics: 3-Hydroxybutyric Acid; Adult; Alcoholism; Diagnosis, Differential; Humans; Hydroxybutyrates; Ketosis | 1993 |
[Clinical study on intraoperative hyperketonemia in non-diabetic surgical patients under general anesthesia].
Topics: 3-Hydroxybutyric Acid; Adult; Anesthesia, General; Diabetes Mellitus; Female; Glucose Tolerance Test | 1993 |
Alcoholic ketoacidosis as a cause of death in forensic cases.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis | 1995 |
Ketosis is involved in the origin of prurigo pigmentosa.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; F | 1996 |
In vitro effect of ketones and hyperglycemia on feline hemoglobin oxidation and D- and L-lactate production.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Cat Diseases; Cats; Erythrocytes; Female; Gl | 1996 |
Detection of ketosis in dairy cows by analysis of exhaled breath.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Breath Tests; Cattle; Cattle Diseases; Chromatography, Gas; | 1996 |
Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum.
Topics: 3-Hydroxybutyric Acid; Abomasum; Animals; Apolipoprotein A-I; Apolipoprotein B-100; Apolipoproteins | 1997 |
Heart failure ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Heart Failure; Humans; Hydroxybutyrates; Ketone Bodies; Ketosi | 1997 |
Use of test day milk fat and milk protein to detect subclinical ketosis in dairy cattle in Ontario.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Cross-Sectional Studies; Dietary Fats; Fema | 1997 |
[Determination of beta-hydroxybutyrate in milk using test strips: a new aid for the diagnosis of subclinical and clinical ketosis in the cow].
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Energy Metabolism; Female; Hydroxybutyrates | 1998 |
Evaluation of five cowside tests for use with milk to detect subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; False Positive Reactions; Female; Hydroxybu | 1998 |
Effect of insulin on intramuscular 3-hydroxybutyrate levels in diabetic rats.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hydroxybutyrates; Hy | 1998 |
Ketogenic diet and the brain.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Brain Diseases; Dietary Carbohydrates; Dietary Fats; | 1997 |
Alcoholic ketoacidosis at autopsy.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Alcoholis | 1998 |
Spontaneous pregnancy toxaemia (ketosis) in sheep and the role of insulin.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Female; Hydroxybutyrates; Hypoglycemic Agents; Insuli | 1998 |
Ketosis resistance in the male offspring of protein-malnourished rat dams.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Cholesterol; Diet, Protein-Restricted; | 1998 |
Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Cell Division; Cells, Cultured; Cytochrome c Group; Diabetes M | 1998 |
A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Epileps | 1999 |
The impact of a monensin controlled-release capsule on subclinical ketosis in the transition dairy cow.
Topics: 3-Hydroxybutyric Acid; Ammonia; Animals; Blood Glucose; Body Composition; Body Weight; Cattle; Cattl | 1999 |
Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Behavior, Animal; Convulsants; Diet; Energy Intake; Growth; K | 1999 |
Attenuation of brain hyperbaric oxygen toxicity by fasting is not related to ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Butylene Glycols; Electroencephalography; | 1999 |
Prevalence of ketonemia and associations with herd size, lactation stage, parity, and postparturient diseases in Jordanian dairy cattle.
Topics: 3-Hydroxybutyric Acid; Animal Husbandry; Animals; Cattle; Cattle Diseases; Female; Jordan; Ketone Bo | 1999 |
Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Composition; Cattle; Cattle Diseases; Fatty Acid | 1999 |
Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Blotting, Northern; Cattle; Cattle Diseases; Fatty Ac | 1999 |
Beta-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes.
Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Cattle Diseases; Chemotaxis, Leukocyte; Culture Media; Femal | 1999 |
Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Body Weight; Convulsants; Diet; Differential Threshold; Disea | 1999 |
Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Convulsants; Flurothyl; Humans; Ketone Bodies; Ketosis; | 1999 |
Higher ketogenic diet ratios confer protection from seizures without neurotoxicity.
Topics: 3-Hydroxybutyric Acid; Animals; Basal Metabolism; Behavior, Animal; Convulsants; Diet; Dietary Fats; | 2000 |
A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion.
Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Convulsants; Diet, Reducing; Dietary Fats; Electroshock; | 2000 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Co | 2000 |
Evaluation of eight cow-side ketone tests in milk for detection of subclinical ketosis in dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cattle; Cattle Diseases; Cell Count; Female; Ketones; | 2000 |
The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Association Learning; Behavior, Animal; Blood Glucose; Dietary Carbo | 2000 |
Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis.
Topics: 3-Hydroxybutyric Acid; Adult; Brain; Fasting; Humans; Ketosis; Lactic Acid; Magnetic Resonance Spect | 2000 |
Induction of the apolipoprotein AI gene by fasting: a relationship with ketosis but not with ketone bodies.
Topics: 3-Hydroxybutyric Acid; Animals; Apolipoprotein A-I; Fasting; Gene Expression Regulation; Intestinal | 2000 |
Holocarboxylase synthetase deficiency: urinary metabolites masked by gross ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis, Lactic; Carbon-Nitrogen Ligases; Carboxy-Lyases; Chi | 2000 |
The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Child; Cost-Benefit Analysis; Dietary Fats; Dietary Proteins; Fas | 2000 |
The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Child; Cost-Benefit Analysis; Dietary Fats; Dietary Proteins; Fas | 2000 |
The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Child; Cost-Benefit Analysis; Dietary Fats; Dietary Proteins; Fas | 2000 |
The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones.
Topics: 3-Hydroxybutyric Acid; Biomarkers; Child; Cost-Benefit Analysis; Dietary Fats; Dietary Proteins; Fas | 2000 |
Ketone bodies in milk and blood of dairy cows: relationship between concentrations and utilization for detection of subclinical ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Animals; Cattle; Cattle Diseases; Female; Ketone Bodi | 2001 |
Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Cell Line, Transformed; Codon, Nonsense; Diabetic Ketoacidosi | 2001 |
Concentrations of ketones in milk in early lactation, and reproductive performance of dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Case-Control Studies; Cattle; Cattle Diseases; Dairying; Fe | 2001 |
Stability of ketone bodies in serum in dependence on storage time and storage temperature.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Blood Preservation; Child; Cryopreservation; Female; Humans; K | 2001 |
Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Adult; Biological Transport; Brain Chemistry; Fasting; Humans; | 2001 |
Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Acetone; Animals; Breath Tests; Chromatography, Gas; Dietary Carbohydrates; D | 2002 |
Dietary L-carnitine supplementation in obese cats alters carnitine metabolism and decreases ketosis during fasting and induced hepatic lipidosis.
Topics: 3-Hydroxybutyric Acid; Animals; Carnitine; Cat Diseases; Cats; Dietary Supplements; Fasting; Fatty A | 2002 |
Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose.
Topics: 3-Hydroxybutyric Acid; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Body Weig | 2001 |
Effects of acute inhibition of fatty acid oxidation on latency to seizure and concentrations of beta hydroxybutyrate in plasma of rats maintained on calorie restriction and/or the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Caloric Restriction; Diet; Dietary Fats; Fatty Acids; Ketosis; Male; | 2002 |
Developmental changes in ketogenic enzyme gene expression during sheep rumen development.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA C-Acetyltransferase; Animals; Coenzyme A Ligases; Epithelium; Fatt | 2002 |
Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Adult; Breath Tests; Diet; Dietary Fats; Epilepsy; Fa | 2002 |
Resistance to ketosis in moderately obese patients: influence of fatty liver.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Fatty Liver; F | 1992 |
Metabolic changes in dairy cows with ketonemia in response to feed restriction and dietary 1,3-butanediol.
Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Butylene Glycols; Cattle; Cattle Diseases; Eating; Ener | 1992 |
Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cattle Diseases; Eating; Fatty Acids, Noneste | 1992 |
Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows.
Topics: 3-Hydroxybutyric Acid; Acetates; Animals; Blood Glucose; Body Weight; Cattle; Cattle Diseases; Eatin | 1991 |
Recovery by mouse embryos following teratogenic exposure to ketosis.
Topics: 3-Hydroxybutyric Acid; Animals; Brain; Ectoderm; Embryo, Mammalian; Female; Hydroxybutyrates; Ketosi | 1991 |
Post-exercise ketosis and the glycogen content of liver and muscle in rats on a high carbohydrate diet.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Body Weight; Dietary Carbohydrates; Glycogen; Hydroxybutyr | 1989 |
Metabolic responses of lactating goats to feed restriction and dietary 1,3-butanediol.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Butylene Glycols; Cattle; Cattle Disease | 1989 |
Metabolic effects of intraruminal administration of 1,3-butanediol or tributyrin in lactating goats.
Topics: 3-Hydroxybutyric Acid; Acidosis; Analysis of Variance; Animals; Blood Glucose; Butylene Glycols; Fem | 1989 |
Effects of 3-hydroxybutyrate and hyperosmolarity on glucagon release from isolated perfused canine pancreas.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Arginine; Dogs; Glucagon; Glucose; Hydroxybutyrates; In Vi | 1989 |
D2-dopaminergic blockade does not influence post-exercise ketosis in non-athletes.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adolescent; Adult; Blood Glucose; Dietary Carbohydrates; Fatty Acid | 1989 |
Placental transfer and fetal effects of maternal sodium beta-hydroxybutyrate infusion in the baboon.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animals; Energy Metabolism; Female; Fetus; Hydroxybutyrates; Ketone | 1989 |
Glycogen metabolism and post-exercise ketosis in carbohydrate-restricted trained and untrained rats.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Glycogen; Hydroxybutyrates; Ketosis; Liver Gl | 1989 |
beta-Adrenergic blockade counteracts starvational ketosis, but aggravates post-exercise ketosis in non-athletes.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adolescent; Adrenergic beta-Antagonists; Adult; Blood Glucose; Fema | 1988 |
Attenuation of postexercise ketosis in fasted endurance-trained rats.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adaptation, Physiological; Animals; Carnitine; Cyclic AMP; Fasting; | 1985 |
Ethanol ingestion and the development of post-exercise ketosis in non-alcoholic human subjects.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; Alcohol Drinking; Blood Glucose; Ethanol; Fatty Acids, Nones | 1988 |
Intraoperative ketoacidosis and malnutrition.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Acute Disease; Drug Therapy, Combination; Female; Gl | 1988 |
Measurement of urinary lactic, 3-hydroxybutyric, pyruvic and acetoacetic acids in a single analysis using selected ion monitoring and stable isotope labelling techniques.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adult; Deuterium; Gas Chromatography-Mass Spectrometry; Humans | 1988 |
The effects of post-exercise glucose and alanine ingestion on plasma carnitine and ketosis in humans.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; Alanine; Carnitine; Fasting; Fatty Acids, Nonesterified; Glu | 1987 |
Effects of hyperglycemia and ketone bodies on the in vitro development of early somite rate embryos.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Congenital Abnormalities; Cu | 1987 |
Clinical and laboratory observations in a child with hepatic phosphorylase kinase deficiency.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Child, Preschool; Glycogen Storage Disease; Histocyto | 1986 |
Effect of 3-hydroxybutyrate infusion on urinary protein excretion in healthy man.
Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Acidosis; Adult; Albuminuria; beta 2-Microglobulin; He | 1986 |
Medium-chain triglycerides in infant formulas and their relation to plasma ketone body concentrations.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Dietary Fats; Fetal Blood; Humans; Hydroxybutyrates; Infant Fo | 1986 |
3-Ketothiolase deficiency.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Acetyl-CoA C-Acyltransferase; Acyl Coenzyme A; Acyltransfe | 1986 |
Post-exercise ketosis in post-prandial exercise: effect of glucose and alanine ingestion in humans.
Topics: 3-Hydroxybutyric Acid; Acidosis; Alanine; Blood Glucose; Fatty Acids, Nonesterified; Glucagon; Gluco | 1985 |
Inhibitory effects of the D(-)isomer of 3-hydroxybutyrate on cardiac non-esterified fatty acid uptake and oxygen demand induced by norepinephrine in the intact dog.
Topics: 3-Hydroxybutyric Acid; Animals; Coronary Circulation; Dogs; Fatty Acids, Nonesterified; Female; Hear | 1985 |
Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabet | 1985 |
Renal hydroxybutyrate and acetoacetate reabsorption and utilization in the rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biological Transport; Carbon Radioisotopes; Glomerula | 1985 |
Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves.
Topics: 3-Hydroxybutyric Acid; Acidosis; Animal Feed; Animals; Butylene Glycols; Cattle; Cattle Diseases; Di | 1985 |
Propionate loading test for liver function in spontaneously ketotic dairy cows.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Fem | 1985 |