thiamine and Acetonemia studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Research Excerpts

Excerpt	Relevance	Reference
"If alcoholic ketoacidosis is suspected, dextrose-containing fluids are recommended over normal saline."	2.53	Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. ( Adkins, DA; Cook, AM; Flannery, AH, 2016)
"Alcoholic ketoacidosis (AKA) is a common reason for investigation and admission of alcohol dependent patients in UK emergency departments."	2.43	Alcoholic ketoacidosis. ( Cruickshank, AM; McGuire, LC; Munro, PT, 2006)
"The metabolic effects of chronic alcohol abuse can induce a broad spectrum of disorders."	1.32	Ketosis and cardiac failure: common signs of a single condition. ( De Wijngaard, S; Diltoer, MW; Hubloue, I; Huyghens, LP; Lauwers, R; Troubleyn, J; Vercammen, MJ, 2004)
"We report 3 patients with alcoholic ketoacidosis (AKA)."	1.32	Alcoholic ketoacidosis associated with multiple complications: report of 3 cases. ( Ishikawa, S; Matsuyama, K; Miyazaki, Y; Tanaka, M, 2004)

Research

Studies (9)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Sequential Organ Failure Assessment (SOFA) Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (44.44)	18.7374
1990's	1 (11.11)	18.2507
2000's	3 (33.33)	29.6817
2010's	1 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Flannery, AH	1
Adkins, DA	1
Cook, AM	1
SULIMOVSKAYA, NA	1
Diltoer, MW	1
Troubleyn, J	1
Lauwers, R	1
De Wijngaard, S	1
Vercammen, MJ	1
Hubloue, I	1
Huyghens, LP	1
Tanaka, M	1
Miyazaki, Y	1
Ishikawa, S	1
Matsuyama, K	1
McGuire, LC	1
Cruickshank, AM	1
Munro, PT	1
Brent, BE	1
Bartley, EE	1
Elpeleg, ON	1
Ruitenbeek, W	1
Jakobs, C	1
Barash, V	1
De Vivo, DC	1
Amir, N	1
Schreier, K	1
Porath, U	1
Barzani, G	1
Liotta, M	1
Olivieri, M	1
Tamburini, G	1
Merli, B	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Thiamine Administration After Cardiac Surgery Trial[NCT04641104]	Phase 4	200 participants (Actual)	Interventional	2020-11-20	Completed
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]	Phase 2	140 participants (Actual)	Interventional	2018-02-05	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization

Hospital Length of Stay

Intervention	score on a scale (Mean)
Treatment Arm	2.9
Placebo Arm	1.93

Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.

Hospital Mortality

Intervention	Days (Mean)
Treatment Arm	11.5
Placebo Arm	11

In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.

ICU Length of Stay

Intervention	Participants (Count of Participants)
Treatment Arm	11
Placebo Arm	13

Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.

ICU Mortality

Intervention	days (Mean)
Treatment Arm	4.76
Placebo Arm	4.66

ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.

Procalcitonin (PCT) Clearance

Intervention	Participants (Count of Participants)
Treatment Arm	6
Placebo Arm	10

PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization

Time to Vasopressor Independence (Hours)

Intervention	Percent (Mean)
Treatment Arm	63
Placebo Arm	58

Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.

Ventilator Free Days

Intervention	hours (Mean)
HAT Treatment	27
Comparator	53

Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization

Article	Year
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Critical care medicine, 2016, Volume: 44, Issue:8 Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni	2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Critical care medicine, 2016, Volume: 44, Issue:8 Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni	2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Critical care medicine, 2016, Volume: 44, Issue:8 Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni	2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Critical care medicine, 2016, Volume: 44, Issue:8 Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni	2016
Alcoholic ketoacidosis. Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:6 Topics: Acidosis; Acute Disease; Alcoholism; Emergency Service, Hospital; Fluid Therapy; Humans; Ketosis; NA	2006
Thiamin and niacin in the rumen. Journal of animal science, 1984, Volume: 59, Issue:3 Topics: Alkyl and Aryl Transferases; Animals; Cattle; Cattle Diseases; Encephalomalacia; Female; Food, Forti	1984
[Congenital metabolic acidosis in the postnatal period]. Deutsche medizinische Wochenschrift (1946), 1978, Jun-02, Volume: 103, Issue:22 Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Fructose-1,6-Diphosphatase Deficiency; Glutarates; G	1978

Article	Year
[The changes of ketonemia in pains and after injection of vitamin B1]. Klinicheskaia meditsina, 1945, Volume: 23, Issue:4 Topics: Blood; Humans; Injections; Ketone Bodies; Ketosis; Pain; Thiamine	1945
Ketosis and cardiac failure: common signs of a single condition. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2004, Volume: 11, Issue:3 Topics: Alcoholism; Beriberi; Cachexia; Diagnosis, Differential; Emergency Medical Services; Female; Heart F	2004
Alcoholic ketoacidosis associated with multiple complications: report of 3 cases. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:10 Topics: Acidosis; Alcoholism; Dehydration; Diabetic Ketoacidosis; Female; Glucose; Humans; Insulin; Ketone B	2004
Congenital lacticacidemia caused by lipoamide dehydrogenase deficiency with favorable outcome. The Journal of pediatrics, 1995, Volume: 126, Issue:1 Topics: Acidosis, Lactic; Carnitine; Dichloroacetic Acid; Dihydrolipoamide Dehydrogenase; Fibroblasts; Human	1995
[Treatment of acetonemic syndromes in children]. La Clinica terapeutica, 1976, Mar-15, Volume: 76, Issue:5 Topics: Acidosis; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Female; Humans; Infant; Ketos	1976

thiamine and Acetonemia