verapamil has been researched along with Atypical Cluster Headache in 86 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In, 508 cluster headache patients diagnosed according to the International Classification of Headache Disorders were genotyped and participated in a semi-structured interview to evaluate treatment response." | 3.01 | Cluster headache polygenetic risk and known functional variants of CYP3A4 are not associated with treatment response. ( Barloese, M; Callesen, I; Chalmer, MA; Hansen, MB; Hansen, TF; Jensen, RH; Lund, N; Ostrowski, SR; Pedersen, AF; Pedersen, OB; Petersen, AS; Sellebjerg, F; Søborg, MK; Søndergaard, HB; Winsvold, BS; Zwart, JA, 2023) |
| "Treatment for cluster headache is currently based on a trial-and-error approach." | 3.01 | Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments-a consensus article. ( Belin, AC; Fronczek, R; Gaul, C; Jensen, RH; Lund, NLT; Meisingset, T; Petersen, AS; Steinberg, A; Tfelt-Hansen, J; Tronvik, E, 2023) |
| "Patients with episodic cluster headaches who were aged between 18 and 65 years and within a current pain episode for not more than 30 days, received 100 mg oral prednisone for 5 days followed by tapering of 20 mg every 3 days, or matching placebo (17 days total exposure)." | 3.01 | Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial. ( Böger, A; Diener, HC; Freilinger, T; Gaul, C; Holle, D; Jansen, JP; Jürgens, TP; Katsarava, Z; Kaube, H; Kleinschnitz, C; Kraya, T; Nägel, S; Obermann, M; Ose, C; Scherag, A; Sonuc, N; Storch, P; Straube, A, 2021) |
| "What this paper adds Cluster headache in children and adolescents is poorly studied." | 2.72 | Cluster headache in children and adolescents: a systematic review of case reports. ( Barbosa, BLF; Bastos, SNMAN; Jevoux, C; Krymchantowski, A; Krymchantowski, AG; Silva, SF; Silva-Néto, RP, 2021) |
| "Cluster headache is a rare, clinically well-characterized disabling disorder that occurs in both episodic and chronic forms." | 2.70 | The use of baclofen in cluster headache. ( Gadoth, N; Hering-Hanit, R, 2001) |
| " The most effective CCH prophylactic drug today is lithium carbonate but long-term use of this drug is limited by the possibility of side effects." | 2.67 | Double blind comparison of lithium and verapamil in cluster headache prophylaxis. ( Bussone, G; Granella, F; Leone, M; Magri, M; Manzoni, GC; Micieli, G; Nappi, G; Peccarisi, C, 1990) |
| "Verapamil has been used in the prevention of CH for almost 3 decades, however, the mode of action and therapeutic target is still unknown." | 2.61 | Verapamil and Cluster Headache: Still a Mystery. A Narrative Review of Efficacy, Mechanisms and Perspectives. ( Barloese, MCJ; Jensen, RH; Petersen, AS; Snoer, A; Soerensen, AMS, 2019) |
| "Cluster headache is characterized by severe, unilateral headache attacks of orbital, supraorbital or temporal pain lasting 15-180 min accompanied by ipsilateral lacrimation, rhinorrhea and other cranial autonomic manifestations." | 2.55 | Cluster headache: present and future therapy. ( Cecchini, AP; Giustiniani, A; Leone, M, 2017) |
| "Cluster headache is a primary headache disorder that can occur in children and adolescents, and is a member of the broader diagnostic group of trigeminal autonomic cephalalgias." | 2.53 | Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions. ( Goadsby, P; Mack, KJ, 2016) |
| "Cluster headache is a rare cause of primary headache in children." | 2.53 | [Cluster headache in pediatric population: four case reports and review of the literature]. ( Alfaro-Iznaola, C; Ballesteros-Garcia, MM; Cuadrado-Martin, M; Natera-de Benito, D; Rodriguez-Diaz, R; Taboas-Pereira, MA, 2016) |
| "Although cluster headache (CH) is the most disabling form of primary headache, little evidences regarding alternative and complementary therapies are available." | 2.50 | Acupuncture in cluster headache: four cases and review of the literature. ( Allais, G; Barbanti, P; Benedetto, C; Borgogno, P; Fofi, L; Quirico, PE; Rolando, S, 2014) |
| "For preventive treatment of cluster headache, calcium channel blocker (verapamil) and steroids are recommended." | 2.49 | [New treatments for cluster headache]. ( Shimizu, T, 2013) |
| "The dose of verapamil used for cluster headache is approximately double the dose used in cardiovascular disease, most likely because verapamil is a substrate for the efflux transporter P-glycoprotein in the blood-brain barrier." | 2.45 | Verapamil for cluster headache. Clinical pharmacology and possible mode of action. ( Tfelt-Hansen, J; Tfelt-Hansen, P, 2009) |
| "The group includes cluster headache (CH), paroxysmal hemicrania (PH), and short-lasting neuralgiform headache with conjunctival injection and tearing (SUNCT)." | 2.44 | [Trigeminal autonomic cephalgias: diagnostic and therapeutic implications]. ( Rosenberg-Nordmann, M; Sprenger, T; Tölle, TR, 2007) |
| "TACs include cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT syndrome)." | 2.44 | [Pathophysiology and treatment of trigeminal autonomic cephalalgias]. ( Cohen, AS; Goadsby, PJ, 2008) |
| "Trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by two main clinical characteristics: pain and oculofacial autonomic phenomena." | 2.42 | Strategies for the treatment of autonomic trigeminal cephalalgias. ( Broggi, G; Bussone, G; Curone, M; D'Amico, D; D'Andrea, G; Franzini, A; Grazzi, L; Leone, M; Mea, E; Tullo, V, 2004) |
| "Management of cluster headache has greatly changed in recent years although most of the drugs used have not received approval for this indications." | 2.41 | [Treatment of cluster headache]. ( Fabre, N, 2000) |
| "Headaches are a common entity in the ambulatory population." | 2.40 | Diagnosis, prophylaxis, and treatment of headaches in the athlete. ( Kaplan, B; Swain, RA, 1997) |
| "Cluster headaches are vascular headaches that predominantly affect males and occur frequently, with cyclic regularity." | 2.38 | Diagnosis and management of cluster headaches. ( Gabai, IJ; Spierings, EL, 1990) |
| "Patients with cluster headache were recruited between September 2016 and January 2019 from 16 hospitals in Korea." | 1.91 | Treatment pattern and response for cluster headache in Korea: A prospective multicenter observation study. ( Ahn, JY; Bae, DW; Cho, SJ; Choi, YJ; Chu, MK; Chung, JM; Chung, PW; Kim, BK; Kim, BS; Kim, SK; Lee, KS; Lee, MJ; Moon, HS; Oh, K; Park, JW; Park, KY; Sohn, JH; Song, TJ, 2023) |
| "Data suggest that cluster headache preventatives act upstream or downstream from the hypothalamus." | 1.72 | Effects of cluster headache preventatives on mouse hypothalamic transcriptional homeostasis. ( Buonvicino, D; Chiarugi, A; Muzzi, M; Pistolesi, A; Urru, M, 2022) |
| "Cluster headache is characterized by recurrent, unilateral attacks of excruciating pain associated with ipsilateral cranial autonomic symptoms." | 1.62 | Machine phenotyping of cluster headache and its response to verapamil. ( Brudfors, M; Cheema, S; Danno, D; Grangeon, L; Matharu, M; Nachev, P; Tso, AR, 2021) |
| "Episodic cluster headache is more responsive to acute therapy than chronic." | 1.62 | Real-life treatment of cluster headache in a tertiary headache center - results from the Danish Cluster Headache Survey. ( Barloese, M; Jensen, RH; Lund, N; Petersen, AS, 2021) |
| "The patient was diagnosed with chronic cluster headache (CCH) according to the third edition of the International Classification of Headache Disorders." | 1.56 | Chronic Cluster Headache with a Pediatric Onset: The First Japanese Case Report. ( Danno, D; Kashiwaya, Y; Kikui, S; Sugiyama, H; Takeshima, T, 2020) |
| "Cluster headache is classified as a primary headache by definition not caused by an underlying pathology." | 1.43 | Chronic cluster headache and the pituitary gland. ( De Pue, A; Lutin, B; Paemeleire, K, 2016) |
| "The prevalence of cluster headache is 0." | 1.38 | Management of cluster headache. ( Jensen, RH; Tfelt-Hansen, PC, 2012) |
| "Cluster headache is a rare primary headache disorder characterized by recurrent, stereotyped short-lasting attacks of severe, unilateral head pain accompanied by autonomic symptoms." | 1.37 | Cluster headache associated with a sixth nerve palsy: a case report. ( Grosberg, BM; Lipton, RB; Robbins, MS; Vollbracht, S, 2011) |
| " Seven (24%) patients presented bradycardia considered as nonserious adverse event (NSAE) and four (14%) patients presented arrhythmia (heart block) considered as serious adverse event (SAE)." | 1.37 | Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day). ( Donnet, A; Lanteri-Minet, M; Piano, V; Silhol, F, 2011) |
| "We report a patient with a history of migraine without aura who developed cluster headache and HC simultaneously." | 1.36 | Coexisting trigeminal autonomic cephalalgias and hemicrania continua. ( Grosberg, BM; Lipton, RB; Robbins, MS, 2010) |
| "Cluster headache is a condition of extremely intense unilateral pain in the ocular or temporal region." | 1.35 | [Cluster headache]. ( Nissilä, M, 2009) |
| "A young woman had typical cluster headache attacks and a pituitary mass lesion." | 1.34 | Typical cluster headache caused by granulomatous pituitary involvement. ( Favier, I; Ferrari, MD; Haan, J; van Duinen, SG, 2007) |
| "Patients with chronic cluster headache have unremitting illness that necessitates daily preventive medical treatment for years." | 1.34 | Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients. ( Burns, B; Goadsby, PJ; Watkins, L, 2007) |
| "Verapamil is an effective prophylactic treatment for cluster headaches and, therefore, is widely used." | 1.33 | Verapamil induced gingival enlargement in cluster headache. ( Ferrari, MD; Goadsby, PJ; Matharu, MS; van Vliet, JA, 2005) |
| "Two cases of cluster headaches triggered by sildenafil are described." | 1.33 | Sildenafil can trigger cluster headaches. ( Evans, RW, 2006) |
| "A case valsalva-induced cluster headache is presented." | 1.33 | Valsalva-induced cluster headache. ( McGeeney, BE, 2006) |
| "Magnetic resonance imaging showed a pituitary adenoma which invaded into right cavernous sinus." | 1.33 | [Cluster like headache in a patient with the Maffucci's syndrome]. ( Imai, N; Kitamura, E; Konisi, T; Okabe, T; Serizawa, M; Suzuki, Y, 2006) |
| "It is useful for refractory cluster headache, is more effective for the episodic form than the chronic form, and has a rapid onset of action." | 1.32 | Outpatient intravenous dihydroergotamine for refractory cluster headache. ( Magnoux, E; Zlotnik, G, 2004) |
| "In episodic cluster headache early treatment onset stopped attacks within 20 days in 80%, late treatment onset was successful within ten days in 67%." | 1.32 | [Prophylactic treatment of cluster headache with verapamil]. ( Stallmach, M, 2003) |
| "A 60-year-old woman with secondary chronic cluster headache had increased serum ferritin and serum transferrin saturation and was homozygous for the C282Y mutation in the HFE gene, which is indicative of hereditary haemochromatosis." | 1.31 | Hereditary haemochromatosis in two cousins with cluster headache. ( Bjerve, KS; Hagen, K; Stovner, LJ; Waage, A, 2002) |
| "In May 1997, a recurrence of the attacks required the readministration of verapamil, 360 mg per day." | 1.31 | Simultaneous occurrence of ipsilateral cluster headache and chronic paroxysmal hemicrania: a case report. ( Albano, O; Bassi, A; Causarano, V; Centonze, A; Centonze, V; Dalfino, L, 2000) |
| "Cluster headache is a rare but very typical disease." | 1.30 | [Cluster headache: misjudged because unknown]. ( Koudstaal, PJ; Ridderikhoff, J, 1997) |
| "After two days of complete remission, cluster headache attacks reappeared and persisted until verapamil, 360 mg a day, was added to indomethacin." | 1.28 | Ipsilateral cluster headache and chronic paroxysmal hemicrania: two case reports. ( Bousser, MG; Tehindrazanarivelo, AD; Visy, JM, 1992) |
| "An open study of verapamil in cluster headache is reported." | 1.28 | Prophylactic treatment of cluster headache with verapamil. ( Gabai, IJ; Spierings, EL, 1989) |
| "15 chronic cluster headache patients in whom pain was induced by nitroglycerin received acute intravenous treatment with a calcium entry blocker." | 1.27 | Calcium entry blocker: treatment in acute pain in cluster headache patients. ( Boiardi, A; Bussone, G; Gemma, M; Peccarisi, C; Porta, E, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.65) | 18.7374 |
| 1990's | 13 (15.12) | 18.2507 |
| 2000's | 41 (47.67) | 29.6817 |
| 2010's | 18 (20.93) | 24.3611 |
| 2020's | 10 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Diener, HC | 2 |
| May, A | 1 |
| Pistolesi, A | 1 |
| Buonvicino, D | 1 |
| Muzzi, M | 1 |
| Urru, M | 1 |
| Chiarugi, A | 1 |
| Petersen, AS | 4 |
| Barloese, M | 2 |
| Lund, N | 2 |
| Pedersen, AF | 1 |
| Søborg, MK | 1 |
| Chalmer, MA | 1 |
| Callesen, I | 1 |
| Winsvold, BS | 1 |
| Zwart, JA | 1 |
| Ostrowski, SR | 1 |
| Pedersen, OB | 1 |
| Sellebjerg, F | 1 |
| Søndergaard, HB | 1 |
| Hansen, MB | 1 |
| Jensen, RH | 5 |
| Hansen, TF | 1 |
| Lee, MJ | 1 |
| Park, JW | 1 |
| Chu, MK | 1 |
| Moon, HS | 1 |
| Chung, PW | 1 |
| Chung, JM | 1 |
| Sohn, JH | 1 |
| Kim, BK | 1 |
| Kim, BS | 1 |
| Kim, SK | 1 |
| Song, TJ | 1 |
| Choi, YJ | 1 |
| Park, KY | 1 |
| Oh, K | 1 |
| Ahn, JY | 1 |
| Lee, KS | 1 |
| Bae, DW | 1 |
| Cho, SJ | 1 |
| Lund, NLT | 1 |
| Fronczek, R | 1 |
| Tfelt-Hansen, J | 2 |
| Belin, AC | 1 |
| Meisingset, T | 1 |
| Tronvik, E | 1 |
| Steinberg, A | 1 |
| Gaul, C | 2 |
| Kikui, S | 1 |
| Sugiyama, H | 1 |
| Danno, D | 2 |
| Kashiwaya, Y | 1 |
| Takeshima, T | 1 |
| Tso, AR | 1 |
| Brudfors, M | 1 |
| Grangeon, L | 1 |
| Cheema, S | 1 |
| Matharu, M | 1 |
| Nachev, P | 1 |
| Obermann, M | 1 |
| Nägel, S | 1 |
| Ose, C | 1 |
| Sonuc, N | 1 |
| Scherag, A | 1 |
| Storch, P | 1 |
| Böger, A | 1 |
| Kraya, T | 1 |
| Jansen, JP | 1 |
| Straube, A | 1 |
| Freilinger, T | 1 |
| Kaube, H | 1 |
| Jürgens, TP | 1 |
| Katsarava, Z | 1 |
| Kleinschnitz, C | 1 |
| Holle, D | 1 |
| Bastos, SNMAN | 1 |
| Barbosa, BLF | 1 |
| Silva, SF | 1 |
| Krymchantowski, AG | 1 |
| Jevoux, C | 1 |
| Krymchantowski, A | 1 |
| Silva-Néto, RP | 1 |
| Leone, M | 4 |
| Giustiniani, A | 1 |
| Cecchini, AP | 1 |
| Barloese, MCJ | 1 |
| Snoer, A | 1 |
| Soerensen, AMS | 1 |
| Shimizu, T | 1 |
| Fofi, L | 1 |
| Allais, G | 1 |
| Quirico, PE | 1 |
| Rolando, S | 1 |
| Borgogno, P | 1 |
| Barbanti, P | 1 |
| Benedetto, C | 1 |
| Donnet, A | 2 |
| Valade, D | 2 |
| Fontaine, D | 1 |
| Koppen, H | 1 |
| Stolwijk, J | 1 |
| Wilms, EB | 1 |
| van Driel, V | 1 |
| Ferrari, MD | 3 |
| Haan, J | 2 |
| De Pue, A | 1 |
| Lutin, B | 1 |
| Paemeleire, K | 1 |
| Mack, KJ | 1 |
| Goadsby, P | 1 |
| Alfaro-Iznaola, C | 1 |
| Natera-de Benito, D | 1 |
| Rodriguez-Diaz, R | 1 |
| Taboas-Pereira, MA | 1 |
| Cuadrado-Martin, M | 1 |
| Ballesteros-Garcia, MM | 1 |
| Özbenli, T | 1 |
| Akpınar, ÇK | 1 |
| Tfelt-Hansen, P | 1 |
| Riederer, F | 1 |
| Selekler, HM | 1 |
| Sándor, PS | 1 |
| Wöber, C | 1 |
| Nissilä, M | 1 |
| Mampreso, E | 1 |
| Maggioni, F | 2 |
| Viaro, F | 1 |
| Disco, C | 1 |
| Zanchin, G | 2 |
| Spierings, EL | 3 |
| Robbins, MS | 2 |
| Grosberg, BM | 2 |
| Lipton, RB | 3 |
| Vollbracht, S | 1 |
| Lanteri-Minet, M | 1 |
| Silhol, F | 1 |
| Piano, V | 1 |
| Ashkenazi, A | 1 |
| Schwedt, T | 1 |
| Leroux, E | 1 |
| Taifas, I | 1 |
| Vicaut, E | 1 |
| Chagnon, M | 1 |
| Roos, C | 1 |
| Ducros, A | 1 |
| Nesbitt, AD | 1 |
| Goadsby, PJ | 6 |
| Tfelt-Hansen, PC | 1 |
| Lohi, J | 1 |
| Dora, B | 1 |
| Lisotto, C | 1 |
| Mainardi, F | 1 |
| Stallmach, M | 1 |
| Mir, P | 1 |
| Alberca, R | 1 |
| Navarro, A | 1 |
| Montes, E | 1 |
| Martínez, E | 1 |
| Franco, E | 1 |
| Cayuela, A | 1 |
| Lozano, P | 1 |
| Magnoux, E | 1 |
| Zlotnik, G | 1 |
| Afridi, S | 1 |
| Bacon, CM | 1 |
| Bowling, J | 1 |
| D'Andrea, G | 2 |
| Terrazzino, S | 1 |
| Leon, A | 1 |
| Fortin, D | 1 |
| Perini, F | 1 |
| Granella, F | 2 |
| Bussone, G | 6 |
| Franzini, A | 1 |
| D'Amico, D | 2 |
| Grazzi, L | 2 |
| Mea, E | 1 |
| Curone, M | 1 |
| Tullo, V | 1 |
| Broggi, G | 1 |
| Matharu, MS | 2 |
| van Vliet, JA | 1 |
| Adams, SM | 1 |
| Standridge, JB | 1 |
| Evans, RW | 2 |
| Rozen, TD | 1 |
| Fattah, QA | 1 |
| Cutrer, FM | 1 |
| Verslegers, WR | 1 |
| Pickut, BA | 1 |
| De Deyn, PP | 1 |
| Kitamura, E | 1 |
| Imai, N | 1 |
| Konisi, T | 1 |
| Suzuki, Y | 1 |
| Serizawa, M | 1 |
| Okabe, T | 1 |
| Gotkine, M | 1 |
| Steiner, I | 1 |
| Biran, I | 1 |
| McGeeney, BE | 1 |
| Favier, I | 1 |
| van Duinen, SG | 1 |
| Perciaccante, A | 1 |
| Fiorentini, A | 1 |
| Mitrevski, M | 1 |
| Tubani, L | 1 |
| Granata, M | 1 |
| Burns, B | 1 |
| Watkins, L | 1 |
| Cohen, AS | 2 |
| Rosenberg-Nordmann, M | 1 |
| Tölle, TR | 1 |
| Sprenger, T | 1 |
| Valença, MM | 1 |
| Andrade-Valença, LP | 1 |
| Martins, C | 1 |
| de Fátima Vasco Aragão, M | 1 |
| Batista, LL | 1 |
| Peres, MF | 2 |
| da Silva, WF | 1 |
| Tobin, J | 1 |
| Flitman, S | 1 |
| Dilli, E | 1 |
| Dodick, DW | 1 |
| Meyer, JS | 1 |
| Hardenberg, J | 1 |
| Catarci, T | 1 |
| Steiner, TS | 1 |
| Shabbir, N | 1 |
| McAbee, G | 1 |
| Figuerola, ML | 1 |
| Levin, G | 1 |
| Leston, J | 1 |
| Barontini, M | 1 |
| Kumar, KL | 1 |
| Colley, CA | 1 |
| Monzillo, PH | 1 |
| Sanvito, WL | 1 |
| Ridderikhoff, J | 1 |
| Koudstaal, PJ | 1 |
| Swain, RA | 1 |
| Kaplan, B | 1 |
| Frediani, F | 1 |
| Moschiano, F | 1 |
| Attanasio, A | 1 |
| Centonze, V | 1 |
| Bassi, A | 1 |
| Causarano, V | 1 |
| Dalfino, L | 1 |
| Centonze, A | 1 |
| Albano, O | 1 |
| Solomon, S | 1 |
| Fabre, N | 1 |
| Pradalier, A | 1 |
| Baudesson, G | 1 |
| Vincent, D | 1 |
| Imberty-Campinos, C | 1 |
| Hering-Hanit, R | 1 |
| Gadoth, N | 1 |
| Sörös, P | 1 |
| Frese, A | 2 |
| Husstedt, IW | 2 |
| Evers, S | 2 |
| Lüttmann, RJ | 1 |
| Erfurth, A | 1 |
| Stovner, LJ | 1 |
| Hagen, K | 1 |
| Waage, A | 1 |
| Bjerve, KS | 1 |
| Tehindrazanarivelo, AD | 1 |
| Visy, JM | 1 |
| Bousser, MG | 1 |
| Solomon, SS | 1 |
| Newman, LC | 1 |
| Markley, HG | 1 |
| Peccarisi, C | 2 |
| Micieli, G | 1 |
| Magri, M | 1 |
| Manzoni, GC | 1 |
| Nappi, G | 1 |
| Gabai, IJ | 2 |
| Diamond, S | 1 |
| Freitag, FG | 1 |
| Prager, J | 1 |
| Gandhi, S | 1 |
| Boiardi, A | 1 |
| Gemma, M | 1 |
| Porta, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190] | Phase 1 | 6 participants (Actual) | Interventional | 2017-06-05 | Terminated (stopped due to Phase II funding not available) | ||
| Randomized Double Blind Placebo Controlled Trial of Verapamil in Chronic Rhinosinusitis[NCT02454608] | 29 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Evidence that the dose is insufficient.) | |||
| A Double Blind Randomized Controlled Trial of Greater Occipital Nerve Infiltration in Cluster Headache[NCT00804895] | Phase 2/Phase 3 | 43 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache[NCT01151631] | Phase 3 | 130 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Randomized Placebo Controlled Study of Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis[NCT02221570] | 100 participants (Anticipated) | Interventional | 2014-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Phase Ib | 0 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements
| Intervention | mmHg (Mean) |
|---|---|
| Treatment | -0.6 |
| Control | 1 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements.
| Intervention | beats per minute (Mean) |
|---|---|
| Treatment | -1.4 |
| Control | 4 |
Minimum Score: 0 Maximum Score: 12 Higher value represents worse outcome. (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -1.3 |
| Control | -0.25 |
Minimum Score: 0 Maximum Score: 24 Higher value represents worse outcome. (NCT02454608)
Timeframe: Week 8
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment | 12.5 |
| Control | 17.7 |
Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -44.03 |
| Control | -6.07 |
Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -27.3 |
| Control | 0.4 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements
| Intervention | mmHg (Mean) |
|---|---|
| Treatment | -4.5 |
| Control | -6.6 |
Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 56
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Medicine Completers, baseline | Medicine Completers, week 56 | Surgical Completers, baseline | Surgical Completers, week 12 | |
| Open Label | 64.3 | 35.0 | 90.0 | 16.7 |
Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 56
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Medicine Completers, baseline | Medicine Completers, week 56 | Surgical Completers, baseline | Surgical Completers, week 12 | |
| Open Label | 31.8 | 24.14 | 72.00 | 8.00 |
26 reviews available for verapamil and Atypical Cluster Headache
| Article | Year |
|---|---|
Drug Treatment of Cluster Headache.
Topics: Cluster Headache; Drug Administration Routes; Humans; Lithium; Oxazolidinones; Oxygen Inhalation The | 2022 |
Cluster headache polygenetic risk and known functional variants of CYP3A4 are not associated with treatment response.
Topics: Cluster Headache; Cytochrome P-450 CYP3A; Genome-Wide Association Study; Humans; Tryptamines; Verapa | 2023 |
Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments-a consensus article.
Topics: Cluster Headache; Consensus; Europe; Humans; Lithium Compounds; Lysergic Acid Diethylamide; Oxygen; | 2023 |
Cluster headache in children and adolescents: a systematic review of case reports.
Topics: Adolescent; Adrenal Cortex Hormones; Blepharoptosis; Child; Child, Preschool; Cluster Headache; Gaba | 2021 |
Cluster headache: present and future therapy.
Topics: Animals; Calcitonin Gene-Related Peptide; Cluster Headache; Electric Stimulation Therapy; Forecastin | 2017 |
Cluster headache.
Topics: Adrenal Cortex Hormones; Calcium Channel Blockers; Cluster Headache; Ergotamine; Humans; Lithium; Tr | 2018 |
Verapamil and Cluster Headache: Still a Mystery. A Narrative Review of Efficacy, Mechanisms and Perspectives.
Topics: Cluster Headache; Humans; Vasodilator Agents; Verapamil | 2019 |
[New treatments for cluster headache].
Topics: Administration, Intranasal; Calcium Channel Blockers; Cluster Headache; Deep Brain Stimulation; Dexa | 2013 |
Acupuncture in cluster headache: four cases and review of the literature.
Topics: Acupuncture Points; Acupuncture Therapy; Adult; Cluster Headache; Combined Modality Therapy; Female; | 2014 |
[Cluster headache treatment].
Topics: Acute Disease; Cluster Headache; Deep Brain Stimulation; Electric Stimulation Therapy; Humans; Lithi | 2015 |
Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions.
Topics: Adolescent; Child; Cluster Headache; Cranial Nerve Diseases; Humans; Hyperbaric Oxygenation; SUNCT S | 2016 |
[Cluster headache in pediatric population: four case reports and review of the literature].
Topics: Adolescent; Child; Child, Preschool; Cluster Headache; Diagnosis, Differential; Female; Flunarizine; | 2016 |
Verapamil for cluster headache. Clinical pharmacology and possible mode of action.
Topics: Brain; Cluster Headache; Humans; Vasodilator Agents; Verapamil | 2009 |
Cluster headache--acute and prophylactic therapy.
Topics: Catheter Ablation; Cluster Headache; Electric Stimulation Therapy; Humans; Lithium Carbonate; Oxygen | 2011 |
Cluster headache.
Topics: Cluster Headache; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Humans; M | 2012 |
Strategies for the treatment of autonomic trigeminal cephalalgias.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Autonomic Nervous System Diseases; Calcium Channe | 2004 |
Practical strategy for detecting and relieving cluster headaches.
Topics: Cluster Headache; Humans; Oxygen; Serotonin Receptor Agonists; Sumatriptan; Vasodilator Agents; Vera | 2005 |
[Trigeminal autonomic cephalgias: diagnostic and therapeutic implications].
Topics: Administration, Intranasal; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cluster Headac | 2007 |
[Pathophysiology and treatment of trigeminal autonomic cephalalgias].
Topics: Administration, Oral; Amines; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroida | 2008 |
Diagnosis, prophylaxis, and treatment of headaches in the athlete.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; | 1997 |
Prophylaxis of cluster headache: current views on drug choice.
Topics: Calcium Channel Blockers; Cluster Headache; Humans; Verapamil | 1999 |
[Treatment of cluster headache].
Topics: Cluster Headache; Ergotamine; Glucocorticoids; Humans; Lithium; Melatonin; Methysergide; Oxygen Inha | 2000 |
[Treatment of cluster headache].
Topics: Anti-Inflammatory Agents; Calcium Channel Blockers; Chronic Disease; Cluster Headache; Combined Moda | 2001 |
Prophylactic therapy of cluster headaches.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cluster Headache; Humans; Lithium; Lithium Carbonate; Methy | 1991 |
Verapamil and migraine prophylaxis: mechanisms and efficacy.
Topics: Animals; Chronic Disease; Clinical Trials as Topic; Cluster Headache; Humans; Migraine Disorders; Re | 1991 |
Diagnosis and management of cluster headaches.
Topics: Adult; Cluster Headache; Ergot Alkaloids; Female; Humans; Male; Oxygen Inhalation Therapy; Verapamil | 1990 |
8 trials available for verapamil and Atypical Cluster Headache
| Article | Year |
|---|---|
Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial.
Topics: Adult; Calcium Channel Blockers; Cluster Headache; Double-Blind Method; Drug Therapy, Combination; D | 2021 |
Suboccipital steroid injections for transitional treatment of patients with more than two cluster headache attacks per day: a randomised, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents; Clust | 2011 |
Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone.
Topics: Adult; Cluster Headache; Drug Administration Schedule; Drug Therapy, Combination; Ergotamine; Humans | 2003 |
Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches.
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cluster Head | 1983 |
Opioid and sympathetic nervous system activity in cluster headache under verapamil or prednisone treatment.
Topics: Catecholamines; Cluster Headache; Enkephalin, Methionine; Humans; Male; Middle Aged; Neutrophils; Pe | 1994 |
Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo.
Topics: Adult; Cluster Headache; Double-Blind Method; Female; Humans; Male; Middle Aged; Verapamil | 2000 |
The use of baclofen in cluster headache.
Topics: Adrenal Cortex Hormones; Adult; Aged; Autonomic Nervous System; Baclofen; Cluster Headache; Drug Adm | 2001 |
Double blind comparison of lithium and verapamil in cluster headache prophylaxis.
Topics: Adult; Chronic Disease; Cluster Headache; Double-Blind Method; Female; Humans; Lithium; Male; Middle | 1990 |
52 other studies available for verapamil and Atypical Cluster Headache
| Article | Year |
|---|---|
Effects of cluster headache preventatives on mouse hypothalamic transcriptional homeostasis.
Topics: Amitriptyline; Animals; Arginine; Arginine Vasopressin; CLOCK Proteins; Cluster Headache; Homeostasi | 2022 |
Treatment pattern and response for cluster headache in Korea: A prospective multicenter observation study.
Topics: Cluster Headache; Humans; Oxygen; Republic of Korea; Tryptamines; Verapamil | 2023 |
Chronic Cluster Headache with a Pediatric Onset: The First Japanese Case Report.
Topics: Child; Cluster Headache; Female; Humans; Japan; Sumatriptan; Verapamil | 2020 |
Real-life treatment of cluster headache in a tertiary headache center - results from the Danish Cluster Headache Survey.
Topics: Cluster Headache; Cross-Sectional Studies; Denmark; Headache; Humans; Oxygen; Sumatriptan; Surveys a | 2021 |
Machine phenotyping of cluster headache and its response to verapamil.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cluster Headache; Female; Humans; Machine Learning; Male; Mid | 2021 |
Cardiac monitoring of high-dose verapamil in cluster headache: An international Delphi study.
Topics: Cardiologists; Cluster Headache; Delphi Technique; Electrocardiography; Humans; Internationality; Ra | 2016 |
Chronic cluster headache and the pituitary gland.
Topics: Adenoma; Cabergoline; Central Nervous System Cysts; Cluster Headache; Diagnosis, Differential; Dopam | 2016 |
Atypically located cluster headache.
Topics: Cluster Headache; Diagnosis, Differential; Humans; Lithium; Male; Middle Aged; Pain Measurement; Vas | 2016 |
Cutaneous allodynia during cluster headache attacks.
Topics: Adult; Anti-Inflammatory Agents; Cluster Headache; Female; Functional Laterality; Humans; Hyperesthe | 2009 |
[Cluster headache].
Topics: Administration, Intranasal; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Cluster Headache; Erg | 2009 |
Efficacy of oxygen inhalation in sumatriptan refractory "high altitude" cluster headache attacks.
Topics: Adult; Altitude Sickness; Atmospheric Pressure; Calcium Channel Blockers; Cluster Headache; Drug Res | 2009 |
Headache - chronic cluster headache: preventive treatment.
Topics: Cluster Headache; Dose-Response Relationship, Drug; Electric Stimulation; Ergotamine; Humans; Vasodi | 2009 |
Coexisting trigeminal autonomic cephalalgias and hemicrania continua.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Brain; Calcium Channel Blockers; Cl | 2010 |
Cluster headache associated with a sixth nerve palsy: a case report.
Topics: Abducens Nerve Diseases; Anti-Inflammatory Agents; Cluster Headache; Dexamethasone; GABA Agents; Hum | 2011 |
Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day).
Topics: Adult; Arrhythmias, Cardiac; Bradycardia; Cluster Headache; Female; Heart Conduction System; Humans; | 2011 |
Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day).
Topics: Adult; Arrhythmias, Cardiac; Bradycardia; Cluster Headache; Female; Heart Conduction System; Humans; | 2011 |
Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day).
Topics: Adult; Arrhythmias, Cardiac; Bradycardia; Cluster Headache; Female; Heart Conduction System; Humans; | 2011 |
Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day).
Topics: Adult; Arrhythmias, Cardiac; Bradycardia; Cluster Headache; Female; Heart Conduction System; Humans; | 2011 |
Management of cluster headache.
Topics: Analgesics; Cluster Headache; Deep Brain Stimulation; Disease Management; Ergotamine; Fructose; Huma | 2012 |
[Headache attacks].
Topics: Calcium Channel Blockers; Cluster Headache; Female; Humans; Middle Aged; Verapamil | 2001 |
Migraine with cranial autonomic features and strict unilaterality.
Topics: Adult; Autonomic Pathways; Calcium Channel Blockers; Cluster Headache; Female; Functional Laterality | 2003 |
Hemicrania continua with contralateral episodic cluster headache: a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cluster Headache; Functional Laterality; Humans; Ind | 2003 |
[Prophylactic treatment of cluster headache with verapamil].
Topics: Adolescent; Adult; Chronic Disease; Cluster Headache; Female; Humans; Male; Middle Aged; Retrospecti | 2003 |
Outpatient intravenous dihydroergotamine for refractory cluster headache.
Topics: Adult; Aged; Ambulatory Care; Analgesics, Non-Narcotic; Chronic Disease; Cluster Headache; Dihydroer | 2004 |
Verapamil and lymphomatoid papulosis in chronic cluster headache.
Topics: Aged; Chronic Disease; Cluster Headache; Humans; Lymphomatoid Papulosis; Male; Verapamil | 2004 |
Elevated levels of circulating trace amines in primary headaches.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cluster Headache; Diet; Female; Headache; H | 2004 |
Verapamil induced gingival enlargement in cluster headache.
Topics: Adult; Calcium Channel Blockers; Cluster Headache; Female; Gingival Overgrowth; Humans; Male; Verapa | 2005 |
Sildenafil can trigger cluster headaches.
Topics: Adult; Calcium Channel Blockers; Cluster Headache; Erectile Dysfunction; Humans; Male; Middle Aged; | 2006 |
Verapamil-responsive hemicrania continua in a patient with episodic cluster headache.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cluster Headache; Female; | 2006 |
Cluster headache with short-lived visual symptoms.
Topics: Aged; Cluster Headache; Female; Humans; Lacrimal Apparatus Diseases; Photophobia; Treatment Outcome; | 2006 |
Paroxysmal neuralgic upper cervical pain attacks: the lower syndrome of cluster headache.
Topics: Adult; Aged; Anticonvulsants; Cluster Headache; Combined Modality Therapy; Diagnosis, Differential; | 2006 |
[Cluster like headache in a patient with the Maffucci's syndrome].
Topics: Adenoma; Cluster Headache; Enchondromatosis; Humans; Magnetic Resonance Imaging; Male; Middle Aged; | 2006 |
Now dear, I have a headache! Immediate improvement of cluster headaches after sexual activity.
Topics: Cardiovascular Agents; Cluster Headache; Coitus; Female; Humans; Indomethacin; Male; Middle Aged; Or | 2006 |
Valsalva-induced cluster headache.
Topics: Cluster Headache; Headache Disorders, Primary; Humans; Male; Middle Aged; Valsalva Maneuver; Vasodil | 2006 |
Typical cluster headache caused by granulomatous pituitary involvement.
Topics: Adult; Cluster Headache; Female; Granuloma; Humans; Magnetic Resonance Imaging; Pituitary Diseases; | 2007 |
Temporary pacemaker in refractory cluster headache treated with verapamil.
Topics: Adult; Biological Clocks; Cluster Headache; Humans; Male; Vasodilator Agents; Verapamil | 2007 |
Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients.
Topics: Adult; Cluster Headache; Deep Brain Stimulation; Electrodes, Implanted; Female; Follow-Up Studies; H | 2007 |
Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy.
Topics: Adolescent; Adult; Aged; Cluster Headache; Cohort Studies; Electrocardiography; Female; Humans; Male | 2007 |
Cluster headache and intracranial aneurysm.
Topics: Afferent Pathways; Calcium Channel Blockers; Carotid Artery, Internal; Cerebral Angiography; Cluster | 2007 |
Cluster-like headaches associated with internal carotid artery dissection responsive to verapamil.
Topics: Anticoagulants; Blepharoptosis; Carotid Artery, Internal, Dissection; Cluster Headache; Diagnosis, D | 2008 |
Extracephalic cluster (cluster sine headache).
Topics: Aged; Cluster Headache; Female; Humans; Migraine with Aura; Sensation Disorders; Verapamil | 2008 |
Verapamil and cluster headache.
Topics: Cluster Headache; Drug Administration Schedule; Humans; Verapamil | 1995 |
Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy.
Topics: Adolescent; Chronic Disease; Cluster Headache; Female; Humans; Treatment Outcome; Verapamil | 1994 |
Verapamil-induced hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Cluster Headache; Humans; Male; Middle Aged; Verapamil | 1994 |
[Cluster-tic syndrome: two case reports].
Topics: Adult; Carbamazepine; Cluster Headache; Humans; Male; Prednisone; Syndrome; Trigeminal Neuralgia; Ve | 1996 |
[Cluster headache: misjudged because unknown].
Topics: Adult; Analgesics; Calcium Channel Blockers; Cluster Headache; Diagnosis, Differential; Humans; Male | 1997 |
Simultaneous occurrence of ipsilateral cluster headache and chronic paroxysmal hemicrania: a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cluster Headache; Humans; Indometha | 2000 |
Is it migraine or cluster?
Topics: Adult; Calcium Channel Blockers; Cluster Headache; Diagnosis, Differential; Female; Humans; Migraine | 2000 |
Cluster headache after dental extraction: implications for the pathogenesis of cluster headache?
Topics: Anti-Inflammatory Agents; Calcium Channel Blockers; Causalgia; Cluster Headache; Drug Therapy, Combi | 2001 |
Corticosteroid-induced acute mania during a cluster headache episode.
Topics: Acute Disease; Adolescent; Age of Onset; Antimanic Agents; Bipolar Disorder; Cluster Headache; Gluco | 2001 |
Hereditary haemochromatosis in two cousins with cluster headache.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain Stem; Calcium Channel Blockers; Cluster Headac | 2002 |
Ipsilateral cluster headache and chronic paroxysmal hemicrania: two case reports.
Topics: Adult; Chronic Disease; Cluster Headache; Drug Therapy, Combination; Humans; Indomethacin; Male; Mid | 1992 |
Prophylactic treatment of cluster headache with verapamil.
Topics: Adolescent; Adult; Aged; Cluster Headache; Female; Humans; Male; Middle Aged; Vascular Headaches; Ve | 1989 |
Treatment of intractable cluster.
Topics: Cluster Headache; Cocaine; Female; Histamine Antagonists; Humans; Lithium; Lithium Carbonate; Male; | 1986 |
Calcium entry blocker: treatment in acute pain in cluster headache patients.
Topics: Blood Pressure; Cluster Headache; Humans; Indomethacin; Lithium; Nitroglycerin; Pain Measurement; Pu | 1986 |