n-caproylglycine profile

n-Caproylglycine, also known as caproylglycine or hexanoylglycine, is a synthetic amino acid derivative. It is a white, crystalline solid that is soluble in water. n-Caproylglycine is primarily studied for its potential as a therapeutic agent. Research has explored its effects on various biological processes, including its anti-inflammatory properties, its ability to inhibit the growth of cancer cells, and its potential as a treatment for neurodegenerative diseases. The compound is synthesized through a chemical reaction between caproic acid (hexanoic acid) and glycine. The study of n-Caproylglycine is driven by its unique chemical structure and the diverse range of biological activities it exhibits, making it a promising candidate for the development of new drugs.'

N-hexanoylglycine : An N-acylglycine in which the acyl group is specified as hexanoyl. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	99463
CHEBI ID	64390
SCHEMBL ID	231559
MeSH ID	M0082950

Synonym
nsc-224460
nsc224460
24003-67-6
CBDIVE_014046
hexanoylglycine
n-hexanoylglycine
2-(hexanoylamino)acetic acid
FT-0669132
n-caproylglycine
nsc 224460
glycine, n-(1-oxohexyl)-
AKOS009109227
n-(1-oxohexyl)glycine
caproylglycine
CHEBI:64390
hexanoyl glycine
SCHEMBL231559
DTXSID60178739
2-hexanamidoacetic acid
n-hexanoylglycine, analytical reference material
J-015309
n-hexanoyl-glycine
Q27133257
EN300-190453
LCZC1205
2-hexanamidoaceticacid
CS-0062285
HY-113150
UV44XX9H2J

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
N-acylglycine	An N-acyl-amino acid in which amino acid specified is glycine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (27.78)	18.7374
1990's	6 (33.33)	18.2507
2000's	5 (27.78)	29.6817
2010's	2 (11.11)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.26%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	4 (21.05%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (73.68%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
3-hydroxyisobutyric acid 3-hydroxyisobutyric acid: RN given refers to cpd without isomeric designation. 3-hydroxyisobutyric acid : A 4-carbon, branched hydroxy fatty acid and intermediate in the metabolism of valine.	1.95	1	0	3-hydroxy monocarboxylic acid
3-phenylpropionic acid 3-phenylpropionic acid: RN given refers to parent cpd. 3-phenylpropionic acid : A monocarboxylic acid that is propionic acid substituted at position 3 by a phenyl group.	2.38	2	0	benzenes; monocarboxylic acid	antifungal agent; human metabolite; plant metabolite
adipic acid adipic acid : An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.	1.96	1	0	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	food acidity regulator; human xenobiotic metabolite
carnitine [no description available]	2.93	4	0	amino-acid betaine	human metabolite; mouse metabolite
octanoic acid octanoic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #1764. octanoic acid : A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.	2.4	2	0	medium-chain fatty acid; straight-chain saturated fatty acid	antibacterial agent; Escherichia coli metabolite; human metabolite
glycine [no description available]	5.63	18	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glyoxylic acid glyoxylic acid: RN given refers to parent cpd. glyoxylic acid : A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.	2	1	0	2-oxo monocarboxylic acid; aldehydic acid	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
decanoic acid decanoate : A fatty acid anion 10:0 that is the conjugate base of decanoic acid.. decanoic acid : A C10, straight-chain saturated fatty acid.	1.98	1	0	medium-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; anti-inflammatory agent; antibacterial agent; human metabolite; plant metabolite; volatile oil component
sebacic acid sebacic acid : An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane.	2.36	2	0	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	human metabolite; plant metabolite
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	1.98	1	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
hexanoic acid hexanoic acid : A C6, straight-chain saturated fatty acid.	1.98	1	0	medium-chain fatty acid; straight-chain saturated fatty acid	human metabolite; plant metabolite
suberic acid suberic acid: used in plastics industry; inhibits activity of some enzymes; RN given refers to parent cpd; structure. suberic acid : An alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.	2.36	2	0	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	human metabolite
s-adenosylmethionine acylcarnitine: structure in first source. S-adenosyl-L-methioninate : A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.	2.03	1	0	sulfonium betaine	human metabolite
beta-hydroxyisovaleric acid 3-hydroxyisovaleric acid : A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.	1.95	1	0	3-hydroxy monocarboxylic acid	human metabolite
n-butyrylglycine butyrylglycine : A N-acylglycine obtained by formal condensation of the carboxy group of butyric acid with the amino group of glycine.	1.99	1	0	N-acylglycine	human urinary metabolite
4-decenoate 4-decenoic acid: RN given refers to (Z)-isomer; RN for cpd without isomeric designation not available 5/88	1.98	1	0
valerates Valerates: Derivatives of valeric acid, including its salts and esters.	1.95	1	0	short-chain fatty acid anion; straight-chain saturated fatty acid anion	plant metabolite
caprylates Caprylates: Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.. octanoate : A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.	2.89	4	0	fatty acid anion 8:0; straight-chain saturated fatty acid anion	human metabolite; Saccharomyces cerevisiae metabolite
5-hydroxyhexanoic acid 5-hydroxyhexanoic acid : A medium-chain fatty acid that is hexanoic acid substituted at position 5 by a hydroxy group.	1.95	1	0	(omega-1)-hydroxy fatty acid; medium-chain fatty acid	human urinary metabolite
2-methylbutyrylglycine 2-methylbutyrylglycine: metabolite of L-isoleucine. N-(2-methylbutanoyl)glycine : A N-acylglycine that is glycine substituted by a 2-methylbutanoyl group at the N atom.	1.99	1	0	N-acylglycine	human metabolite
n-isovalerylglycine N-isovalerylglycine: urinary metabolite of isovaleric acid in isovaleric acidemia (sweaty feet syndrome). N-isovalerylglycine : An N-acylglycine in which the acyl group is specified as isovaleryl.	2.4	2	0	N-acylglycine	human urinary metabolite
3-phenylpropionylglycine 3-phenylpropionylglycine: found in urine of patients suffering from medium-chain acyl-CoA dehydrogenase deficiency; RN refers to HCl	3.07	5	0	aromatic ketone
suberylglycine suberylglycine: found in urine of patients with C(6)-C(10)-dicarboxylIC aciduria; RN is from 9th CI, Chem Subs Index; structure	2.9	4	0	N-acylglycine
n-isobutyrylglycine N-isobutyrylglycine: found in urine of patients with glyceric acidemia. N-isobutyrylglycine : An N-acylglycine in which the acyl group is specified as isobutryl.	1.99	1	0	N-acylglycine	human urinary metabolite
octanoylcarnitine octanoylcarnitine: RN given refers to cpd without isomeric designation. O-octanoyl-L-carnitine : The L-enantiomer of an O-octanoylcarnitine.	2.05	1	0	O-octanoylcarnitine; saturated fatty acyl-L-carnitine	human metabolite
deoxyguanosine [no description available]	2.15	1	0	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine 8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.	2.15	1	0	guanosines	biomarker

Condition	Relationship Strength	Studies
Autism Spectrum Disorder Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)	2.15	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.72	3
Diseases, Metabolic [description not available]	2.04	1
Metabolic Diseases Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)	2.04	1
Lipid Metabolism, Inborn Error [description not available]	2.68	3
Eye Disorders [description not available]	2.04	1
Eye Diseases Diseases affecting the eye.	2.04	1
Fasting Hypoglycemia HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.	1.95	1
Hypoglycemia A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.	1.95	1
Deficiency, Riboflavin [description not available]	1.99	1
Plant Poisoning Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.	1.95	1
Emesis [description not available]	1.95	1
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	1.95	1
Fatty Liver with Encephalopathy [description not available]	1.97	1
Cot Death [description not available]	1.97	1

n-caproylglycine

Description

Cross-References

Synonyms (29)

Roles (1)

Drug Classes (1)

Research

Studies (18)

Market Indicators

Research Demand Index: 11.27

Study Types