phenobarbital has been researched along with Fatty Liver with Encephalopathy in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on the available data it seems that one may postulate the following conclusions: (1) that the distribution factors as well as changes in drug elimination capacities seem to play a role, perhaps with differing relative importance, during each of the maturational periods; (2) that the physicochemical properties of a drug and its dosage, as well as changes in the volume of distribution in children, in the course of certain disease states may have a significant effect on kinetics of drug disposition in the body; (3) that systemic clearance, a model independent parameter, rather than elimination half-life, a hybrid pharmacokinetic parameter, more accurately reflects elimination of some drugs from the body; (4) that each drug and every clinical situation may require the evaluation of the direct effect on pharmacokinetic processes, since general principles may not always apply; (5) that drug disposition studies should also be performed, if possible, on patients under actual clinical situations and receiving the usual therapeutic regime, and (6) that the half-life of colistin is independent of postnatal age which should serve as a warning not to generalize about drug excretion in the young infant." | 2.37 | Clinical pharmacokinetics of changes in drug elimination in children. ( Prandota, J, 1985) |
| "Status epilepticus was treated with intravenous infusion of thiamylal sodium." | 1.29 | [A case of adult Reye's syndrome with favorable outcome despite status epilepticus]. ( Arai, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berlin, CM | 1 |
| Seghieri, G | 1 |
| De Giorgio, LA | 1 |
| Innocenti, F | 1 |
| Pettiná, G | 1 |
| Zolfanelli, F | 1 |
| Apicella, P | 1 |
| Arai, M | 1 |
| Venes, JL | 1 |
| Shaywitz, BA | 1 |
| Spencer, DD | 1 |
| Haller, JS | 1 |
| Prandota, J | 1 |
2 reviews available for phenobarbital and Fatty Liver with Encephalopathy
| Article | Year |
|---|---|
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A | 1983 |
Clinical pharmacokinetics of changes in drug elimination in children.
Topics: Adult; Anti-Bacterial Agents; Brain Injuries; Child; Child, Preschool; Colistin; Cystic Fibrosis; Di | 1985 |
4 other studies available for phenobarbital and Fatty Liver with Encephalopathy
| Article | Year |
|---|---|
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb | 1982 |
[A case of adult Reye's syndrome with favorable outcome despite status epilepticus].
Topics: Adolescent; Anticonvulsants; Humans; Male; Phenobarbital; Reye Syndrome; Status Epilepticus | 1996 |
Management of severe cerebral edema in the metabolic encephalopathy of Reye-Johnson syndrome.
Topics: Adolescent; Ammonia; Brain Edema; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Infa | 1978 |
Reye syndrome: diagnostic and therapeutic considerations.
Topics: Adolescent; Amino Acids; Brain; Child; Exchange Transfusion, Whole Blood; Fatty Liver; Glucose; Huma | 1977 |