| Assay ID | Title | Year | Journal | Article |
|---|
| AID173445 | Antagonism of metrazole-induced clonic convulsions in rats after ip injection | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
| AID223126 | Compound was tested for ethanol potentiation expressed as loss of righting reflex (anesthesia) | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID35392 | In vitro efficacy calculated by chlorine current assay on alpha-1-beta-2-gamma-2 (GABA-A) receptor subtype | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID124224 | In vivo efficacy is evaluated by percent control of cerebellar GMP levels in (drug+stress) treated mice/mice under stress | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID39931 | Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
| AID73539 | Displacement of [3H]-Ro-15-4513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in Sf9 cells | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID196345 | Inhibition of [35S]TBPS binding to GABA-A Benzodiazepine receptor of rat brain membranes | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID112327 | Ethanol potentiation was measured against LORR | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID196364 | In vitro [36Cl]-uptake in rat cerebrocortical synaptoneurosomes | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID72906 | Displacement of [3H]Flunitrazepam from GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in Sf9 cells | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID72136 | Inhibition of [3H]flunitrazepam binding to GABA-A receptor of rat cortical membranes | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID177961 | Antagonistic activity against metrazole-induced clonic convulsions in rat after ip injection | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID112191 | In vivo antagonistic activity against benzodiazepine in mice | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID73226 | Displacement of [3H]flunitrazepam from GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in Sf9 cells | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID112326 | Ethanol potentiation activity was measured as loss of traction response in male CF-1 mice after oral administration | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID222344 | Compound was tested for Acute electroshock physical dependence activity (drug MA50/V122 MA50); No significant activity | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID44593 | In vitro GABA-mediated chloride current in A293 cells expressing GABA-A benzodiazepine receptor alpha-1-beta-2-gamma-2 subunits at 5 uM | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID72305 | In vitro inhibition of [35S]TBPS binding in rat brain membranes, activity expressed as [35S]TBPS shift value | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID123132 | In vivo acute electroshock physical dependence activity in mice; Not active. | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID223125 | Antagonism of benzodiazepine traction in mice | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID72779 | In vitro efficacy for GABA-A alpha-1-beta-2-gamma-2 subtype expressed in A293 cells in Cl- current assay | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
| AID73072 | Displacement of [3H]-Ro- 15-4513 from alpha-6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
| AID39930 | Binding affinity against benzodiazepine receptor (BzR) in rat cortical membranes determined by competition experiments with radiolabeled [3H]flunitrazepam (Fnz) | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID114819 | Ability to antagonize the muscle relaxation effect in mice caused by a benzodiazepine full agonist, triazolam. | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID221056 | Ability to antagonize metrazole-induced seizures (clonic and tonic) in mice after intraperitoneal injection | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID40672 | Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| AID223127 | Compound was tested for ethanol potentiation expressed as the loss of traction response (muscle relaxation) | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID72594 | In vitro efficacy by [35S]t-butyl-bicyclophosphorothionate (TBPS) binding to the picrotoxin convulsant site on the GABA-A receptor chloride complex. | 1996 | Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
| 3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex. |
| AID108875 | Acute electroshock physical dependence activity was evaluated; IA=Inactive | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex. |
| AID72593 | Binding to GABA-A receptor complex relative to TBPS binding to picrotoxin convulsant site | 1996 | Journal of medicinal chemistry, Nov-08, Volume: 39, Issue:23
| High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines. |
| AID177313 | In vivo efficacy evaluated for ability to antagonize metrazole induced clonic convulsions in rat after ip injection | 1999 | Journal of medicinal chemistry, Apr-08, Volume: 42, Issue:7
| Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |