| Assay ID | Title | Year | Journal | Article |
|---|
| AID556070 | Antiviral activity against 1 MOI Bovine viral diarrhea virus NADL infected in MDBK cells assessed as reduction in viral titer after 72 hrs by plaque forming assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID1412112 | Inhibition of almond beta-glucosidase pre-incubated for 5 mins followed by p-nitrophenyl-beta-D-glucopyranoside substrate addition and measured after 30 mins by spectrophotometric assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID698123 | Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV NADL infected in MDBK cells | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. |
| AID482201 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 50 uM after 60 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID556086 | Antiviral activity against Dengue virus C infected in african green monkey Vero cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID482220 | Cytotoxicity against human fibroblast at 300 uM after 24 hrs by MTT assay | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID556072 | Selectivity index, ratio of CC50 for bovine MDBK cells to EC50 for 1 MOI Bovine viral diarrhea virus infected in bovine MDBK cells | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID652495 | Increase in beta-glucocerebrosidase L444P mutant activity in lymphoblasts obtained from Gaucher disease patient after 3 days by fluorimetric analysis | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID731606 | Induction of beta glucosidase N370S mutant (unknown origin) at 10 nM relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID326300 | Inhibition of recombinant wild-type glucocerebrosidase | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Aug-07, Volume: 104, Issue:32
| Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. |
| AID699362 | Stabilization of recombinant imiglucerase at 50 uM at 48 degC after 60 mins by fluorimetry relative to incubation at 37 degC | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID652482 | Inhibition of beta-glucocerebrosidase in human fibroblasts assessed as stabilization ratio at 100 uM after 1 hr thermal denaturation at 48 degC by spectrophotometric analysis | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID699211 | Agonist activity at glucosylceramidase N370S mutant in lymphoblast obtained from Gaucher disease patient using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 5 nM for 3 days measured 2 hrs post substrate addition by fluorescence | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID698125 | Antiviral activity against 1 MOI BVDV NADL infected in MDBK cells assessed as reduction in viral titer after 22 hrs | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. |
| AID592238 | Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 7.4 after 10 mins by fluorometric analysis | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID652484 | Inhibition of wild type beta-glucocerebrosidase in human fibroblasts assessed as 4-methyumbelliferone formation at 50 uM after 24 hrs by fluorimetric analysis | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID700849 | Activation of Beta-glucocerebrosidase G202R mutant in cell based assay | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID592295 | Inhibition of glucocerebrosidase in human intact fibroblasts at 50 uM after 24 hrs by fluorometric analysis | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID579726 | Activation of beta-glucocerebrosidase in human N370S cells assessed as increase of residual activity at 0.1 uM after 3 days relative to control | 2011 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 21, Issue:5
| Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. |
| AID699347 | Inhibition of lysosomal beta-glucosidase in human fibroblast using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 50 uM for 24 hrs before substrate addition measured after 2 hrs by fluorimetry | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID1596611 | Induction of apoptosis in human CuFi1 cells incubated for 48 hrs by Muse Annexin V based cell counter assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID1596607 | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level at 0.1 uM pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR anal | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID326315 | Increase in glucocerebrosidase protein localization in lysosomes of human N370S cells at 40 uM | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Aug-07, Volume: 104, Issue:32
| Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. |
| AID1412119 | Ratio of IC50 for inhibition of recombinant human GBA using compound incubated at pH 5.2 for 24 hrs prior to test to IC50 for inhibition of recombinant human GBA using compound incubated at pH 7 for 24 hrs prior to test | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID700850 | Activation of Beta-glucocerebrosidase N370S mutant in cell based assay | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID326304 | Inhibition of rice alpha-glucosidase | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Aug-07, Volume: 104, Issue:32
| Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. |
| AID556089 | Cytotoxicity against african green monkey Vero cells by MTT assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID556071 | Cytotoxicity against MDBK cells by MTT assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID482197 | Competitive inhibition of beta-glucocerebrosidase at pH 5.2 by Lineweaver-Burke plot analysis | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID482196 | Inhibition of recombinant beta-glucocerebrosidase at pH 5.2 after 10 mins by fluorimetry | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID699343 | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 5.2 by Dixon plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID482200 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 50 uM after 40 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID592297 | Inhibition of glucosylceramide synthase in human A549 cells at 10 uM after 35 mins by fluorometric analysis | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID1412117 | Inhibition of recombinant human GALC at pH 5.2 pre-incubated for 10 mins followed by 4-methylumbelliferyl-beta-D-galactopyranoside substrate addition and measured after 20 mins by fluorescence assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID326306 | Increase in glucocerebrosidase activity in human N370S mutant cells at 40 uM by pulse-chase assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Aug-07, Volume: 104, Issue:32
| Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. |
| AID764875 | Competitive inhibition of human beta-glucocerebrosidase by Lineweaver-Burk double reciprocal plot method | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. |
| AID1596603 | Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID764868 | Induction of alpha-glucosidase in human GM00372 cells using 4-methylumbelliferyl alpha-D-glucoside as substrate at <6.25 uM after 4 days by fluorescence spectrophotometry relative to untreated control | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. |
| AID482203 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 100 uM after 40 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID1412113 | Inhibition of bovine liver beta-galactosidase pre-incubated for 5 mins followed by p-nitrophenyl-beta-D-galactopyranoside substrate addition and measured after 30 mins by spectrophotometric assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID592301 | Inhibition of yeast alpha-glucosidase | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID699344 | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 7.0 by Dixon plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID731608 | Induction of beta glucosidase N370S mutant (unknown origin) at 10 uM relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID592236 | Inhibition of alpha-galactosidase from coffee beans | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID652472 | Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 5.2 | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID592302 | Inhibition of bovine liver beta-galactosidase | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID553256 | Inhibition of lactase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553257 | Inhibition of maltase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID482199 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 50 uM after 20 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID698124 | Cytotoxicity against MDBK cells assessed as cell viability by MTT assay | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. |
| AID350171 | Activation of beta-glucocerebrosidase N370S mutant in Goucher lymphoblasts cocultured with HL60 cells at 1 uM after 3 days relative to control | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease. |
| AID1596606 | Inhibition of NLGase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay relative to control | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID1412116 | Inhibition of recombinant human GBA pre-incubated for 30 mins followed by 4-methylumbelliferyl-beta-D-glucopyranoside substrate addition and measured after 10 mins using compound incubated at pH 5.2 for 24 hrs prior to test by fluorescence assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID1440982 | Chaperone activity assessed as enhancement of GCase N370S mutant enzyme in fibroblasts derived from type 2 gaucher disease patient up to 2 uM treated for 5 days prior to addition of 4-methylumbelliferyl beta-D-glucopyranoside as substrate by luminescence | 2017 | Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
| Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease. |
| AID764869 | Induction of alpha-glucosidase in human GM00372 cells using 4-methylumbelliferyl alpha-D-glucoside as substrate at 6.2 uM after 4 days by fluorescence spectrophotometry relative to untreated control | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. |
| AID553258 | Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide synthase in mouse RAW cells | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID592235 | Inhibition of rice alpha-glucosidase | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID553252 | Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553255 | Inhibition of sucrase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID731621 | Induction of beta glucosidase N370S mutant activity in primary skin fibroblast derived from Gaucher disease patient at 30 uM after 5 days relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID1412110 | Inhibition of yeast alpha-glucosidase pre-incubated for 5 mins followed by p-nitrophenyl-alpha-D-glucopyranoside substrate addition and measured after 30 mins by spectrophotometric assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID699840 | Activation of human beta-glucocerebrosidase N370S/N370S mutant at 10 nM relative to control | 2012 | Journal of medicinal chemistry, Aug-09, Volume: 55, Issue:15
| Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease. |
| AID556087 | Antiviral activity against West Nile virus infected in baby hamster kidney cells assessed as reduction in viral titer after 72 hrs by plaque reduction assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID592300 | Cytotoxicity against human wild type fibroblasts at up to 300 uM after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID764876 | Inhibition of human beta-glucocerebrosidase at 20 uM by fluorescence spectrophotometry | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. |
| AID482195 | Inhibition of recombinant beta-glucocerebrosidase at pH 7.4 after 10 mins by fluorimetry | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID1412115 | Inhibition of recombinant human GBA pre-incubated for 30 mins followed by 4-methylumbelliferyl-beta-D-glucopyranoside substrate addition and measured after 10 mins using compound incubated at pH 7 buffer for 24 hrs prior to test by fluorescence assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID556088 | Cytotoxicity against BHK cells by MTT assay | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. |
| AID652471 | Inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by spectrophotometric analysis at pH 7 | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID1412111 | Inhibition of green coffee beans alpha-galactosidase pre-incubated for 5 mins followed by p-nitrophenyl-alpha-D-galactopyranoside substrate addition and measured after 30 mins by spectrophotometric assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID699355 | Inhibition of GBA2 activity in mouse tissue homogenate at 50 uM | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID1596604 | Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay relative to | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID699346 | Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition by Dixon plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID1596605 | Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID699345 | Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition by Lineweaver-Burk plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID482204 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 100 uM after 60 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID1596612 | Cytotoxicity against human CuFi1 cells assessed as reduction in cell viability incubated for 48 hrs by Muse cell analyser method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID699364 | Agonist activity at glucosylceramidase N444P mutant in lymphoblast obtained from gauchers patient using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 1 to 5000 nM for 3 days measured 2 hrs post substrate addition by fluorescence | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID699341 | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 5.2 by Lineweaver-Burk plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID553253 | Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID699342 | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 7.0 Lineweaver-Burk plot assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. |
| AID1631446 | Antiviral activity against Dengue virus 2 NGC infected in BHK21 cells after 48 hrs by plaque reduction assay | 2016 | Journal of medicinal chemistry, 06-23, Volume: 59, Issue:12
| The Medicinal Chemistry of Dengue Virus. |
| AID482207 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 150 uM after 60 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID482205 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 150 uM after 20 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID652490 | Increase in beta-glucocerebrosidase N370S mutant activity in lymphoblasts obtained from Gaucher disease patient at 5 uM after 3 days by fluorimetric analysis | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID326310 | Increase in glucocerebrosidase activity in human N370S mutant cells at 13.3 uM by pulse-chase assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Aug-07, Volume: 104, Issue:32
| Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. |
| AID592294 | Enzyme stabilization ratio of recombinant glucocerebrosidase activity at 48 degC to at 37 degC at 100 uM after 60 mins | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID482223 | Inhibition of beta-glucocerebrosidase in human fibroblast at 50 uM after 24 hrs by fluorescence assay | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID1460459 | Inhibition of endoplasmic reticulum alpha-glucosidase in HEK293 cells infected with DENV assessed as reduction in viral infection | 2017 | ACS medicinal chemistry letters, Feb-09, Volume: 8, Issue:2
| Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction. |
| AID1412114 | Inhibition of Penicillium decumbens naringinase pre-incubated for 5 mins followed by p-nitrophenyl-beta-D-glucopyranoside substrate addition and measured after 30 mins by spectrophotometric assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID652473 | Competitive inhibition of human recombinant beta-glucocerebrosidase assessed as 4-methyumbelliferone formation after 30 mins by Lineweaver-Burk plot analysis at pH 5.2 | 2011 | ACS medicinal chemistry letters, Aug-11, Volume: 2, Issue:8
| The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease. |
| AID592293 | Competitive inhibition of recombinant glucocerebrosidase | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID553254 | Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID764873 | Induction of beta-glucocerebrosidase N370S mutant in human GM00372 cells using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate at 12.5 uM by fluorescence spectrophotometry relative to untreated control | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. |
| AID1412120 | Chaperone activity at GBA N370S mutant in Gaucher disease patient-derived fibroblasts assessed as restoration of enzyme activity at 1 to 10000 nM after 4 days by 4-methylumbelliferyl-beta-D-glucopyranoside substrate based fluorescence assay | 2017 | MedChemComm, Nov-01, Volume: 8, Issue:11
| Orthoester functionalized |
| AID592298 | Inhibition of glucosylceramide synthase in human A549 cells at 50 uM after 35 mins by fluorometric analysis | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. |
| AID482202 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 100 uM after 20 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID482206 | Binding affinity to recombinant beta-glucocerebrosidase assessed as enzymatic activity at 150 uM after 40 mins by thermal stabilization assay relative to control | 2010 | Journal of medicinal chemistry, Jul-22, Volume: 53, Issue:14
| Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. |
| AID1797728 | In Vitro Enzyme Inhibition from Article 10.1016/j.bmc.2006.08.003: \\Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.\\ | 2006 | Bioorganic & medicinal chemistry, Dec-01, Volume: 14, Issue:23
| Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |