suramin has been researched along with Lysosomal Enzyme Disorders in 3 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin is a polysulfonated naphthylurea currently investigated for the treatment of advanced malignancy." | 1.28 | A suramin derivative induces enterocyte-like differentiation of human colon cancer cells without lysosomal storage disorder. ( Baghdiguian, S; Fantini, J; Marvaldi, J; Nickel, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gritli-Linde, A | 1 |
| Ruch, JV | 1 |
| Mark, MP | 1 |
| Lécolle, S | 1 |
| Goldberg, M | 1 |
| Baghdiguian, S | 2 |
| Boudier, JA | 1 |
| Verrier, B | 1 |
| Zappitelli, JP | 1 |
| Fantini, J | 2 |
| Nickel, P | 1 |
| Marvaldi, J | 1 |
3 other studies available for suramin and Lysosomal Enzyme Disorders
| Article | Year |
|---|---|
Effects of suramin, a polyanionic drug inducing lysosomal storage disorders on tooth germs in vitro.
Topics: Animals; Autoradiography; Basement Membrane; Collagen; Female; Fluorescent Antibody Technique; Lysos | 1994 |
[Suramin induces lysosomal storage disorder in HT29-D4 cells during a mechanism of polarized endocytosis].
Topics: Adenocarcinoma; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Colonic Neopla | 1992 |
A suramin derivative induces enterocyte-like differentiation of human colon cancer cells without lysosomal storage disorder.
Topics: Cell Differentiation; Colonic Neoplasms; Humans; Lysosomal Storage Diseases; Lysosomes; Suramin; Tum | 1990 |