chloroquine has been researched along with Lysosomal Enzyme Disorders in 5 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Fedele, AO | 1 |
| Proud, CG | 1 |
| Öhlinger, K | 1 |
| Absenger-Novak, M | 1 |
| Meindl, C | 1 |
| Ober, J | 1 |
| Fröhlich, E | 1 |
| REWCASTLE, NB | 1 |
| HUMPHREY, JG | 1 |
| Soyombo, AA | 1 |
| Tjon-Kon-Sang, S | 1 |
| Rbaibi, Y | 1 |
| Bashllari, E | 1 |
| Bisceglia, J | 1 |
| Muallem, S | 1 |
| Kiselyov, K | 1 |
5 other studies available for chloroquine and Lysosomal Enzyme Disorders
| Article | Year |
|---|---|
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling.
Topics: A549 Cells; AMP-Activated Protein Kinases; Autophagosomes; Autophagy; Basic Helix-Loop-Helix Leucine | 2020 |
Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.
Topics: Amiodarone; Animals; Cations; Cell Line; Chloroquine; Humans; Lysosomal Storage Diseases; Macrophage | 2020 |
VACUOLAR MYOPATHY: CLINICAL, HISTOCHEMICAL, AND MICROSCOPIC STUDY.
Topics: Aspartate Aminotransferases; Biopsy; Chloroquine; Drug Therapy; Electromyography; Histocytochemistry | 1965 |
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity.
Topics: Acridine Orange; Calcium; Calcium Signaling; Carboxylic Acids; Cell Line; Cell Membrane; Chloroquine | 2006 |