| Assay ID | Title | Year | Journal | Article |
|---|
| AID356788 | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356794 | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID1533278 | Selectivity ratio of Ki for human HexB to Ki for recombinant human OGA expressed in Escherichia coli BL21 (DE3) | 2018 | ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12
| Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors. |
| AID515847 | Activation of PDK1 | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356816 | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356796 | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356818 | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID1172854 | Inhibition of Talaromyces flavus beta-N-acetylhexosaminidase GH20 using p-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucosaminide substrate at pH 7.0 and 25 degC | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline. |
| AID731640 | Binding affinity to human placental beta hexosaminidase | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID515850 | Inhibition of human placental lysosomal hexosaminidase A at 5 uM | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356804 | Pharmacological chaperone effect on beta Hex A beta-P504S/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID515842 | Inhibition of human O-GlcNAcase after 5 mins by Lineweaver-Burke plot analysis | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID515848 | Activation of AKT | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356812 | Pharmacological chaperone effect on beta Hex A alpha G269S/IV6 + 1G>A mutant in fibroblasts from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID1172855 | Inhibition of Streptomyces plicatus beta-N-acetylhexosaminidase GH20 using p-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucosaminide substrate at pH 7.0 and 25 degC | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline. |
| AID515845 | Induction of hyper-O-GlcNAc-ylation in human HeLa cells assessed as increase of O-GlcNAc level at 40 uM after 48 hrs Western blotting | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356779 | Activation of beta Hex A alpha IVS9 + 1G>A/IVS8-7G>A mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity at 300 ug/ml relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356815 | Activation of on beta Hex A beta R505Q/delta-16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356790 | Pharmacological chaperone effect on beta Hex A beta-T150P/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID331671 | Inhibition of Streptomyces plicatus N-acetyl-hexosaminidase | 2008 | Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
| N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. |
| AID356817 | Pharmacological chaperone effect on beta Hex A beta G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID1172856 | Inhibition of Bacteroides thetaiotaomicron beta-N-acetylglucosaminidase GH84 using p-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucosaminide substrate at pH 7.0 and 25 degC | 2014 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 24, Issue:22
| Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline. |
| AID748369 | Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-A using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as release of 4-Methylumbelliferyl fluorophore measured for 7 mins | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human β-N-Acetyl-d-hexosaminidase. |
| AID356792 | Pharmacological chaperone effect on beta Hex A beta-G353R/IVS12-26G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID515851 | Inhibition of human placental lysosomal hexosaminidase B at 5 uM | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356811 | Pharmacological chaperone effect on beta Hex A alpha G269S/c.1278ins TACT mutant in fibroblasts from Tay-Sachs disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356784 | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356806 | Pharmacological chaperone effect on beta Hex A beta-P504S/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356800 | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID515844 | Induction of hyper-O-GlcNAc-ylation in human HT-29 cells assessed as increase of O-GlcNAc level at 40 uM after 48 hrs Western blotting | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356798 | Pharmacological chaperone effect on beta Hex A beta-P417L/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID1533276 | Inhibition of recombinant human OGA expressed in Escherichia coli BL21 (DE3) using varying levels of pNP-beta-GlcNAc as substrate by Lineweaver-burk plot analysis | 2018 | ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12
| Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors. |
| AID331673 | Inhibition of human OGA | 2008 | Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
| N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. |
| AID356820 | Pharmacological chaperone effect on beta Hex A beta P504S/delta16kb mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356802 | Pharmacological chaperone effect on beta Hex A beta-R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID331672 | Inhibition of human beta hexosaminidase | 2008 | Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
| N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. |
| AID731639 | Induction of beta hexosaminidase activity in fibroblasts derived from TSD patient at 250 uM after 4 to 6 days by fluorescence assay relative to control | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Pharmacological chaperones as therapeutics for lysosomal storage diseases. |
| AID356814 | Activation of on beta Hex A beta R505Q/IVS11 + 5G>A mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID515846 | Inhibition of insulin-induced GLUT4 translocation into plasma membrane of mouse differentiated 3T3L1 cells at 40 uM after 16 hrs by Western blotting relative to control | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID1533277 | Inhibition of human HexB | 2018 | ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12
| Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors. |
| AID356786 | Pharmacological chaperone effect on beta Hex A beta-C137Y/C137Y mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX S activity at 300 mg/ml by immunoselection assay relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID748368 | Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as release of 4-Methylumbelliferyl fluorophore measured for 7 mins | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human β-N-Acetyl-d-hexosaminidase. |
| AID515849 | Effect on GLUT4 level in mouse differentiated 3T3L1 cells | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID356778 | Activation of beta Hex A alpha G269S/c.1278insTACT mutant isolated from Tay-Sachs disease patient assessed as increase in HEX A activity at 300 ug/ml relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID356819 | Pharmacological chaperone effect on beta Hex A beta delta16kb/P417L mutant in fibroblasts from Sandhoff disease patient assessed as increase in HEX A activity relative to control | 2007 | The Journal of biological chemistry, Mar-23, Volume: 282, Issue:12
| Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis. |
| AID515843 | Competitive inhibition of Streptomyces plicatus hexosaminidase | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| OGA inhibition by GlcNAc-selenazoline. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2008 | Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
| N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2009 | The Journal of biological chemistry, Apr-24, Volume: 284, Issue:17
| Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2008 | Journal of molecular biology, Mar-14, Volume: 377, Issue:1
| Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2001 | The Journal of biological chemistry, Mar-30, Volume: 276, Issue:13
| Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2001 | The Journal of biological chemistry, Mar-30, Volume: 276, Issue:13
| Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |