sinbaglustat: an antineopl agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9859470 |
| CHEMBL ID | 1651553 |
| SCHEMBL ID | 15698558 |
| MeSH ID | M0452371 |
| Synonym |
|---|
| bdbm50335397 |
| n-pentyl-l-ido-1-deoxynojirimycin |
| CHEMBL1651553 , |
| SCHEMBL15698558 |
| ogt-2378 |
| sinbaglustat (ogt2378) |
| (2s,3r,4r,5s)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol |
| 3,4,5-piperidinetriol, 2-(hydroxymethyl)-1-pentyl-, (2s,3r,4r,5s)- |
| 441061-33-2 |
| unii-t5y7nb5m2u |
| (+)-ogt-2378 |
| sinbaglustat [inn] |
| sinbaglustat |
| T5Y7NB5M2U , |
| (2s,3r,4r,5s)-2-(hydroxymethyl)-1-pentyl-3,4,5-piperidinetriol |
| MS-23342 |
| HY-129411 |
| CS-0105345 |
| AKOS040758136 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "p.o. treatment with OGT2378 starting 3 days before intradermal tumor inoculation of 4 x 10(4) MEB4 cells, and continuing for 4 weeks, resulted in a 10-fold lower mean tumor volume at the end of treatment (60 versus 538 mm(3), P < 0.0001)." | ( Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Hettmer, S; Ladisch, S; Smith, P; Weiss, M, 2003) | 0.63 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase | Mus musculus (house mouse) | IC50 (µMol) | 1,000.0000 | 0.4000 | 0.7500 | 1.5000 | AID553255 |
| Ceramide glucosyltransferase | Mus musculus (house mouse) | IC50 (µMol) | 15.0000 | 0.2000 | 1.4667 | 4.0000 | AID553252 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 (µMol) | 1,000.0000 | 0.0300 | 2.3589 | 8.8000 | AID553253 |
| Lysosomal alpha-glucosidase | Mus musculus (house mouse) | IC50 (µMol) | 1,000.0000 | 4.0000 | 7.0000 | 9.0000 | AID553257 |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | IC50 (µMol) | 0.2500 | 0.0003 | 0.0897 | 0.3000 | AID553254 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID553257 | Inhibition of maltase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553252 | Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553255 | Inhibition of sucrase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553258 | Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide synthase in mouse RAW cells | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553254 | Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553253 | Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553256 | Inhibition of lactase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2 | Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.87) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (40.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3 (60.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||