Galactocerebrosidase

A galactocerebrosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54803]

GALCERase;
EC 3.2.1.46;
Galactocerebroside beta-galactosidase;
Galactosylceramidase;
Galactosylceramide beta-galactosidase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-nonyl-1-deoxynojirimycin	Homo sapiens (human)	IC50	30.0000	1	1

This protein enables 1 target(s):

Target	Category	Definition
galactosylceramidase activity	molecular function	Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46]

This protein is located in 1 target(s):

Target	Category	Definition
lysosomal lumen	cellular component	The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]

This protein is active in 1 target(s):

Target	Category	Definition
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

This protein is involved in 3 target(s):

Target	Category	Definition
galactosylceramide catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. [GOC:ai]
myelination	biological process	The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. [GOC:dgh, GOC:mah]
glycosphingolipid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732]