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carbamazepine and Cleft Spine

carbamazepine has been researched along with Cleft Spine in 11 studies

Carbamazepine: A dibenzazepine that acts as a sodium channel blocker. It is used as an anticonvulsant for the treatment of grand mal and psychomotor or focal SEIZURES. It may also be used in the management of BIPOLAR DISORDER, and has analgesic properties.
carbamazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.

Research Excerpts

ExcerptRelevanceReference
" However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified."8.82Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003)
" However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified."4.82Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003)
" This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age."3.88Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. ( Baldessarini, RJ; Patel, N; Viguera, AC, 2018)
" To assess the impact of influencing AED prescribing practices on spina bifida and cleft palate we searched the literature for estimates of the association between valproic acid or carbamazepine use during pregnancy and these defects and summarized the associations using meta-analyses."3.77Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. ( Boulet, SL; Broussard, CS; Devine, OJ; Duwe, KN; Flak, AL; Gilboa, SM; Honein, MA; Moore, CA; Werler, MM, 2011)
"The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)."3.68[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991)
"Neural tube defects (NTDs), including spina bifida and anencephaly, are common congenital malformations that occur when the neural tube fails to achieve proper closure during early embryogenesis."2.42Pathobiology and genetics of neural tube defects. ( Finnell, RH; Gould, A; Spiegelstein, O, 2003)
"The congenital dermal sinus is an abnormal epithelium-lined sinus tract between the skin surface and deeper tissues."1.32Spinal congenital dermal sinus associated with upper thoracic meningocele. Case Report. ( Kara, NN, 2003)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (54.55)18.2507
2000's3 (27.27)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Patel, N1
Viguera, AC1
Baldessarini, RJ1
Gilboa, SM1
Broussard, CS1
Devine, OJ1
Duwe, KN1
Flak, AL1
Boulet, SL1
Moore, CA1
Werler, MM1
Honein, MA1
Finnell, RH1
Gould, A1
Spiegelstein, O1
Yerby, MS1
Kara, NN1
Oakeshott, P3
Hunt, G1
Tanaka, H1
Takeda, A1
Izumi, M1
Okada, H1
Ishikawa, S1
Hunt, GM1
Rosa, FW1

Reviews

3 reviews available for carbamazepine and Cleft Spine

ArticleYear
Pathobiology and genetics of neural tube defects.
    Epilepsia, 2003, Volume: 44 Suppl 3

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Genetic Predisposition to Dis

2003
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
    Neurology, 2003, Sep-01, Volume: 61, Issue:6 Suppl 2

    Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci

2003
Spina bifida in infants of women treated with carbamazepine during pregnancy.
    The New England journal of medicine, 1991, Mar-07, Volume: 324, Issue:10

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Human

1991

Other Studies

8 other studies available for carbamazepine and Cleft Spine

ArticleYear
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
    Journal of clinical psychopharmacology, 2018, Volume: 38, Issue:1

    Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Fol

2018
Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States.
    American journal of medical genetics. Part C, Seminars in medical genetics, 2011, Aug-15, Volume: 157C, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Cleft Palate; Female; Humans; Pregnancy; Pregnancy Complications; Pr

2011
Spinal congenital dermal sinus associated with upper thoracic meningocele. Case Report.
    Neurosurgical focus, 2003, Jul-15, Volume: 15, Issue:1

    Topics: Abnormalities, Multiple; Adult; Carbamazepine; Electroencephalography; Headache; Humans; Hypesthesia

2003
Prevention of neural tube defects.
    Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889

    Topics: Abnormalities, Drug-Induced; Carbamazepine; Female; Folic Acid; Humans; Neural Tube Defects; Pregnan

1994
Sodium valproate, carbamazepine and spina bifida.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 1991, Volume: 41, Issue:352

    Topics: Carbamazepine; Female; Humans; Pregnancy; Spinal Dysraphism; Valproic Acid

1991
Spina bifida in infants of women taking carbamazepine.
    The New England journal of medicine, 1991, Aug-29, Volume: 325, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Comp

1991
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
    Rinsho shinkeigaku = Clinical neurology, 1991, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta

1991
Carbamazepine and spina bifida.
    BMJ (Clinical research ed.), 1991, Sep-14, Volume: 303, Issue:6803

    Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Female; Humans; Infant, Newborn; Pregnancy; Spina

1991