valproic acid has been researched along with Cleft Spine in 23 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| " This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age." | 3.88 | Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. ( Baldessarini, RJ; Patel, N; Viguera, AC, 2018) |
| " To assess the impact of influencing AED prescribing practices on spina bifida and cleft palate we searched the literature for estimates of the association between valproic acid or carbamazepine use during pregnancy and these defects and summarized the associations using meta-analyses." | 3.77 | Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. ( Boulet, SL; Broussard, CS; Devine, OJ; Duwe, KN; Flak, AL; Gilboa, SM; Honein, MA; Moore, CA; Werler, MM, 2011) |
| " In a search for protection against neural tube defects, we investigated the effect of methionine on the incidence of VPA-induced spina bifida in the mouse." | 3.69 | Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics. ( Ehlers, K; Elmazar, MM; Nau, H, 1996) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "A pregnancy was classified as exposed to VPA in the critical time window if this exposure period overlapped with the first 55 days of pregnancy." | 1.91 | Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida. ( Dathe, K; Haug, U; Kollhorst, B; Onken, M; Schaefer, C; Schink, T; Thöne, K, 2023) |
| "Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete closure of the neural tube." | 1.91 | A Shared Pathogenic Mechanism for Valproic Acid and ( Huang, J; Luo, J; Parent, JM; Sexton, JZ; Sudyk, R; Takla, TN; Tidball, AM; Vora, NL; Walker, JC, 2023) |
| " The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period." | 1.39 | Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013) |
| "Our cases were spina bifida registrations and all other malformed registrations (excluding folic acid sensitive malformations) were used as controls." | 1.36 | Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? ( Bakker, MK; de Jong-van den Berg, LT; Jentink, J; Nijenhuis, CM; Wilffert, B, 2010) |
| " The concordance is apparent both by en masse correlation of fold-changes and by detailed similarity of dose-response profiles of individual genes." | 1.33 | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. ( Berman, MG; Gentleman, RC; Green, JB; Gurvich, N; Klein, PS; Wittner, BS, 2005) |
| "Valproic acid (VPA) is an antiepileptic drug used clinically." | 1.32 | Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study. ( Emmanouil-Nikoloussi, EN; Foroglou, NG; Kerameos-Foroglou, CH; Thliveris, JA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Haug, U | 3 |
| Kollhorst, B | 3 |
| Schink, T | 3 |
| Thöne, K | 3 |
| Dathe, K | 3 |
| Schaefer, C | 3 |
| Onken, M | 3 |
| Takla, TN | 1 |
| Luo, J | 1 |
| Sudyk, R | 1 |
| Huang, J | 1 |
| Walker, JC | 1 |
| Vora, NL | 1 |
| Sexton, JZ | 1 |
| Parent, JM | 1 |
| Tidball, AM | 1 |
| Oakley, GP | 1 |
| Suri, R | 1 |
| Socol, DK | 1 |
| Gitlin, M | 1 |
| Patel, N | 1 |
| Viguera, AC | 1 |
| Baldessarini, RJ | 1 |
| Vajda, FJ | 1 |
| O'Brien, TJ | 1 |
| Graham, JE | 1 |
| Lander, CM | 1 |
| Eadie, MJ | 1 |
| Jentink, J | 1 |
| Bakker, MK | 1 |
| Nijenhuis, CM | 1 |
| Wilffert, B | 1 |
| de Jong-van den Berg, LT | 1 |
| Gilboa, SM | 1 |
| Broussard, CS | 1 |
| Devine, OJ | 1 |
| Duwe, KN | 1 |
| Flak, AL | 1 |
| Boulet, SL | 1 |
| Moore, CA | 1 |
| Werler, MM | 1 |
| Honein, MA | 1 |
| Yerby, MS | 1 |
| Emmanouil-Nikoloussi, EN | 1 |
| Foroglou, NG | 1 |
| Kerameos-Foroglou, CH | 1 |
| Thliveris, JA | 1 |
| Alsdorf, R | 1 |
| Wyszynski, DF | 1 |
| Gurvich, N | 1 |
| Berman, MG | 1 |
| Wittner, BS | 1 |
| Gentleman, RC | 1 |
| Klein, PS | 1 |
| Green, JB | 1 |
| Artama, M | 1 |
| Auvinen, A | 1 |
| Raudaskoski, T | 1 |
| Isojärvi, I | 1 |
| Isojärvi, J | 1 |
| Oakeshott, P | 2 |
| Hunt, G | 1 |
| Ehlers, K | 1 |
| Elmazar, MM | 1 |
| Nau, H | 2 |
| Briner, W | 1 |
| Lieske, R | 1 |
| Robert, E | 1 |
| Prieto, L | 1 |
| Martínez-Frías, ML | 2 |
| Omtzigt, JG | 1 |
| Los, FJ | 1 |
| Pijpers, L | 1 |
| Lindhout, D | 1 |
| Tanaka, H | 1 |
| Takeda, A | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
3 reviews available for valproic acid and Cleft Spine
| Article | Year |
|---|---|
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip; | 2005 |
Sodium valproate and spina bifida.
Topics: Female; Humans; Pregnancy; Spinal Dysraphism; Valproic Acid | 1990 |
20 other studies available for valproic acid and Cleft Spine
| Article | Year |
|---|---|
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.
Topics: Abortion, Induced; Child; Female; Humans; Infant; Live Birth; Pregnancy; Spinal Dysraphism; Valproic | 2023 |
A Shared Pathogenic Mechanism for Valproic Acid and
Topics: Anencephaly; Animals; Brain; Female; Glycogen Synthase Kinase 3 beta; Humans; Mice; Mice, Knockout; | 2023 |
Classifying by cause and preventing the many causes of spina bifida and anencephaly.
Topics: Anencephaly; Anticonvulsants; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Food, Fo | 2020 |
Standard of Care: Reasonable But Not Perfect.
Topics: Abnormalities, Drug-Induced; Adult; Arnold-Chiari Malformation; Female; Humans; Hydrocephalus; Infan | 2020 |
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Fol | 2018 |
Dose dependence of fetal malformations associated with valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F | 2013 |
Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Dietary Supplements; Female; Fol | 2010 |
Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States.
Topics: Anticonvulsants; Carbamazepine; Cleft Palate; Female; Humans; Pregnancy; Pregnancy Complications; Pr | 2011 |
Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fetus; Gestational Age; Growt | 2004 |
Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Enzyme Inhibitors; Female; Gene Expression Pr | 2005 |
Antiepileptic drug use of women with epilepsy and congenital malformations in offspring.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cardiovascular Abnormalities; Cleft Palate; Coh | 2005 |
Prevention of neural tube defects.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Female; Folic Acid; Humans; Neural Tube Defects; Pregnan | 1994 |
Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Embryonic and Fetal Development; Female; Incidence | 1996 |
Arnold-Chiari-like malformation associated with a valproate model of spina bifida in the rat.
Topics: Animals; Arnold-Chiari Malformation; Brain; Disease Models, Animal; Female; Fetus; Litter Size; Lumb | 1995 |
[Example of teratogen detection using a birth defects registry: depakine and spina bifida].
Topics: Anticonvulsants; Drug Utilization; Female; France; Humans; Population Surveillance; Pregnancy; Prena | 1996 |
Case-control studies using only malformed infants: are we interpreting the results correctly?
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Congenital Abnormalities; Data Interpretation, St | 1999 |
The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.
Topics: Amniocentesis; Amniotic Fluid; Drug Therapy, Combination; Epilepsy; Female; Gas Chromatography-Mass | 1992 |
Valproic acid and spina bifida.
Topics: Case-Control Studies; Female; Humans; Infant; Pregnancy; Spain; Spinal Dysraphism; Time Factors; Val | 1991 |
Sodium valproate, carbamazepine and spina bifida.
Topics: Carbamazepine; Female; Humans; Pregnancy; Spinal Dysraphism; Valproic Acid | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |