metformin has been researched along with Acanthosis Nigricans in 22 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Acanthosis Nigricans: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the treatment of a 14-year-old Indian boy with acanthosis nigricans and hyperinsulinaemia with metformin in an attempt to improve his skin lesions." | 7.69 | Effect of metformin on glucose disposal and hyperinsulinaemia in a 14-year-old boy with acanthosis nigricans. ( Amiel, SA; Cranston, I; Green, AA; Lee, PJ; O'Rahilly, S, 1997) |
| "Obesity is often accompanied by insulin resistance and/or hyperinsulinemia." | 6.72 | Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study. ( Bellot-Rojas, P; Caracas-Portilla, N; Cardoso-Saldaña, G; Jurado-Santacruz, F; Posadas-Romero, C; Posadas-Sanchez, R; Zamora-Gonzalez, J, 2006) |
| " We report a case of a 55-year-old obese male who developed acanthosis nigricans with striking papillomatosis and tripe palms who experienced improvement on a long-term tapering dosage of isotretinoin, with additional benefit with the addition of metformin." | 5.32 | Improvement of acanthosis nigricans on isotretinoin and metformin. ( Mason, CL; Messingham, M; Myers, LM; Strauss, JS; Walling, HW, 2003) |
| " Weight loss, lifestyle modification and combined hormonal pill and metformin are considered first-line treatment." | 3.96 | Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome): an extreme subphenotype of polycystic ovary syndrome. ( Dahiya, R; Kimble, R; O'Brien, B, 2020) |
| "A MEDLINE literature search was conducted (1950-January 2008) using the search terms acanthosis nigricans (AN), metformin, rosiglitazone, octreotide, retinoic acid, acitretin, etretinate, and isotretinoin." | 3.74 | Treatment options in insulin resistance obesity-related acanthosis nigricans. ( Benavides, S; Romo, A, 2008) |
| "The aim of the present study was to evaluate the effect of metformin in very obese subjects with acanthosis nigricans." | 3.71 | Therapeutic approach in insulin resistance with acanthosis nigricans. ( Dakovska, L; Kirilov, G; Koev, D; Tankova, T, 2002) |
| "We report the treatment of a 14-year-old Indian boy with acanthosis nigricans and hyperinsulinaemia with metformin in an attempt to improve his skin lesions." | 3.69 | Effect of metformin on glucose disposal and hyperinsulinaemia in a 14-year-old boy with acanthosis nigricans. ( Amiel, SA; Cranston, I; Green, AA; Lee, PJ; O'Rahilly, S, 1997) |
| "Obesity is often accompanied by insulin resistance and/or hyperinsulinemia." | 2.72 | Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study. ( Bellot-Rojas, P; Caracas-Portilla, N; Cardoso-Saldaña, G; Jurado-Santacruz, F; Posadas-Romero, C; Posadas-Sanchez, R; Zamora-Gonzalez, J, 2006) |
| "Testing for hyperinsulinemia is essential, also if a gene mutation is confirmed." | 2.46 | FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature. ( Benfeldt, E; Blomberg, M; Jeppesen, EM; Skovby, F, 2010) |
| "Women with severe insulin resistance are a unique subset of polycystic ovary syndrome." | 2.41 | Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. ( Barbieri, RL, 2000) |
| "Type 2 diabetes can present as diabetic ketoacidosis in obese adolescent subjects." | 1.32 | Type 2 diabetes presenting as diabetic ketoacidosis in adolescence. ( Cox, J; Elkeles, RS; Elwig, C; Poulter, C; Valabhji, J; Watson, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, YY | 1 |
| Jiajue, JRZ | 1 |
| Chen, MP | 1 |
| Lu, L | 1 |
| Yu, M | 1 |
| Wang, LJ | 1 |
| O'Brien, B | 1 |
| Dahiya, R | 1 |
| Kimble, R | 1 |
| Rizzo, A | 1 |
| Tognetti, L | 1 |
| Rubegni, P | 1 |
| Cinotti, E | 1 |
| Chang, JE | 1 |
| Choi, MS | 1 |
| Majore, S | 1 |
| Agolini, E | 1 |
| Micale, L | 1 |
| Pascolini, G | 1 |
| Zuppi, P | 1 |
| Cocciadiferro, D | 1 |
| Morlino, S | 1 |
| Mattiuzzo, M | 1 |
| Valiante, M | 1 |
| Castori, M | 1 |
| Novelli, A | 1 |
| Grammatico, P | 1 |
| Giri, D | 1 |
| Alsaffar, H | 1 |
| Ramakrishnan, R | 1 |
| Kępczyńska-Nyk, A | 1 |
| Muszel, M | 1 |
| Radziszewski, M | 1 |
| Wocial, K | 1 |
| Valizadeh, N | 1 |
| Tehrani, MR | 1 |
| Amoli, MM | 1 |
| Bandarian, F | 1 |
| Wasniewska, M | 1 |
| Arrigo, T | 1 |
| Crisafulli, G | 1 |
| Lombardo, F | 1 |
| Messina, MF | 1 |
| Salzano, G | 1 |
| Valenzise, M | 1 |
| De Luca, F | 1 |
| Blomberg, M | 1 |
| Jeppesen, EM | 1 |
| Skovby, F | 1 |
| Benfeldt, E | 1 |
| Tankova, T | 1 |
| Koev, D | 1 |
| Dakovska, L | 1 |
| Kirilov, G | 1 |
| Valabhji, J | 1 |
| Watson, M | 1 |
| Cox, J | 1 |
| Poulter, C | 1 |
| Elwig, C | 1 |
| Elkeles, RS | 1 |
| Walling, HW | 1 |
| Messingham, M | 1 |
| Myers, LM | 1 |
| Mason, CL | 1 |
| Strauss, JS | 1 |
| Hoppin, AG | 1 |
| Katz, ES | 1 |
| Kaplan, LM | 1 |
| Lauwers, GY | 1 |
| Bellot-Rojas, P | 1 |
| Posadas-Sanchez, R | 1 |
| Caracas-Portilla, N | 1 |
| Zamora-Gonzalez, J | 1 |
| Cardoso-Saldaña, G | 1 |
| Jurado-Santacruz, F | 1 |
| Posadas-Romero, C | 1 |
| Inagaki, K | 1 |
| Suzuki, A | 1 |
| Nagata, M | 1 |
| Sekiguchi, S | 1 |
| Itoi, T | 1 |
| Asano, S | 1 |
| Hiroaki, K | 1 |
| Hayakawa, N | 1 |
| Oda, N | 1 |
| Itoh, M | 1 |
| Romo, A | 1 |
| Benavides, S | 1 |
| Lee, PJ | 1 |
| Cranston, I | 1 |
| Amiel, SA | 1 |
| O'Rahilly, S | 1 |
| Green, AA | 1 |
| Roeleveld-Versteegh, AB | 1 |
| Jansen, M | 1 |
| De Vroede, M | 1 |
| Pinhas-Hamiel, O | 1 |
| Zeitler, P | 1 |
| Rique, S | 1 |
| Ibáñez, L | 1 |
| Marcos, MV | 1 |
| Carrascosa, A | 1 |
| Potau, N | 1 |
| Barbieri, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Randomized Trial Using Oral Metformin Versus Placebo in the Treatment of Acanthosis Nigricans in Children With Obesity[NCT02438020] | Phase 4 | 30 participants (Anticipated) | Interventional | 2015-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Acanthosis Nigricans
| Article | Year |
|---|---|
A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders.
Topics: Acanthosis Nigricans; Acne Vulgaris; Dermatitis, Allergic Contact; Hidradenitis Suppurativa; Humans; | 2020 |
FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature.
Topics: Acanthosis Nigricans; Adolescent; Blood Glucose; C-Peptide; Dwarfism; Female; Gonadotropin-Releasing | 2010 |
Induction of ovulation in infertile women with hyperandrogenism and insulin resistance.
Topics: Acanthosis Nigricans; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; In | 2000 |
1 trial available for metformin and Acanthosis Nigricans
| Article | Year |
|---|---|
Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study.
Topics: Acanthosis Nigricans; Administration, Oral; Adult; Female; Humans; Hypoglycemic Agents; Insulin; Ins | 2006 |
18 other studies available for metformin and Acanthosis Nigricans
| Article | Year |
|---|---|
[The 495th case: young female-hyperandrogenemia-severe insulin resistance].
Topics: Acanthosis Nigricans; Adult; Diabetes Mellitus; Female; Hirsutism; Humans; Insulin; Insulin Resistan | 2022 |
Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome): an extreme subphenotype of polycystic ovary syndrome.
Topics: Acanthosis Nigricans; Child; Contraceptives, Oral, Hormonal; Female; Humans; Hyperandrogenism; Insul | 2020 |
Acanthosis nigricans monstre successfully treated with topical tacalcitol, metformin, and oral contraceptives.
Topics: Acanthosis Nigricans; Contraceptives, Oral; Dihydroxycholecalciferols; Female; Humans; Metformin | 2020 |
Clinical presentation and molecular characterization of a novel patient with variant POC1A-related syndrome.
Topics: Acanthosis Nigricans; Adult; Age of Onset; Cell Cycle Proteins; Computer Simulation; Congenital Hype | 2021 |
Acanthosis Nigricans and Its Response to Metformin.
Topics: Acanthosis Nigricans; Adolescent; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; | 2017 |
[Woman 19-old with hirsutism, obesity and acanthosis nigricans].
Topics: Acanthosis Nigricans; Female; Hirsutism; Humans; Hyperandrogenism; Insulin Resistance; Metformin; Ob | 2016 |
Severe acanthosis nigricans in a 17 year-old female with partial lipodystrophic syndrome.
Topics: Acanthosis Nigricans; Adolescent; Diet Therapy; Diet, Carbohydrate-Restricted; Diet, Fat-Restricted; | 2008 |
Recovery of acanthosis nigricans under prolonged metformin treatment in an adolescent with normal weight.
Topics: Acanthosis Nigricans; Adolescent; Follow-Up Studies; Humans; Hypoglycemic Agents; Insulin Resistance | 2009 |
Therapeutic approach in insulin resistance with acanthosis nigricans.
Topics: Acanthosis Nigricans; Adolescent; Adult; Body Mass Index; Body Weight; Diabetes Complications; Diabe | 2002 |
Type 2 diabetes presenting as diabetic ketoacidosis in adolescence.
Topics: Acanthosis Nigricans; Adolescent; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; | 2003 |
Improvement of acanthosis nigricans on isotretinoin and metformin.
Topics: Acanthosis Nigricans; Administration, Oral; Axilla; Drug Administration Schedule; Drug Therapy, Comb | 2003 |
Case records of the Massachusetts General Hospital. Case 31-2006. A 15-year-old girl with severe obesity.
Topics: Acanthosis Nigricans; Adolescent; Body Mass Index; Diabetes Mellitus, Type 2; Fatty Liver; Female; G | 2006 |
[Metformine hydrochloride reduces both acanthosis nigricans and insulin resistance in Japanese young female].
Topics: Acanthosis Nigricans; Adult; Asian People; Diet, Diabetic; Female; Humans; Hypoglycemic Agents; Insu | 2006 |
Treatment options in insulin resistance obesity-related acanthosis nigricans.
Topics: Acanthosis Nigricans; Adolescent; Adult; Calcitriol; Humans; Hyperinsulinism; Hypoglycemic Agents; I | 2008 |
Effect of metformin on glucose disposal and hyperinsulinaemia in a 14-year-old boy with acanthosis nigricans.
Topics: Acanthosis Nigricans; Administration, Oral; Adolescent; Blood Glucose; Glucose Clamp Technique; Gluc | 1997 |
[A twelve-year old girl with diabetes mellitus type 2].
Topics: Acanthosis Nigricans; Candidiasis, Vulvovaginal; Child; Diabetes Mellitus; Diabetes Mellitus, Type 2 | 1998 |
Clinical problem-solving. The importance of a name.
Topics: Acanthosis Nigricans; Adolescent; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1999 |
Effects of metformin on androgens and insulin concentrations in type A insulin resistance syndrome.
Topics: Acanthosis Nigricans; Adolescent; Androgens; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hypo | 2000 |