tretinoin and Acanthosis-Nigricans

Acanthosis nigricans (AN) is a skin disorder with hyperpigmented and velvety plaques without a standardized treatment regimen. We aimed to compare the efficacy and safety profile of 0.025% and 0.05% tretinoin creams in managing AN. An 8-week, randomized double-blinded study was conducted in adults with AN. Participants were instructed to apply tretinoin cream on their posterior neck. Narrowband reflectance spectrophotometry was used to measure skin improvement through melanin (M) and erythema (E) indices at each follow-up visits at weeks 2, 4, and 8. Improvements in Acanthosis nigricans scoring chart (ANSC), investigator- and patient-global evaluation (IGE and PGE) and adverse cutaneous irritations were also scored. Both the 0.025% and 0.05% tretinoin creams were efficacious in acanthosis nigricans treatment with 17.1 ± 8.0% improvement and 18.4 ± 9.8% improvement after 8 weeks treatment by reflectance spectrophotometry measurement, respectively. There were generally no significant differences in efficacy, improvements in ANSC, IGE, and PGE scores, and local cutaneous irritations between the two groups. The 0.025% and 0.05% tretinoin demonstrate similar efficacy and safety profiles in the management of AN. Both concentrations are well tolerated with mild degree of local cutaneous irritation.

Topics: Acanthosis Nigricans; Administration, Cutaneous; Adult; Humans; Immunoglobulin E; Skin; Treatment Outcome; Tretinoin

Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans.. This was an 8-week trial, double-blind, randomized, comparative study of topical 10% urea and 0.025% tretinoin for the treatment of the neck hyperpigmentation. The Mexameter MX18 was used for assessing treatment efficacy. The global evaluation scale was also used to evaluate the overall success rate at weeks 2, 4, and 8 of the study.. There was a statistically significant difference between 10% urea and 0.025% tretinoin in the treatment of acanthosis nigricans (. Both medications significantly improved neck hyperpigmentation. However, the efficacy of 0.025% tretinoin was significantly better than 10% urea in the treatment of acanthosis nigricans.. TCTR20180703003.

Topics: Acanthosis Nigricans; Humans; Keratolytic Agents; Randomized Controlled Trials as Topic; Tretinoin; Urea

Acanthosis nigricans is a common dermatological problem. There are currently limited clinical trials to determine the efficacy and safety of laser treatments. To compare the efficacy of fractional 1550-nm erbium fiber laser versus 0.05% tretinoin cream for the treatment of acanthosis nigricans at neck, a randomized, controlled, assessor-blinded study was conducted in 18 subjects with acanthosis nigricans at the neck. All patients were treated with both fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream on each side of the neck. The laser side was treated with three treatment sessions, with a 4-week interval of 1550-nm fractional erbium laser. Another side was treated with 0.05% tretinoin cream daily at bedtime for 12 weeks. We evaluated at baseline, with a 4-week interval until 4 weeks after the last treatment. The efficacy was assessed by skin color ratio, melanin index, average roughness, photographic evaluation, patients' satisfaction, and the adverse effects. At the study endpoint, week 12, the mean Visiometer-average roughness showed greater reduction in laser-treated side (24.65%) than tretinoin side (22.94%) (p = 0.004). Laser-treated side also showed greater percentage of skin color ratio reduction, melanin index reduction, and better mean of photographic-based evaluation percentage change from the baseline than tretinoin side with no significant different (p = 0.331, p = 0.116, p = 0.327, respectively). The study showed one post-inflammatory hyperpigmentation in tretinoin side. Regarding to the average roughness, fractional 1550-nm erbium fiber laser was superior to 0.05% tretinoin cream for treatment of neck-acanthosis nigricans with less side effect. Fractional 1550-nm erbium fiber laser could be considered as an alternative treatment for acanthosis nigricans.

Topics: Acanthosis Nigricans; Adult; Combined Modality Therapy; Erbium; Female; Humans; Lasers, Solid-State; Male; Melanins; Middle Aged; Patient Satisfaction; Prospective Studies; Treatment Outcome; Tretinoin; Young Adult

There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date.. To assess the efficacy of topical 0.1% adapalene gel compared to 0.025% tretinoin cream in the treatment of childhood AN.. An 8-week, randomized, split-neck, comparative study between topical 0.1% adapalene gel and 0.025% tretinoin cream for the treatment of neck hyperpigmentation associated with AN was performed. M index measured by a narrowband reflectance spectrophotometer and both investigator's global evaluation (IGE) and parent's global evaluation (PGE) scales were used to evaluate efficacy.. There was no statistically significant difference between 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of AN-associated hyperpigmentation (P = 0.56). Mean differences in M indices between week 0 and week 8 of 0.1% adapalene and 0.025% tretinoin treatment were 24.2 ± 7.9% and 23.8 ± 8.3% improvement, respectively. Regarding treatment efficacy, 90.0% and 85.0% of participants had more than 75% improvement in IGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively. In addition, 75.0% and 65.0% of participants had more than 75.0% improvement in PGE in 0.1% adapalene and 0.025% tretinoin treatment sides, respectively.. Lack of histopathological evaluations.. We found no significant difference between topical 0.1% adapalene gel and 0.025% tretinoin in the treatment of AN.

Topics: Acanthosis Nigricans; Adapalene; Administration, Cutaneous; Adolescent; Child; Dermatologic Agents; Double-Blind Method; Female; Gels; Humans; Keratolytic Agents; Male; Neck; Skin Cream; Treatment Outcome; Tretinoin

Topics: Acanthosis Nigricans; Emollients; Humans; Retinoids; Tretinoin

Acanthosis nigricans (AN) is a common dermatological issue with several therapeutic modalities to treat. Despite retinoid is the first drug of choice in the treatment, the fractional-ablative carbon dioxide (CO. To decide whether fractional-ablative CO. In this study, twenty Egyptian cases with neck-AN were enrolled, where each case was exposed to four sessions with 2 weeks apart of both fractional CO. We found a highly statistically significant improvement among both treated groups regarding (ANASI) score and dermatologist's assessments. Bedside, the degree of sulci cutis, cristae cutis, brown-to-dark brown dots, and milia-like cysts, dermoscopic sign improvement was evident in both treated groups. However, fractional CO. Fractional CO

Topics: Acanthosis Nigricans; Carbon Dioxide; Chemexfoliation; Humans; Lasers, Gas; Treatment Outcome; Tretinoin

Acanthosis nigricans (OMIM ID % 100600) is a dermatosis characterized by velvety hyperpigmentation, skin thickening, and papillomatosis. It mainly affects flexural areas. In most cases, the generalized form is related to malignancy in adults; it is rarely reported in the absence of systemic disease in children and adolescents. The present report is aimed at describing an unusual case of generalized acanthosis nigricans in a 17 year-old patient, in which, after extensive investigation (clinical, laboratorial and by imaging methods) no association with systemic disease was found.

Topics: Acanthosis Nigricans; Adolescent; Dermatologic Agents; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lactic Acid; Skin Pigmentation; Tretinoin

Eight cases of the acanthosis nigricans form of epidermal nevus have been described in literature. The present case is impressive and has an extensive segmental distribution. Although etiological factors, such as mutations in the FGFR3 gene, are becoming recognized, treatment options remain limited. We present a case of a 14-year-old male with multiple hyperpigmented, hyperkeratotic plaques on the upper body, axillae, and groin with a segmental distribution following Blaschko lines. Histopathological investigation showed aspects of both acanthosis nigricans and epidermal nevus. So far, screening has not revealed any internal abnormalities. As previous cases show a clear association with internal diseases, repetitive screening for internal diseases and syndromes is suggested in the case of the acanthosis nigricans form of epidermal nevus. Treatment of the condition remains a challenge.

Topics: Acanthosis Nigricans; Adolescent; Antineoplastic Agents; Humans; Male; Nevus; Skin Neoplasms; Tretinoin

Topics: Acanthosis Nigricans; Administration, Topical; Adult; Drug Combinations; Female; Fluocinolone Acetonide; Humans; Hydroquinones; Treatment Outcome; Tretinoin

Topics: Acanthosis Nigricans; Axilla; Causality; Disease Progression; Groin; Humans; Keratolytic Agents; Medical History Taking; Neck; Nursing Assessment; Patient Education as Topic; Physical Examination; Tretinoin

Acanthosis nigricans (AN) is a cutaneous marker of various underlying systemic conditions. To date, no satisfactory topical therapy for this cutaneous disorder has been described. The following is a report of the successful use of a combination of 12% ammonium lactate cream and 0.05% tretinoin cream to treat AN associated with obesity.

Topics: Acanthosis Nigricans; Administration, Topical; Adolescent; Drug Therapy, Combination; Humans; Keratolytic Agents; Lactic Acid; Male; Obesity; Quaternary Ammonium Compounds; Tretinoin

Topics: Acanthosis Nigricans; Adult; Disease Progression; Edema; Fingers; Foot Deformities, Congenital; Hand Deformities, Congenital; Humans; Keratoderma, Palmoplantar; Keratosis; Lip; Male; Mouth; Mouth Mucosa; Nose; Toes; Tretinoin

Topics: Acanthosis Nigricans; Humans; Male; Middle Aged; Tretinoin

Topics: Acanthosis Nigricans; Biopsy; Child; Diagnosis, Differential; Female; Humans; Tretinoin

After a brief introduction about the classification and clinicopathological findings of acanthosis nigricans, we present a clinical case of the familial type of acanthosis nigricans in a woman with lesions beginning in childhood and with three family members affected. We comment the characteristics that permit us to individualize this condition from the other forms of benign acanthosis nigricans.

Topics: Acanthosis Nigricans; Adult; Female; Humans; Salicylates; Salicylic Acid; Tretinoin

Topics: Acanthosis Nigricans; Adult; Female; Humans; Tretinoin

Topics: Acanthosis Nigricans; Administration, Topical; Adolescent; Central Nervous System Diseases; Diverticulum; Female; Gastrointestinal Diseases; Humans; Skin; Sural Nerve; Tretinoin; Vitamin A; Vitamin A Deficiency