spironolactone has been researched along with Acanthosis Nigricans in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Acanthosis Nigricans: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone and oral contraceptives have been used separately with some success in the treatment of hirsutism." | 3.67 | Prolonged suppression of hirsutism with combination therapy in an adolescent with insulin resistance and acanthosis nigricans. ( Moore, DC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amesse, LS | 1 |
| Ding, X | 1 |
| Pfaff-Amesse, T | 1 |
| Azziz, R | 1 |
| Zemtsov, A | 1 |
| Wilson, L | 1 |
| Moore, DC | 1 |
4 other studies available for spironolactone and Acanthosis Nigricans
| Article | Year |
|---|---|
From HAIR-AN to eternity.
Topics: Acanthosis Nigricans; Child; Female; Hirsutism; Humans; Hyperandrogenism; Insulin Resistance; Polycy | 2002 |
The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response.
Topics: Acanthosis Nigricans; Adolescent; Contraceptives, Oral; Drug Therapy, Combination; Female; Humans; H | 1994 |
Successful treatment of hirsutism in HAIR-AN syndrome using flutamide, spironolactone, and birth control therapy.
Topics: Acanthosis Nigricans; Adolescent; Androgen Antagonists; Contraceptives, Oral, Combined; Contraceptiv | 1997 |
Prolonged suppression of hirsutism with combination therapy in an adolescent with insulin resistance and acanthosis nigricans.
Topics: Acanthosis Nigricans; Adolescent; Drug Therapy, Combination; Ethinyl Estradiol; Female; Hirsutism; H | 1987 |