ecteinascidin 729: a complex structure that includes isoquinolines joined by a cyclic ester; Guanine N2 alkylator with potent antiproliferative activity; a marine natural product from Ecteinascidia turbinata; metabolite of ecteinascidin-743 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 368263 |
CHEMBL ID | 1998895 |
MeSH ID | M0263498 |
Synonym |
---|
ecteinascidin 729 |
NSC638718 , |
nsc-638718 |
NCI60_012920 |
CHEMBL1998895 |
et-729 |
[(1s,12s,26s)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21-dimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2h-isoquinoline]-22-yl] acetate |
Excerpt | Reference | Relevance |
---|---|---|
" Intraperitoneal bioavailability varied over a wide range (20-91%)." | ( Preclinical pharmacology of ecteinascidin 729, a marine natural product with potent antitumor activity. Ames, MM; Reid, JM; Walker, DL, 1996) | 0.29 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 4 (80.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 1 (20.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 1 (20.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 3 (60.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |