naphthoquinones and Sarcoma--Synovial

naphthoquinones has been researched along with Sarcoma--Synovial* in 1 studies

Other Studies

1 other study(ies) available for naphthoquinones and Sarcoma--Synovial

Article	Year
Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp. Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4 Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM. Topics: Actinomycetales; Dinoprostone; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Prostaglandin Antagonists; Sarcoma, Synovial	2013

Article

Year

Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp.

Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.

Topics: Actinomycetales; Dinoprostone; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Molecular Structure; Naphthoquinones; Nuclear Magnetic Resonance, Biomolecular; Prostaglandin Antagonists; Sarcoma, Synovial

2013