morphinans and Sarcoma--Synovial

morphinans has been researched along with Sarcoma--Synovial* in 1 studies

Other Studies

1 other study(ies) available for morphinans and Sarcoma--Synovial

Article	Year
pH-dependent, stereoselective dimerization of sinomenine. Organic letters, 2008, Sep-04, Volume: 10, Issue:17 In a continuing study on discovery of more potent derivatives of sinomenine (1), a clinically available alkaloid for rheumatoid arthritis (RA) treatment, oxidation of sinomenine provided two unique stereoisomers, disinomenines 2 and 3. The structure of 3 was determined by MS, NMR, and X-ray analysis. The formation of 2 and 3 via oxidation of sinomenine by potassium permanganate (KMnO4) exhibited a pH-dependent stereoselectivity. The bioassay results using human synovial sarcoma cells (SW982) showed that 2 inhibited, while 3 stimulated, IL-6 production. Topics: Cell Line, Tumor; Crystallography, X-Ray; Dimerization; Humans; Hydrogen-Ion Concentration; Interleukin-6; Morphinans; Oxidation-Reduction; Sarcoma, Synovial; Stereoisomerism	2008

Article

Year

pH-dependent, stereoselective dimerization of sinomenine.

Organic letters, 2008, Sep-04, Volume: 10, Issue:17

In a continuing study on discovery of more potent derivatives of sinomenine (1), a clinically available alkaloid for rheumatoid arthritis (RA) treatment, oxidation of sinomenine provided two unique stereoisomers, disinomenines 2 and 3. The structure of 3 was determined by MS, NMR, and X-ray analysis. The formation of 2 and 3 via oxidation of sinomenine by potassium permanganate (KMnO4) exhibited a pH-dependent stereoselectivity. The bioassay results using human synovial sarcoma cells (SW982) showed that 2 inhibited, while 3 stimulated, IL-6 production.

Topics: Cell Line, Tumor; Crystallography, X-Ray; Dimerization; Humans; Hydrogen-Ion Concentration; Interleukin-6; Morphinans; Oxidation-Reduction; Sarcoma, Synovial; Stereoisomerism

2008