panobinostat and Sarcoma--Synovial

Soft tissue sarcomas (STS) are rare tumours for which treatment options are limited in the advanced setting. Histone deacetylase inhibitors have shown activity in preclinical models of STS.. We conducted a single-arm, open-label, multicentre phase II study to assess the efficacy and tolerability of panobinostat given orally, 40 mg thrice weekly in patients with advanced pretreated STS. The primary endpoint was the 3-month progression-free rate.. Forty-seven STS patients were enrolled between January 2010 and December 2010. Median age was 59 (range 21-79) years, 22 (47%) patients were males. Panobinostat dose was lowered to 20 mg thrice weekly after nine patients were enrolled, based on the recommendation of an independent safety committee. The most common grade 3/4 adverse events were thrombocytopenia, fatigue, lymphopenia and anaemia. Forty-five patients were evaluable for the primary endpoint. Among them, nine patients (20%, 95% CI (10-35%)) were progression-free at 3 months. No partial response was seen, but 17 patients (36%) had stable disease (SD) as their best response. Six patients were progression-free at 6 months.. Panobinostat was poorly tolerated at 40 mg thrice a week. Efficacy in unselected advanced STS was limited, although some patients had prolonged SD.

Topics: Adult; Aged; Antineoplastic Agents; Disease-Free Survival; Female; Humans; Hydroxamic Acids; Indoles; Leiomyosarcoma; Liposarcoma; Liposarcoma, Myxoid; Male; Middle Aged; Nerve Sheath Neoplasms; Panobinostat; Salvage Therapy; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Endometrial Stromal; Sarcoma, Synovial; Treatment Outcome; Young Adult