valproic acid has been researched along with Hypospadias in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 7.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 7.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 3.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 3.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| " The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period." | 1.39 | Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vajda, FJ | 1 |
| O'Brien, TJ | 1 |
| Graham, JE | 1 |
| Lander, CM | 1 |
| Eadie, MJ | 1 |
| Källén, B | 1 |
| Rodríguez-Pinilla, E | 1 |
| Mejías, C | 1 |
| Prieto-Merino, D | 1 |
| Fernández, P | 1 |
| Martínez-Frías, ML | 1 |
3 other studies available for valproic acid and Hypospadias
| Article | Year |
|---|---|
Dose dependence of fetal malformations associated with valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F | 2013 |
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna | 2004 |
Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Female; Humans; Hypospadias; Infant, Newborn; Logis | 2008 |