dibutyl phthalate has been researched along with Hypospadias in 26 studies
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 7.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| "Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development." | 5.62 | The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate. ( Feng, X; Gao, Y; Huang, E; Zhang, Y; Zhou, Y, 2021) |
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 3.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| " Rats were dosed during pregnancy with antiandrogens singly or in pairs at dosage levels equivalent to about one half of the ED50 for hypospadias or epididymal agenesis." | 2.45 | Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. ( Furr, JR; Gray, LE; Hotchkiss, AK; Howdeshell, KL; Lambright, CR; Rider, CV; Wilson, VS, 2009) |
| "For the treatment of hypospadias, a significant number of studies focus on penile reconstruction." | 1.72 | Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate. ( Cong, R; Ji, C; Luan, J; Song, N; Wang, S; Wang, Y; Yao, L; Zhang, Q; Zhang, T; Zhou, R; Zhou, X, 2022) |
| "Hypospadias and cryptorchidism are the most common congenital malformations in male neonates, both of which are also the important clinical manifestations of testicular dysgenesis syndrome and share a same origin." | 1.72 | Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males. ( Abulimiti, G; Cong, R; Ji, C; Luan, J; Song, N; Wang, Y; Yang, J; Yao, L; Zhang, Q; Zhang, X; Zhou, X, 2022) |
| "Dibutyl phthalate (DBP) was used at a high dose level (750 mg/kg bw/day) as an established positive control substance for anti-androgenic effects on the developing male reproductive tract." | 1.56 | Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window. ( Inglis, F; Langsch, A; Otter, R; Palermo, C; Shoker, S; van den Driesche, S, 2020) |
| " With exposed dose increasing, the serum testosterone (T) levels of male rats inversely decreased, and in the same dosage group the serum T levels of hypospadiac rats were significantly lower than the levels of nonhypospadiac counterparts." | 1.34 | Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). ( Jiang, J; Ma, L; Wang, X; Yuan, L; Zhang, W, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 15 (57.69) | 24.3611 |
| 2020's | 7 (26.92) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, X | 5 |
| Wang, S | 1 |
| Zhou, R | 1 |
| Zhang, T | 1 |
| Wang, Y | 4 |
| Zhang, Q | 3 |
| Cong, R | 2 |
| Ji, C | 2 |
| Luan, J | 2 |
| Yao, L | 2 |
| Song, N | 2 |
| Zhang, X | 1 |
| Abulimiti, G | 1 |
| Yang, J | 1 |
| Hua, S | 1 |
| Shi, F | 1 |
| Xie, Z | 1 |
| Wu, L | 1 |
| Dai, M | 1 |
| Zhang, Y | 3 |
| Xu, X | 1 |
| Zhu, Y | 1 |
| Jiang, J | 2 |
| Elwood, JM | 1 |
| Zhao, S | 3 |
| Pan, L | 2 |
| Chen, M | 2 |
| Zhu, YP | 5 |
| Han, BM | 2 |
| Xia, SJ | 4 |
| Jiang, JT | 7 |
| Zhao, W | 3 |
| Sun, WL | 5 |
| Zhou, Z | 1 |
| van den Driesche, S | 1 |
| Shoker, S | 1 |
| Inglis, F | 1 |
| Palermo, C | 1 |
| Langsch, A | 1 |
| Otter, R | 1 |
| Feng, X | 1 |
| Huang, E | 1 |
| Gao, Y | 1 |
| Zhou, Y | 2 |
| Li, EH | 4 |
| Wei, HB | 1 |
| Lhuangi, BG | 1 |
| Xu, ZH | 1 |
| Zhang, DH | 1 |
| Li, D | 1 |
| Bei, XY | 1 |
| Shen, C | 1 |
| Wood, K | 3 |
| Zhao, Z | 1 |
| Liu, GC | 1 |
| Fu, W | 1 |
| Li, N | 1 |
| Chen, X | 1 |
| Zhang, W | 4 |
| Yuan, J | 1 |
| Feng, J | 1 |
| Zhong, C | 1 |
| Xu, DL | 2 |
| Liu, ZH | 2 |
| Ruan, Y | 1 |
| Li, X | 1 |
| Li, J | 1 |
| Rider, CV | 1 |
| Wilson, VS | 1 |
| Howdeshell, KL | 1 |
| Hotchkiss, AK | 1 |
| Furr, JR | 1 |
| Lambright, CR | 1 |
| Gray, LE | 1 |
| Zhu, YJ | 1 |
| Ma, L | 3 |
| Zhang, J | 1 |
| Hong, Y | 2 |
| Liao, K | 1 |
| Liu, Q | 2 |
| Liu, GH | 1 |
| Kim, TS | 1 |
| Jung, KK | 1 |
| Kim, SS | 1 |
| Kang, IH | 1 |
| Baek, JH | 1 |
| Nam, HS | 1 |
| Hong, SK | 1 |
| Lee, BM | 1 |
| Hong, JT | 1 |
| Oh, KW | 1 |
| Kim, HS | 1 |
| Han, SY | 1 |
| Kang, TS | 1 |
| Chang, JK | 1 |
| Shen, BX | 1 |
| Wei, YF | 1 |
| Zhang, LF | 2 |
| Feng, NH | 1 |
| Liu, SB | 1 |
| Ma, Z | 1 |
| Sun, XW | 1 |
| Qin, C | 1 |
| Stratton, HJ | 1 |
| Zhou, YJ | 1 |
| Wei, JF | 1 |
| Carran, M | 1 |
| Shaw, IC | 1 |
| McBride, D | 1 |
| Schep, L | 1 |
| Elwood, M | 1 |
| Borman, B | 1 |
| Nakahara, H | 1 |
| Shono, T | 1 |
| Suita, S | 1 |
| Yuan, L | 1 |
| Wang, X | 1 |
1 review available for dibutyl phthalate and Hypospadias
| Article | Year |
|---|---|
Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development.
Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Complex Mixtures; Dibutyl Phthalate; Dieth | 2009 |
25 other studies available for dibutyl phthalate and Hypospadias
| Article | Year |
|---|---|
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Topics: Animals; bcl-2-Associated X Protein; Body Weight; Caspase 3; Dibutyl Phthalate; Erectile Dysfunction | 2022 |
Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Endocrine Disruptors; Female; Genitalia; Humans; Hypospa | 2022 |
Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats.
Topics: Animals; Cytokines; Dibutyl Phthalate; Endothelium, Vascular; Epithelial-Mesenchymal Transition; Fem | 2023 |
Hypospadias, cryptorchidism, and breast cancer in children born to New Zealand servicemen who served in Malaya and may have had exposure to dibutyl phthalate: review of a previous study and updated review of international literature.
Topics: Breast Neoplasms; Child; Cryptorchidism; Dibutyl Phthalate; Female; Humans; Hypospadias; Malaysia; M | 2023 |
Di-n-butyl phthalate induced autophagy of uroepithelial cells via inhibition of hedgehog signaling in newborn male hypospadias rats.
Topics: Animals; Animals, Newborn; Autophagy; Cells, Cultured; Dibutyl Phthalate; Epithelial Cells; Gene Exp | 2019 |
Di-n-butyl phthalate (DBP) reduces epithelial-mesenchymal transition via IP3R in hypospadias during maternal exposure.
Topics: Animals; beta Catenin; Cadherins; Calcium; Dibutyl Phthalate; Epithelial Cells; Epithelial-Mesenchym | 2020 |
Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptors; | 2020 |
The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate.
Topics: Animals; Autophagy; Dibutyl Phthalate; Female; Fibroblasts; Humans; Hypospadias; Male; Maternal Expo | 2021 |
[Hypospadias induced by maternal exposure to di-n-butyl phthalate and its mechanisms in male rat offspring , , , , ,].
Topics: Animals; Body Weight; Bone Morphogenetic Protein 4; Dibutyl Phthalate; Female; Fibroblast Growth Fac | 2017 |
Maternal exposure to di-n-butyl phthalate (DBP) promotes epithelial-mesenchymal transition via regulation of autophagy in uroepithelial cell.
Topics: Animals; Autophagy; Cells, Cultured; Dibutyl Phthalate; Epithelial-Mesenchymal Transition; Female; H | 2018 |
Role of PERK-eIF2α signaling pathway in fetal male rats with hypospadias induced by di-n-butyl phthalate.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Dibutyl Phthalate; eIF-2 Kinase; Eukaryotic I | 2018 |
The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats.
Topics: Anal Canal; Animals; Biomarkers; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug | 2015 |
Prenatal exposure to di-n-butyl phthalate (DBP) differentially alters androgen cascade in undeformed versus hypospadiac male rat offspring.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Dibutyl Phthalate; Endocrine Disruptors; Female; Hyp | 2016 |
Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring.
Topics: Animals; Animals, Newborn; Anorectal Malformations; Dibutyl Phthalate; DNA-Binding Proteins; Female; | 2016 |
Di-n-butyl phthalate induced hypospadias relates to autophagy in genital tubercle via the PI3K/Akt/mTOR pathway.
Topics: Animals; Apoptosis; Autophagy; Carrier Proteins; Dibutyl Phthalate; Female; Fetus; Hypospadias; Male | 2017 |
Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Animals, Newborn; Bone Morphogenetic Proteins; Dibutyl Phthalate; Female; Fetal Development | 2009 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
[Proteomic analysis of the testis and differential expression of Annexin A3 in hypospadiac rats].
Topics: Animals; Animals, Newborn; Annexin A3; Dibutyl Phthalate; Epispadias; Female; Hypospadias; Male; Mat | 2010 |
The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Environmental Pollutants; Female; Fibroblast Gro | 2012 |
[Expression of Notch1 in the genital tubercle of male rats with hypospadias induced by Di-n-butyl phthalate].
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Hypospadias; Male; Rats; Rats, Sprague-Dawley; Receptor, | 2012 |
New Zealand Malayan war veterans' exposure to dibutylphthalate is associated with an increased incidence of cryptorchidism, hypospadias and breast cancer in their children.
Topics: Acaricides; Adult; Breast Neoplasms; Clothing; Cryptorchidism; Dibutyl Phthalate; Female; Genital Di | 2012 |
Comment on Carran and Shaw's "New Zealand Malayan war veterans' exposure to dibutylphthalate" article.
Topics: Acaricides; Breast Neoplasms; Cryptorchidism; Dibutyl Phthalate; Female; Humans; Hypospadias; Male; | 2012 |
Increases in disease in Malayan war veterans' children may be misleading.
Topics: Acaricides; Breast Neoplasms; Cryptorchidism; Dibutyl Phthalate; Female; Humans; Hypospadias; Male; | 2012 |
[Effects of prenatal exposure to phthalate ester on both testicular descent and urogenital development in rats].
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Female; Hypospadias; Male; Pregnancy; Prenatal Exposure | 2003 |
Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Animals, Newborn; Birth Weight; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Re | 2007 |