flutamide has been researched along with Hypospadias in 9 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 7.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology." | 7.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 7.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| "The incidence of hypospadias increased with the dose of flutamide (0, 29." | 3.73 | [Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006) |
| "The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring." | 3.72 | Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004) |
| "To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology." | 3.72 | [A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004) |
| "Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls." | 3.72 | Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004) |
| "The incidence of hypospadias is increasing in young boys, but it remains unclear whether human exposure to endocrine disrupting chemicals plays a role." | 1.35 | Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Kortenkamp, A; Scholze, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rübben, I | 1 |
| Stein, R | 1 |
| Kim, TS | 1 |
| Jung, KK | 1 |
| Kim, SS | 1 |
| Kang, IH | 1 |
| Baek, JH | 1 |
| Nam, HS | 1 |
| Hong, SK | 1 |
| Lee, BM | 1 |
| Hong, JT | 1 |
| Oh, KW | 1 |
| Kim, HS | 1 |
| Han, SY | 1 |
| Kang, TS | 1 |
| Kurokawa, S | 1 |
| Kojima, Y | 1 |
| Mizuno, K | 1 |
| Kamisawa, H | 1 |
| Tozawa, K | 1 |
| Kohri, K | 1 |
| Hayashi, Y | 1 |
| Källén, B | 1 |
| He, H | 1 |
| Zhang, W | 1 |
| Zhu, J | 1 |
| Goto, K | 1 |
| Koizumi, K | 1 |
| Takaori, H | 1 |
| Fujii, Y | 1 |
| Furuyama, Y | 1 |
| Saika, O | 1 |
| Suzuki, H | 1 |
| Saito, K | 1 |
| Suzuki, K | 1 |
| Li, Y | 1 |
| Zhang, H | 1 |
| Wang, WD | 1 |
| Liang, Y | 1 |
| Wu, DS | 1 |
| Christiansen, S | 1 |
| Scholze, M | 1 |
| Axelstad, M | 1 |
| Boberg, J | 1 |
| Kortenkamp, A | 1 |
| Hass, U | 1 |
| Silversides, DW | 1 |
| Price, CA | 1 |
| Cooke, GM | 1 |
1 review available for flutamide and Hypospadias
| Article | Year |
|---|---|
[Hypospadias : Insights and challenges].
Topics: Animals; Disease Models, Animal; Female; Flutamide; Humans; Hypospadias; Male; Mice; Plastic Surgery | 2017 |
8 other studies available for flutamide and Hypospadias
| Article | Year |
|---|---|
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
Association of prolactin-induced protein with preputial development of hypospadias.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Carrier Proteins; Case-Control S | 2012 |
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna | 2004 |
[A mouse model of hypospadias induced by flutamide].
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Fetus; Flutamide; Hypospadias; Male; | 2004 |
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation | 2004 |
[Impact of flutamide on sex differentiation in rats].
Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren | 2006 |
Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat.
Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Flutamide; Hypospadias; Male; Oxazoles; Ra | 2008 |
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestationa | 1995 |