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flutamide and Hypospadias

flutamide has been researched along with Hypospadias in 9 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.

Research Excerpts

ExcerptRelevanceReference
"The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring."7.72Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004)
"To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology."7.72[A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."7.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
"The incidence of hypospadias increased with the dose of flutamide (0, 29."3.73[Impact of flutamide on sex differentiation in rats]. ( Li, Y; Liang, Y; Wang, WD; Wu, DS; Zhang, H, 2006)
"The use of valproic acid during human pregnancy increases the risk of hypospadias in the offspring."3.72Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats. ( Källén, B, 2004)
"To establish a mouse model of hypospadias induced by flutamide to further studying molecular mechanisms of hypospadias etiology."3.72[A mouse model of hypospadias induced by flutamide]. ( He, H; Zhang, W; Zhu, J, 2004)
"Flutamide, when administered subcutaneously to female rats at doses of 3, 10, or 30 mg/kg/day during late pregnancy (gestational days 16-21), significantly and dose-dependently decreased anogenital distance (AGD) of the male offspring in each dose group compared to controls."3.72Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy. ( Fujii, Y; Furuyama, Y; Goto, K; Koizumi, K; Saika, O; Saito, K; Suzuki, H; Suzuki, K; Takaori, H, 2004)
"The incidence of hypospadias is increasing in young boys, but it remains unclear whether human exposure to endocrine disrupting chemicals plays a role."1.35Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. ( Axelstad, M; Boberg, J; Christiansen, S; Hass, U; Kortenkamp, A; Scholze, M, 2008)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rübben, I1
Stein, R1
Kim, TS1
Jung, KK1
Kim, SS1
Kang, IH1
Baek, JH1
Nam, HS1
Hong, SK1
Lee, BM1
Hong, JT1
Oh, KW1
Kim, HS1
Han, SY1
Kang, TS1
Kurokawa, S1
Kojima, Y1
Mizuno, K1
Kamisawa, H1
Tozawa, K1
Kohri, K1
Hayashi, Y1
Källén, B1
He, H1
Zhang, W1
Zhu, J1
Goto, K1
Koizumi, K1
Takaori, H1
Fujii, Y1
Furuyama, Y1
Saika, O1
Suzuki, H1
Saito, K1
Suzuki, K1
Li, Y1
Zhang, H1
Wang, WD1
Liang, Y1
Wu, DS1
Christiansen, S1
Scholze, M1
Axelstad, M1
Boberg, J1
Kortenkamp, A1
Hass, U1
Silversides, DW1
Price, CA1
Cooke, GM1

Reviews

1 review available for flutamide and Hypospadias

ArticleYear
[Hypospadias : Insights and challenges].
    Der Urologe. Ausg. A, 2017, Volume: 56, Issue:10

    Topics: Animals; Disease Models, Animal; Female; Flutamide; Humans; Hypospadias; Male; Mice; Plastic Surgery

2017

Other Studies

8 other studies available for flutamide and Hypospadias

ArticleYear
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:21-22

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht

2010
Association of prolactin-induced protein with preputial development of hypospadias.
    BJU international, 2012, Volume: 109, Issue:6

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Blotting, Western; Carrier Proteins; Case-Control S

2012
Valproic acid is known to cause hypospadias in man but does not reduce anogenital distance or causes hypospadias in rats.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:1

    Topics: Androgen Antagonists; Animals; Anticonvulsants; Female; Flutamide; Humans; Hypospadias; Male; Pregna

2004
[A mouse model of hypospadias induced by flutamide].
    Zhonghua nan ke xue = National journal of andrology, 2004, Volume: 10, Issue:3

    Topics: Androgen Antagonists; Animals; Disease Models, Animal; Female; Fetus; Flutamide; Hypospadias; Male;

2004
Effects of flutamide on sex maturation and behavior of offspring born to female rats treated during late pregnancy.
    The Journal of toxicological sciences, 2004, Volume: 29, Issue:5

    Topics: Androgen Antagonists; Animals; Animals, Newborn; Body Weight; Cryptorchidism; Dose-Response Relation

2004
[Impact of flutamide on sex differentiation in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:2

    Topics: Androgen Antagonists; Animals; Cryptorchidism; Female; Flutamide; Hypospadias; Male; Pregnancy; Pren

2006
Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat.
    International journal of andrology, 2008, Volume: 31, Issue:2

    Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Flutamide; Hypospadias; Male; Oxazoles; Ra

2008
Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice.
    Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:11

    Topics: Androgen Antagonists; Androgens; Animals; Epididymis; Female; Flutamide; Genitalia, Male; Gestationa

1995