Giant Osteoid Osteoma

A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue. It occurs frequently in the spine of young persons. (From Dorland, 27th ed; Stedman, 25th ed)

Synonym
Giant Osteoid Osteoma
Osteoma, Giant Osteoid
Osteoblastoma

Excerpt	Reference
"Osteoblastoma is a rare primary bone tumor that is curable by complete excision."	( Aribal, E; Ataoglu, O; Berberoglu, S; Oguz, A, 1997)
"The benign osteoblastoma is rarely seen as a tumor of the facial bone in infancy or early childhood."	( Imai, K; Matsuda, Y; Sakamoto, H; Sung, KC; Tajima, S; Toda, C; Tsujiguchi, K, 1997)
"Osteoblastoma is a benign bone tumor with uncertain radiologic and typical histologic pattern that, in most cases, can be diagnosed without any problems."	( Adler, CP, 2000)
"Benign osteoblastoma is an unusual primary bone tumor."	( Bilgic, B; Gunaldi, O; Gunes, M; Tanriverdi, O; Tugcu, B, 2008)
"Osteoblastoma is an extremely rare entity that represents less than 1% of all bone tumors, and affects twice as many males as females with peak incidence between 15 and 20 years."	( Rybak, LD; Steiner, GC; Villalobos, CE; Wittig, JC, 2010)
"Osteoblastoma is similar to OO in their histopathology features, but emerges frequently in the spine, and has a larger diameter than OO."	( Chechick, A; Eshed, I; Gerniak, A; Liberman, B; Shabshin, N; Weiss, I, 2010)
"Osteoblastomas are rare tumors accounting for approximately 1% of all primary bone tumors."	( Huellner, M; Kuttenberger, J; Merwald, M; Strobel, K; Zenklusen, HR, 2013)
"Osteoblastoma is a relatively rare benign primary bone tumor and occurs predominantly in patients younger than 20 y."	( Al-Muqbel, KM; Al-Omari, MH; Alqudah, MA; Audat, ZA, 2013)
"Frontal sinus osteoblastoma is a rare condition."	( Hicks, KL; Humphreys, IM; Moe, KS, 2018)
"Epithelioid osteoblastoma is a clinically aggressive subtype of osteoblastoma that favors the mandible and the maxilla."	( Al-Ibraheem, A; Barakat, A; Dergham, MY; Haddad, H; Haidar, MB; Hourani, M; Khoury, N; Maroun, G; Saleh, A; Yacoub, B, 2019)

Excerpt	Reference
"Osteoblastoma has been reported to be metabolically active on (18)F-FDG PET imaging, with an average standarized uptake value of 3."	( Al-Muqbel, KM; Al-Omari, MH; Alqudah, MA; Audat, ZA, 2013)
"The malignant osteoblastoma has poor prognosis, thus the search for novel and more efficient chemo-agents against this disease is urgent."	( Dai, J; Guo, ZX; Wang, XD; Zhang, Y; Zhen, YF; Zhu, LQ, 2013)

Excerpt	Reference
"Osteoblastoma affecting the calvarium is extremely rare."	( Bilgic, B; Gunaldi, O; Gunes, M; Tanriverdi, O; Tugcu, B, 2008)

Excerpt	Reference
"We report a 32-year-old male with an osteoblastoma of this sternum who was treated with an en-bloc resection and reconstruction with Marlex((R)) and a methylmethacrylate plate."	( Rybak, LD; Steiner, GC; Villalobos, CE; Wittig, JC, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (4.35)	23.3326
1990's	9 (19.57)	12.5806
2000's	14 (30.43)	18.1394
2010's	15 (32.61)	28.8240
2020's	6 (13.04)	9.53

Drug	Relationship Strength	Studies	Trials
aspirin	low	1	0
pamidronate	low	1	0
sodium fluoride	medium	1	1
ticlopidine	low	1	0
trifluoperazine	low	1	0
methylmethacrylate	low	1	0
4-butyrolactone	low	1	0
technetium	low	1	0
titanium	low	1	0
gadolinium	low	1	0
tetradecanoylphorbol acetate	low	1	0
8-bromo cyclic adenosine monophosphate	low	1	0
gallium citrate	low	1	0
propiconazole	low	1	0
clopidogrel	low	1	0
vanadates	low	1	0
glucose, (beta-d)-isomer	low	1	0
fluorodeoxyglucose f18	low	8	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
lanosterol	low	1	0
isomethyleugenol	low	1	0
thiourea	low	1	0
tamoxifen	low	1	0
salinomycin	low	1	0
dinoprostone	low	1	0
calcitriol	low	1	0
6-ketoprostaglandin f1 alpha	low	1	0
genistein	low	1	0
thromboxane b2	low	1	0
ligustilide	low	1	0
strontium	low	1	0
gallium	low	1	0
phosphorus	low	1	0
salubrinal	low	1	0
radium	medium	1	1
s-nitroso-n-acetylpenicillamine	low	1	0
sq-23377	low	1	0
staurosporine	low	1	0
bufotalin	low	1	0
jaw	low	1	0
technetium tc 99m sestamibi	low	1	0
phytoestrogens	low	1	0
kiss1 protein, human	low	1	0
technetium tc 99m medronate	low	6	0
sapropterin	low	1	0

Protein Targets (535)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	10	0	0	10
pregnane X nuclear receptor	6	0	0	6
peroxisome proliferator-activated receptor delta	6	0	0	6
Solute carrier organic anion transporter family member 2A1	0	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
thioredoxin reductase	2	0	0	2
GLS protein	2	0	0	2
AR protein	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
thyroid stimulating hormone receptor	6	0	0	6
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	5	0	0	5
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen nuclear receptor alpha	8	0	0	8
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	3	0	0	3
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
Bloom syndrome protein isoform 1	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	4
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	6	0	6
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	0	6
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	5	0	0	5
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	4	0	0	4
PPM1D protein	3	0	0	3
Microtubule-associated protein tau	7	0	0	7
thioredoxin glutathione reductase	1	0	0	1
mitogen-activated protein kinase 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	8	0	0	8
peripheral myelin protein 22	5	0	0	5
Interferon beta	5	0	0	5
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 3A4	0	4	1	6
Androgen receptor	0	2	0	3
Cytochrome P450 2D6	0	2	0	2
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	2	0	3
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	4	0	4
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Chain A, Cruzipain	3	0	0	3
Luciferase	3	0	0	3
acid sphingomyelinase	2	0	0	2
acetylcholinesterase	3	0	0	3
PAX8	0	0	0	1
glp-1 receptor, partial	5	0	0	5
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
TDP1 protein	7	0	0	7
GLI family zinc finger 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	5	0	0	5
farnesoid X nuclear receptor	5	0	0	5
G	3	0	0	3
67.9K protein	4	0	0	4
Parkin	2	0	0	2
peroxisome proliferator activated receptor gamma	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
heat shock protein 90	0	0	1	1
caspase-3	2	0	0	2
calcineurin A1, putative	0	0	1	1
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
cytochrome P450 2D6 isoform 1	4	0	0	4
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	6	0	0	6
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
snurportin-1	1	0	0	1
melanocortin receptor 4	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	5	0	0	5
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
lamin isoform A-delta10	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Glutathione reductase, mitochondrial	0	1	0	2
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	5	0	0	5
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Trypanothione reductase	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Alpha-synuclein	2	0	0	2
Histamine H2 receptor	5	0	0	5
Spike glycoprotein	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
TAR DNA-binding protein 43	2	0	0	2
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	5	0	0	5
Inositol hexakisphosphate kinase 1	3	0	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
nonstructural protein 1	2	0	0	2
chromobox protein homolog 1	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	4	0	4
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	4	0	4
P2Y purinoceptor 12	0	1	0	1
regulator of G-protein signaling 4	3	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
BRCA1	1	0	0	1
ATAD5 protein, partial	4	0	0	4
Thrombopoietin	3	0	0	3
Neuraminidase	0	1	0	1
P53	1	0	0	1
Alpha-mannosidase	0	1	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
glucokinase regulatory protein	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
DNA polymerase beta	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
tyrosine-protein kinase Yes	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
pyruvate kinase PKM isoform b	1	0	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Transthyretin	0	1	0	1
Estrogen receptor	0	4	2	7
Glucocorticoid receptor	0	0	0	1
Sex hormone-binding globulin	0	0	1	1
Tyrosine-protein kinase Fyn	0	2	0	2
Cyclin-dependent kinase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	2	6
Ornithine decarboxylase	1	0	0	1
Sialidase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Tyrosinase	0	1	0	1
Steroid hormone receptor ERR1	0	2	0	2
Aromatase	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Androgen receptor	0	3	0	3
Protein kinase C alpha type	0	3	1	4
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Cruzipain	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Adenosine receptor A2a	0	4	0	4
Adenosine receptor A1	0	4	0	4
Sodium-dependent serotonin transporter	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Oxysterols receptor LXR-beta	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
MO15-related protein kinase Pfmrk	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Aldehyde oxidase	0	1	0	1
Oxysterols receptor LXR-alpha	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Estrogen receptor beta	0	4	2	6
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Sialidase-2	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chymotrypsinogen A	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Alpha-crystallin B chain	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Lanosterol 14-alpha demethylase	0	0	0	1
14-alpha sterol demethylase	0	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
heat shock protein 90, putative	0	0	0	1
Adenosine transporter 1	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Nitric oxide synthase, brain	0	0	1	1
Carbonic anhydrase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, CES1 protein	0	1	0	1
Fumarate hydratase	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
DNA polymerase III, partial	1	0	0	1
polyprotein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
arylsulfatase A	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
caspase-3	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	2	1	3
Protein kinase C alpha type	0	2	0	2
Protein kinase C beta type	0	2	1	3
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Protein kinase C delta type	0	2	0	2
Protein kinase C epsilon type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Protein kinase C eta type	0	1	1	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	1	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	2	1	3
Protein kinase C theta type	0	1	1	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	2	1	3
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Serine/threonine-protein kinase D1	0	1	1	2
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Emopamil-binding protein-like	0	2	0	2
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	2	0	2
Luciferin 4-monooxygenase	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Ras guanyl-releasing protein 3	0	0	1	1
isocitrate dehydrogenase 1, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
5-hydroxytryptamine receptor 2A	0	1	1	2
Urease subunit alpha	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Bile salt export pump	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Genome polyprotein	0	1	0	1
NFKB1 protein, partial	1	0	0	1
Smad3	1	0	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Beta-glucuronidase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	0	1	1
Calmodulin-1	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	0	1	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
D(2) dopamine receptor	0	1	1	2
Calmodulin	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Calcium-dependent protein kinase 4	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Receptor-type tyrosine-protein phosphatase F	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

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Overview

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Treatment

Research

Studies (46)

Protein Targets (535)

Giant Osteoid Osteoma

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (46)

Drugs Studied (56)

Protein Targets (535)