Compounds > nequinate
Page last updated: 2024-12-06

nequinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

nequinate: minor descriptor (75-88); on line & & INDEX MEDICUS search QUINOLINES (75-88) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID26383
CHEMBL ID2104807
CHEBI ID166580
SCHEMBL ID1509158
MeSH IDM0159808

Synonyms (74)

Synonym
CHEBI:166580
methyl 6-butyl-4-oxo-7-phenylmethoxy-1h-quinoline-3-carboxylate
NCGC00181762-01
methyl benzoquate
methyl 7-benzyloxy-6-butyl-4-oxo-1h-quinoline-3-carboxylate
13997-19-8
6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-3-quinolinecarboxylic acid methyl ester
D05144
nequinate (usan)
nequinate
FT-0658003
A807605
methyl 6-butyl-4-oxidanylidene-7-phenylmethoxy-1h-quinoline-3-carboxylate
6-butyl-4-oxo-7-phenylmethoxy-1h-quinoline-3-carboxylic acid methyl ester
nequinate [usan:inn]
unii-91ze013933
nequinato [inn-spanish]
91ze013933 ,
nequinato
ici 55052
ay 20385
methyl 7-(benzyloxy)-6-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylate
einecs 237-796-6
nequinatum [inn-latin]
nequinatum
ai3-52600
ay-20,385
ay 20,385
3-quinolinecarboxylic acid, 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-, methyl ester
ici 55,052
cas-13997-19-8
tox21_112945
dtxsid2048610 ,
dtxcid5028536
methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
ay-20385
CHEMBL2104807
ici-55052
neoquate
AKOS015895762
nequinate [inn]
nequinate [usan]
nequinate [green book]
methyl benzoquate [mart.]
nequinate [mi]
methyl-7-benzyloxy-6-butyl-1,4-dihydro-4-oxoquinoline-3-carboxylate
SCHEMBL1509158
NNOPDLNHPOLRRE-UHFFFAOYSA-N
tranil
statyl
3-quinolinecarboxylic acid, 7-(benzyloxy)-6-butyl-1,4-dihydro-4-oxo-, methyl ester
7-benzyloxy-6-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methyl ester
6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-3-quinolinecarboxylic acidmethyl ester
methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate #
neqoinate
mequinate
statoquate
methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate
AC-24658
J-522568
nequinate, vetranal(tm), analytical standard
methyl 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-3-quinolinecarboxylate, 9ci
methyl benzoquate, ban
methyl 7-(benzyloxy)-6-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 8ci
J-007341
mfcd00867198
DB11433
DS-16282
HY-116433
BCP13128
tert-butyl4-chloro-3-hydroxypyridin-2-ylcarbamate
CS-0065468
Q27271439
H10632

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
quinolinesA class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1149070Anticoccidal activity against Eimeria tenella assessed as improved weight gain in chicken at 0.002%, po1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Products from furans. 1. Sunthesis and anticoccidial and antimicrobial activity of 5-amino-5,6-dihydro-6-methoxy-2-methyl-2-(4'-biphenylyl)-2H-pyran-3(4H)-ones and related compounds.
AID1149069Anticoccidal activity against Eimeria acervulina assessed as improved weight gain and mortality in chicken relative to noninfected control1976Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
Products from furans. 1. Sunthesis and anticoccidial and antimicrobial activity of 5-amino-5,6-dihydro-6-methoxy-2-methyl-2-(4'-biphenylyl)-2H-pyran-3(4H)-ones and related compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (58.33)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's2 (16.67)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.99 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.13 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (7.14%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amprolium
Amprolium: A veterinary coccidiostat that interferes with THIAMINE metabolism.. amprolium : An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.. amprolium(1+) : A pyridinium ion that is the cationic portion of amprolium, a veterinary drug which is used for prevention of coccidiosis in poultry and cattle.		2.3820pyridinium ioncoccidiostat
dinitolmide
Dinitolmide: A coccidiostat for poultry.		1.9710dinitrotoluene
sulfaquinoxaline
Sulfaquinoxaline: An antiprotozoal agent used to combat coccidial infections of swine, cattle, fowl, and other veterinary animals. Also used in controlling outbreaks of fowl typhoid and fowl cholera and in treatment of infectious enteritis.		1.9610benzenes;
sulfonamide
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		4.8681monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		1.9910azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
nicarbazin
Nicarbazin: An equimolar complex of 4,4'-Dinitrocarbanilide and 2-Hydroxy-4,6-dimethylpyrimidine. A coccidiostat for poultry.		2.3920organic molecular entity
clopidol
pharmcoccide: Russian drug; no other info available 1/1/79		4.4551chloropyridine
buquinolate
[no description available]		7.0610
halofuginone
[no description available]		1.9910quinazolines
monensin
Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.. monensin A : A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.		1.9910cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal		antifungal agent;
coccidiostat;
ionophore
diclazuril
[no description available]		1.9710nitrile
salinomycin
salinomycin: from Streptomyces albus; RN given refers to parent cpd; structure		2.3820polyketide;
spiroketal		animal growth promotant;
potassium ionophore
robenidine
Robenidine: An anticoccidial agent mainly for poultry.		4.2641
chiniofon
Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.		2.0610
piperidines
Piperidines: A family of hexahydropyridines.		1.9910
narasin
narasin: related to salinomycin & A28086B; structure; RN given refers to parent cpd		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Besnoitiasis
[description not available]		04.6161
Liver Diseases, Parasitic
Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).		02.3620
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		03.3511
Poultry Diseases
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.		02.6730