salinomycin and Poisoning

A flock of 4287 heavy hybrid turkey hens were accidentally fed broiler premix containing salinomycin sodium and suffered a 34.5% death loss. Measures taken to ensure food safety for the remaining flock and consumer food safety included feed record studies, on-farm veterinary consultation, diagnostic laboratory studies, and CgFARAD and CFIA consultation. The remaining turkeys were processed 3 weeks after the initial toxicosis with no evidence of lesions that would render the product unfit for human consumption.

Topics: Animal Feed; Animals; Coccidiostats; Consumer Product Safety; Female; Humans; Meat; Poisoning; Poultry Diseases; Pyrans; Turkeys

24 cases of salinomycin poisoning in horses occurring recently in Silesia are discussed. All of these horses, used for riding-purposes, were fed with concentrate containing 61 mg/kg salinomycin as faulty prepared by the manufacturer. Each horse received approximately two to three kilograms of this forage. All horses developed severe clinical signs of intoxication. Despite therapy eight horses died within three to six days. Ten others became recumbent and had to be euthanased. Only six horses survived. Clinical and laboratory examinations were performed and are discussed. Laboratory examination of blood included red blood cell count, haematocrit, concentration of haemoglobin, enzyme activities of ASAT, ALAT and AP, also levels of urea, creatinine, sodium, potassium, magnesium, calcium and inorganic phosphor. Blood gas was also analysed. The dominating laboratory results were very high enzyme levels and alkalosis. The most characteristic clinical change appeared as paralysis of the hindlimbs.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Electrolytes; Erythrocyte Count; Euthanasia; Germany; Hematocrit; Hemoglobins; Horse Diseases; Horses; Male; Poisoning; Poland; Pyrans

Topics: Animals; Coccidiostats; Ionophores; Kidney; Liver; Lung; Poisoning; Pyrans; Swine; Urinary Bladder

Experimentally induced salinomycin toxicosis in weanling pigs showed typical clinical signs of an intoxication with a polyether antibiotic. Severe ataxia and recumbency were the most prominent symptoms, which could be attributed to acute skeletal muscle necrosis by estimation of muscle enzyme activities (creatine kinase, aspartate aminotransferase) and histopathological examination. Intoxication had neither influence on concentrations of vitamin E and selenium-dependent glutathione peroxidase in plasma and different organs nor on contents of fatty acids in skeletal muscles. No signs of increased lipid peroxidation in muscle tissue could be found. Prophylactic application of vitamin E or selenium one day before administration of salinomycin as well as treatment on the following days produced no protective effects. The treated pigs showed equal clinical and pathomorphological alterations as the untreated animals, although applications caused a significant increase of alpha-tocopherol and glutathione peroxidase concentrations in blood and different organs.

Topics: Animals; Anti-Bacterial Agents; Poisoning; Pyrans; Selenium; Swine; Swine Diseases; Vitamin E

Topics: Animal Feed; Animals; Diagnosis, Differential; Diterpenes; Poisoning; Pyrans; Swine; Swine Diseases

Topics: Animals; Anti-Bacterial Agents; Diterpenes; Drug Combinations; Poisoning; Pyrans; Swine; Swine Diseases