salinomycin has been researched along with Clostridium-Infections* in 3 studies
2 trial(s) available for salinomycin and Clostridium-Infections
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Effect of salinomycin in the control of Clostridium perfringens type C infections in sucklings pigs.
The ability of salinomycin to control Clostridium perfringens type C infection in sows and their offspring was examined under field conditions. Two groups of sows and their offspring were offered feed either medicated with 60 ppm salinomycin or free of antibiotics, and their performance was compared. The number of piglets with diarrhoea, the duration of the diarrhoea, and the mortality of the piglets during the lactation period were markedly lower in the group given salinomycin. In addition, laboratory examinations showed that the numbers of carrier piglets and sows were reduced after treatment with Salinomycin. Finally, the sows treated with salinomycin lost less weight during the lactation period and weaned more and heavier piglets than the untreated sows. It was concluded that salinomycin incorporated in the diet can be used for controlling C perfringens type C infection in sows and their offspring. Topics: Animals; Animals, Suckling; Anti-Bacterial Agents; Clostridium Infections; Clostridium perfringens; Female; Pyrans; Swine; Swine Diseases; Treatment Outcome | 1996 |
The effect of salinomycin on the control of Clostridium perfringens type-A infection in growing pigs.
Salinomycin (SAL), an ionophorous polyether antibiotic with growth promoter properties in pigs, has proved to be effective in controlling swine dysentery, porcine intestinal adenomatosis, and porcine haemorrhagic enteropathy. This study examines the ability of SAL to control C. perfringens type-A infection in growing pigs under field conditions. For 2 months, two groups of weaned pigs were offered feed either free of antibiotics, or medicated with 60 ppm and 30 ppm SAL for the first and second month respectively, and were compared with regard to their performance. The results showed that, whilst treatment did not have an effect on the mortality of pigs, the duration of pig diarrhoea during the trial period has been markedly reduced in the SAL group. Laboratory examinations have additionally shown that the number of carrier piglets has been reduced by SAL medication. Finally, treated pigs gained more weight and had a better feed-conversion ratio than untreated pigs during the 2-month trial period. It was concluded that SAL at the registered dose range, used as performance enhancer, can be helpful in controlling C. perfringens type-A infection in growing pigs. Topics: Animals; Anti-Bacterial Agents; Clostridium Infections; Clostridium perfringens; Diarrhea; Dose-Response Relationship, Drug; Female; Male; Pyrans; Swine; Swine Diseases | 1995 |
1 other study(ies) available for salinomycin and Clostridium-Infections
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Effects of salinomycin and Bacillus subtilis on growth performance and immune responses in broiler chickens.
The present study was undertaken to compare the effect of salinomycin and Bacillus subtilis on growth performance, serum antibody levels against Clostridium spp. and Eimeria spp., and cytokine mRNA expression levels in broiler chickens raised in the used litter. Broiler chickens fed a diet containing salinomycin showed lower (P < 0.05) body weights compared with the control diet-fed counterparts. Serum nitric oxide levels were significantly (P < 0.05) elevated in chickens fed the B. subtilis-enriched diet compared with those on either the salinomycin-fed or control diet-fed chickens. None of the dietary treatments affected (P > 0.05) serum antibody levels against Clostridium perfringens toxins. Both salinomycin and B.subtilis significantly lowered (P < 0.05) the serum levels of Eimeria-specific antibodies compared with the control group. Salinomycin, but not B. subtilis, significantly modulated (P < 0.05) the expression of cytokines encoding interferon-γ (IFN-γ), interleukin10 (IL-10) and tumor necrosis factor superfamily 15 (TNFSF15) compared with the control group. In conclusion, dietary salinomycin and B. subtilis affected serum anticoccidial antibody and intestinal cytokine expression, but failed to improve growth performance in broiler chickens. Further study is warranted to investigate the mode of action of salinomycin on host immune response and growth performance in broiler chickens. Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Antibodies, Protozoan; Bacillus subtilis; Body Weight; Chickens; Clostridium; Clostridium Infections; Coccidiosis; Cytokines; Dietary Supplements; Eimeria; Female; Poultry Diseases; Probiotics; Pyrans | 2014 |